Gene AqueK416 (A.queenslandica)

AqueK416

Species: A.queenslandica
Alias: AqueK416
External Links:
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Aque1

Sequence

Name Sequence Type Origin Length Description Download
AqueK416.AA Protein None 922 None Fasta, JSON
AqueK416.kin_dom Protein Kinase Domain None 167 None Fasta, JSON

Protein domain

Protein domains of AqueK416.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3_2 AqueK416.AA SH3_2 564-612 16 9e-06 23.15 Pfam 1-68 (68) Show / Hide 
Range on Protein: 564-612
Range on HMM: 1-68/68
Sequence Identity: 16% (11 aa)

ICVAQADYNN----TI-----ISFKKGEIFQLS-------KNGYEV-QSLETGQK--GAVPISCVGPS
 ...  ||..    .      ..||||... .         |....  .. .|..  | .|...| . 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase AqueK416.AA SFK-Src 675-878 44 1.2e-79 235.56 In-house 26-235 (259) Show / Hide 
Range on Protein: 675-878
Range on HMM: 26-235/259
Sequence Identity: 44% (93 aa)

VLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLSR---YSFAPAELIYITAQVVNGMIYLGEQYYIHCDLRAA
| .||   . . .| ||.|| ..|||  .  | || |||   | ||.||||  | |   |      |     |.  .|||  || || .| ..| || | 
VAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAAR

NILVGEYNTVKIANFHFAQHLNGNKY-WIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQ--GYRMIIPED
|.|||. |..|.. |  .  |  .   .  .|  |  |.|||||  . ||  |||||||||||. |.|| |  ||||||| ||.  | .  ||||  |  
NVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPPN

CPEPFQQLMF
||. . ..||
CPDEYYKIMF
Kinase AqueK416.AA Src 677-877 46 1.1e-77 263.56 In-house 28-234 (255) Show / Hide 
Range on Protein: 677-877
Range on HMM: 28-234/255
Sequence Identity: 46% (96 aa)

IKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLS----RYSFAPAELIYITAQVVNGMIYLGEQYYIHCDLRAAN
.||   ..  .| ||.||.|.|||  | .. || ||..| |.|||||.|.||.| . |       .    .||...||| .|| ||... ||| ||.|.|
VKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARN

ILVGEYNTVKIANFHFAQHLN--GNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPEDCP
.|||| | .|.| |  |. .    . |   ..  |. |.|||||  . .|  ||||||||||||.|.||.|  ||||||| ||...| .||||  |. ||
VLVGENNVCKVADFGLARLIKEDDDEY-CARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCP

EPFQQ-LM
. . . .|
DELYEQIM
Kinase AqueK416.AA SrcA 675-877 49 4.8e-66 207.52 In-house 26-229 (250) Show / Hide 
Range on Protein: 675-877
Range on HMM: 26-229/250
Sequence Identity: 49% (103 aa)

VLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGN----LKKHLSRYSFAPAELIYITAQVVNGMIYLGEQYYIHCDLRA
| |||     .  | ||.|| |.|||  . .. || |   | | ||||| |..|     ||..  .|   | .|. ..||| .|| |.    ||| ||||
VAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLP-QLVDMAAQVAEGMAYMERMNYIHRDLRA

ANILVGEYNTVKIANFHFAQHLNGNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPEDCP
|||||||.   ||| |  |  .. | |   .  .|  |.|||||     |  |||||||||||| |||||| .||||| | ||.| | .||.|  |.|||
ANILVGENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYHMPCPQDCP

EPFQQLM
|   .||
ESLHELM
Kinase AqueK416.AA Frk 675-877 47 8.9e-65 221.51 In-house 26-235 (260) Show / Hide 
Range on Protein: 675-877
Range on HMM: 26-235/260
Sequence Identity: 47% (99 aa)

VLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLS-----RYSFAPAELIYITAQVVNGMIYLGEQYYIHCDLR
| .||  .  .  . ||.|| |.||| .  .| || ||| | | ||.|||| || |...|        .    .|. ..|||  || || .| ||| || 
VAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLA

AANILVGEYNTVKIANFHFAQHLNGNKYWIIEERT--KLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPE
| |.|||| | .||| |  |  |  ..  | | |.  .. |.|||||    |.  |||||||||||| |..| | .||||||| ||.. | .||||  | 
ARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPP

DCPEPFQQLM
.||. . ..|
NCPQQLYEIM
Kinase AqueK416.AA Pkinase_Tyr 675-877 40 3.7e-64 217.9 Pfam 31-249 (270) Show / Hide 
Range on Protein: 675-877
Range on HMM: 31-249/270
Sequence Identity: 40% (88 aa)

VLIKTN--ITADIT--QERFLKEANILKKL-NYESIICLYGVCT-KEYP--FYIVTELMNHGNLKKHLSRY-----SFAPAELIYITAQVVNGMIYLGEQ
| .|.    . .    .| |..||.|.|.| . . |..|||||| .. |   |||.|.| ||.|...| .      .. . .|. . .|. .|| || ..
VAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

YYIHCDLRAANILVGEYNTVKIANFHFAQHL-NGNKYWII-EERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLP-YPGMTNVEVVEAV-
 .|| ||.| |.||.| |.|||. |  |  . |   | .   . .|| |.|.|||    ..  .||||||||.|.||..| |  | ||||.| ||.|.. 
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIY

PQGYRMIIPEDCPEPFQQLM
 .|||| .||.||..  .||
EDGYRMPCPENCPDEIYDLM
Kinase AqueK416.AA SrcB 675-877 46 4.5e-61 205.32 In-house 26-229 (251) Show / Hide 
Range on Protein: 675-877
Range on HMM: 26-229/251
Sequence Identity: 46% (95 aa)

VLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLSRYS---FAPAELIYITAQVVNGMIYLGEQYYIHCDLRAA
| .||     .  | ||.|||..|.|  . .. || | ||| | ||.|| |..| |   |   .    .   || ..||.  || |. .. ||| |||||
VAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAA

NILVGEYNTVKIANFHFAQHLNGNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPEDCPE
|||| |    ||| |  |  .. | |    |  |  |.|||||        |||||||||||| |.|| | .||||||| ||.... .||||  |. |||
NILVSETLCCKIADFGLARIIEDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPE

PFQQLM
   ..|
ELYNIM
Kinase AqueK416.AA Abl 668-877 41 2.7e-60 199.65 In-house 20-231 (252) Show / Hide 
Range on Protein: 668-877
Range on HMM: 20-231/252
Sequence Identity: 41% (89 aa)

FKQHKWSVLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHL---SRYSFAPAELIYITAQVVNGMIYLGEQYYI
.|.|.  | .||     .  . ||||| |.|..  . .. | ||||.| ||||.|| | .|||  .|   .| .  .  |.|. .|.  || || .. .|
WKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRHFI

HCDLRAANILVGEYNTVKIANFHFAQHLNGNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMI
| || | | |||| . ||.| |  |  .... |   .   |  |.|||||    |.  .||||| ||.||||. | |  ||||.   .| . . .|||| 
HRDLAARNCLVGEHHIVKVADFGLARMMKDDTY-TAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRME

IPEDCPEPFQQLM
 || ||.   .||
RPEGCPPKVYELM
Kinase AqueK416.AA Src-Echino1 675-878 43 4.8e-60 205.79 In-house 26-232 (252) Show / Hide 
Range on Protein: 675-878
Range on HMM: 26-232/252
Sequence Identity: 43% (91 aa)

VLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLSRYSFA---PAELIYITAQVVNGMIYLGEQYYIHCDLRAA
| .||     ...  || |||..||. .| |. .| ||  . | |||||||..|||...| |        ..|| . |..  || |||.. ..| || | 
VAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLIDMGAHIASGMDYLGSKNVVHRDLAAR

NILVGEYNTVKIANFHFAQHLNGNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPEDCPE
|.|||. | .|||.|  |. .. . | . ..  || |.|||||     |  |||||||||||. |.|| | .|||||.| ||.. | .||||  ...||.
NVLVGKGNVCKIADFGLARMMQKDVY-CGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPGMMNREVLDQVDRGYRMPKMHHCPD

PFQQL-MF
   .. |.
SLYMMCMM
Kinase AqueK416.AA TK 689-877 21 1.4e-58 194.61 In-house 84-465 (486) Show / Hide 
Range on Protein: 689-877
Range on HMM: 84-465/486
Sequence Identity: 21% (81 aa)

RFLKEANILKKLN-----YESIICLYGVCTKE------------YPFYIVTELMNHGN----LKKHLSRYS-----------------------------
.||.||...|...      . |. ||||||..             |..||.|.|.||.    |...| . .                             
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD

------------------------------------------------FAPAELIYITAQVVNGMIYLGEQ------YYIHCDLRAANILVGEYNT----
                                                . ...|. . .|. .|| || ..       ..| || | |.|||| |.    
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH

-------VKIANFH--------FAQHL-NGNKYWIIEE-----------------------RTKLAIRWTAPEWHT---------LNRLGIKSDVWSFGI
       .||| |          |  . ..  |.  ..                       ..|| |||.|||  .          ..  .||||||||.
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

LLWELVTKGNLPYPG-MTN---------VEVVEAVPQG--------------YRMIIPEDCP--------------EPFQQLM
|.||..| |  ||.| |.|          ||.| . .|              .||  |..||              | ...||
LMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLM
Kinase AqueK416.AA UTK 687-877 34 3.1e-55 187.39 In-house 47-275 (296) Show / Hide 
Range on Protein: 687-877
Range on HMM: 47-275/296
Sequence Identity: 34% (79 aa)

QE---RFLKEAN---ILKKLN-YESIICLYGVCTKEYPFYIVTELMNHGNLKKHLSRYSFAPA---------ELIYITAQVVNGMIYLGEQYYIHCDLRA
.|   .|..||.   ..|...  .... |.||||.| |..||||.|  |.| . | | . .|          ....  ... .|| || .. ..|.|| |
PEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAA

ANILVGEY-------NTVKIANFH---FAQHLN---------GNKYWIIEERTKLAIRWTAPEWHTLN-RLGIKSDVWSFGILLWELVTKGNLPYPGMTN
 |.||..        ...|||.|    ..  .|         .  |    ......|||.|||  | . |  .||||||||...||..| |.||||||.|
RNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSN

VEVVEAVPQG--YRMIIPEDCPEPFQQLM
..|...|  |  |||  |.|||.|  .||
MQVWHQVCNGGRYRMPCPWDCPHPVYRLM
Kinase AqueK416.AA Src-Unclassified 688-871 37 8.1e-55 186.38 In-house 42-256 (284) Show / Hide 
Range on Protein: 688-871
Range on HMM: 42-256/284
Sequence Identity: 37% (81 aa)

ERFL--------KEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHGNLKKHLSRYS---FAPAEL------------IYITAQVVNGMIYLGEQYYI
| ||        .||.|.||.    .. ||.||..| |.||.||.|  | |   |           ..            ..| ||| .|| || .  |.
EAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYV

HCDLRAANILVGEYN-----TVKIANFHFA-QHLNGNKYWIIEERTKLAIRWTAPEWHTLNRLGIKSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVP
| || | |.|.|. |      ||.. |  |   | .    .     .. . |.|||  .     |||||||.||||||. |||  ||||| | ||.| | 
HRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVE

QGYRMIIP--EDCPE
 ||||  |  . ||.
RGYRMPKPTNHYCPD
TyrKc AqueK416.AA TyrKc 660-894 31 6.2e-44 153.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 660-894
Range on HMM: 1-280/280
Sequence Identity: 31% (91 aa)

LQLLRT------------QNFKQHKWSVLIKTNITADITQERFLKEANILKKL--NYESIICLYGVCTKE-------YPFYIVTELMNHGNLKKHLSRYS
..|...            .        | .|.       .| |..||.|..||  . . |..||||||..        | .||.|.| ||.||..| .. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--FAPAELIYITAQVVNGMIYLGEQYYIHCDLRAANILVGEYNTVKIANFHFAQHLNGN-------KYWIIEE--RTK--LAIRWTAPEWHTLNRLGIKS
  . ...|...  |. .|| || .. .|| || | |.|||| .||||. |  .  .          .|    |   .|  | |||.|||    ..  .||
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVWSFGILLWELVTKGNLPYPG-----MTNVEVVEAVPQGYRMIIPED--------CPEPFQQLMFLLPTPMCLPF---------SLSLSI
||||||...||. | |  ||||     |.| ||.| | ||||| .|..        ||.   |.|      .|  .          .   .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK-----QCWHEDPEDRPTFSEIHECF
Kinase AqueK416.AA Pkinase 675-877 21 8.1e-19 67.62 Pfam 31-270 (293) Show / Hide 
Range on Protein: 675-877
Range on HMM: 31-270/293
Sequence Identity: 21% (52 aa)

VLIKTNITADITQERFL-KEANILKKLNYESIICLYGVCTKEYPFYIVTELMNHG----NLKKHLS---RYSF--APAELIYITAQVVNGMIYLGEQYYI
.. | ..  .  |....  |. |.|.|| . |. ||.... .   |.|.|....|     |. ..|   . .|   . |.. .  |.. |. |. ..  |
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII

HCDLRAANILVGEYNTV----KIANFHFAQHLNGNKYWIIEERTKLA--IRWTAPEWHT-LNRLGIKSDVWSFGILLWELVTKGNLPYPGM----TNVEV
|.||  .|||. . ...    ||. | .| ...   |   .  | ..  ... |||..   .  | |.|.||.|..|.|... |..|.||     . .. 
HRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQ

VEAVPQGYRMIIPEDCP-----------------------EPFQQLM
 . . .  . ....|.|                       |......
MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI
S_TKc AqueK416.AA S_TKc 634-898 17 6.5e-16 56.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 634-898
Range on HMM: 1-231/231
Sequence Identity: 17% (53 aa)

ILLDETI------------SDDEKAKHFIKIIADDNHTLQLLRTQNFKQHKWSVLIKTNITADITQERFLKEANILKKLNYESIICLYGVCTKEYPFYIV
  . ..|              . . .  ||||                                  |....| .|||| . . |. ||.|.     .|.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMV

TELMNH--GNLKKHLSRYS-------FAPAELIYITAQVVNGMIYLGEQYYIHCDLRAANILVGEYNTVKIANFHFAQHLNGNKYWIIEERTKLAIRWTA
.|....  |.|.... ..        | . .  ....|..... |. ..  ||.||  .|||. |  ..||. | .| .|                 . |
MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMA

PEWHTLNRLGI-KSDVWSFGILLWELVTKGNLPYPGMTNVEVVEAVPQGYRMIIPEDCPEPFQQLMFLLPT--PMCLPFSLSLSI-------SHWS
||       |  |.|.||.|..|.|... |  |.|   .....  .            .... ...  . .  |   |    .           | 
PEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF