Gene AqueK398 (A.queenslandica)

AqueK398

Species: A.queenslandica
Alias: AqueK398
External Links:
Annotation:

Classification

Group: TK
Family: REF

Sequence

Name Sequence Type Origin Length Description Download
AqueK398.AA Protein None 1187 None Fasta, JSON
AqueK398.kin_dom Protein Kinase Domain None 323 None Fasta, JSON

Protein domain

Protein domains of AqueK398.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK398.AA TyrKc 744-1066 31 1.6e-126 427.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-280/280
Sequence Identity: 31% (112 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKG-NNPHVVNMIGCVTIQ-------EPLCLI
.. .| ||||.||||..|. |                   ||.| ||. |    ..||..|.. |. .  | ..|..|...|..| |       |||...
ITLGKKLGEGAFGEVYKGTWK-----------------IQVAVKMLKEDA----REDFMREARIMCKL--GGHHPNIVRLYGVCTQQGRNFMYIEPLMIV

TEFVKHGDLLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLASLGIVHRD
.|...||||..||.. |.                                                     .    ||||..|||.|||.|.| ...|||
MEYMPHGDLKDYLRKHRPK----------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRD

LACRNILVDDGKSLKISDFGMSRLVAAN-------DVYIKNT--RGR--MPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGFPYPT-----ITNS
||.||.||....  ||||||.|| .          |.| | .   |.  .| .|||.|.|  ..|||.||||..||..||| |.|. |||      ..|.
LAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ

ELLEHLQKGIRLEKPEN--------CSEDVYKIMLECWKSDPSERLSFTALRAKF
|..|....| |...|.|        |....|.||..||. ||..| .|.... .|
EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK398.AA Pkinase_Tyr 744-1066 32 2e-126 428.8 Pfam 1-270 (270) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-270/270
Sequence Identity: 32% (109 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSE--KMDFLQEIETMKCVAKGNNPHVVNMIGCVT-IQEP--LCLITEF
..  | ||||.||||..|. ||           .   .  ||.| || .|. ..  . ||..|...||    |..|..|...|..|  .||  .....|.
ITFGKKLGEGAFGEVYKGTWKG----------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL--GHHPNIVRLYGVCTDQGEPNQIYIVMEY

VKHGDLLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLASLGIVHRDLAC
..|||||.||.. |                                                 .. . ..   ||....|||.|||.|.| ...|||||.
MPHGDLLDYLRKHR-------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

RNILVDDGKSLKISDFGMSRLVAANDVY-IKNTRGRMPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGFP-YPTITNSELLEHL-QKGIRLEKPE
||.||....  ||.|||..|..   | |  | . |..| |||| |.| ...|||.||||..||..||| |.|. | || ..|.|..|.. ..| |...||
RNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPE

NCSEDVYKIMLECWKSDPSERLSFTALRAKF
||....|..|..||. ||..| .|.... ..
NCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK398.AA TK 744-1066 20 1.1e-111 375.86 In-house 1-486 (486) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-486/486
Sequence Identity: 20% (110 aa)

VVVEKRLGEGCFG---EVFQGVVKGPINNSKVQASF-----------KNAICPVVAIKLLKSTASGSEKM-------------DFLQEIETMKCVA--KG
....| |||| ||   ||..| ..|.. .   ...            |.  .  ||.| ||.... |...             |||.| | ||     .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NNPHVVNMIGCVTIQ------------EPLCLITEFVKHGD----LLSYLQSIRK---------------------------------------------
. |..|...|..| .            ||.....|...|||    |..||.. |.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------MIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLASL-----
                   | ....  .                                          . ..   || ...|||.|||.|.|.     
DDDLIKDHPPPLTTKDLLQMAWQWC-LT----------------------------------------CKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI

-GIVHRDLACRNILVDDGKS-----------LKISDFGMS--------RLVAANDVYIKNT------------------------RGRMPWKWMAIESIT
 ..||||||.||.||....             ||.|||.|        | .  .| | . .                        .|..| .||| |...
QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN

NRE---------FTTASDVWAYGVTLWEIATLG-GFPYPTITN---------SELLEHLQKG--------------IRLEKPENCS--------------
 |.         |||.||||..||..||| |.| . .|. ..|          |..|.|..|               |...|..|.              
DRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPP

EDVYKIMLECWKSDPSERLSFTALRAKF
|..| .|..||. ||..| .|..|. ..
EEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK398.AA TK-Unique 744-1066 34 2.6e-102 346.23 In-house 1-294 (294) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-294/294
Sequence Identity: 34% (119 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICP-VVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVT-IQEPLCLITEFVKH
..|....||| ||.|. | |.|..         |.   . .||.|.||  |.. .|.|||.||. ||  ..|  |..|...|| |  .|| ..| |..  
LEVGDVIGEGAFGQVWRGEVWGIW---------KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMK--ELGDHPNIVQCLGCCTKSDEPWMIIMEYCPC

GDLLSYLQSIRKM---------IAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLAS--LG
|.|..||.. |.          .                                    .. ..||.|  |  .|..  |..||.|||.|||.|||   .
GNLQHYLRTCRPAMRQHQTYGNLK----------------------------------FDFHHMPDKPRTE--PISPKDLYHFAWQIACGMEYLASQRKK

IVHRDLACRNILVDDGKSLKISDFGMSRLVAANDVYIKN-TRGRMPWKWMAIESIT--NREF-TTASDVWAYGVTLWEIATLGGFPYPTITNSELLEHLQ
||||||. ||.|. ..| .||.||||.| | .| ||... ..||.| .||| ||.    . . || ||||..||..|||.|||..||| . .....|...
IVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR

KGIRLEKPENC-SEDVYKIMLECWKSDPSERLSFTALRAKF
.| |...||.| |...|..| .||...|.|| ||.... ..
DGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK398.AA UTK 744-1066 28 2.1e-91 309.97 In-house 1-296 (296) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-296/296
Sequence Identity: 28% (100 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMD----FLQEIE---TMKCVAKGNNPHVVNMIGCVTIQEPLCLIT
|   ..||.| ||||. . .. . . ....         .||.| ....|..  ...    |. |      ||...    |.|....| .| .||....|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEM---------DVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH--WHPNVLRLVGVCTQEEPWMIVT

EFVKHGDLLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVN---LLSFAYQIASGMEFLASLGIVH
|. . |||.|||.. |.                                                   .. ....   .|..|..||.||..|.| |.||
EYMENGDLRSYLRRHRPTPP------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVH

RDLACRNILVDDG-------KSLKISDFG---MSRLVA---------ANDVYIKNTRGRMPWKWMAIESITNR-EFTTASDVWAYGVTLWEIATLGGFPY
||||.||.||..         . ||.|||   |||.|.           . | .. ..|.|..||| |..|..  |||.||||..||..||| | |  ||
RDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPY

PTITNSELLEHLQKG--IRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKF
| ..| .... . .|   |...|. |...||..|..||..||.|| .|  |....
PGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK398.AA VEGFR 748-1066 33 4.6e-91 308.85 In-house 5-332 (332) Show / Hide 
Range on Protein: 748-1066
Range on HMM: 5-332/332
Sequence Identity: 33% (116 aa)

KRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTI---QEPLCLITEFVKHGDL
| ||.| || | ... .| |.        | . | .|| | ||..|  ||.   . |.. .. . .  |  |||. ||.|.   . ||  | |....| |
KMLGRGAFGQVHEASAFG-IR--------KMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLN--VVNFLGCCTKNIQKGPLMVIVEYCCFGNL

LSYLQSIRKM-IAYR---------------QNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVS--VPDGPYSELGE--IDSVNLLSFAYQIASGME
..|| . |.   .|                | ... . ...|  |.       |.   .   | ...   ||  .... .  .... |.....|.| |||
SNYLRTKRMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSF------QSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGME

FLASLGIVHRDLACRNILVDDGKSLKISDFGMSRL-VAANDVYIKNTR-GRMPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGFPYPTIT-NSEL
||||  ..||||| ||||..  . .||.||| .|     .. | . .. || | ||||.|||  . .|| ||||.||| |||| .||| |||..  . |.
FLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEF

LEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKF
   |  | |...|. |   .|.|||.||  .| || .| .|  ..
CNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase AqueK398.AA Src 744-1066 30 3e-80 272.34 In-house 1-255 (255) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-255/255
Sequence Identity: 30% (98 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVKHGD
.  ...||.|.||||..|. .| ..               ||.| ||.     .  .||||...|| .     ...|..   ..  ||   .||. .|| 
IKLCRKLGQGQFGEVWMGYWNGNTK---------------VAVKTLKPGT--MSPEAFLQEAQIMKKLRH---EKLVQLYAVCSQEEPIYIVTEYMSHGS

LLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLASLGIVHRDLACRNILV
|| ||.                                                    .| ...   .|...| |.|.||..| |  ..||||| ||.||
LLDYLKK--------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLV

DDGKSLKISDFGMSRLVAAN-DVYIKNTRGRMPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGFPYPTITNSELLEHLQKGIRLEKPENCSEDVY
...   |. |||  ||.  . |.|   .  ..|.||.| | |. . ||. |||| .|. |.|| | |  |||  || | |.....| |. .|.|| . .|
GENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELY

K-IMLECWKSDPSERLSFTALRAKF
. |||.||..|| .|  |  |. ..
EQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK398.AA FGFR 912-1066 50 3.5e-75 255.7 In-house 138-293 (293) Show / Hide 
Range on Protein: 912-1066
Range on HMM: 138-293/293
Sequence Identity: 50% (79 aa)

LLSFAYQIASGMEFLASLGIVHRDLACRNILVDDGKSLKISDFGMSRLVAANDVYIKNTRGRMPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGF
| |.|||.| |||.|||  ..||||| ||.|| |.  .||.||| .| .  .| | |.| || | |||| |.   | .|. |||| ||| |||| |.|| 
LVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQ

PYPTIT-NSELLEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKF
|||.|    || . |. | |.|||.|||...| .| .||.  |..| .|. |   .
PYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK398.AA Ret 912-1068 48 7.2e-71 241.29 In-house 137-293 (293) Show / Hide 
Range on Protein: 912-1068
Range on HMM: 137-293/293
Sequence Identity: 48% (76 aa)

LLSFAYQIASGMEFLASLGIVHRDLACRNILVDDGKSLKISDFGMSRLVAANDVYIKNTRGRMPWKWMAIESITNREFTTASDVWAYGVTLWEIATLGGF
..||| ||  || .|... .|||||| ||.|| .|. .|||||| .| |   | |.|  ..| | |||||||     .|| |||| .|| .||| |.|. 
IISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGAN

PYPTITNSELLEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKFDS
||| |.   | . |  | | . |||||| .|.||. |||  |  | .|  .   |  
PYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase AqueK398.AA KIN6 912-1066 41 9.3e-70 229.66 In-house 146-305 (305) Show / Hide 
Range on Protein: 912-1066
Range on HMM: 146-305/305
Sequence Identity: 41% (67 aa)

LLSFAYQIASGMEFLASLGIVHRDLACRNILVDDGK---SLKISDFGMSRLVAANDVYIKNTRGR-MPWKWMAIESITNREFTTASDVWAYGVTLWEIAT
|..||.||. |||.|.| ...||||| ||.||. |    . ||||||. |.  .     .   ||  | |||| |..   || . |||| .|| ..|. .
LYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFS

LGGFPYPTIT-NSELLEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKF
||. |||..    |..||. .| |...|..|.| .|.||  || ..|..|  |. .| .|
LGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase AqueK398.AA EGFR 905-1067 43 5.6e-66 217.99 In-house 96-258 (258) Show / Hide 
Range on Protein: 905-1067
Range on HMM: 96-258/258
Sequence Identity: 43% (71 aa)

GEIDSVNLLSFAYQIASGMEFLASLGIVHRDLACRNILVDDGKSLKISDFGMSRLVAANDVYIKNTRGRMPWKWMAIESITNREFTTASDVWAYGVTLWE
..| | .|| ...|||.||..|    .|||||| ||.||   .  || |||...|  ...  ..   |.|| ||||.|.| .| .| .||||.||||.||
DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWE

IATLGGFPYPTITNSELLEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKFD
. | |. ||  |  .|  . |.|| ||. |..|. ||| .|. ||  |.  |  |  | ..|.
LMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK398.AA RTKB 899-1066 39 7.5e-64 214.14 In-house 98-264 (264) Show / Hide 
Range on Protein: 899-1066
Range on HMM: 98-264/264
Sequence Identity: 39% (67 aa)

GPYSELGEIDSVNLLSFAYQIASGMEFLASLGIVHRDLACRNILVDDGKSLKISDFGMSRLVAANDVYIKNTRGRMPWKWMAIESITNREFTTAS-DVWA
.. .. . . . .|..|. |||.|| || . ...||||. ||.||| . . ||.||||.| .   ..  . |  |.| ||||.||.  | .|| | |||.
ASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECY--ETTCTRLPIKWMAPESWAHRIYTTKSGDVWS

YGVTLWEIATLGGFPYPTITNSELLEHLQKGIRLEKPENCSEDVYKIMLECWKSDPSERLSFTALRAKF
.||| ||| .||| ||..  | .....| .| ||.||.  .  .. ||  ||  ....| .|..| . |
FGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase AqueK398.AA Pkinase 744-1066 18 1.1e-31 113.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 744-1066
Range on HMM: 1-293/293
Sequence Identity: 18% (68 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEK--MDFL-QEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVK
 ......|.| ||.|.... ||                 .||.| .|     |.|   ... .||. || . .  |  .| ......    .....|.. 
YHIGRKIGSGSFGCVYKCHHKGTGK--------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPN--IVRLYDWFEDKDHIYMVMEYCE

HG----DLLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEI--DSVNLLSFAYQIASGMEFLASLGIVHR
.|    || .|..                                                    .. | .  .   . ...|||..|.|.. | ||.||
GGLYVMDLFDYIST---------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR

DLACRNILVDDGKSL----KISDFGMSRLV-AANDVYIKNTRGRMPWKWMAIESIT-NREFTTASDVWAYGVTLWEIATLGGFPYPTI----TNSELLEH
||   |||.|.   .    ||.||| ....   |..   .|.   || .|| | |  ... ....|.|..|..|.| .. | .|.|      .  . .. 
DLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPW-YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQM

LQKGIRLEKPENCS-----------------------EDVYKIMLECWKSDPSERLSFTALRAK--F
...  . . .....                       |.  ...  |.. ||..|.... .     |
ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK398.AA S_TKc 744-1070 18 2.3e-30 108.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 744-1070
Range on HMM: 1-231/231
Sequence Identity: 18% (61 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVKH--
  . . .|.| ||.|.... |.                 .|||| .|         ....||. .|     . |..|.....    . |....|.. .  
YEILRKIGKGAFGKVYKCRHKK--------------TGRIVAIKIIK--------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDL

GDLLSYLQSIRKMIAYRQNQASNSAKTGSKASDPNPYMIPSLEVDSPSRKSVVSVPDGPYSELGEIDSVNLLSFAYQIASGMEFLASLGIVHRDLACRNI
|||..|... ..   ...                                               ..     ...|||....|.. |.||.||||   ||
GDLFDYIKKRGRHGLRFP-----------------------------------------------FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENI

LVDDGKSLKISDFGMSRLVAANDVYIKNTRGRMPWKWMAIESITNREFTT-ASDVWAYGVTLWEIATLGGFPYPTITNSELLEHLQKGIRLEKPENCSED
|.|.   .||.|||..|..         |       .|| | .    ... ..|.|. |..|.| .. |  |.|  .  ......            |..
LLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPE

VYKIMLECWKSDPSERLSFTALRA-----KFDSLI
.  ..  |.. ||..|..   . .     | .  .
AKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK398.AA KIN6 744-855 32 6.1e-25 79.19 In-house 1-116 (305) Show / Hide 
Range on Protein: 744-855
Range on HMM: 1-116/305
Sequence Identity: 32% (39 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASF-------KNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLIT
.. .. ||.| |. |. | .|| .  ...  .         .  |. .|.| | | |   .. ||..||. ||    | .||.||| ||||  ...||. 
IHKDHKLGHGAFCNVYKGKIKGKSPIMQWINRVNMRIEMMRYQDCQ-CAVKMLPSHADEMAHHDFMHEIAFMKQL--GHHPHLVNMLGCVTNSYKPCLVV

EFVKHGDLLSYLQSIRKMI
|.  |.||| ||. ... .
EYCCHMDLLKYLRNRCQYM
Kinase AqueK398.AA FGFR 743-852 33 1e-16 53.46 In-house 1-100 (293) Show / Hide 
Range on Protein: 743-852
Range on HMM: 1-100/293
Sequence Identity: 33% (37 aa)

LVVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVKHG
|... | |||||||.|  . .|| | ... ..         ||.| ||. ..  .  |   |.|.|| .  | .. ..| .|| | . ||  | |. .||
LTLG-KMLGEGCFGQVWMAEAKG-IDCDRPEKEI------TVAVKMLKMNHTDKDLSDLVSEMEMMKMI--GKHKNIINLLGCCTQEGPLYVIVEYCHHG

DLLSYLQSIR
 |  .|.. |
NLRDFLRARR
Kinase AqueK398.AA Ret 784-857 38 1.5e-09 28.69 In-house 32-106 (293) Show / Hide 
Range on Protein: 784-857
Range on HMM: 32-106/293
Sequence Identity: 38% (30 aa)

VAIKLLKST-ASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQE--PLCLITEFVKHGDLLSYLQSIRKM-IAY
||.| ||   |. || .| | | .  | |   | |||.   |  . ..  |.||| |. | | | ..|   ||   .|
VAVKMLKRNTANSSEYHDLLSEFQLLKQV---NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSRKIGPYY
Kinase AqueK398.AA RTKB 744-852 35 4.8e-09 26.66 In-house 1-97 (264) Show / Hide 
Range on Protein: 744-852
Range on HMM: 1-97/264
Sequence Identity: 35% (39 aa)

VVVEKRLGEGCFGEVFQGVVKGPINNSKVQASFKNAICPVVAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVKHGD
|   . ||.| ||||||. |. .  | . |.         .| | ||  ||  |. ||..|.  || .  |  |.|. .||     ||. |  |.  .| 
VWLGEKLGNGAFGEVFQAWVRNRHMN-TEQS---------CAAKVLKPGASYEERQDFCSEMTVMKEL--GWHPNVIGIIGHCLQDEPYILLVELCELGN

LLSYLQSIR
|  ||   |
LRDYLRMCR
Kinase AqueK398.AA EGFR 784-855 27 2.3e-05 13.56 In-house 31-98 (258) Show / Hide 
Range on Protein: 784-855
Range on HMM: 31-98/258
Sequence Identity: 27% (20 aa)

VAIKLLKSTASGSEKMDFLQEIETMKCVAKGNNPHVVNMIGCVTIQEPLCLITEFVKHGDLLSYLQSIRKMI
|||| |. . . . . ..|.|   |  |   ..||.| ..|    .. . |.| .  .| || |..  .  |
VAIKVLREQTGPKANEEMLDEAYVMASV---DHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNI
Kinase AqueK398.AA EGFR 744-762 42 0.00765 5.07 In-house 1-19 (258) Show / Hide 
Range on Protein: 744-762
Range on HMM: 1-19/258
Sequence Identity: 42% (8 aa)

VVVEKRLGEGCFGEVFQGV
.   | || | || |. |.
LKKVKVLGSGAFGTVYKGI
Kinase AqueK398.AA Ret 744-761 38 0.040766 2.97 In-house 1-18 (293) Show / Hide 
Range on Protein: 744-761
Range on HMM: 1-18/293
Sequence Identity: 38% (7 aa)

VVVEKRLGEGCFGEVFQG
 . .. |||| || |  .
LQLDDTLGEGHFGQVVKA