Gene AqueK483 (A.queenslandica)

AqueK483

Species: A.queenslandica
Alias: AqueK483
External Links:
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: TESK

Sequence

Name Sequence Type Origin Length Description Download
AqueK483.AA Protein None 400 None Fasta, JSON
AqueK483.kin_dom Protein Kinase Domain None 171 None Fasta, JSON

Protein domain

Protein domains of AqueK483.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK483.AA TESK 196-398 44 3.5e-100 317.13 In-house 1-242 (292) Show / Hide 
Range on Protein: 196-398
Range on HMM: 1-242/292
Sequence Identity: 44% (109 aa)

EKIGSGFFAEVYKVRHKLTDEIMVLKVNK----GLTGTKTRQEVELLKRLHHPNILHYIGSCIHNGQLHPLTEFVNGGTLKSLIQDVEKNPFPPEQRIQL
|||||||| |||||||. .  .||||.||         .. .||.|. .| ||||| . | |.|.||||.|||..|||.|  |  | .. . .  |.|.|
EKIGSGFFSEVYKVRHRASGQVMVLKMNKQKIWRANRHNMLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLAD-SELHLSWTQKIHL

SLDMAMGMEYLHNNGMLHRDFNSHNCLLR-KEGDRYTAVVADFGLA----------------------------------TKNPNLIKKLRR-NQSMVGT
 .| | || |||  |  |||  | ||| | .. . |.|||.|||||                                   | |      |.   . ||.
AYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAVVGDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLEKIPVYCMDSRKEKMAVVGS

PYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKDADPDEIPR
||||||||| | .|.|||| .|.|||||||. |  |||| .||
PYWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPR
Kinase AqueK483.AA LISK 197-398 37 1.1e-92 301.5 In-house 1-245 (296) Show / Hide 
Range on Protein: 197-398
Range on HMM: 1-245/296
Sequence Identity: 37% (93 aa)

KIGSGFFAEVYKVRHKLTDEIMVLKVNKG--------LTGTKTRQEVELLKRLHHPNILHYIGSCIH-NGQLHPLTEFVNGGTLKSLIQDVE--KNPFPP
.||.|||..|||..|. | . |..| ..          .  .. .||...|.| ||||....| | | .||||..||..|||.|. .. |..  | |.| 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLR-KEGDRYTAVVADFGLA-----TKNP---------------------NLIKKL---RRN--QSMV
.||. ..|| | ||.||| .. .||| .|.|||.| .. ......|.|||.|     ..|.                     . |.|    .|.   ...
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GTPYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKDADPDEIPR
|||||||||.| |..|.|..| .|.|||||||. |..||||  ||
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPR
Kinase AqueK483.AA TKL 198-389 24 2.9e-62 213.19 In-house 1-286 (364) Show / Hide 
Range on Protein: 198-389
Range on HMM: 1-286/364
Sequence Identity: 24% (71 aa)

IGSGFFAEVYKVRHKLTD--------EIMVLKVNKGLTG------------------------------TKTRQEVELLKRLHHPNILHYIGSCIHNGQ-
||||.|.|||| ... ..        . .. |. |                                   . ..|. ...||.||||....|.|. ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LHPLTEFVNGGT-LKSLIQDVEKNPFPPEQRIQLSLDMAMGMEYLHNNG--------MLHRDFNSHNCLLRKEGD-----------RY
            |.  .|.. ||. |  |.         ..||....||.| ||.|||...        ..||| .|.|.|. . .             .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

TAVVADFGLATKNPNLIKKLR----------------RNQSMVGTPYWMAPEVL----------------HGKEYNEKADTYSYGIVLCEIVSRK
.. ..||||.. . .  .. .                .. . .|||.|||||||                .|.||.||.| ||.||||.||..|.
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase AqueK483.AA TKL-Unique 194-389 31 1.8e-53 183.95 In-house 1-225 (290) Show / Hide 
Range on Protein: 194-389
Range on HMM: 1-225/290
Sequence Identity: 31% (71 aa)

RIEKIGSGFFAEVYKVRHKLTDE-IMVLKVNKGLTGTKTR---QEVELLKRLH-HPNILHYIGSCI----HNGQLHPLTEFVNGGTLKSLIQD-------
 ..|||.| ...|||. .. ..  | ....| ..  ....    || ..|.|| ||||.||.| |.    .....   .|...||.| .....       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VEKNPFPPEQRIQLSLDMAMGMEYLHNNG--MLHRDFNSHNCLLRKE--GDRYTAVVADFGLATKNPNLIKKLRR------NQSMVGTPYWMAPEVLHG
  ........||... .|.| ||.|||...  ..|||  | | |.  .     . . ..||||.. | . .|.  .      ||. .|.. ||||||| .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--KEYNEKADTYSYGIVLCEIVSRK
  . |.||.| ||.|||| ||..||
NFCQYSEKSDVYSFGIVLWEIATRK
Kinase AqueK483.AA STE 192-389 24 2.6e-44 153.52 In-house 1-265 (359) Show / Hide 
Range on Protein: 192-389
Range on HMM: 1-265/359
Sequence Identity: 24% (66 aa)

FERIEKIGSGFFAEVYKVRHKL---------------TDEIMVLKVNK----------------GLTGTKTR----QEVELLKRLH--HPNILHYIGSCI
.|.|||||.| | .||| ...                | |||  |. .                  . .. .    .|....|...  |||| .|.|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HNG-------QLHPLTEFVNGGTLKSLIQ---DVEKN---------PFPPEQRIQLSLDMAMG-MEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADFG
..|       .|.   |...||.| ..|.    . |.         .|| .| .    .   | ..|||...  |||  . | ||        .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

LATKNPNLIKKL-------------RRNQSMVGTPYWMAPEVLHG------KEYNEKADTYSYGIVLCEIVSRK
....  . . ..              .....|||| ||||||. .      |.|..|.| .| |....| .  |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase AqueK483.AA MLK 192-389 26 7.5e-42 142.98 In-house 1-233 (291) Show / Hide 
Range on Protein: 192-389
Range on HMM: 1-233/291
Sequence Identity: 26% (65 aa)

FERIEKIGSGFFAEVYKVRHKLTD----EIMVLKVN-----KGLTG---TKTRQEVELLKRLHHPN----ILHYIGSCIHNGQ-LHPLTEFVNGGTLKSL
..  |.|||| | .|.| | . .|    .. | .|.     |. |.    . ..|...|..| |||    |    | |. ... .  ..|.. || | ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IQDVEKNPF------------PPEQRIQLSLDMAMGMEYLHNNG---MLHRDFNSHNCLLR------KEGDRYTAVVADFGLATKNPNLIKKLRRN-Q--
. . .....            .... .. .|..| ||.|||..      ||| .||| |.       ..|   |....|||...       .. .. .  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG---TLKICDFGTSR-------DWHQMCTNM

-SMVGTPYWMAPEVL---HGKEYNEKADTYSYGIVLCEIVSRK
 |. ||. ||||||.    .  |.||.| .|.|.|| |...|.
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase AqueK483.AA Pkinase 192-389 28 4.6e-41 146.28 Pfam 1-209 (293) Show / Hide 
Range on Protein: 192-389
Range on HMM: 1-209/293
Sequence Identity: 28% (61 aa)

FERIEKIGSGFFAEVYKVRHKLTDEIMVLKVNKGLTGTKTRQ-------EVELLKRLHHPNILHYIGSCIHNGQLHPLTEFVNGG----TLKSLIQDVEK
.....||||| |..||| .|| | .| ..|. |  .  .  .       |....|||.||||. .....  .. ..  .|...||     |...|.  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NPF--PPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDR-YTAVVADFGLATK-NPNLIKKLRRNQSMVGTPYWMAPEVLH-GKEYNEKADT
..|  .... .   . .. |.||.|..| .|||  . |.|. ..|.   .  ..||||| . .   . . . ... .|||..|||||.  |..|  |.| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSYGIVLCEIVSRK
.|.|..| | ....
WSCGCILYEMLCGR
Kinase AqueK483.AA LISK-DD1 234-394 31 7.4e-41 142.05 In-house 44-233 (290) Show / Hide 
Range on Protein: 234-394
Range on HMM: 44-233/290
Sequence Identity: 31% (61 aa)

EVELLKR---LHHPNILHYIGSCIH-------------NGQLHPLTEFVNGGTLKSLIQDVE-----------KNPFPPEQRIQLSLDMAMGMEYLHNNG
|.. ||    . |||| ..|| | |             .. |. .|||..|| |  .. ..            | |.| . |. ..|| | .|.||| ..
EIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKN

MLHRDFNSHNCLLRKE-GDRYTAVVADFGLATKNPNLIKK----LRRNQSMVGTPYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKDADPD
 .|||  | | |. .    .... | |||.| .   . .|      |  ...||. ||||||. | .|.. .| .|.|.|| |. .||. |..
IIHRDLKSKNILVDENGDSQWRIKVCDFGFARM---FEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKR
Kinase AqueK483.AA STE20 192-389 30 4.3e-40 139.51 In-house 1-224 (288) Show / Hide 
Range on Protein: 192-389
Range on HMM: 1-224/288
Sequence Identity: 30% (70 aa)

FERIEKIGSGFFAEVYKVRHKLTDEIM-------VLKVNKG----LTGTKTRQEVELLKRLHHPNILHYIGSCIHN----GQLHPLTEFVNGGTLKSLIQ
.| .||||.| . .|||..|| |.|.        .....|            .|.  .|...|||| .|.|| . .     .|  . |. .||.|  ...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---DVEKN----PFPPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADFGLATKNPNLIK-----KLRRNQSMVGTPYWMAPEVL
     .||    |.  ||      ..  | .|||.|.. |||  . | || ..|.   .  ||||.. .   |.|     . .. ...|||||||||||.
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGE---VKLADFGVCAQ---LTKHGRDTMQFKRNTFVGTPYWMAPEVI

HG-----KEYNEKADTYSYGIVLCEIVSRK
 .     |.|..|.| .| || ..| . ..
QCMEGPDKGYDYKCDIWSLGITAIEMAEGE
Kinase AqueK483.AA Dicty4 232-390 37 6.2e-40 130.97 In-house 46-215 (277) Show / Hide 
Range on Protein: 232-390
Range on HMM: 46-215/277
Sequence Identity: 37% (67 aa)

RQEVELLKRLHHPNILHYIGSCI----HNGQLHPLTEFVNGGTLKSLIQD-------VEKNPFPPEQR-IQLSLDMAMGMEYLHN-N-GMLHRDFNSHNC
|.||.... . ||||.   |.|.    | | .   ||..  |.| ||. |         | ..|   | ... .| | || .||. |   .|||  ||| 
RKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL

LLRKEGDRYTAVVADFGLATKNPNLIKKLRRNQS----MVGTPYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKD
|  |    ... |.||||..    ..||   ..     ..||| ||||||. ...|||||| ||.|||| ||. |..
LVDKN---WRVKVCDFGLSQ----YMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQE
Kinase AqueK483.AA S_TKc 192-399 26 2.4e-33 118.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 192-399
Range on HMM: 1-231/231
Sequence Identity: 26% (67 aa)

FERIEKIGSGFFAEVYKVRHKLTDEIMVLKVNKGLTGTKTRQEVELLKRLHHPNILHYIGSCIHNGQLHPLTEFVNG--GTLKSLIQDVEKNP----FPP
.| ..|||.| |..|||.||| |..|. .|. |     ..|.|...||. ||||| ...... . . |.  .|...|  |.|...|..  ...    ||.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

EQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADFGLATKNPNLIKKLRRNQSMVGTPYWMAPEVLHGKEYNE-KADTYSYGIVLCE
 .   .   .. ..||.|..| .|||    | || .     .  ..|||||..            ...|||..||||||    |.  |.| .| |..| |
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

IVS------RKDA--------------------DPD--------E-------IPRK
 ..        ..                    ||.        .        |  
MLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK483.AA LIMK 234-336 45 1.1e-32 108.63 In-house 46-144 (287) Show / Hide 
Range on Protein: 234-336
Range on HMM: 46-144/287
Sequence Identity: 45% (47 aa)

EVELLKRLHHPNILHYIGSCIHNGQLHPLTEFVNGGTLKSLIQDVEKNPFPPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADF
||  .  | ||..| .||       |. .||.. ||.|| .|.|. . |||  ||. .  | | || |||  .  ||| |||||| | ..   . |||||
EVKVMRCLDHPHVLKFIGVLYKDKRLNMVTEYIKGGCLKNIIHDMDQ-PFPWQQRVRFARDIACGMSYLHSMCIIHRDLNSHNCLVREDR---SVVVADF

GLA
|||
GLA
Kinase AqueK483.AA Pkinase_Tyr 192-336 27 9.3e-26 87.86 Pfam 1-158 (270) Show / Hide 
Range on Protein: 192-336
Range on HMM: 1-158/270
Sequence Identity: 27% (45 aa)

FERIEKIGSGFFAEVYKVRHK----LTDEIMVLKVNKGLTGTKT------RQEVELLKRL-HHPNILHYIGSCI-HNGQ--LHPLTEFVNGGTLKSLIQD
 . ..|.|.| | |||| . |     |.     |. |  .  .        .|....| | |||||. ..| |. . ..  .   .|.. .| |..  ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

V--EKNPFPPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADFGLA
   .|.|..... .| ... |.|||||..... |||    |||. .  .. .. ..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLA
Kinase AqueK483.AA LIMK 352-398 59 2e-25 83.5 In-house 192-238 (287) Show / Hide 
Range on Protein: 352-398
Range on HMM: 192-238/287
Sequence Identity: 59% (28 aa)

MVGTPYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKDADPDEIPR
.||.||||||| . ||.|.|| | .|.|||.|||. |  |.|| .||
VVGNPYWMAPEMMNGKSYDEKVDVFSFGIVMCEIIGRVYACPDCMPR
Kinase AqueK483.AA TyrKc 192-400 19 8.8e-15 16.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-400
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FERIEKIGSGFFAEVYKVRHKLTDEIMV----LKVNKGLTGTKTRQEVELLKRL--HHPNILHYIGSCIHN-------GQLHPLTEFVNGGTLKSLIQDV
 . ..|.|.|.| |||| . |    |.|    || ..       ..| .....|  |||||.  .| |..        ..|  ..|.. .| ||. ... 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EKNPFPPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCLLRKEGDRYTAVVADFGLATKNPNL--------IKKLRR--NQSMVGTPYWMAPEVLHGKE
... ..... .. ... | |||||| ..  |||    |||. ...   |. ..||||. .  .          .. .   .  ..    |||||..  ..
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YNEKADTYSYGIVLCEIVSRKDADPDE----------------------IPRK-------------------------------------L
...| | .|.|... || .. .  . .                      .|                                       .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK483.AA Pkinase_Tyr 358-388 35 4.5e-08 27.96 Pfam 180-210 (270) Show / Hide 
Range on Protein: 358-388
Range on HMM: 180-210/270
Sequence Identity: 35% (11 aa)

WMAPEVLHGKEYNEKADTYSYGIVLCEIVSR
|||||... .....| | .|.|... ||...
WMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase AqueK483.AA LIMK 196-221 50 3e-06 17.41 In-house 5-30 (287) Show / Hide 
Range on Protein: 196-221
Range on HMM: 5-30/287
Sequence Identity: 50% (13 aa)

EKIGSGFFAEVYKVRHKLTDEIMVLK
|. | |||  . || |. | |.||.|
EVLGKGFFGQAIKVTHRQTGEVMVMK
Kinase AqueK483.AA Dicty4 192-208 47 0.026587 3.68 In-house 1-17 (277) Show / Hide 
Range on Protein: 192-208
Range on HMM: 1-17/277
Sequence Identity: 47% (8 aa)

FERIEKIGSGFFAEVYK
  . ..||.| |.||||
INIEQRIGKGSFGEVYK
Kinase AqueK483.AA LISK-DD1 197-208 58 0.040546 3.75 In-house 1-12 (290) Show / Hide 
Range on Protein: 197-208
Range on HMM: 1-12/290
Sequence Identity: 58% (7 aa)

KIGSGFFAEVYK
.||.| |. |||
EIGKGSFGKVYK