Gene AqueK480 (A.queenslandica)

AqueK480

Species: A.queenslandica
Alias: AqueK480
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
AqueK480.AA Protein None 523 None Fasta, JSON
AqueK480.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of AqueK480.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK480.AA TKL 20-292 16 1.1e-40 141.5 In-house 1-364 (364) Show / Hide 
Range on Protein: 20-292
Range on HMM: 1-364/364
Sequence Identity: 16% (64 aa)

LGKGSYGLVCLGEWLG----------VPVAVRKLHE---SLFTLSK--------------CEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYG--IHDSS-
.|.|..| |. |.| |           .||| |...   ..||..               ...|  .  . .. |.  . .|.|||||.|.|  .  .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------IQGELSLISDTY----LVQELLCVSLNARNRQKPRLSYRNVLDLSIGITGGLRYLHERS------NPITHQDLTSKNILLSLAGI-------
         .|.| .. . .    |   |.                   ......|  |. ||| .        || | ||.|||||.   .        
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY

-------PKISDLGIAKILNSTCESFA----------------RHSRRPGTELYMPPEVKMADGEDRK-----------TYDYRVDIYSLGVIVLEMSIG
       .||.|.|... .. . .. .                ..... ||  .|.||| . ......           .|. ..|.|| |..  |.  .
NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR

RDPVASEAF-------------RICENEGFQIVPE------IERRQNDLEEVLDSPLYNIILACLTN-INDRPDAINVYEKL
. | . . .              .. ..| .  .         . .   ..  . .. ...  |     ..|| .  . ..|
CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase AqueK480.AA Pkinase 14-227 26 4.2e-30 107.52 Pfam 1-205 (293) Show / Hide 
Range on Protein: 14-227
Range on HMM: 1-205/293
Sequence Identity: 26% (62 aa)

VHSSRLLGKGSYGLVCLGEWLGVP--VAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYGIHDSSIQGELSLISDTYLVQELL-CV-
 |  | .|.||.| |... . | .  ||| ..  .  . |.......|.     ||.  .  ||||||| .|..  .         .. |.|.|.. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGL

---SLN----ARNRQKPRL--SYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLAGIP----KISDLGIAKILNSTCESFARHSRRPGTELYM
   .|     .  ... ..  |.. . .    |  || |.|..   | | || . |||..  | .    ||.| |.|| .. .  .   ...  ||  ||
YVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFC-GTPWYM

PPEVKMADGEDRKTYDYRVDIYSLGVIVLEM
.||| .    ... |...||..|.|.|. ||
APEVIR----GGQYYGPKVDMWSCGCILYEM
S_TKc AqueK480.AA S_TKc 14-296 20 1.3e-24 89.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-296
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

VHSSRLLGKGSYGLVCLGEWLG--VPVAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYGIHDSSIQGELSLISDTYLVQELLCV--
 .  |..|||..| |... . .    ||. ...                 . . .|.  | . .||||| .|.. ..         .. |.| |..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDL

-SLNARNRQKPR------LSYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILNSTCESFARHSRRPGTELYMPPEVKM
 .|  . ....|      ..   .  .   |  .| |.|..   | | ||   ||||.     ||.| |.|..|          .   ||  ||.|||  
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-

ADGEDRKTYDY-RVDIYSLGVIVLEMSIGRDPVASEAFRICENEGFQIVPEIERRQNDLEEVLDSPLYNIILACLT-NINDRPDAINVYE-----KLSEL
        |.. ..|..|.|.|. ||  |. |   . ... .. |                  .... ..|  ||. . ..|| |  . .     |. . 
-------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

M
.
F
Kinase AqueK480.AA STE 136-233 30 1.5e-22 76.5 In-house 163-267 (359) Show / Hide 
Range on Protein: 136-233
Range on HMM: 163-267/359
Sequence Identity: 30% (35 aa)

G-LRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILNSTCE------------SFA-RHSRRPGTELYMPPEVKMADGED-RKTYDYRVDIYSL
| | |||.    | | |. . ||||      |..| |....|....             . . .     ||  .| ||| . .|.. .| ||...||.||
GLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSL

GVIVLEMSIGRDP
|  ..||  |. |
GCTIIEMATGKPP
Kinase AqueK480.AA Ciliate-E2 114-231 24 1.2e-19 64.11 In-house 126-293 (365) Show / Hide 
Range on Protein: 114-231
Range on HMM: 126-293/365
Sequence Identity: 24% (42 aa)

RNRQKPRLSY---------RNVLDLSIGITG---------------GLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILN---------STC
.|..| |..          . .....  |.                .|.|||.. | | | |.   |||.     .||.|.|..|...         . |
KNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQC

E-------------------SFARHSRRPGTELYMPPEVKMADGED----RKTYDYRVDIYSLGVIVLEMSIGR
.                   ..  . .  ||  ||.||. .  ..|    .| ||| .||.|||||  ||  |.
KWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase AqueK480.AA TKL-Unique 111-227 26 7.9e-19 63.17 In-house 97-221 (290) Show / Hide 
Range on Protein: 111-227
Range on HMM: 97-221/290
Sequence Identity: 26% (34 aa)

LNARNRQKPRLSYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLA-----GIPKISDLGIAKILNSTCESFARHS------RRPGTELYMPPE
.|  |...  |.. ..... | | .|. ||| .. ||.| ||.|.|.|.. .        ||.| |..|....  ..... .       | |. ..|.||
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

VKMADGEDRKTYDYRVDIYSLGVIVLEM
| .      ..|.  .|.|| |... |.
VLRMNF---CQYSEKSDVYSFGIVLWEI
Kinase AqueK480.AA STE-Unique 136-233 26 5.8e-17 56.29 In-house 415-552 (616) Show / Hide 
Range on Protein: 136-233
Range on HMM: 415-552/616
Sequence Identity: 26% (37 aa)

GLRYLHERSNPITHQDLTSKNILLSLAG-----IPKISDLGIAKILNST-----------------------------------CESFARHSRRPGTELY
|| ||| . ||| | || . ||...  |       ||.| |.|...                                        .     . .||. |
GLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCY

MPPEVKMADGEDRKTYDYRVDIYSLGVIVLEMSIGRDP
| ||| .      . || .|||.||| ....|  | .|
MCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPP
Kinase AqueK480.AA Ciliate-E2-Unclassified 136-231 32 1.9e-15 50.08 In-house 155-267 (352) Show / Hide 
Range on Protein: 136-231
Range on HMM: 155-267/352
Sequence Identity: 32% (37 aa)

GLRYLHERSNPITHQDLTSKNILLSLAG---IPKISDLGIAKILNST------------CESFARHSRRPGTELYM----PPEVKMADGEDRKTYDYRVD
|| |||.    | | |..  |||..  |    .||.|.||.| ...               .. . . . ||  ||    .||| .  . | ..  | .|
GLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCD

IYSLGVIVLEMSIGR
|.|||||  ||  |.
IWSLGVILYEMLFGY
TyrKc AqueK480.AA TyrKc 14-292 20 5.4e-15 19.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-292
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

VHSSRLLGKGSYGLVCLGEWLGVPVAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQL--NHPNIVSFYGIHDSSIQGELSLI---SDTYLVQELLC
..  . || | .| |..|.|  ..||| .|.|.              ...| .|   . .|  .||||| .||.   . ||.          ..| |. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRN--FMYIEPLMIVMEYMP

V-SLNARNRQKPR-LSYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILNST------CESFAR----HSRRPGTELYM
  .|. . | . . |. .  |. .. |  | .|||..  .. | ||   |.|..  .. |||| | .. . .        .        ... .     |
HGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

PPEVKMADGEDRKTYDYRVDIYSLGVIVLEM-SIGRDPVASEAFRICENEGFQIVPEIERR-QNDLEEV--------LDSPLYNIILACLTN-INDRPDA
.||.      . ...    |..| ||   |. . |  |   ....    . ....  ....   .  .           . .|.|.. |     .|||  
APECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

INVYEKL
 ...|..
SEIHECF
Kinase AqueK480.AA NEK4 121-227 38 1.2e-14 49.24 In-house 99-195 (257) Show / Hide 
Range on Protein: 121-227
Range on HMM: 99-195/257
Sequence Identity: 38% (41 aa)

LSYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILNSTCESFARHSRRPGTELYMPPEVKMADGEDRKTYDYRVDIYSL
|. . |..  . |  .| |.||.   | | ||   || |    | || |.||...||  |. .|  .   ||  || ||.        . |||. ||.||
LEEYQVVEWFVQIAMALQYMHEKH--ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCD-MA--KTMIGTPYYMSPECFGN-----RPYDYKSDIWSL

GVIVLEM
|  | ||
GCCVYEM
Kinase AqueK480.AA STE20 136-227 37 2.6e-12 41.58 In-house 129-220 (288) Show / Hide 
Range on Protein: 136-227
Range on HMM: 129-220/288
Sequence Identity: 37% (36 aa)

GLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAKILNS--TCESFA-RHSRRPGTELYMPPEVKMADGEDRKTYDYRVDIYSLGVIVLEM
|| |||  || | | |. . ||||.  |  |..| | .  |..  . .... .     ||  .| ||| . ..  .| |||..||.|||   .||
GLDYLH--SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGR-DTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEM
Kinase AqueK480.AA TKL-Unique 16-85 31 3.8e-11 35.71 In-house 1-64 (290) Show / Hide 
Range on Protein: 16-85
Range on HMM: 1-64/290
Sequence Identity: 31% (23 aa)

SSRLLGKGSYGLVCLGEWLGVPVAVRKLH-ESLFTLSKCEEEKTRTLKAFVSEVGTLFQLN-HPNIVSFYGI
 . ..| |.|| |. |.| | |||. ..| .... ... .|        | .|| ..  |. ||||| ..|.
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQE--------FENEVNWMKKLHYHPNIVHYMGY
Kinase AqueK480.AA LISK-DD1 19-85 35 5.4e-10 32.57 In-house 1-65 (290) Show / Hide 
Range on Protein: 19-85
Range on HMM: 1-65/290
Sequence Identity: 35% (25 aa)

LLGKGSYGLVCLGEWLGVPVAVRKLHESLFTLSKCEEEKTRTLKAFVS-EVGTLFQ---LNHPNIVSFYGI
  ||||.| | .|...|.|||. |.|..  .. . . .|      |.  |...|     . ||||| |.||
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWK------FMQREIKMLKNLLNIRHPNIVQFIGI
Pkinase_Tyr AqueK480.AA Pkinase_Tyr 14-85 31 6e-10 34.32 Pfam 1-72 (270) Show / Hide 
Range on Protein: 14-85
Range on HMM: 1-72/270
Sequence Identity: 31% (25 aa)

VHSSRLLGKGSYGLVCLGEWL------GVPVAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQL-NHPNIVSFYGI
..  . ||.|..| |..|.|       ..|||| .| |      .. .|    ...| .|. .. || .|||||..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE------GAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGV
Kinase AqueK480.AA LISK 19-85 30 7.2e-10 28.03 In-house 1-64 (296) Show / Hide 
Range on Protein: 19-85
Range on HMM: 1-64/296
Sequence Identity: 30% (21 aa)

LLGKGSYGLVCLGEWL--GVPVAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYGI
 .|||..| |  |...  | ..|. ..|..  .. . |     ..| .  || ..  | ||||| |.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPE-----YQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK480.AA LISK 127-227 22 7.5e-09 24.67 In-house 104-232 (296) Show / Hide 
Range on Protein: 127-227
Range on HMM: 104-232/296
Sequence Identity: 22% (30 aa)

LDLSIGITGGLRYLHERSNPITHQDLTSKNILLS----LAGIPKISDLGIAKILNSTCES-------------------------FARHSRRP------G
.... .|  |..|||..   | | ||.|||.|..         |. |.| |.... .  |                          ..  .|.      |
VKIALDIACGMSYLHSMN--IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTICG

TELYMPPEVKMADGEDRKTYDYRVDIYSLGVIVLEM
|.  |.||. . .    . ||...|..| |....|.
TPYWMAPEM-LLG----QSYDESCDVFSFGIVLCEI
Kinase AqueK480.AA STE 15-86 19 5e-08 24.56 In-house 1-99 (359) Show / Hide 
Range on Protein: 15-86
Range on HMM: 1-99/359
Sequence Identity: 19% (19 aa)

HSS-RLLGKGSYGLVCLGEWL-----------------GVPVAVRKLHESLFTLSKCE-------EEK-TRTLKAFVSEVGTLFQLN--HPNIVSFYGIH
    . .|||..| |...                    |. .|. ... .  . .. |       | | .  .. .  |. .. ..|  ||||| .|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY
Kinase AqueK480.AA LISK-DD1 129-227 28 1.7e-07 23.42 In-house 128-224 (290) Show / Hide 
Range on Protein: 129-227
Range on HMM: 128-224/290
Sequence Identity: 28% (31 aa)

LSIGITGGLRYLHERSNPITHQDLTSKNILLSLA---GI-PKISDLGIAKILNSTCESFARHSRRP------GTELYMPPEVKMADGEDRKTYDYRVDIY
.. .|  . .|||...  | | || |||||..      .  |. |.| |.... .  .      ..      ||.  |.|||    |..   ||...|..
IALDIACAMAYLHSKN--IIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQ-----NNRHMTICGTDNWMAPEVIL--GMS---YDWSCDVF

SLGVIVLEM
| |.  ||.
SFGMVLLEL
Kinase AqueK480.AA STE20 20-86 31 2.4e-05 15.82 In-house 7-73 (288) Show / Hide 
Range on Protein: 20-86
Range on HMM: 7-73/288
Sequence Identity: 31% (23 aa)

LGKGSYGLVCLGEWL--GVP----VAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYGIH
.|.|||| |...     |      ||..|.      |.||..|.   ..  . |.  . |..|||||..|| .
IGQGSYGKVYKAYHKPTGEYCNQRVAIKKMN-----LEKCDNEQ-DEWEDIQKEISIMKQCKHPNIVKYYGSY
Kinase AqueK480.AA STE-Unique 15-84 25 0.000683 9.05 In-house 1-68 (616) Show / Hide 
Range on Protein: 15-84
Range on HMM: 1-68/616
Sequence Identity: 25% (18 aa)

HSSRLLGKGSYGLVCLGE--WLGVPVAVRKLHESLFTLSKCEEEKTRTLKAFVSEVGTLFQLNHPNIVSFYG
  .  .|.|| | | . .   .. ..|. ..|.  |. .. |       . ..||. ..  |.|.|||  ||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEP----LVNMIISEIEIMKCLHHQNIVKYYG
Kinase AqueK480.AA Pkinase_Tyr 114-174 28 0.000818 13.54 Pfam 99-159 (270) Show / Hide 
Range on Protein: 114-174
Range on HMM: 99-159/270
Sequence Identity: 28% (18 aa)

RNR--QKPRLSYRNVLDLSIGITGGLRYLHERSNPITHQDLTSKNILLSLAGIPKISDLGIAK
|..  .|..|.    |. .. |  |. ||...   . | ||  .|.|..  .. ||.| | |.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase AqueK480.AA Ciliate-E2 14-83 18 0.004165 6.49 In-house 1-98 (365) Show / Hide 
Range on Protein: 14-83
Range on HMM: 1-98/365
Sequence Identity: 18% (18 aa)

VHSSRLLGKGSYGLVCLGEWLGVPV------------------AVRKLHESLFTLSKCEEEKTRTLKAFVSEVG----------TLFQLNHPNIVSFY
    ...|.|..| |....   |.                    | .    . ...| . | .   .    |.            |.|||||||. .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
Kinase AqueK480.AA NEK4 62-82 52 0.052416 3.22 In-house 43-63 (257) Show / Hide 
Range on Protein: 62-82
Range on HMM: 43-63/257
Sequence Identity: 52% (11 aa)

KAFVSEVGTLFQLNHPNIVSF
||   |.  | || |||||..
KAAEHEAQLLSQLKHPNIVEY