Gene AqueK489 (A.queenslandica)

AqueK489

Species: A.queenslandica
Alias: AqueK489
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK489.AA Protein None 1814 None Fasta, JSON
AqueK489.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of AqueK489.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_TYP AqueK489.AA LRR_TYP 210-233 25 0.003826 17.69 SMART 1-24 (24) Show / Hide 
Range on Protein: 210-233
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

FNNLQKVQMHHNRITDIPHELFSL
  ||..   ..|..| .|...|. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK489.AA LRR_1 212-233 29 0.00731 14.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 212-233
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLQKVQMHH-N--RIT-DIPHE-LFSL
|||.  . . |  ..| .||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC AqueK489.AA LRR_BAC 233-252 30 0.623623 2.79 SMART 1-20 (20) Show / Hide 
Range on Protein: 233-252
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

LPRIKDIDLSFNLISALPSS
 |..| .. |.| .. ||  
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK489.AA LRR_1 235-256 22 1.071191 6.64 Pfam 1-26 (26) Show / Hide 
Range on Protein: 235-256
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

RIKDIDLSF-N--LIS-ALPSS-IHSN
... .|||  |   ..  .|.| . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK489.AA LRR_1 189-211 22 51.265856 0.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 189-211
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

SFTYVGLSS-N--LL-KCIPEQILRFN
. ..  ||. |   | ..||. ..   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK489.AA LRR_1 260-281 40 0.000214 19.76 Pfam 1-26 (26) Show / Hide 
Range on Protein: 260-281
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLQSLNLSN-N--NLT-QLPSY-FKHS
.||.|.||. |  ||| ..|.  | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK489.AA LRR_TYP 260-280 50 0.019307 13.9 SMART 3-24 (24) Show / Hide 
Range on Protein: 260-280
Range on HMM: 3-24/24
Sequence Identity: 50% (11 aa)

SLQSLNLSNNNLTQLPSY-FKH
.|..|.||||.||.||.  | .
NLRELDLSNNQLTHLPPGAFQG
LRR_BAC AqueK489.AA LRR_BAC 258-277 50 0.025568 13.38 SMART 1-20 (20) Show / Hide 
Range on Protein: 258-277
Range on HMM: 1-20/20
Sequence Identity: 50% (10 aa)

ANSLQSLNLSNNNLTQLPSY
 ..|..|| |||.|| ||  
PPHLKWLNVSNNQLTELPEL
LRR_1 AqueK489.AA LRR_1 282-303 22 0.036352 11.85 Pfam 1-26 (26) Show / Hide 
Range on Protein: 282-303
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

HLRSLDISS-N--LFS-SVPDC-LTVM
.|..||.|. |   .. ..|.  .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_BAC AqueK489.AA LRR_BAC 280-299 30 0.138458 7.78 SMART 1-20 (20) Show / Hide 
Range on Protein: 280-299
Range on HMM: 1-20/20
Sequence Identity: 30% (6 aa)

HSHLRSLDISSNLFSSVPDC
 .||..|..|.|  .. |. 
PPHLKWLNVSNNQLTELPEL
LRR_TYP AqueK489.AA LRR_TYP 281-303 30 0.30321 4.1 SMART 2-24 (24) Show / Hide 
Range on Protein: 281-303
Range on HMM: 2-24/24
Sequence Identity: 30% (7 aa)

SHLRSLDISSNLFSSVPDCLTVM
..||.|| |.| ....|. .   
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK489.AA LRR_1 305-327 29 0.011975 13.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 305-327
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

HLTTLNISS-N-IGIE-IIPYE-LGNL
.|..|..|. |   ..  || . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
COR AqueK489.AA COR 691-717 24 0.000813 7.89 In-house 229-261 (434) Show / Hide 
Range on Protein: 691-717
Range on HMM: 229-261/434
Sequence Identity: 24% (8 aa)

SQYQIQRLYKF------ESLPMSLWPRLLSHLL
......| |..        ||...|||.. .|.
DCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLH
Kinase AqueK489.AA TKL 965-1137 19 2.3e-23 80.98 In-house 124-364 (364) Show / Hide 
Range on Protein: 965-1137
Range on HMM: 124-364/364
Sequence Identity: 19% (49 aa)

SMEDVILEHTISVSPFLRMRIVYQLASALKTLHSLK--------IIHRNVCLENIIVYSL---------SLDEQVNIKLG--GFSRSCLEMSQGLAVG--
| .....       . .|.|.... |...  ||| .        ||||.   .|| | .          .  .....|..  |.||.  ....  . .  
SLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTT

------------EHGRFP------APEMSNYL---------------YEYDQRADVFSFAFTSYEILTRKKLKCRKGVRFQTA---------------TG
             ...        |||. .                 .||....||.||.   .|||||..        ..                  .
MMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-------PYYDYPYMPMIFQDPFEEMFMM

NAD---RPNLK----------PLNGLCPYFTPLLDKCWNNDPHKRPYFIEILHQF
..|   || ..          | .   | .  |. .||. ||.||| | |||...
VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK489.AA LRRK 981-1080 29 9.8e-14 44.95 In-house 165-279 (351) Show / Hide 
Range on Protein: 981-1080
Range on HMM: 165-279/351
Sequence Identity: 29% (34 aa)

LRMRIVYQLASALKTLHSLK--IIHRNVCLENIIVYSLSLD-------EQVNIKLG--GFSR--SCLEMSQGLAVGEHGRFPAPEMSNYL--YEYDQRAD
|. .|..| |.... ||| .  ||||.   .||.. |.. .       ..|..|..  | ||  .|. |.    ...  .. |||  .|    ||.. .|
LKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVD

VFSFAFTSYEILTRK
..||.   .|.|||.
CYSFGMILWELLTRQ
Kinase AqueK489.AA RIPK 1065-1137 28 2.9e-12 38.06 In-house 210-290 (290) Show / Hide 
Range on Protein: 1065-1137
Range on HMM: 210-290/290
Sequence Identity: 28% (23 aa)

DVFSFAFTSYEILTRKKLKCRKGVRFQTATGNA--DRPNLKPLNGLCPY------FTPLLDKCWNNDPHKRPYFIEILHQF
|| |||.. .|.||.|.    ..   .  .  .   ||.|.|..  .|          |. .||  || .|| |.|.  ..
DVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
S_TKc AqueK489.AA S_TKc 893-1138 18 1.2e-10 -20.92 SMART 14-231 (231) Show / Hide 
Range on Protein: 893-1138
Range on HMM: 14-231/231
Sequence Identity: 18% (49 aa)

TVFKGEYGS--VPIAVKPYPPPNDRSANNPFLSFWHEITTLQYATQTDQCPYIIDPLLATTDPFSLVFSFAMF--CSMEDVILEHTIS-----VSPFLRM
.|.|.   .     |.|  .            ... ||  |.   . .    ..|      | . .|. ..     .. |.| ..         ..    
KVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

RIVYQLASALKTLHSLKIIHRNVCLENIIVYSLSLDEQVNIKLGGFSRSCLEMSQGLAVGEHGRFPAPEMSNYLYEYDQ-RADVFSFAFTSYEILTRKKL
...||...||. .||..|||| .  ||| . .       .||.. |  ...     . .  .  . |||.      |.  ..|. |.  . || |... .
FYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--TTFCGTPW--YMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPP

KCRKGVRFQTATGNADRPNLKPLNGLCPYFTPLLDKCWNNDPHKRPYFIEIL--------HQFT
 .    .     |              | .  ...||.. || |||   |.|        |.. 
FP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK489.AA MLK 1109-1137 56 1.2e-10 31.15 In-house 251-280 (280) Show / Hide 
Range on Protein: 1109-1137
Range on HMM: 251-280/280
Sequence Identity: 56% (17 aa)

CP-YFTPLLDKCWNNDPHKRPYFIEILHQF
||  .  |.  ||| |||||| | |||.|.
CPEPWAKLMQDCWNQDPHKRPKFSEILQQL
TyrKc AqueK489.AA TyrKc 893-1137 19 9.8e-09 -81.45 SMART 14-280 (280) Show / Hide 
Range on Protein: 893-1137
Range on HMM: 14-280/280
Sequence Identity: 19% (56 aa)

TVFKGEYGSVPIAVKPYPPPNDRSANNPFLSFWHEITTLQYA-TQTDQCPYIIDPLLATT---------DPFSLVFSFAMFCSMEDVILEHTISVSPFLR
.|.||..  .. |||   .            | .|.  .        . | |.  . . |         .|  .|. ..   .  | . .|   ...   
EVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGG---HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDL

MRIVYQLASALKTLHSLKIIHRNVCLENIIVYSLSLDEQVNIKLGGFSRSCLEMSQ--------GLAVGE--HGR--FP----APEMSNYLYEYDQRADV
  . .| |.    ||| ..|||     |. |     .|.  .| . |  |    .            . |  .|.  .|    |||  || ...    ||
LSFCWQIACGMEYLHSKNCIHRDLAARNCLV-----GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY-GKFTTKSDV

FSFAFTSYEILTR-KKLKC------RKGVRFQTATGNADRPNLKPLN-------GLCPYFTPLLDKCWNNDPHKRPYFIEILHQF
.||  . .||.|. ..          .  .      . .|.   | .            .. .  .||. ||..|| | || ..|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK489.AA TKL-Unique 1115-1137 47 1.4e-08 26.53 In-house 268-290 (290) Show / Hide 
Range on Protein: 1115-1137
Range on HMM: 268-290/290
Sequence Identity: 47% (11 aa)

LLDKCWNNDPHKRPYFIEILHQF
|...||. || .||.|.||.|  
LIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK489.AA MLK 1115-1137 52 4.4e-08 24.26 In-house 269-291 (291) Show / Hide 
Range on Protein: 1115-1137
Range on HMM: 269-291/291
Sequence Identity: 52% (12 aa)

LLDKCWNNDPHKRPYFIEILHQF
|. .||| |||||| | .|. ..
LMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK489.AA TKL-Unique 978-1080 27 1.5e-07 22.87 In-house 108-225 (290) Show / Hide 
Range on Protein: 978-1080
Range on HMM: 108-225/290
Sequence Identity: 27% (32 aa)

SPFLRMRIVYQLASALKTLHSLK--IIHRNVCLENIIVYSLSLDEQVNIKLGGFSRSCLEMSQ-GLAVGEHG-----------RFPAPEMSNYL-YEYDQ
.. .|.... . |... .||...  ||||.    |. | . |   ..|||. .|. | .  .     ..||            |  |||. . . . |..
NMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSE

RADVFSFAFTSYEILTRK
 .||.||..  .||.|||
KSDVYSFGIVLWEIATRK
Kinase AqueK489.AA Dicty5 1115-1141 44 2.5e-07 21.26 In-house 234-260 (260) Show / Hide 
Range on Protein: 1115-1141
Range on HMM: 234-260/260
Sequence Identity: 44% (12 aa)

LLDKCWNNDPHKRPYFIEILHQFTKPM
|  |||   ||.|| |.||.  | . .
LIKKCWQQKPHNRPSFKEICKYFESII
Kinase AqueK489.AA HH498 1047-1080 38 2e-06 16.03 In-house 190-223 (284) Show / Hide 
Range on Protein: 1047-1080
Range on HMM: 190-223/284
Sequence Identity: 38% (13 aa)

RFPAPEMSNYLYEYDQRADVFSFAFTSYEILTRK
|. |||       |.  .||||.|   .|..||.
RWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTRE
Kinase AqueK489.AA LRRK 1110-1139 33 2e-06 19.02 In-house 322-351 (351) Show / Hide 
Range on Protein: 1110-1139
Range on HMM: 322-351/351
Sequence Identity: 33% (10 aa)

PYFTPLLDKCWNNDPHKRPYFIEILHQFTK
...  |...||..|| ||| |..|. .   
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK489.AA Dicty4 1110-1139 34 2e-06 17.5 In-house 246-277 (277) Show / Hide 
Range on Protein: 1110-1139
Range on HMM: 246-277/277
Sequence Identity: 34% (11 aa)

PYFTPLLDKCWNNDPHKRPYFIEILHQ--FTK
| .. |. .||..|| .|| | ||. .     
PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK489.AA Jak 988-1024 29 5e-06 17.39 In-house 126-162 (299) Show / Hide 
Range on Protein: 988-1024
Range on HMM: 126-162/299
Sequence Identity: 29% (11 aa)

QLASALKTLHSLKIIHRNVCLENIIVYSLSLDEQVNI
|.......|.. ..||..||  ||.| .  ... |.|
QICWGMHYLEDKRYIHGDVCARNILVDREGHWCCVKI
Kinase AqueK489.AA HH498 1115-1137 34 2.3e-05 12.53 In-house 262-284 (284) Show / Hide 
Range on Protein: 1115-1137
Range on HMM: 262-284/284
Sequence Identity: 34% (8 aa)

LLDKCWNNDPHKRPYFIEILHQF
|.  ||.  |  || | .|.   
LIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK489.AA RIPK 981-1013 40 9.5e-05 12.07 In-house 108-142 (290) Show / Hide 
Range on Protein: 981-1013
Range on HMM: 108-142/290
Sequence Identity: 40% (14 aa)

LRMRIVYQLASALKTLHSLK--IIHRNVCLENIIV
|| |.... ...   ||| .  ||||   .||| |
LRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILV
Kinase AqueK489.AA Dicty5 1060-1080 47 0.000116 11.97 In-house 180-200 (260) Show / Hide 
Range on Protein: 1060-1080
Range on HMM: 180-200/260
Sequence Identity: 47% (10 aa)

YDQRADVFSFAFTSYEILTRK
|.| .||.||.   .|..|||
YHQKCDVYSFGIVLWEMFTRK
Kinase AqueK489.AA Jak 1118-1139 36 0.000329 10.96 In-house 278-299 (299) Show / Hide 
Range on Protein: 1118-1139
Range on HMM: 278-299/299
Sequence Identity: 36% (8 aa)

KCWNNDPHKRPYFIEILHQFTK
.||..||..|| |  |. .. .
QCWHYDPNQRPSFRTIIRDLNQ
Kinase AqueK489.AA Dicty4 1059-1080 50 0.000334 10.11 In-house 193-214 (277) Show / Hide 
Range on Protein: 1059-1080
Range on HMM: 193-214/277
Sequence Identity: 50% (11 aa)

EYDQRADVFSFAFTSYEILTRK
.|.. |||.||.   .|||||.
PYNEKADVYSFGIVLWEILTRQ
Kinase AqueK489.AA Pkinase 984-1004 42 0.00377 12.22 Pfam 112-132 (293) Show / Hide 
Range on Protein: 984-1004
Range on HMM: 112-132/293
Sequence Identity: 42% (9 aa)

RIVYQLASALKTLHSLKIIHR
...||....|. .|| .||||
FYMYQILRGLEYCHSMGIIHR
Kinase AqueK489.AA Dicty5 980-1013 29 0.009712 5.25 In-house 104-137 (260) Show / Hide 
Range on Protein: 980-1013
Range on HMM: 104-137/260
Sequence Identity: 29% (10 aa)

FLRMRIVYQLASALKTLHSLKIIHRNVCLENIIV
|... .    | ... |||  |||| .   |. .
FQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLI
Kinase AqueK489.AA MLK 975-1004 30 0.019257 4.44 In-house 119-151 (291) Show / Hide 
Range on Protein: 975-1004
Range on HMM: 119-151/291
Sequence Identity: 30% (10 aa)

ISVSPFLRMRIVYQLASALKTLHSLK---IIHR
. ... . |.. .| |...  |||..   ||||
RVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR
Kinase AqueK489.AA Pkinase 1115-1137 36 0.089876 7.35 Pfam 269-293 (293) Show / Hide 
Range on Protein: 1115-1137
Range on HMM: 269-293/293
Sequence Identity: 36% (9 aa)

LLDKCWNNDPHKRPYFIEILHQ--F
....|.. ||.||| . .||.   |
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK489.AA Jak 1058-1079 29 0.138733 1.63 In-house 202-224 (299) Show / Hide 
Range on Protein: 1058-1079
Range on HMM: 202-224/299
Sequence Identity: 29% (7 aa)

YEYDQRADVFSFA-FTSYEIL-TR
|.. . .|..||.  | .||. ..
YLT-LAMDKWSFGRVTLWEICNCY
Kinase AqueK489.AA MLK 1060-1080 38 0.225982 0.68 In-house 213-233 (291) Show / Hide 
Range on Protein: 1060-1080
Range on HMM: 213-233/291
Sequence Identity: 38% (8 aa)

YDQRADVFSFAFTSYEILTRK
|.  .||.|..   .|.|||.
YSEKCDVWSWGVVLWEMLTRE