Gene AqueK405 (A.queenslandica)
AqueK405
Species: A.queenslandica
Alias: AqueK405
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK405.AA | Protein | None | 223 | None | Fasta, JSON |
| AqueK405.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of AqueK405.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK405.AA | Ryk | 3-212 | 41 | 4e-71 | 224.1 | In-house | 94-292 (292) | Show / Hide |
Range on Protein: 3-212 Range on HMM: 94-292/292 Sequence Identity: 41% (91 aa) SDLEQPMLLYPKSS-FGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHEN---LHVKIGDRGLSWD .| . |. .|| . .| || | . | . ..... . ||||.|| |.. || || ... ||||.| || .| | | ||| | || | EDHDPPFVCYPHMNNWGNLKQFLQDCR----H-DKPKCH---QAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRD FYPEDYNTI---EERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCW | ||. | | |||||. | | | ||. |||||||| .|| || |..||... |. | .|| | ||.|| |||| || | || LFPMDYHCLGDNENR----------PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCW ALTPSDRPRFSHLTVRL .. | .|| |. | | HCMPEERPTFQQLVQCL |
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| Kinase | AqueK405.AA | Pkinase_Tyr | 46-212 | 42 | 3e-65 | 221.6 | Pfam | 108-270 (270) | Show / Hide |
Range on Protein: 46-212 Range on HMM: 108-270/270 Sequence Identity: 42% (72 aa) ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFG ....||. .. |.|.|| .| .|. .| |||.||. ..||..|||.| ||. | |..|| . |||| |.|||| |......... ||||||| LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKL-----PIKWMAPECINYGKFTTKSDVWSFG VVLWEIMTRGKTP-YEDVLPENMLNYL-TTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL |..|||.|.|..| |... .| ...|. |.|.|.|.||||.. .|| ||. |.|||.|| . .| VLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | AqueK405.AA | TK | 18-212 | 21 | 5.7e-63 | 209.64 | In-house | 140-486 (486) | Show / Hide |
Range on Protein: 18-212 Range on HMM: 140-486/486 Sequence Identity: 21% (75 aa) GT----LKTLLLKTREGGGI---MLPGNNSGQCTY---------------------------------------------------------ISTHDLVF | |.. | | |... ........ . ...|.|. GDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL- ISEQVARGMYHLTRK------GQVHKDLACRNIYIHENLH-----------VKIGDRG--------LSWDFYP-EDYNTIEERGG-----------GGDE .. |.|.|| .| .| . || |||.||. ..||.. .||.| | |. | |. .|| . ...|. . |. MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDY TIA-----YPVKWMAAEVLS---------DKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLP----------ENMLNYLTTG--------------HRLP . . |..||| |.| ...... ||||||||..|||.|.|..|| .. . ...||..| .|.| YRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMP QPKNCP--------------DDLFSLMGWCWALTPSDRPRFSHLTVRL ||..|| .... || ||.. |.|||.|| | .| QPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | AqueK405.AA | TK-Unique | 6-212 | 31 | 1e-56 | 194.11 | In-house | 78-294 (294) | Show / Hide |
Range on Protein: 6-212 Range on HMM: 78-294/294 Sequence Identity: 31% (70 aa) EQPMLLYPKSSFGTLKTLLLKTREG--GG-------IMLPGNNSGQCTY-ISTHDLVFISEQVARGMYHLTR--KGQVHKDLACRNIYIHENLHVKIGDR |..|.... . |.| ..| ..| . .. . .. ..... |. || .||. . |.|.|| .| . |. ||.||. ||. . |.. .||.| EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDF GLSWDFY-PEDYNTIEERGGGGDETIAYPVKWMAAEVLS--DKRY-SSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNC-PDDLF |.. | | ...|......| |..||| |.|. .. | .. ||||||||..|||.| |..|| .. ...... .. |.|.|||..| ..... GMARDVYTNGVYSMMCSQGRI-------PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMY SLMGWCWALTPSDRPRFSHLTVRL .|| || . |..|| |. .. || NLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | AqueK405.AA | Met | 57-206 | 42 | 2.3e-55 | 179.86 | In-house | 112-271 (271) | Show / Hide |
Range on Protein: 57-206 Range on HMM: 112-271/271 Sequence Identity: 42% (70 aa) QVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDF-YPEDYNTIEERGGGGDETI--AYPVKWMAAEVLS--------DKR-YSSSSDVWSF |||.|| . . || |||||| . | . ||..| ||. | | | . ..| |||||| | | . | ... |||||| QVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQM------HHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSF GVVLWEIMTRGKTPYEDVLP-ENMLNYLTTG--HRLPQPKNCPDDLF-SLMGWCWALTPSDRPRFS |||.|| |||| .|| .| . . .| .| ||||| ||| | .| || .| ||| || GVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS |
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| Kinase | AqueK405.AA | UTK | 3-212 | 28 | 1.2e-50 | 171.54 | In-house | 80-296 (296) | Show / Hide |
Range on Protein: 3-212 Range on HMM: 80-296/296 Sequence Identity: 28% (66 aa) SDLEQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHEN-------LHVKIGDRG- .. |..|... . | | ..| . |. . .. .. . |... . ..|||| .| ..| || |||.||...|.. . .||.| | TQEEPWMIVTEYMENGDLRSYLRRHRPTPP--------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGR --LSWDFYPEDYNTIEERGGGGDETIA-----YPVKWMAAEVLSDK-RYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTG--HRLPQPKNCP .| . . . . | .. .. | |..||| |.| . |....|||||||||.|||.|.|..||.. .. . .. | .|.|.|. || GGMSRRVNTFH-FSN--RYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCP DDLFSLMGWCWALTPSDRPRFSHLTVRL .... || ||. .|..||.| |. .. HPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | AqueK405.AA | Axl | 5-210 | 41 | 1.9e-49 | 170.63 | In-house | 79-267 (267) | Show / Hide |
Range on Protein: 5-210
Range on HMM: 79-267/267
Sequence Identity: 41% (86 aa)
LEQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDY
. .|| . | .| | | || | | | |. . || .| || | . .|.||| || ..|.. | . | ||| | ||
IPKPMVILPFMKHGDLHTFLLYSRLG----------DQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDY
NTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPR
| | ||||.| | | |. | | ||||.||| .|||||||.||| | . | .|| |||| ||..| |.|. || || . | |||
Y----RQG---CIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPS
FSHLTV
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FSVLRE
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| Kinase | AqueK405.AA | EGFR | 46-213 | 36 | 4.2e-49 | 161.07 | In-house | 98-258 (258) | Show / Hide |
Range on Protein: 46-213 Range on HMM: 98-258/258 Sequence Identity: 36% (62 aa) ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFG | ..|. . |.|.||. | . || ||| ||. . |||| | ||. .. . | . .. || |.|||| |... ..| . |||||.| IGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLA-KLLEHDEKEYHAQGG------KMPIKWMALECIHHRCYTHQSDVWSYG VVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRLK | .||.|| |. ||. . .. . | | |||||..| |.. .| || . . ||.| |. ..| VTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK |
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| Kinase | AqueK405.AA | Src | 40-212 | 34 | 9.6e-45 | 149.92 | In-house | 88-255 (255) | Show / Hide |
Range on Protein: 40-212 Range on HMM: 88-255/255 Sequence Identity: 34% (60 aa) SGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFY--PEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSS .|.. ... .|. .. |||.|| | .. .| ||| ||. . ||. .|..| || . . |. . |.||.| | .. |.. DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--------GAKFPIKWTAPEAINYGRFTI SSDVWSFGVVLWEIMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFS-LMGWCWALTPSDRPRFSHLTVRL |||||||. |.||.|.|..||. . | . | |.|.|.|||| |. .| || .| .|| | | | KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | AqueK405.AA | Frk | 51-216 | 36 | 1e-43 | 149.2 | In-house | 100-260 (260) | Show / Hide |
Range on Protein: 51-216 Range on HMM: 100-260/260 Sequence Identity: 36% (61 aa) LVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWE || .. ||| || | . .|.||| ||. . |.. .|| | || . .. . | | | . .|.|| | | .... |||||||..| | LVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHG-----ARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE IMTRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRLKEFY |.| |. || . ..|. . | |.||| ||| |...| || | || | | .|.... IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | AqueK405.AA | FGFR | 121-212 | 46 | 1.1e-39 | 132.86 | In-house | 201-293 (293) | Show / Hide |
Range on Protein: 121-212 Range on HMM: 201-293/293 Sequence Identity: 46% (43 aa) PVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIMTRGKTPYEDVL-PENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL |.|||| | | |. | . |||||.|| |||||| | .|| .. | . || .|||. |.||. ... .| || |..|| | | | PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL |
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| TyrKc | AqueK405.AA | TyrKc | 1-212 | 27 | 2.3e-36 | 128.05 | SMART | 17-280 (280) | Show / Hide |
Range on Protein: 1-212 Range on HMM: 17-280/280 Sequence Identity: 27% (78 aa) HA--------------------------SDL------------------------EQPMLLYPKSSFGTLKTLLLKTREGGGIMLPGNNSGQCTYISTHD .. . | |..|.. . | || | |.|. ... | KGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---------------LCMKD LVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPE-------DYNTIEERGGGGDETIA-YPVKWMAAEVLSDKRYSSSSDVW |. .. |.|.|| .| .|. .| |||.||. ..||..|||.| ||| | | . || . |..|| . |..||| |.. ...... |||| LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG----KTMLPIRWMAPECINYGKFTTKSDVW SFGVVLWEIMTRGKTPYED-----VLPENMLNYLTTGHRLPQPKN--------CPDDLFSLMGWCWALTPSDRPRFSHLTVRL ||||..|||.|.|..||.. . .. ...|. .|.|.|||.| |||.....| .||. |.|||.|| . .. SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | AqueK405.AA | Pkinase | 44-203 | 21 | 2.1e-16 | 59.07 | Pfam | 101-282 (293) | Show / Hide |
Range on Protein: 44-203 Range on HMM: 101-282/293 Sequence Identity: 21% (41 aa) TYI--STHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHV----KIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLS-DKRYS . . | ... |. |..||.... ..| .| || || |..| |. ||.| ||. |. . .. |.. .|| ||. .. |. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG SSSDVWSFGVVLWEIMTRGKTPYEDV-------LPENMLNYLTTGHRLPQPKNCP-------------------DDLFSLMGWCWALTPSDRP ...|.||.|..|.| .. |..|. . . . . . . . . |. |. ... ... ||... |..|| PKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP |
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| Kinase | AqueK405.AA | S_TKc | 16-216 | 15 | 2.2e-10 | -24.63 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 16-216 Range on HMM: 11-231/231 Sequence Identity: 15% (41 aa) SFGTLKTLLLKT----------------------------------------------REG--GGIMLPGNNSGQ---CTYISTHDLVFISEQVARGMYH .||. . | .| | . . | . ... . |. |..... . AFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEY LTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSS-SSDVWSFGVVLWEIMTRGKTPYEDVL . ..| .| || || . | |.||.| ||. . |. .|| ||| |. ..|.||.|..|.| .. |..|.. CHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--Q PENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTV-----RLKEFY .. |.. . .... ... |. |..|| . .. .. MQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | AqueK405.AA | FGFR | 46-104 | 40 | 4.8e-09 | 26.9 | In-house | 133-191 (293) | Show / Hide |
Range on Protein: 46-104 Range on HMM: 133-191/293 Sequence Identity: 40% (24 aa) ISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHENLHVKIGDRGLSWDFYPEDY .. ||| . |||||| | . .| ||| ||. . .. || | ||. | || LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDY |
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