Gene AqueK491 (A.queenslandica)

AqueK491

Species: A.queenslandica
Alias: AqueK491
External Links:
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK491.AA Protein None 2663 None Fasta, JSON
AqueK491.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of AqueK491.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank AqueK491.AA Ank 45-77 42 3.3e-08 33.84 Pfam 1-33 (33) Show / Hide 
Range on Protein: 45-77
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

QGNTALHVACYYGERECASILLHYKAEVNAKGA
 |.|.||.||..|  |... || . |.|||.  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK491.AA Ank 20-44 32 0.008318 14.38 Pfam 9-33 (33) Show / Hide 
Range on Protein: 20-44
Range on HMM: 9-33/33
Sequence Identity: 32% (8 aa)

AAMWGDVALLESLLSNGADPNLPNS
|...|..  .. ||..|||.|. . 
ACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK491.AA Ank 78-128 21 0.083357 10.77 Pfam 1-33 (33) Show / Hide 
Range on Protein: 78-128
Range on HMM: 1-33/33
Sequence Identity: 21% (11 aa)

EGKIPLHRAVLGVCVLEPGPKYQSREQISENQIDLVKLLVGNGSKVTFHDG
.|  ||| |..                    ... ||.|...|  |  .| 
DGFTPLHLACRCG------------------HTEVVKMLLQHGADVNAQDD
Ank AqueK491.AA Ank 129-149 33 32.774066 1.41 Pfam 1-21 (33) Show / Hide 
Range on Protein: 129-149
Range on HMM: 1-21/33
Sequence Identity: 33% (7 aa)

YGDTPYDAALQCDFYECAELL
.|.||   | .|. .|....|
DGFTPLHLACRCGHTEVVKML
Ank AqueK491.AA Ank 184-214 35 0.000794 18.06 Pfam 1-31 (33) Show / Hide 
Range on Protein: 184-214
Range on HMM: 1-31/33
Sequence Identity: 35% (11 aa)

EYMTLLMIASREGHSAIVDYLIDIGAKVTHT
. .| |..|.| ||  .| .|.. || | ..
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQ
Ank AqueK491.AA Ank 221-241 42 0.000398 19.14 Pfam 4-24 (33) Show / Hide 
Range on Protein: 221-241
Range on HMM: 4-24/33
Sequence Identity: 42% (9 aa)

TALHYAAENGHADVIKTLIKR
|.||.|...||..|.| |...
TPLHLACRCGHTEVVKMLLQH
Ank AqueK491.AA Ank 257-274 61 0.013341 13.64 Pfam 6-23 (33) Show / Hide 
Range on Protein: 257-274
Range on HMM: 6-23/33
Sequence Identity: 61% (11 aa)

LHLAARNGHADTVKVLLD
||||.|.||.. || ||.
LHLACRCGHTEVVKMLLQ
Ank AqueK491.AA Ank 312-334 47 6.8e-05 21.92 Pfam 1-23 (33) Show / Hide 
Range on Protein: 312-334
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

EGRTPLHEAVIGGHTDIVSMFVK
.|.|||| |.. |||..|.|...
DGFTPLHLACRCGHTEVVKMLLQ
Ank AqueK491.AA Ank 396-428 51 6.6e-08 32.78 Pfam 1-33 (33) Show / Hide 
Range on Protein: 396-428
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

MGRTPLHEASRLGFTEMIEILQEGGADVNAIMR
.|.|||| |.| | ||... | . ||||||  .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank AqueK491.AA Ank 437-462 38 0.015062 13.45 Pfam 1-26 (33) Show / Hide 
Range on Protein: 437-462
Range on HMM: 1-26/33
Sequence Identity: 38% (10 aa)

ADLTALVQAAMTNDVKMVRFLLQHGA
   |.|  |.. .....|..||||||
DGFTPLHLACRCGHTEVVKMLLQHGA
LRR_TYP AqueK491.AA LRR_TYP 574-598 32 0.007705 16.68 SMART 1-24 (24) Show / Hide 
Range on Protein: 574-598
Range on HMM: 1-24/24
Sequence Identity: 32% (8 aa)

LKNLLRLELNRNNISSLPVSDDWEC
| || .| |..|....|| .. ...
LPNLRELDLSNNQLTHLP-PGAFQG
LRR_1 AqueK491.AA LRR_1 553-574 25 0.176137 9.42 Pfam 1-26 (26) Show / Hide 
Range on Protein: 553-574
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALSQLNISD-N--KLN-ELPVA-IFQL
 |  |..|. |  .|  ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK491.AA LRR_1 576-598 29 0.653935 7.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 576-598
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLLRLELNR-N--NIS-SLPVSDDWEC
|| .| |.. |  |.. ..| |    .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK491.AA LRR_1 600-621 37 0.000364 18.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 600-621
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLEHIDMSH-N--QLT-SLPPL-LFTL
.|.|.|.|. |  .|| ..||  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK491.AA LRR_TYP 600-621 50 0.007139 16.79 SMART 3-24 (24) Show / Hide 
Range on Protein: 600-621
Range on HMM: 3-24/24
Sequence Identity: 50% (11 aa)

SLEHIDMSHNQLTSLPPLLFTL
.|.. | |.||||.||| .|  
NLRELDLSNNQLTHLPPGAFQG
LRR_TYP AqueK491.AA LRR_TYP 622-644 30 0.766284 0.8 SMART 2-24 (24) Show / Hide 
Range on Protein: 622-644
Range on HMM: 2-24/24
Sequence Identity: 30% (7 aa)

PELKELCANNNAIRDVPIEVWKA
|.|.||  .||... .| ...  
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK491.AA LRR_1 646-667 29 1.687619 5.94 Pfam 1-26 (26) Show / Hide 
Range on Protein: 646-667
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLQKLLLQK-N--RLE-SFPSP-FLSP
.||.| |.  |  .|. ..|.  | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK491.AA LRR_TYP 794-817 45 6.8e-05 23.51 SMART 1-24 (24) Show / Hide 
Range on Protein: 794-817
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LFQLETLDLSYNELTLIPQGLCCL
| .|..||||.| || .|.|..  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK491.AA LRR_1 796-817 40 0.001274 17.01 Pfam 1-26 (26) Show / Hide 
Range on Protein: 796-817
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

QLETLDLSY-N--ELT-LIPQG-LCCL
.|..||||. |   ||  || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK491.AA LRR_TYP 819-839 34 0.586799 1.75 SMART 2-24 (24) Show / Hide 
Range on Protein: 819-839
Range on HMM: 2-24/24
Sequence Identity: 34% (8 aa)

PKLLKLHLHHNNLSSL--GTITD
|.| .|.|..|.|..|  |.  .
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK491.AA LRR_1 820-850 18 4.863172 4.31 Pfam 1-26 (26) Show / Hide 
Range on Protein: 820-850
Range on HMM: 1-26/26
Sequence Identity: 18% (7 aa)

KLLKLHLHH-N--NLS-SLGTITDYPSEIEL--IDGC
.| .|.| . |  ||. .          |    . ..
NLQHLDLSGCNCCNLTGH----------IPPSCF-NL
LRR_TYP AqueK491.AA LRR_TYP 897-918 29 0.320737 3.9 SMART 1-24 (24) Show / Hide 
Range on Protein: 897-918
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LRKLGYLKLAHNKLVDV--QLFRT
|..|  | | .|.|  .  ..|. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK491.AA LRR_1 899-919 22 71.33363 0.17 Pfam 1-26 (26) Show / Hide 
Range on Protein: 899-919
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

KLGYLKLAH-N--KLV-DVQL--FRTT
.| .| | . |  .|. ...   |   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP AqueK491.AA LRR_TYP 998-1020 33 0.091336 8.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 998-1020
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

YPQLSTLDLGHNKLRSVPSHI-HL
 |.| .|||..|.|...|. . . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 AqueK491.AA LRR_1 1000-1021 25 0.706931 7.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1000-1021
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

QLSTLDLGH-N--KL-RSVPSH-IHLI
.| .|||.. |  .| ...|.  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 AqueK491.AA LRR_1 1023-1045 25 0.096914 10.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1023-1045
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLAVLTISH-N-ASI-DTLPLE-LSNL
.| .| .|. |  .. ...| . . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC AqueK491.AA ROC 1089-1310 25 1.2e-41 137.23 In-house 1-215 (215) Show / Hide 
Range on Protein: 1089-1310
Range on HMM: 1-215/215
Sequence Identity: 25% (66 aa)

YESMKLMLVGLQKQGKTTLLTRLREINEVRTPISTFNERKEGETVSAAVSLKPGGITGASSFFRRIGSRDAPLSTVGVD-LGLWKYRKD--LEPSYRGKK
. .|||||.| .. |||.|. .|.  .  .....                                   .   .|.|.. .  |.. ..   .       
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC-------------------------------DKGNHPTTHGIEPIQQWVLDCKDMMF-------

SVPLRSVTFYTWDFGGQEEYYATHQCFLSN-RSLYLVIFNVCD----GEDG----IDS--LELWLHNIQARAPE--------SPVIIVGTHSDLLKEDK-
  . . ..|  |||||||.|.|||| ||.| ||.||....  .    |..     .    || || .|..|.|         |||||||||.|   ... 
RKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDN

--EQRKQELTNYLEKLRDLGLPQI----------KEVRFVGCPTSGKAEGVSELRVA
  .|.|| .    .|||.  .|.|          ...  | | |.   .|...|| .
KVYQHKQCC-RMWQKLRNK-FPNICHSWMQIEHYQGFFHVDCETG--CKGIDKLRHH
Miro AqueK491.AA Miro 1197-1259 25 1.9e-10 39.54 Pfam 73-140 (140) Show / Hide 
Range on Protein: 1197-1259
Range on HMM: 73-140/140
Sequence Identity: 25% (17 aa)

WDFGGQEEYYATHQCF--LSNRSLYLVIFNVCDGE--DGIDSLELWLHNIQARAPE-SPVIIVGTHSD
||.||.|. ...|. |  . ... ... . ..|.|  .  ...  || ...... . .|||.||.. |
WDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
Miro AqueK491.AA Miro 1093-1111 21 0.579836 5.65 Pfam 1-19 (140) Show / Hide 
Range on Protein: 1093-1111
Range on HMM: 1-19/140
Sequence Identity: 21% (4 aa)

KLMLVGLQKQGKTTLLTRL
|....| .. ||.... ..
KVVVCGDKGCGKSSFIHQY
COR AqueK491.AA COR 1327-1494 21 9.5e-32 100.0 In-house 1-209 (434) Show / Hide 
Range on Protein: 1327-1494
Range on HMM: 1-209/434
Sequence Identity: 21% (46 aa)

IGGNKVKLLE---------QPVPSSYLRLEERMRELVVKCQSEVDVSPVMKESEFFEAVQDII-----------PNPRELNQAVTFLHENGVLLHYA---
|..   |...         |||| |......  .|.  |  ..   .|.|  .||.. .|.               . ||......||. |...|.    
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMR-KWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWD

-TPALNHLYFIDPQWLCDMLAHVVTIPEVNRFIQRGSGPEAGI-LKTSVLSHIFKGK----------LFPHTLRNEYIELLSKFEVALLLDR--------
  | |. ....||||.|.|..|.... |...|.    .   || .... |..|....           .|... . ..||. |||... .|         
HDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHK---LHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQ

--NRMLVPSMLPS
   . |.|..||.
ETTTYLIPQLLPD
COR AqueK491.AA COR 1568-1590 37 0.000764 7.98 In-house 233-261 (434) Show / Hide 
Range on Protein: 1568-1590
Range on HMM: 233-261/434
Sequence Identity: 37% (11 aa)

LRRFYFM------KYVPSGFWPRLISRFL
||| | .      .. |.|||||.. |..
LRRHYHYCMDHHHMFLPAGFWPRFQVRLH
Kinase AqueK491.AA LRRK 1968-2227 28 4.6e-61 209.17 In-house 1-310 (351) Show / Hide 
Range on Protein: 1968-2227
Range on HMM: 1-310/351
Sequence Identity: 28% (92 aa)

VDRGKFVASGSFG-EIYHGAIY-------------------PHLSASDDEGREVAIKIDKQDR--------------------------KHFNMETAAKA
. ... . .|.|| ..| .                      .  . |.| . .||||. . |.                             |.| ...|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YTEIRAEVALLKDLDHEYIINFIGLTLQPLCFMLEWASKGSLHGILQSYYRTD-----SKVSPWTLVEAGRQVANGLSYLHSRN--VVYYDLKSPNILVF
. | | ||... .|.| .|.. .|....|||. .| |. |.|.  |... ..       . |. .. .   |.| |. ||||.|  ... ||||||||..
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

EFP---SADESLRVSLESSPVLDKLGKFPVHVKITDLGISR--KITPGG-VVGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQ-FPFER
..|   | .                 . .|..|| | ||||  .... | . |. |.| .|||||.|| |.| .|||||..||||...|||  | .||. 
SSPQNHSPN---------------YPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDE

QN----L-MHNQIEKLVVDGARPSI
 .    . ...|||... .| ||.|
HDFFDHMQWMEQIEDKIIEGLRPTI
Kinase AqueK491.AA TKL 1974-2227 23 1.5e-48 167.59 In-house 1-319 (364) Show / Hide 
Range on Protein: 1974-2227
Range on HMM: 1-319/364
Sequence Identity: 23% (83 aa)

VASGSFGEIYHGAIY------PHLSASDDEGREVAIKIDKQDRKHFNME-------------------TAAKAYTEIRAEVALLKDLDHEYIINFIG---
. ||.|||.|.|         |    | | |..||.|. |..   ....                   .| ..  ... |. ... |.|. |. |.|   
IGSGGFGEVYKGKWRGWGGKCP----S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCC

------LTLQP------LCFMLEWASKGSLHGILQSYYRTDSKVSPWTL-VEAGRQVANGLSYLHSRN--------VVYYDLKSPNILVFEF---PSADE
        ..|      ||.  |....|||. .|.           | . .   ...| |..||||.|        ... ||||.||||.|     | ..
CPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NY

SLRVSLESSPVLDKLGKF----PVHVKITDLGISRKITPGGVVGY---------------------KGTPAFMAPEILR-------YVG------KEACT
.                .    ....||.|.|.|| ... |                          |||..||||.||       .||      ..  .
M----------------YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

EKVDVFSFGMFMYELLAQQFPFERQNLMHNQIE-------KLVVD-GARPSI
||.||.|||. ..|.|. . |.. .. |  ..        ..|.| | || |
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPI
Kinase AqueK491.AA Pkinase 1968-2219 22 4e-32 114.67 Pfam 1-228 (293) Show / Hide 
Range on Protein: 1968-2219
Range on HMM: 1-228/293
Sequence Identity: 22% (60 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGRE-VAIKIDKQDRKHFNMETAAKAYTEIRAEVALLKDLDHEYIINFIGLTL--QPLCFMLEWASKG---
  .|. . |||||.           . .   .. ||.|| | .... ... ..       .|....| |.|..|. ...     . ... .|.. .|   
YHIGRKIGSGSFGCV--------YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-SLHGILQ-SYYRTDSKVSPWTLVEAGRQVANGLSYLHSRNVVYYDLKSPNILVFEFPSADESLRVSLESSPVLDKLGKFPVHVKITDLGISRK--ITPG
 .|. ... ..... .  |.|..    .|.. || |.||..... |||. |||. . .  |.                    .|||.| |....  . ..
MDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--------------------CVKICDFGLAKQFDY-NN

GVVGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQFPFERQN----LMHNQIEKLV
.  .. ||| .||||..|  | .  . |||..|.|  .||.|  ..||  .       |.|.....
SMTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMIC
Kinase AqueK491.AA Ciliate-E2 2087-2249 21 2.1e-29 98.11 In-house 152-335 (365) Show / Hide 
Range on Protein: 2087-2249
Range on HMM: 152-335/365
Sequence Identity: 21% (48 aa)

RQVAN---------------GLSYLHSRN-VVYYDLKSPNILVFEFPSADESLRVSLESSPVLDKLGKFPVHVKITDLGISRKITPG-------------
.|...               .| ||||.| ... |.|  |||.                             .||.|.|.|.|...              
KQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWY

-------GVVGYK-------------GTPAFMAPEILRYVG------KEACTEKVDVFSFGMFMYELLAQQFPFERQNLMHNQIEKLVVDGARPSIQNKV
       .  ||              ||| .||||||.. .      ..  ..|.|..|.|. .||.|  ..||       .||..  .|   |  |.. 
MFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKD-

TSACIVTLP-----IDISSQVPD
|  ||   .      ..| .. |
TQ-CI-Q-CKWKSWKKWSQECKD
Kinase AqueK491.AA S_TKc 1968-2309 17 6.3e-29 103.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 1968-2309
Range on HMM: 1-231/231
Sequence Identity: 17% (64 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGREVAIKIDKQDRKHFNMETAAKAYTEIRAEVALLKDLDHEYIINFIGLTL-QPLCFMLEWASK--GSLH
 . .. . .|.||. | .            ||.||||| |                 || |...||  .|..|.....    . |.. .| ..   |.|.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLF

GILQSYYR--TDSKVSPWTLVEAGRQVANGLSYLHSRNVVYYDLKSPNILVFEFPSADESLRVSLESSPVLDKLGKFPVHVKITDLGISRKITPGGVVGY
 ..... |  .... .. .     .|....| |.||..... |||  |||. |                          |.||.| |..|..       .
DYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------------------HIKICDFGLARQL-----TTF

KGTPAFMAPEILRYVGKEACTE-KVDVFSFGMFMYELLAQQFPFERQNLMHNQIEKLVVDGARPSIQNKVTSACIVTLPIDISSQVPDDGSTSETSLTPS
 ||| .||||.|        .  |.|. |.|  .||.|. . ||.     .... |...                                         
CGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------------------------------------

VSQYHTNVVRGDLQEEVWFCSKEKD---DQTLE-RASSRLSFVSFRG------RANFV
                    |.|     .. |.   . |..               ..
--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK491.AA MLK 1968-2205 26 2.8e-25 80.31 In-house 1-226 (280) Show / Hide 
Range on Protein: 1968-2205
Range on HMM: 1-226/280
Sequence Identity: 26% (66 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGREVAIKIDKQDRKHFNMETAAKAYTEIRAEVALLKDLDHEYIINFIGLTLQ--PLCFMLEWASKGSLHG
..  . . .| ||..| .           .| |||.|. .|| ..  |  . .   ..| |  |.. | |. ||   |  |.   || ..|..  |||  
LKIKEIIGNGGFGKVYRAQW---------KGEEVAVKAHRQDPEQ-DMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNR

ILQSYYRTDSKVSPWTLVEAGRQVANGLSYLHSRN---VVYYDLKSPNILVFEFPS---ADESLRVSLESSPVLDKLGKFPVHVKITDLGISRKITPGGV
..        .. |  ||.   |.| |. |||      ..  |||| |||. |       .| .. .       ... .     |||| |. |. .    
VCAGK-----RIPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCN--KQLKITDFGLAREWHKTTR

VGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQFPF
    || | ||||...   .    .  || |.|  . |||    |.
MSAAGTYAWMAPEVIK---ESTWSKGSDVWSYGVLLWELLTGEVPY
Kinase AqueK491.AA MLK 2014-2206 25 3e-25 84.64 In-house 22-237 (291) Show / Hide 
Range on Protein: 2014-2206
Range on HMM: 22-237/291
Sequence Identity: 25% (60 aa)

NME-----TAAKAYT--------------EIRAEVALLKDLDHEY----IINFIGLTLQP---LCFMLEWASKGSLHGIL---QSYYR-------TDSKV
|..      | |...              ... |. .|. |.|.     || | |  |||   .|  .|....|||. .|   .|           |  .
NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVY

SPWTLVEAGRQVANGLSYLHSRN---VVYYDLKSPNILVF--EFPSADESLRVSLESSPVLDKLGKFPVH---VKITDLGISRKITPGGVV---GYKGTP
..  ..    |.|.|..||||     .. .||||.|||.   .                      . . |   .||.| |.||...  .     . .||.
DHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEIC----------------------H-DMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTY

AFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQFPFE
|.||||..     | ..||.||.|.|. ..|.|. . |..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK
Kinase AqueK491.AA TK 1968-2199 15 3.7e-24 77.24 In-house 1-388 (486) Show / Hide 
Range on Protein: 1968-2199
Range on HMM: 1-388/486
Sequence Identity: 15% (65 aa)

VDRGKFVASGSFG---EIYHGAIYPHLSASDDEG------------------REVAIKIDKQDRKHFNMETAAKAYTEIR----------AEVALLKD--
.  ||   .| ||   |.| |  ...     ...                   .||.|. | .  .  .|  .   .. |          .| ....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSL

LDHEYIINFIGLTLQP--------------LCFMLEWASKGS----LHGILQSYYRTDSK----------------------------------------
..|. |....|  .|.              .. ..|....|.    |.  |..  .. ..                                        
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VSPWTLVEAGRQVANGLSYLHSR------NVVYYDLKSPNILVFE-------FPSADESLRVSLESSP
                                ... .|.   .|.|.|..||||.      |.|  ||   |.||.|       |               
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHF---------------

VLDKLGKFPVHVKITDLGIS--------RKITPGGVVGYKGTPAF----------------------------MAPEILRY-VGKEA-----CTEKVDVF
     . .. ..||.| | |        |.| ...    |...                              |||| |.. |  ||     .|.| ||.
-----DGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVW

SFGMFMYELL
||| .|.|..
SFGVLMWEIF
Kinase AqueK491.AA Pkinase_Tyr 1968-2199 24 1.3e-20 70.39 Pfam 1-208 (270) Show / Hide 
Range on Protein: 1968-2199
Range on HMM: 1-208/270
Sequence Identity: 24% (61 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGREVAIKIDKQDRKHFNMETAAKA--YTEIRAEVALLKDL-DHEYIINFIGLTL---QP--LCFMLEWAS
.  ||   .|.|||.|.|  ..     |... .||.|. |.        .  ..    .  .|....| | .|. |....|  .   .|  ..  .| . 
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKMLKE-------GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

KGSLHGILQSYYRTDSKVSPWTLVEAGRQVANGLSYLHSRNVVYYDLKSPNILVFEFPSADESLRVSLESSPVLDKLGKFPVHVKITDLGISRKI-----
.|.|.  |..    . .... .|..  .|.|.|..||.|.| .  ||   |.|| |                        . .|||.| | .| |     
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------------------------NNVVKICDFGLARDIYNDDY

----TPGGVVGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELL
    . || .  | .    ||| ..|     .|.| || |||  |.|..
YYRKRGGGKLPIKWM----APECINYGK---FTTKSDVWSFGVLMWEIF
Kinase AqueK491.AA STE 1968-2236 16 7.1e-20 66.95 In-house 1-331 (359) Show / Hide 
Range on Protein: 1968-2236
Range on HMM: 1-331/359
Sequence Identity: 16% (60 aa)

VDRGKFVASGSFGEIYHGA------IYPHLSAS---DDEGREVAIK---IDKQDRKHFN-------METAAKAYTEIRAEVALLKDLD--HEYIINFIGL
 .. ... .|.||. | ..      |. .        . |. .|||   ..... |  .       . .  .   .|  |. ..|...  |..|....| 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

TLQP---------LCFMLEWASKGSLHGILQSYYRTD----------SKVSPWTLVEAGRQVANG-LSYLHSRNVVYYDLKSPNILVFEFPSADESLRVS
 ..          |.  .|. . |||  |....| .           ....   .    ||.  | |.|||| ...  |.|. |||.             
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------------

LESSPVLDKLGKFPVHVKITDLGISRKITP----------------GGVVG--YKGTPAFMAPEILRY--VG-KEACTEKVDVFSFGMFMYELLAQQFPF
                ||..| |.. ..|.                ..       ||| .||||...    | .  ...|.|. |.|  . |..  . |.
----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW

-ERQNL-MHNQIEKL-----------VVDGARPSIQN-------------------KVTSACI
 . ... .  .| .            .|.|  |....                   |... ..
HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFK
Kinase AqueK491.AA Dicty4 2143-2227 31 4.3e-17 53.7 In-house 153-240 (277) Show / Hide 
Range on Protein: 2143-2227
Range on HMM: 153-240/277
Sequence Identity: 31% (29 aa)

VKITDLGISR----KITPGG-VVGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQFPFE--RQNLMHNQIEKLVVD-GARPSI
||..|.|.|.     .. .    . .|||. ||||...   ... .||.||.|||.  .|.|  | |.    ...|  |.  .|.. . ||.|
VKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM---HQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYM--QFVRAVCNKKLRPPI
Kinase AqueK491.AA CAMK 2087-2206 23 6.6e-17 50.34 In-house 186-335 (425) Show / Hide 
Range on Protein: 2087-2206
Range on HMM: 186-335/425
Sequence Identity: 23% (39 aa)

RQVANGLSYLHSRNVVYYDLKSPNILVF-EFPSADESLRVSLESSPVLDKLGKFPVH--------VKITDLGISRKITPGGVVG----------------
||.. .. |.||.|.|  |||  |||.   ... |  . . .                       .||.| | ..|..||                    
RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDP-V-E-HD-------------EIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTT

---------YKGTPAFMA-PEILRYVG-----------KEACTEKVDVFSFGMFMYELLAQQFPFE
         . |||..|| ||.|.. |           |. ...|.|. | |  .| .|   .||.
PTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase AqueK491.AA TyrKc 1968-2265 21 9.1e-17 48.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 1968-2265
Range on HMM: 1-280/280
Sequence Identity: 21% (71 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGREVAIKIDKQDRKHFNMETAAKAYTEIRAEVALLKDL--DHEYIINFIGLTL---------QPLCFMLE
.  ||   .| |||.|.|  .          ..||.|  | |              ... |  ... |  .|. |....|  .         .||.  .|
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

WASKGSLHGILQSYYRTDSKVSPWTLVEAGRQVANGLSYLHSRNVVYYDLKSPNILVFEFPSADESLRVSLESSPVLDKLGKFPVHVKITDLGISRKITP
 ...|.|.  |... ..   ... .|..   |.|.| .||||.|..  ||   |.|| |                          .|||.| | ||.|. 
YMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------------TVKISDFGLSRDIYD

G------GVVGYK----GTP-----AFMAPEILRYVGKEA-CTEKVDVFSFGMFMYELLAQ-QFPFER---QNLMHNQIEKLVVDGARPSIQNKV-----
.      . .  |    |.        |||| .    ..  .|.| ||.|||  |.|..   | | .    | .   .. ..| .| |. .   .     
DDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF

--TSACIVTLPIDISSQVPDDGSTSETSLTPSVSQY
   .. . ..  .     |.|  | ..     ... 
VCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase AqueK491.AA LZK 2032-2126 32 2.1e-14 44.88 In-house 41-129 (241) Show / Hide 
Range on Protein: 2032-2126
Range on HMM: 41-129/241
Sequence Identity: 32% (32 aa)

LKDLDHEYIINFIGL-TLQPL-CFMLEWASKGSLHGILQSYYRTDSKVSPWTLVEAGRQVANGLSYLHSRNVVYYDLKSPNILVFEFPSADESLRVS
|  |.|. ||.| |  |. |  | ..|. ..| |  .|    |   .. |  .|.  .|.|.|. |||.  ..  ||||||||.    |........
LRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVL----RERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILI----SHNDVVKIC
Kinase AqueK491.AA LZK 2143-2205 40 5.6e-12 36.59 In-house 126-187 (241) Show / Hide 
Range on Protein: 2143-2205
Range on HMM: 126-187/241
Sequence Identity: 40% (26 aa)

VKITDLGISRKITPG--GVVGYKGTPAFMAPEILRYVGKEACTEKVDVFSFGMFMYELLAQQFPF
||| | | |.           . || | ||||. |   .| | ||||..|||  . |.|    |.
VKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIR---NEPCSEKVDIWSFGVVLWEMLTCEIPY
Kinase AqueK491.AA Dicty4 1968-2113 26 5.7e-12 36.39 In-house 1-147 (277) Show / Hide 
Range on Protein: 1968-2113
Range on HMM: 1-147/277
Sequence Identity: 26% (43 aa)

VDRGKFVASGSFGEIYHGAIYPHLSASDDEGREVAIKIDKQDRKHFNMETAAKAYTEIRAEVALLKDLDHEYIINFIGLTL----QP--LCFMLEWASKG
 .....  .||||| | |            | |||.|. . .   |  ..     .| |.||.... . |  |. | |  .    .|  .|   |  .||
INIEQRIGKGSFGEVYKGTW---------RGKEVAVKKLNNHNQNFDENM----LNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKG

SLHGILQS--YYRTDSKVSPWTLVEA----GRQVANGLSYLHSRN--VVYYDLKSPNILV
.|. .| .      .|. ..|.|...    .. .| |. .||..|  ..  |||| |.||
NLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV
Kinase AqueK491.AA CAMK 1994-2044 24 6.9e-07 17.47 In-house 28-104 (425) Show / Hide 
Range on Protein: 1994-2044
Range on HMM: 28-104/425
Sequence Identity: 24% (19 aa)

SDDEGREVAIKI--------------------DKQDRKHFNMETAAKAYTEIRAEVALLKD-------LDHEYIINFI
. . |..|||||                    ||.  || . .. .|   ..| |....|        |||. ||...
YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLY