AqueK503

Species: A.queenslandica
Alias: AqueK503
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a1

Sequence

Name Sequence Type Origin Length Description Download
AqueK503.AA Protein None 369 None Fasta, JSON
AqueK503.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of AqueK503.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK503.AA TKL 22-276 20 4.3e-34 119.58 In-house 1-364 (364) Show / Hide
Range on Protein: 22-276
Range on HMM: 1-364/364
Sequence Identity: 20% (74 aa)

LGRGSYGVVNELRVNG----------NQCAGKKLNDLL-----------------------AMEDSLLSEFGNAII-LHRQQHHPNIVKLLG-VHYPS--
.|.|..|.|   . .|          .  | ||..                          ..| | . .| .  | .... .|||||...| . .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GSAPLPMLVMEYLPY-SLLQLIEGRVAINKEAILLDVANGLDYLHLKR------PPIIHRNIKASNILLTVGHN--------------AKITD
       |. . ...|||| |  ||| ..       .  . ||.| |..||| ..      ||||||..| .|||.    .              .||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

LSMSKFGDALKQHHYTTAP-------------GNHFM-----MPPEALVHNP---------------VYNKKLDVFSFGCLILHMFTGNIIVPTDQYEPK
.  |.| .  ..   |                 ..       |.||.|  ..                |..| ||.||| ..  ..|. .  | ..| . 
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYM

PHDPG----SYVKISEWNRRAKYIK------------PVLDHRLIPVAMNCLQDDPFKRLNASDIIEII
|....     . ..   ...   |.            |  .....  .. | . || ||.....|....
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase AqueK503.AA TK 20-205 14 2.6e-26 84.57 In-house 5-384 (486) Show / Hide
Range on Protein: 20-205
Range on HMM: 5-384/486
Sequence Identity: 14% (54 aa)

KELGRGSYG---VVNELRVNGN---------------------------QCAGKKLNDLLAMEDSLLSE--------------FGNAIILHRQ--QHHPN
|.||.| .|   .| . ...|                            ..| | | .  ||..    .              . ... . ..   ||||
KKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPN

IVKLLG-VHYPSGS--------APLPMLVMEYLPY-----SLLQLIEGRVAINKEA--------------------------------------------
||.|.| .. . ..         . .|.|||| |.     ||..    .    ..                                             
IVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDL

----------------------------------ILLDVANGLDYLHLKRP----PIIHRNIKASNILLTVGHN-----------AKITDLSMSK-----
                                  . ...|.|. ||| |.      ..||.. | |.|.. ...           .||.|  .|.     
IKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGV

FGDALKQHHYTTAPGNHFM----------------------------MPPEALVHNP--------VYNKKLDVFSFGCLI
   .. .... .. ... .                            |.||.| ..         ..  | ||.|||.|.
LARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

S_TKc AqueK503.AA S_TKc 16-281 23 3.1e-25 91.06 SMART 1-231 (231) Show / Hide
Range on Protein: 16-281
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

RVTRKELGRGSYGVVNELRVNG--NQCAGKKLNDLLAMEDSLLSEFGNAIILHRQQHHPNIVKLLGVHYPSGSAPLPMLVMEYLPY---SLLQLIEGRVA
    ...|.|..|.|   | ..   ..| |...            . . | .... ||||||||..| .         .||||..    .|...|. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

------INKEA---ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNK-KLDVFS
      ..      ..  ....|.|.| .   |||| .| .||||.   . ||.|  ....         ||  |  . |.|| |     |.| | |. |
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWS

FGCLILHMFTGNIIVPTDQYEPKPHDPGSYVKISEWNRRAKYIKPVLDHRLIPVAMNCLQDDPFKRLNASDIIE----IIIRLQL
.||..  |..|    |         ..    |.              .. ..   ..||| || ||. | .. .    | .   .
CGCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK503.AA STE 17-212 21 8e-23 77.5 In-house 1-265 (359) Show / Hide
Range on Protein: 17-212
Range on HMM: 1-265/359
Sequence Identity: 21% (60 aa)

VTR-KELGRGSYG-VVNELRVN----------------GNQCAGKKLN------------------DLLAMEDSLLSEFGNAIILHRQQH-HPNIVKLLG
 .. ...|.|..| |.  ....                |. .| |..|                  .    ....| |     |... .| |||||| .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIK---IMKKCNHMHPNIVKYYG

VHYPSGSA----PLPMLVMEYLP-YSLLQLIEGRVAINK-------------EAIL----LDVANG-LDYLHLKRPPIIHRNIKASNILLTVGHNAKITD
 ..  |          ..|||..  || ..|. .  ..|             | ..     ..  | |.||| ..  |||| ||..||||     .|..|
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD

LSMSKFGDA--------------LKQH-HYTTAPGNHFMMPPEALVH-----NPVYNKKLDVFSFGCLILHMFTGN
   ..  .               . .  . .|  |    | || .       .. |. | |. |.||.|..| ||.
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

Kinase AqueK503.AA HH498 113-213 36 3.8e-20 60.19 In-house 123-224 (284) Show / Hide
Range on Protein: 113-213
Range on HMM: 123-224/284
Sequence Identity: 36% (37 aa)

KEAILLDVANGLDYLHL-KRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNKKLDVFSFGCLILHMFTG
|  | .|||.| .|||    .|||||     |||.     |.. |   | |   .     |  |||   | ||    .  | .| ||||..  |  |.|.
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTR

NI
 .
EV

Pkinase AqueK503.AA Pkinase 16-276 22 4.2e-20 72.17 Pfam 1-293 (293) Show / Hide
Range on Protein: 16-276
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

RVTRKELGRGSYGVVNELRVNGNQ--CAGKKLNDLLAMEDSLLSEFG--NAIILHRQQHHPNIVKLLGVHYPSGSAPLPMLVMEYLPY-----SLLQLIE
 .. . .|.||.|.| . .  |..   | |...   . .. . . .    . |..|  .|||||.|... .  .. .   .||||..      .|  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIY--MVMEYCEGGLYVMDLFDYIS

----GRV--AINK-EAILLDVANGLDYLHLKRPPIIHRNIKASNILLT-VGHNA---KITDLSMSKFGDALKQHHYTTAPGNHFMMPPEALVHNPVYNKK
    |..    .    ... .. ||.|.| .   |||| .| .|||.   ||..   ||.|   .|. |  ... .||  |  . |.|| . ... | .|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVFSFGCLILHMFTGNIIVPTD-------QYEPKPHDPGSYVKISEWNRRAKY------------IKPVLDHRLIPVAMNCLQDDPFKRLNASDIIEI-
 |..|.||..  |..|. . | .       |..    . |  .. .... . ..              . ..  .. .  .||. || ||..| .| .  
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-I
 .
WF

Kinase AqueK503.AA Ciliate-E2 16-212 19 5.4e-19 61.82 In-house 1-293 (365) Show / Hide
Range on Protein: 16-212
Range on HMM: 1-293/365
Sequence Identity: 19% (58 aa)

RVTRKELGRGSYGVVNELRVNGNQC-------------------AGKKLNDLLAMEDSLLSEFGNAIILHRQQH----------------HPNIVKLLGV
    | .|.|..|.| . .|  .|.                   . .|.  .  |. . . .. . | . |. .                ||||.|.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HY--PSGSAPLPMLVMEYLPY-SLLQLIE------------GRVAINKEAIL---LDVAN---------------GLDYLHLKRPPIIHRNIKASNILLT
 .     .     |||||. . .|...|.            .   .. . |.     ...               .| ||| | . ||||.|| .|||. 
FQEKDDNNI---YLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

VGHNAKITDLSMSKFGD------------------------------ALKQHHYTTAPGNHFMMPPEALVHNPV--------YNKKLDVFSFGCLILHMF
     ||.|. .||. |                               ..|. . |  |.   |.|| |   .         |..| |..|.|...  | 
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TGN
.|.
FGK

Kinase AqueK503.AA TK-Unique 71-210 25 1.3e-18 60.87 In-house 63-234 (294) Show / Hide
Range on Protein: 71-210
Range on HMM: 63-234/294
Sequence Identity: 25% (45 aa)

HPNIVKLLGVHYPSGSAPLPMLVMEYLPYS-LLQLIEGRVAINKEA-----------------------------ILLDVANGLDYLHLKRPPIIHRNIK
|||||..||.   |.    .|..|||.|.. |. ..  .    ..                              .. ..|.|. ||.  |  |.||.. 
HPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLC

ASNILLTVGHNAKITDLSMSKFGDALKQHHYTT--APGNHFMMPPEALV--HNPVYNKKLDVFSFGCLILHMFT
|.|.||| ....||.|. |.. ... ...  ..   .  .  |.||.|   |.. .. | || |||.|.  .||
ARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase AqueK503.AA TKL-Unique 116-202 36 2.7e-18 61.25 In-house 115-215 (290) Show / Hide
Range on Protein: 116-202
Range on HMM: 115-215/290
Sequence Identity: 36% (37 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVG-----HNAKITDLSMSKFGDALKQHHYT--------TAPGNHFMMPPEALVHN-PVYNKKLDVFSF
. .|.| |..||| . ||||||..| ||.|.. .      |.|| | . ||| .   .  ..        |  |. . |.|| |  |   |..| ||.||
MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSF

G
|
G

Kinase AqueK503.AA MLK 71-213 26 4.5e-17 55.87 In-house 64-234 (291) Show / Hide
Range on Protein: 71-213
Range on HMM: 64-234/291
Sequence Identity: 26% (48 aa)

HPN----IVKLLGVHYPSGSAPL-PMLVMEYLPY-SLLQLIEG-RVAIN----------------KEAILLDVANGLDYLHL-KRPPIIHRNIKASNILL
|||    |....||   . . |    .||||... ||  .. | |  ..                .  . |..|.|..|||  ...||||| .| .|||.
HPNNHPCIIQFYGV---CLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI

TV------GHNAKITDLSMSKFGDALKQHHY----TTAPGNHFMMPPEAL--VHNPVYNKKLDVFSFGCLILHMFTGNI
.       . ..||.|     || . . |.     . ..|.   | ||..    .  |..| ||.|.| ..  |.|. .
DEICHDMHHGTLKICD-----FGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV

Kinase AqueK503.AA STE-Unique 116-211 20 4.8e-16 52.97 In-house 408-549 (616) Show / Hide
Range on Protein: 116-211
Range on HMM: 408-549/616
Sequence Identity: 20% (29 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGH-----NAKITDLSMSKFGDALKQ-------------------------------------HHYTT
... .. ||.||| .. |||||..|..||... .      ..|| |   .. . .                                           ..
YTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKY

APGNHFMMPPEALVHN----PVYNKKLDVFSFGCLILHMFTG
 .|. . | || .  .      |. | |..|.||...|| .|
CCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCG

Kinase AqueK503.AA TyrKc 16-276 24 5.8e-15 19.28 SMART 1-280 (280) Show / Hide
Range on Protein: 16-276
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

RVTRKELGRGSYGVVNELRVNGNQCAGKKLNDLLAMEDSLLSEFGNAIILHRQ-QHHPNIVKLLGVHYPSG----SAPLPMLVMEYLPY-SLLQLIEGRV
 .  |.||.| .|.| . . .  |.| |.|..    .  ...|   | |...   ||||||.|.||   .|    ... .|.|||| |. .|.. .  . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMRE---ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

----AINKEAILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSKFGDAL----KQHHYTTA---PGNHFM-----MPPEALVHNPVYN
       .  . ...|.| .||| |  ..||| . | |.|.. .| .||.|  .|....        . | ..    | ..|     |.||.. .. ...
PKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KFT

KKLDVFSFGCLILHMFTGNIIVPTDQYEPKPHDP-----GSYVKISEWNRRAKYIKPVLD----------HRLIPVAMNCLQDDPFKRLNASDIIEII
 | ||.||| ..  .||         |  .|.        |   . |. .. .. ..  .            .  .   | . || .| . |.|.|..
TKSDVWSFGVCMWEIFT---------YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK503.AA TKL-ciliate1 116-158 37 1.8e-12 39.03 In-house 108-150 (279) Show / Hide
Range on Protein: 116-158
Range on HMM: 108-150/279
Sequence Identity: 37% (16 aa)

ILLDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLS
.. |.| |. ||| . .|.|||..|  |||. .  . ||.. .
WCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFP

Pkinase_Tyr AqueK503.AA Pkinase_Tyr 10-161 26 1.1e-11 40.21 Pfam 1-159 (270) Show / Hide
Range on Protein: 10-161
Range on HMM: 1-159/270
Sequence Identity: 26% (44 aa)

LILQRVRVTRKELGRGSYGVVNELRVN------GNQCAGKKLNDLLAMEDS-LLSEFGNAIILHRQQ-HHPNIVKLLGVHY-PSGSAPLPMLVMEYLPY-
... ..      ||.|..|.| . . .      . ..| |.|..  ||..  .. .| . . . .|  ||||||.|.|| .  ...   ...|||| |. 
ITFGKK------LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHG

SLLQLIEG----RVAINKEAIL---LDVANGLDYLHLKRPPIIHRNIKASNILLTVGHNAKITDLSMSK
.||         . ... . .|   ...|.|..||. |.  .||| . | |.|.| .. .||.|  ...
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLAR

Kinase AqueK503.AA STE-Unique 17-79 28 2e-05 14.56 In-house 1-68 (616) Show / Hide
Range on Protein: 17-79
Range on HMM: 1-68/616
Sequence Identity: 28% (20 aa)

VTRKELGRGSYGVVNELR--VNGNQCAGKKLNDLLAMEDS----LLSEFGNAIILHRQQHHPNIVKLLG
.    .|||| |.|.  .  .....|| |..  |    |.    | . . . | ..   ||.||||..|
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIH-LKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYG

Kinase AqueK503.AA TKL-ciliate1 251-276 34 8.4e-05 12.37 In-house 254-279 (279) Show / Hide
Range on Protein: 251-276
Range on HMM: 254-279/279
Sequence Identity: 34% (9 aa)

LIPVAMNCLQDDPFKRLNASDIIEII
.. . | |.  .| || |.. ||.|.
FHNLMMRCWCQNPNKRPNFNEIIQIL

Ubiquitin AqueK503.AA ubiquitin 318-367 38 2.3e-10 41.18 Pfam 22-73 (73) Show / Hide
Range on Protein: 318-367
Range on HMM: 22-73/73
Sequence Identity: 38% (20 aa)

ELKDAITKLKGIPYEHIRLLYEGRQL-ADDMTFKDYKIEKFA-KIYLSLRLI
.|| .| .  ||| . .||.|.|.||  |..| .||.|.. . .|.. ||. 
QLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHMVLRQR

Rad60-SLD AqueK503.AA Rad60-SLD 314-356 34 2e-06 28.43 Pfam 22-65 (73) Show / Hide
Range on Protein: 314-356
Range on HMM: 22-65/73
Sequence Identity: 34% (15 aa)

TRIIELKDAITKLKGIPY-EHIRLLYEGRQLADDMTFKDYKIEK
|.. .|..|  | .|||  . .||.. | .| ...|..|| .|.
TTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTVEDYDMED

UBQ AqueK503.AA UBQ 300-365 32 0.000121 22.67 SMART 1-72 (72) Show / Hide
Range on Protein: 300-365
Range on HMM: 1-72/72
Sequence Identity: 32% (24 aa)

TNFFCNISE--DSF-----YET-RIIELKDAITKLKGIPYEHIRLLYEGRQLADDMTFKDYKIEKFAKIYLSLR
 . |.  ..  ..|       .  . |||..| ...||| | .||.|.|. | || |  ||.|.. ..|.| .|
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR