Gene AqueK404 (A.queenslandica)

AqueK404

Species: A.queenslandica
Alias: AqueK404
External Links:
Annotation:

Classification

Group: TK
Family: Ryk

Sequence

Name Sequence Type Origin Length Description Download
AqueK404.AA Protein None 245 None Fasta, JSON
AqueK404.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of AqueK404.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK404.AA Ryk 26-234 42 7.6e-71 223.19 In-house 95-292 (292) Show / Hide 
Range on Protein: 26-234
Range on HMM: 95-292/292
Sequence Identity: 42% (91 aa)

DLEQPMLLYPKSS-FGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHEN---LHVKIGDRGLSWDF
| . |. .||  . .| ||  | . |    .  .....   . ||||.||    |.. || || ... ||||.| || .| |    | ||| |  || | 
DHDPPFVCYPHMNNWGNLKQFLQDCR----H-DKPKCH---QAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRDL

YPEDYNTI---EERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWA
 | ||.     | |          |||||. | |  | ||. |||||||| .|| || |..||... |. | .||  | ||.|| |||| ||  |  ||.
FPMDYHCLGDNENR----------PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWH

LTPSDRPRFSHLTVRL
. | .|| |. |   |
CMPEERPTFQQLVQCL
Kinase AqueK404.AA Pkinase_Tyr 68-234 42 3e-65 221.6 Pfam 108-270 (270) Show / Hide 
Range on Protein: 68-234
Range on HMM: 108-270/270
Sequence Identity: 42% (72 aa)

ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFG
....||. .. |.|.|| .| .|. .| |||.||. ..||..|||.| ||. | |..||  .  ||||       |.|||| |......... |||||||
LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKL-----PIKWMAPECINYGKFTTKSDVWSFG

VVLWEIMTRGKTP-YEDVLPENMLNYL-TTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL
|..|||.|.|..| |... .| ...|.   |.|.|.|.||||.. .||  ||.  |.|||.|| .  .|
VLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK404.AA TK 40-234 21 5.7e-63 209.64 In-house 140-486 (486) Show / Hide 
Range on Protein: 40-234
Range on HMM: 140-486/486
Sequence Identity: 21% (75 aa)

GT----LKTLLLKTREGGGI---MLPGNNSGQCTY---------------------------------------------------------ISTHDLVF
|     |.. | | |...       ........ .                                                         ...|.|. 
GDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-

ISEQVARGMYHLTRK------GQVHKDLACRNIYIHENLH-----------VKIGDRG--------LSWDFYP-EDYNTIEERGG-----------GGDE
.. |.|.|| .| .|      . || |||.||. ..||..           .||.| |        |. | |. .|| . ...|.           . |.
MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDY

TIA-----YPVKWMAAEVLS---------DKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLP----------ENMLNYLTTG--------------HRLP
. .      |..||| |.|          ...... ||||||||..|||.|.|..||   ..          . ...||..|              .|.|
YRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMP

QPKNCP--------------DDLFSLMGWCWALTPSDRPRFSHLTVRL
||..||              .... ||  ||.. |.|||.|| |  .|
QPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK404.AA TK-Unique 23-234 31 6e-57 194.89 In-house 73-294 (294) Show / Hide 
Range on Protein: 23-234
Range on HMM: 73-294/294
Sequence Identity: 31% (71 aa)

TVKDLEQPMLLYPKSSFGTLKTLLLKTREG--GG-------IMLPGNNSGQCTY-ISTHDLVFISEQVARGMYHLTR--KGQVHKDLACRNIYIHENLHV
..|. |..|....  . |.| ..| ..| .  ..       . .. ..... |. || .||. .  |.|.|| .| .  |. ||.||. ||. . |.. .
CTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVC

KIGDRGLSWDFY-PEDYNTIEERGGGGDETIAYPVKWMAAEVLS--DKRY-SSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNC-
||.| |.. | | ...|......|         |..||| |.|.  .. | .. ||||||||..|||.| |..|| .. ...... .. |.|.|||..| 
KICDFGMARDVYTNGVYSMMCSQGRI-------PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCC

PDDLFSLMGWCWALTPSDRPRFSHLTVRL
......||  || . |..|| |. .. ||
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK404.AA Met 79-228 42 2.3e-55 179.86 In-house 112-271 (271) Show / Hide 
Range on Protein: 79-228
Range on HMM: 112-271/271
Sequence Identity: 42% (70 aa)

QVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDF-YPEDYNTIEERGGGGDETI--AYPVKWMAAEVLS--------DKR-YSSSSDVWSF
|||.||  .  .  || ||||||  . | . ||..| ||. |  |   |   .      ..|     |||||| | |         . | ... ||||||
QVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQM------HHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSF

GVVLWEIMTRGKTPYEDVLP-ENMLNYLTTG--HRLPQPKNCPDDLF-SLMGWCWALTPSDRPRFS
|||.|| |||| .|| .| .    . .| .|   |||||  ||| |   .|  ||  .| ||| ||
GVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK404.AA UTK 23-234 28 3.3e-51 173.41 In-house 78-296 (296) Show / Hide 
Range on Protein: 23-234
Range on HMM: 78-296/296
Sequence Identity: 28% (66 aa)

TVKDLEQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHEN-------LHVKIGDR
.. . |..|...   . | | ..| . |.  .        .. .. . |...  . ..|||| .| ..| || |||.||...|..       . .||.| 
VCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADF

G---LSWDFYPEDYNTIEERGGGGDETIA-----YPVKWMAAEVLSDK-RYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTG--HRLPQPKN
|   .| . . .   .   | .. ..  |      |..||| |.| .  |....|||||||||.|||.|.|..||..   .. .  .. |  .|.|.|. 
GRGGMSRRVNTFH-FSN--RYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWD

CPDDLFSLMGWCWALTPSDRPRFSHLTVRL
||.... ||  ||. .|..||.|  |. ..
CPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK404.AA Axl 25-232 41 1.8e-49 170.68 In-house 77-267 (267) Show / Hide 
Range on Protein: 25-232
Range on HMM: 77-267/267
Sequence Identity: 41% (86 aa)

KDLEQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPE
. . .|| . |   .| | | ||  | |           |  |. .  ||     .| ||  |  .  .|.||| ||  ..|.. | . | |||   |  
QRIPKPMVILPFMKHGDLHTFLLYSRLG----------DQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSG

DYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDR
||     | |        ||||.| | | |. | | ||||.||| .|||||||.|||  |  . | .||  |||| ||..| |.|. ||  || . | ||
DYY----RQG---CIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDR

PRFSHLTV
| || |  
PSFSVLRE
Kinase AqueK404.AA EGFR 68-235 36 4.2e-49 161.07 In-house 98-258 (258) Show / Hide 
Range on Protein: 68-235
Range on HMM: 98-258/258
Sequence Identity: 36% (62 aa)

ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFG
|  ..|.  . |.|.||. |  .  || ||| ||. .    |||| | ||. .. . | . ..  ||        |.|||| |... ..| . |||||.|
IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLA-KLLEHDEKEYHAQGG------KMPIKWMALECIHHRCYTHQSDVWSYG

VVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRLK
| .||.|| |. ||. .  ..  . |  | |||||..|  |.. .|  || . .  ||.|  |. ..|
VTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
TyrKc AqueK404.AA TyrKc 2-234 28 6.7e-48 166.36 SMART 16-280 (280) Show / Hide 
Range on Protein: 2-234
Range on HMM: 16-280/280
Sequence Identity: 28% (84 aa)

YEGYLTNAEDDVEGAIPVIIKTVK---------------DL------------------------EQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNS
|.| ..         |.| .|..|                |                        |..|..    . | ||  | |.|.           
YKGTWK---------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----------

GQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPE-------DYNTIEERGGGGDETIA-YPVKWMAAEVLSD
     ... ||. .. |.|.|| .| .|. .| |||.||. ..||..|||.| ||| | | .       || .  |..||     .  |..||| |.. .
-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG----KTMLPIRWMAPECINY

KRYSSSSDVWSFGVVLWEIMTRGKTPYED-----VLPENMLNYLTTGHRLPQPKN--------CPDDLFSLMGWCWALTPSDRPRFSHLTVRL
..... ||||||||..|||.|.|..||..     . .. ...|. .|.|.|||.|        |||.....| .||.  |.|||.|| .  ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK404.AA Src 62-234 34 9.6e-45 149.92 In-house 88-255 (255) Show / Hide 
Range on Protein: 62-234
Range on HMM: 88-255/255
Sequence Identity: 34% (60 aa)

SGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFY--PEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSS
.|.. ...  .|. .. |||.||  | ..  .| ||| ||. . ||. .|..| ||   .    . |.  .            |.||.| | ..  |.. 
DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--------GAKFPIKWTAPEAINYGRFTI

SSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFS-LMGWCWALTPSDRPRFSHLTVRL
 |||||||. |.||.|.|..||.    .  |  .  | |.|.|.|||| |.  .|  ||  .| .|| |  |   |
KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK404.AA Frk 73-238 36 1e-43 149.2 In-house 100-260 (260) Show / Hide 
Range on Protein: 73-238
Range on HMM: 100-260/260
Sequence Identity: 36% (61 aa)

LVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWE
|| .. ||| ||  |  .  .|.||| ||. . |.. .|| | ||   .  .. .  | | |     . .|.|| | |    ....  |||||||..| |
LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHG-----ARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

IMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRLKEFY
|.| |. ||  .   ..|. .  | |.||| |||  |...|  ||   |  || |  |  .|....
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase AqueK404.AA FGFR 143-234 46 1.1e-39 132.86 In-house 201-293 (293) Show / Hide 
Range on Protein: 143-234
Range on HMM: 201-293/293
Sequence Identity: 46% (43 aa)

PVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVL-PENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL
|.|||| | | |. | . |||||.|| |||||| | .||  ..  | .  || .|||.  |.||. ... .|  ||   |..|| |  |   |
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase AqueK404.AA Pkinase 66-225 21 2.1e-16 59.07 Pfam 101-282 (293) Show / Hide 
Range on Protein: 66-225
Range on HMM: 101-282/293
Sequence Identity: 21% (41 aa)

TYI--STHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHV----KIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLS-DKRYS
. .  | ... |.  |..||.... ..| .| ||   || |..| |.    ||.| ||.  |.        .  ..   |..    .|| ||.  .. |.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

SSSDVWSFGVVLWEIMTRGKTPYEDV-------LPENMLNYLTTGHRLPQPKNCP-------------------DDLFSLMGWCWALTPSDRP
...|.||.|..|.| .. |..|. .          . . . . .  . . |. |.                   ... ... ||... |..||
PKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
S_TKc AqueK404.AA S_TKc 2-238 15 5.4e-11 -15.66 SMART 16-231 (231) Show / Hide 
Range on Protein: 2-238
Range on HMM: 16-231/231
Sequence Identity: 15% (42 aa)

YEGYLTN---------------------AEDDVEGAIPVIIKTVKDLEQPMLLYPKSSF--GTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISE
| .. ..                      .      |  .. .  | .   .     .   |.|.... | . .|.          . ...  .  |.  
YKCRHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL----------RFPFPE-HARFYMY

QVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSS-SSDVWSFGVVLWEIMTRG
|..... .. ..| .| ||   || . |  |.||.| ||.  .                 |.     .|| |||    |.  ..|.||.|..|.| .. |
QICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-G

KTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTV-----RLKEFY
..|..   .. |.. .            .... ...  |.   |..||    .       .. .. 
YPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK404.AA FGFR 68-126 40 4.8e-09 26.9 In-house 133-191 (293) Show / Hide 
Range on Protein: 68-126
Range on HMM: 133-191/293
Sequence Identity: 40% (24 aa)

ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDY
..  ||| .  ||||||  |  .  .| ||| ||. . ..   || | ||. |    ||
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDY