Gene AqueK474 (A.queenslandica)

AqueK474

Species: A.queenslandica
Alias: AqueK474
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
AqueK474.AA Protein None 211 None Fasta, JSON
AqueK474.kin_dom Protein Kinase Domain None 209 None Fasta, JSON

Protein domain

Protein domains of AqueK474.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK474.AA TKL 1-211 22 2.3e-49 170.29 In-house 79-364 (364) Show / Hide 
Range on Protein: 1-211
Range on HMM: 79-364/364
Sequence Identity: 22% (67 aa)

MIRLKHPNLLPLLGYTSNQST-------------LCLVYPYMALGS-LDKHLSRLELGNERRFQILRDIASGLHYLHT----GCGEI--LVHRDVKSANI
|.||.|||.....||  . .              ||.|. |.  || |. ..       ..|... .|||.|..|||.    .|.    ..||| ||.||
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNI

LLDQNWR--------------GVLTDFGIARTLSLET------TTVV-----------TQRIVGTRVYMSPEYCT-----------------GLVSPSAD
|.|.||.                ..|||..|..| ..      ||.            | ...||  .|.||                    .  |...|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VYSLGVVILELVFGCLALHSPKGSDTDII-----SFLDECDNTAEFYLS---------CWSRSDGERLEELAEKCTNPYRDQRPTIAKVLEKL
||| |.|. |.. .|.  . .. .. ..       |   ||.     .          |.  .  ... .|...| ..  ..||.  ..|..|
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK474.AA IRAK 1-147 36 2.2e-38 133.7 In-house 57-221 (317) Show / Hide 
Range on Protein: 1-147
Range on HMM: 57-221/317
Sequence Identity: 36% (60 aa)

MIRLKHPNLLPLLGYTSNQSTLCLVYPYMALGSLDKHLSRLELGNE-------RRFQILRDIASGLHYLHTGC-GEILVHRDVKSANILLDQNWRGVLTD
. |. |||..||.|| .  . .|||||||. |||   |. .   .        .|. |.  .| |...||.   .  . |.|.|||||||||.    ..|
CCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICD

FGIAR----TLSLETTTV---VTQRIVGTRVYMSPEYCT---GLVSPSADVYSLGVVILELVFGC
|| .|    . ..| .|.    |....||  || ||. .   |  ..  |||| |.|.||.. ||
FGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGC
Kinase AqueK474.AA TKL-Unique 1-148 27 1.6e-28 97.75 In-house 49-226 (290) Show / Hide 
Range on Protein: 1-148
Range on HMM: 49-226/290
Sequence Identity: 27% (50 aa)

MIRLK-HPNLLPLLGYTS----NQSTLCLVYPYMALGSLDKHLS-----------RLELGNERRFQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQ
| .|. |||.. . ||.      .. .|.|  |. .|||...|.            ..| ...| .. .|||.|..|||.  .    ||| || |.|.|.
MKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDN

N-----WRGVLTDFGIARTLSLETTTVVT-------QRIVGTRVYMSPEYCTG---LVSPSADVYSLGVVILELVFGCL
|     |.  . |||.....| .... ..       |  .|.  .|.||  ..   . | ..|||| |.|  |.. ...
NSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase AqueK474.AA Pkinase 3-211 20 8.1e-28 99.45 Pfam 56-293 (293) Show / Hide 
Range on Protein: 3-211
Range on HMM: 56-293/293
Sequence Identity: 20% (50 aa)

RLKHPNLLPLLGYTSNQSTLCLVYPYMALG----SLDKHLS---RLEL--GNERRFQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRG----V
||.||| . |...  . . ...| .|.  |    .|  ..|   .  .    .    ... |..|| |.|  .    .|||.|..|||.|.|        
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVK

LTDFGIARTLSLETTTVVTQRIVGTRVYMSPEYCT--GLVSPSADVYSLGVVILELVFGCLALHSP----KGSDTDIISFLDECDNTAEFYLSCWSRSDG
..|||.|. .. .   . .. ..||. ||.|| .      .|..|..|.|... |...| .   .     .  | . . ... .  . . .   |..|  
ICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWP--WWCSIS

-----------------ERLEELAEKCTNPYRDQRPTIAKVLEK--L
                 | . .. ..| ..   .|||.. .|.   .
YFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK474.AA STE 1-147 26 5.8e-25 85.14 In-house 82-265 (359) Show / Hide 
Range on Protein: 1-147
Range on HMM: 82-265/359
Sequence Identity: 26% (51 aa)

MIRLK--HPNLLPLLGY-------TSNQSTLCLVYPYMALGSLDKHLS-RLELGN-------------ERRF-QILRDIASG-LHYLHTGCGEILVHRDV
| ...  |||    .|.       ..| ..|...  ||. ||||. .  . . |.             |     |.|.|  | |.|||       .|||.
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDI

KSANILLDQNWRGVLTDFGIARTLSLE--------------TTTVVTQRIVGTRVYMSPEYCTGLVSP-------SADVYSLGVVILELVFGC
|.|||||       |.|||..  |. .              |.   .. .|||  .|.||  ..  ..       ..|..||| .|.|.. |.
KPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase AqueK474.AA TK 1-211 13 2.5e-24 77.79 In-house 92-486 (486) Show / Hide 
Range on Protein: 1-211
Range on HMM: 92-486/486
Sequence Identity: 13% (52 aa)

MIRLK-----HPNLLPLLGYTSNQST------------LCLVYPYMALGS----LDKHLSRLE-------------------------------------
|  ..     |||.. |.|. . . .            ...|  ||..|.    |...| .                                       
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

----------------------------------------LGNERRFQILRDIASGLHYLHTG-CGEI---LVHRDVKSANILLDQNWR-----------
                                        |  ...  . ..||.|. |||   |      .||||.   |.|...| .           
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPV

GVLTDFGIA--------RTLSLETTTVVTQ-RIV--------------------GTRV---YMSPEYCT----------GLVSPSADVYSLGVVILELVF
  ..||| .        | .  ..  .... . .                    |...   .|.||  .          |  ..  ||.|.||.. |.. 
CKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

GCLALHSPKGSD---------TDIISFLDEC---------DNTAEFYLSCWSRSDG-------------ERLEELAEKCTNPYRDQRPTIAKVLEKL
 . .   .  |.         .... .| .          .    . . .                   | ...|  .| ..  ..||| . ..|.|
YGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK474.AA LISK 53-144 28 4.5e-19 58.42 In-house 108-233 (296) Show / Hide 
Range on Protein: 53-144
Range on HMM: 108-233/296
Sequence Identity: 28% (37 aa)

RDIASGLHYLHTGCGEILVHRDVKSANILLDQN----WRGVLTDFGIARTLSLETTT-------------------------VV---TQR----IVGTRV
.|||.|. |||  .    .||| || |.|...|    || ...||| ||... |                            .    . .    |.||  
LDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTICGTPY

YMSPEYCTGLV-SPSADVYSLGVVILELV
 |.|| ..|   . |.||.| |.| .|..
WMAPEMLLGQSYDESCDVFSFGIVLCEII
Kinase AqueK474.AA MLK 3-144 26 7.3e-19 62.17 In-house 61-230 (291) Show / Hide 
Range on Protein: 3-144
Range on HMM: 61-230/291
Sequence Identity: 26% (45 aa)

RLKHPN----LLPLLGY-TSNQSTLCLVYPYMALGSLDKHLSRLE---------------LGNERRFQILRDIASGLHYLHTGCGEILVHRDVKSANILL
.|.|||      ...|  ..... .|.|  |.. |||   |   .                  .  ...  ..|.|.||||      ..||| || |||.
ILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI

DQ------NWRGVLTDFGIARTLSLETTTVVTQRIVGTRVYMSPEYC----TGLVSPSADVYSLGVVILELV
|.      .   . .|||..| ..  . |  . .. ||  .|.||       . .| ..||.| |||. |..
DEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase AqueK474.AA UTK 1-97 27 6.1e-18 57.97 In-house 63-176 (296) Show / Hide 
Range on Protein: 1-97
Range on HMM: 63-176/296
Sequence Identity: 27% (32 aa)

MIRLK-HPNLLPLLGYTSNQSTLCLVYPYMALGSLDKHLS--RLELG-------NERRFQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQN-----
| ... |||.| |.|. .... ...|. ||. |.|.. |   | ...       ...| .  .|||.|..|||.     .||||.   |.|....     
MKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHS---CGFVHRDLAARNCLVHMHRMMWH

--WRGVLTDFG---IAR
  .  .. |||    .|
CMMVCKIADFGRGGMSR
Kinase AqueK474.AA ULK 3-146 21 5.6e-17 56.82 In-house 69-248 (324) Show / Hide 
Range on Protein: 3-146
Range on HMM: 69-248/324
Sequence Identity: 21% (40 aa)

RLKHPN--LLPLLGYTSNQ--STLCLVYPYMALGSLDKHLSRLELGNERR-----------FQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWR
.|||||     |. .. ..    ..... |   | |.. . .    .|              |....|..|. .||    .  .||| | .|||.  .  
ELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHK---HNIIHRDIKPQNILIHNGQP

GV------------LTDFGIARTLSL-ETTTVVTQRIV------GTRVYMSPEYCTGL-----VSPS-ADVYSLGVVILELVFG
.             ..||| |...   .    ..| .|      ||  ||.|.   |.      . . .|..|||... |...|
KTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase AqueK474.AA LISK-DD1 53-143 39 5.9e-16 54.35 In-house 130-224 (290) Show / Hide 
Range on Protein: 53-143
Range on HMM: 130-224/290
Sequence Identity: 39% (39 aa)

RDIASGLHYLHTGCGEILVHRDVKSANILLDQN----WRGVLTDFGIARTLSLE--TTTVVTQRIVGTRVYMSPEYCTGLV-SPSADVYSLGVVILEL
.|||..  |||      ..||| || |||.| |    ||. . ||| ||...     .   .  |.||   |.|| ..|.  . |.||.| |.| |||
LDIACAMAYLHS---KNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLEL
Kinase AqueK474.AA Pkinase_Tyr 1-99 28 2.6e-15 52.5 Pfam 57-161 (270) Show / Hide 
Range on Protein: 1-99
Range on HMM: 57-161/270
Sequence Identity: 28% (31 aa)

MIRL-KHPNLLPLLGYTS-NQST--LCLVYPYMALGSLDKHLSRL-----ELGNERRFQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGVLT
|  | .|||.. |.|  .  .    ...| .||..|.|...| .       |  ..  |. ..||.|. ||.      ..|||.   |.|.. |     .
MKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKIC

DFGIARTL
||| ||..
DFGLARDI
Kinase AqueK474.AA S_TKc 1-209 18 8.4e-14 25.52 SMART 18-220 (231) Show / Hide 
Range on Protein: 1-209
Range on HMM: 18-220/231
Sequence Identity: 18% (46 aa)

MIRLK------------------------HPNLLPLLGYTSNQSTLCLVYPYMAL--GSLDKHLSRLE-------LGNERRFQILRDIASGLHYLHTGCG
 .  |                        |||.  |...  . . |..|  |.    |.| ... .         .   .   ... |...| |.|    
CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG-

EILVHRDVKSANILLDQNWRGVLTDFGIARTLSLETTTVVTQRIVGTRVYMSPEYCTGLVSP-SADVYSLGVVILELVFGCLALHSPKGSDTDIISFLDE
   .|||.| .|||||.  .  ..|||.|| |           ..||. ||.|| .    .. ..|..|.|... |.. |.   .     .  ..  .  
--IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-

CDNTAEFYLSCWSRSDGERLEELAEKCTNPYRDQRPTIAKVLE
                 . . .. .|| .   ..|||. ..|.
----------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase AqueK474.AA TyrKc 2-211 17 8.2e-11 -47.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-211
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

IR--------------------------------------------L--KHPNLLPLLGYTSNQ-------STLCLVYPYMALGSLDKHLSRLE--LGNE
|.                                            |  .|||.. |.|. . |         |..|  ||..|.|...| . .  | ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

RRFQILRDIASGLHYLHTGCGEILVHRDVKSANILLDQNWRGVLTDFGIARTLSLE------TTTVVTQRIVGTR--V---YMSPEYC-TGLVSPSADVY
   ..  .||.|  |||      ..|||    |.|.. | .   .||| .| .  .      . . ...   |..  .    |.||   .|  ..  ||.
DLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SLGVVILELVFGCLALHSP----KGSDTDIISFLDECDNTAEFYLSCWSR--------SDGERLEELAEKCTNPYRDQRPTIAKVLEKL
| ||.. |.   .   ..     . |....| ....      ... .              |  . . ..| .   ..||| . . |..
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-----YRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK474.AA TKL-Unique 184-211 21 0.174824 1.22 In-house 263-290 (290) Show / Hide 
Range on Protein: 184-211
Range on HMM: 263-290/290
Sequence Identity: 21% (6 aa)

ERLEELAEKCTNPYRDQRPTIAKVLEKL
... .| ..| ..  .|||.   ....|
KEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK474.AA IRAK 201-211 36 0.355676 0.12 In-house 307-317 (317) Show / Hide 
Range on Protein: 201-211
Range on HMM: 307-317/317
Sequence Identity: 36% (4 aa)

RPTIAKVLEKL
|...|.|...|
RCDMAWVMQQL