Gene AqueK418 (A.queenslandica)

AqueK418

Species: A.queenslandica
Alias: AqueK418
External Links:
Annotation:

Classification

Group: TK
Family: Src
Subfamily: Src-Aque1

Sequence

Name Sequence Type Origin Length Description Download
AqueK418.AA Protein None 441 None Fasta, JSON
AqueK418.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of AqueK418.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 AqueK418.AA SH3 55-112 32 1.2e-11 45.95 SMART 1-58 (58) Show / Hide 
Range on Protein: 55-112
Range on HMM: 1-58/58
Sequence Identity: 32% (19 aa)

SKQKSRHSFQALHKDGLSFKKGEVLKVVKNEDDEWWYMQSFHTDNIGDVPISYIIPIE
 . .  ...|| . | ||||||... |.. .||.||. .  .| ..| .| .|. .|.
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 AqueK418.AA SH3_1 58-90 41 5e-06 23.49 Pfam 1-34 (49) Show / Hide 
Range on Protein: 58-90
Range on HMM: 1-34/49
Sequence Identity: 41% (14 aa)

KSRHSFQALHKDGLSFKKGEVLKVVKNEDD-EWW
.  . .|| . | ||||||....|.. .|| .||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWW
SH3_2 AqueK418.AA SH3_2 68-111 23 0.000799 16.28 Pfam 14-68 (68) Show / Hide 
Range on Protein: 68-111
Range on HMM: 14-68/68
Sequence Identity: 23% (13 aa)

KDG-----LSFKKGEVLKVV---KNEDDEWWYM-QSFHTDNI--GDVPISYIIPI
...     |.||||.|.||    . ..|.||.   .  .     | .|.... ..
CNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 AqueK418.AA SH2 122-209 25 3e-06 27.88 SMART 1-87 (87) Show / Hide 
Range on Protein: 122-209
Range on HMM: 1-87/87
Sequence Identity: 25% (23 aa)

HVYYH-IMDHNVAKERLSRQADTQKGSFLINKSERKPGVPRQHTLILNNGVITTYHRIHFSL-NKCSIGK--SVWFDSLNDLVHHYMMKADG
. .||  ..   | . | ..   . |.||.  ||.    |.. .| .  .      ||. .  .| .|.   ...|.|| .||.||.  ..|
QPWYHGNISREEAEQLLKNP-GMPDGDFLVRDSES---NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 AqueK418.AA SH2 175-203 38 0.000694 13.23 Pfam 51-81 (81) Show / Hide 
Range on Protein: 175-203
Range on HMM: 51-81/81
Sequence Identity: 38% (12 aa)

YH-RIHFSLNK-CSIGKSVWFDSLNDLVHHY
.| ||..  |.   |.  . |.||..||.||
KHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase AqueK418.AA SFK-Src 239-441 44 1.4e-83 247.47 In-house 1-207 (259) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-207/259
Sequence Identity: 44% (92 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTT---NNLTPAELVD
|.  |   .||||. |||.| .   | .||     . .| |   | .. || | | | || |||   |.||.|||| .| | |||       |.   |||
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

IAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKY-WTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPY
 | ||  || || .| ..|  | |  .| | ||..|.. | ..  |  .   .| .||    |.|||||  . |. ||||||||||||. |. | | .||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMTHKE
|||| .|
PGMTNME
Kinase AqueK418.AA Src 239-441 44 4.5e-79 268.3 In-house 1-208 (255) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-208/255
Sequence Identity: 44% (92 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLT----TNNLTPAELV
||. . . .||||| |.|.|.|. .| .||  . .  .| |   |.|. || |.....|| ||..  | |||||.| .|.| |||     . .|   .|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLN--GNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHM
|.| || ||| ||... |||  | |. .| | || .|.| | ||. .    . | . ..|  . |.|||||  . .. .||||||||||||.|. |.| .
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEY-CARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRV

PYPGMTHKE
|||||| .|
PYPGMTNHE
Kinase AqueK418.AA Frk 239-441 44 1.9e-66 227.06 In-house 1-210 (260) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-210/260
Sequence Identity: 44% (93 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLT-----TNNLTPAEL
|.. . . .||||| | | |  . || .||  .  .  . |.  | |. || |  .|.|| ||| . |.||.|||| .| |..||       ...   .|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

VDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKY--WTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGH
||.| ||  || || .| |||  | |  .|.| .| .||| | ||  |  ..   .    |  . |.|||||    |. .|||||||||||| |. | |.
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

MPYPGMTHKE
||||||| .|
MPYPGMTNAE
Kinase AqueK418.AA Pkinase_Tyr 239-441 40 1.9e-65 222.25 Pfam 1-223 (270) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-223/270
Sequence Identity: 40% (90 aa)

IKFSKCINAGQFGETWKGVWK-----GEGPVMIKTN--IATNIT--QETFIDAANILAKL-HHKNIISLYGVCT-ENYP--LYIVTELMINGNLKDYLTT
|.| | . .|.||| .||.||     .. || .|.    |.     .| |.  |.|. .| ||.||..|||||| .  |  .|||.|.| .|.|.||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N-----NLTPAELVDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHL-NGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSF
.     .||. .|.....|. .|| || .. .||  | |  .|.. ||.|||. | ||  . |   | .. .|. | |.|.|||    .  ..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GILLWELATKGHMP-YPGMTHKE
|.|.||. | | .| ||||.  |
GVLMWEIFTYGEQPTYPGMSNEE
Kinase AqueK418.AA SrcA 239-441 46 7.9e-65 203.61 In-house 1-204 (250) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-204/250
Sequence Identity: 46% (95 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYL---TTNNLTPAELVD
|.  . .  |.||| | | | |.  | |||     .  |.|.. | |. ||.|  .. || |  |  |.||||| |  | | |.|   .  .|   .|||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEE-PIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVD

IAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPYP
.| || ||| |.    |||  |.|| || | |   ||| | ||  .. | | | . |.   |.|||||        |||||||||||| || ||| .|||
MAAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP

GMTHKE
||  .|
GMNNRE
Kinase AqueK418.AA Src-Echino1 239-441 42 1.8e-63 217.17 In-house 1-205 (252) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-205/252
Sequence Identity: 42% (87 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTTNNLT---PAELVD
 .. | |  |..|| |||||.|. || .||     ...  |.  ||.. |. |..|. .| || .. |.||||||| ||||.|||  ..      ..|.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

IAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPYP
.  ..  || |||.....| .| |  .|.|  | .|||.| ||. .. . | . . |  | |.|||||     .  |||||||||||. |. | | .|||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQ-GAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYP

GMTHKE
||. .|
GMMNRE
Kinase AqueK418.AA TK 239-441 20 1.5e-61 204.83 In-house 1-412 (486) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-412/486
Sequence Identity: 20% (85 aa)

IKFSKCINAGQFG---ETWKGVWKGEG--------------------------PVMIKTNIAT-NITQETFID--------------AANILAKLH----
|.. | . .||||   | .|| |.|..                          || .|.  .. . .|| |.|               |.......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNIISLYGVCTEN------------YPLYIVTELMINGN----LKDYLTTN-----------------------------------------------
 |.||..||||||..             |..||.|.| .|.    |.||| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------NLTPAELVDIAIQVTEGMIYLGEQ------DYIHCNLKAASILLGYNNT-----------VKIANFH---
                              .||...|. .. |. .|| || ..       ..| .| |  .|.| ||.           .||| |    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAQHL-NGNKYWTVEE-----------------------GTELAIRWTAPEGYT---------LNQLSIKSDVWSFGILLWELATKG-HMPYPGM
     ||  . ..  |.....                       |. | |||.|||  .          .  ..||||||||.|.||. | |  ..|.||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TH---------KE
..         .|
SNQDVWKDGDNQE
Kinase AqueK418.AA Abl 239-437 40 3.1e-61 202.82 In-house 1-202 (252) Show / Hide 
Range on Protein: 239-437
Range on HMM: 1-202/252
Sequence Identity: 40% (83 aa)

IKFSKCINAGQFGETWKGVWKGEGP-VMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTTNN---LTPAELV
|   . .  ||.|| ..||||  .  | .||    ..  . |.  | |. ...|.|.. | ||||   | ||.|| | .||| |||  ..   |..  |.
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPY
 .| |.. || || ....||  | |   |.| .. ||.| | ||  .... | | . |    |.|||||.   |. |.||||| ||.||||.|| |  ||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTY-TAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PGM
||.
PGI
Kinase AqueK418.AA SrcB 239-441 43 2e-60 203.06 In-house 1-204 (251) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-204/251
Sequence Identity: 43% (89 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTTNN---LTPAELVD
.|. | . |||||| | | ....  | .||     .  | |.. ||.. .| |. .. || | |   |.||.|| | .| | |.| |..   |.   |.|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

IAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPYP
.. |..||| |. .. |||  |.|| ||       ||| | ||  .. | | |  ||    |.|||||        |||||||||||| |. | |..|||
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEY-TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GMTHKE
|||  |
GMTNPE
Kinase AqueK418.AA SRM 240-441 43 1.9e-58 194.07 In-house 2-206 (253) Show / Hide 
Range on Protein: 240-441
Range on HMM: 2-206/253
Sequence Identity: 43% (89 aa)

KFSKCINAGQFGETWKGVWKGEGPVMIKTNIATN-ITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTTNN---LTPAELVD
 . .   .| ||| | | |||. .| ||     | . |...      . || || ||.|. ||.   | ||.||||  |||  || . .   |   .|.|
TLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLLD

IAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELAIRWTAPEGYTLNQLSIKSDVWSFGILLWELATKGHMPYP
.| || ||| || || |||  | |  .| | ||. |.. | ||  .    |     .    ..|||||       |.|||||||||||.|. |.| .|||
FACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIY-SPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMTHKE
|||  |
GMTNHE
Kinase AqueK418.AA Src-Unclassified 239-437 37 9.4e-58 196.6 In-house 1-231 (284) Show / Hide 
Range on Protein: 239-437
Range on HMM: 1-231/284
Sequence Identity: 37% (86 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIAT---NITQETFI--------DAANILAKLHHKNIISLYGVCTENYPLYIVTELMINGNLKDYLTTNN
..  . .  ||||| |.| |.|   | .||  .        | |           |.|. |. | |.. ||.||..  | ||.||.|||| | ..| .  
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

---LTPAEL------------VDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNN-----TVKIANFHLA-QHLNGNKYWTVEEGTELAIRWTAPEGYT
   |   ..            |||| ||  || || .  |.|  | |  .| | ||      ||.. | ||   | .        |  . . |.|||  .
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

LNQLSIKSDVWSFGILLWELATKGHMPYPGM
    ||||||||.||||||..|||  |||||
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGM
Kinase AqueK418.AA TyrKc 239-441 32 7.1e-35 123.09 SMART 1-265 (280) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-265/280
Sequence Identity: 32% (87 aa)

IKFSKCINAGQFGETWKGVWKGEGPVMIKTNIATNITQETFIDAANILAKL--HHKNIISLYGVCTEN-------YPLYIVTELMINGNLKDYLTTNN--
|.. | .  |.||| .||.||   .| .|.  .    .| |.. |.|. ||  ||.||. ||||||.         ||.||.|.| .|.|||||  .   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LTPAELVDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGN-------KYWTVEE--GTE--LAIRWTAPEGYTLNQLSIKSDV
|....|.....|. .|| || .. .||  | |  .|.| |.||||. | |.  .          .| .. |  |.   | |||.|||    .  ..||||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSFGILLWELATKGHMPYPG-----------------------MTH---------------------KE
||||...||. | | .||||                       . .                     .|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
Kinase AqueK418.AA Pkinase 239-436 26 4.8e-23 82.58 Pfam 1-214 (293) Show / Hide 
Range on Protein: 239-436
Range on HMM: 1-214/293
Sequence Identity: 26% (58 aa)

IKFSKCINAGQFGETWKGVWKGEG-PVMIKTNIATNITQETFIDAAN-----ILAKLHHKNIISLYGVCTENYPLYIVTELMING----NLKDYLT---T
... ..| .| ||. .|...||.|  | .|.    ..  .  . ...     |...|.|.||. ||......  .|.|.|.. .|     |.||..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NNL--TPAELVDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTV----KIANFHLAQH--LNGNKYWTVEEGTELAIRWTAPEGYT-LNQLSIKSDV
...  .. |. ... |. .|. |. ..  ||. || . ||.  |...    ||. | || .  .  |   |.  ||   ... |||     .  . |.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT---PWYMAPEVIRGGQYYGPKVDM

WSFGILLWELATKGHMPYPG
||.|..|.|... |. |.||
WSCGCILYEMLC-GRPPFPG
Kinase AqueK418.AA S_TKc 239-441 23 4.7e-14 29.15 SMART 1-220 (231) Show / Hide 
Range on Protein: 239-441
Range on HMM: 1-220/231
Sequence Identity: 23% (57 aa)

IKFSKCINAGQFGETWKGVWKG-EGPVMIKTNIATNITQETFIDAANILAKLHHKNIISLYGVCTENYPLYIVTELMIN--GNLKDYLTTNN-------L
 .. . |  | ||. .|...|.    | ||         |...   .|| | ||.||. ||.|. .   ||.|.|.. .  |.|.||.  ..       .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TPAELVDIAIQVTEGMIYLGEQDYIHCNLKAASILLGYNNTVKIANFHLAQHLNGNKYWTVEEGTELA--IRWTAPEGYTLNQLSI-KSDVWSFGILLWE
.. .   .. |. ... |. ..  ||. || . |||    ..||. | || .|           | .     . |||     . .  |.|.||.|..|.|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LATKGHMPYPGMTHK-------------------------------E
... |  |.|   ..                               .
MLC-GYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ