Gene AqueK509 (A.queenslandica)
AqueK509
Species: A.queenslandica
Alias: AqueK509
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK509.AA | Protein | None | 345 | None | Fasta, JSON |
| AqueK509.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of AqueK509.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK509.AA | TKL | 21-277 | 20 | 2.7e-41 | 143.5 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 21-277
Range on HMM: 1-364/364
Sequence Identity: 20% (74 aa)
LGRGAYGVATEVIVSE----------TTCAAKKLHDAIVQVHTL-------------------------KKFGDEVLLHSEQRHPNIVQLIG-VYYPPH-
.|.|..|. . .. | ||.. .. .|. ... |....| |||||||..| . .||.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
---------SQLPMLVMEYLPL-S-LTQCLKEKELPLQMKYSILLDVAKGLCYLHGKRP-----KAIVHRDLTANNVLLTSSYS--------------AK
. ...|||| | | | . . .. . .. ||.|.|..||| ..| ..|.||||. .|.|. . . .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK
ISDLGVSRLVDTFKK------------------NHLTTVPGNAMVMPPEALKDNP---------------VYDHKLDVFSYGCLILHILTGQFPQPTNQF
|.|.| || ... .. ... |. |. |.||.|.... |. | ||.|.| .. |||.. | . .
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY
VPEPGR--VKSFIEVSEWDRRLSYIEDIPK--------ENE---LLPLARDCLDDAPTGRPEMIESYQFV
|. .. .. .... ... | .|.. .. . |. || | |. || . | .
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | AqueK509.AA | TKL-Unique | 17-202 | 27 | 3.9e-31 | 107.11 | In-house | 1-215 (290) | Show / Hide |
Range on Protein: 17-202
Range on HMM: 1-215/290
Sequence Identity: 27% (59 aa)
TGKELGRGAYGVATEVIVSETTCAAKKLH-DAIVQVHTLKKFGDEVLLHSEQR-HPNIVQLIGVYY---PPHSQLPMLVMEYLPL-SLTQCLK-------
.. .|.|.||. .. . | |..| . . ...| .|| . . . |||||...|. .. ... .||||.|. || |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNM-CIVMEYCPGGSLYDVLHQNNNNNN
----EKELPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSS-----YSAKISDLGVSRLVDTFKKNHLT--------TVPGNAMVMPPEAL
...|..|..... .|.|.|..||| . |. | ||||. |.|... ...||.| | |.. .. |. .. |. |.. |.|| |
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL
KDN-PVYDHKLDVFSYG
..| |. | ||.|.|
RMNFCQYSEKSDVYSFG
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| S_TKc | AqueK509.AA | S_TKc | 15-277 | 22 | 4.6e-30 | 107.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-277
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)
KETGKELGRGAYGVATEVIVSE--TTCAAKKLHDAIVQVHTLKKFGDEVLLHSEQRHPNIVQLIGVYYPPHSQLPMLVMEYLPL---SLTQCLKEKE---
| ....|.||.|. .. . .| |... ... |. .... .|||||.|..|.. . .||||.. .| . .|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDLGVSRLVDTFKKNHLTTVPGNAMVMPPEALKDNPVYDH-KLDVFSY
.| . ... ....| |.| .. |.|||| |.||.. ||.| |..|.. ||. | |.|| | |.. | |. |
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC
GCLILHILTGQFPQPTNQFVPEPGRVKSFIEVSEWDRRLSYIEDIPKENELLPLARDCLDDAPTGRPEMIESYQ---------FV
||.. |.|. | | .. ... |.. . | ||. |. || | | ..
GCILYEMLCGYPPFP---------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK509.AA | TK | 18-205 | 15 | 1.3e-29 | 95.78 | In-house | 4-384 (486) | Show / Hide |
Range on Protein: 18-205
Range on HMM: 4-384/486
Sequence Identity: 15% (60 aa)
GKELGRGAYG---VATEVIVSE---------------------------TTCAAKKLHD-AIVQVHTLKK--------------FGDEVLLHSE--QRHP
||.||.|..| . . .. . |..| | |.. . . . . | . .. .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP
NIVQLIG------------VYYPPHSQLPMLVMEYLPL-----SLTQCLKEKE-----------------------------------------------
|||.|.| | . |.. .|.|||| |. || . |...
NIVRLYGVCTQGEPKPCFEV-V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD
------------------------------LPLQMKYSILLDVAKGLCYLHGKRP---KAIVHRDLTANNVLLTSSYS-----------AKISDLG----
|... . . ...|.|. ||| |. . .||||| | |.|..... .||.| |
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----VSRLVD---TFKKNHLTTVPGNAMV-----------------------MPPEALKDNP--------VYDHKLDVFSYGCLI
.| .. . . ...... |.||.|.|. .. .| ||.|.|.|.
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM
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| Kinase | AqueK509.AA | Pkinase_Tyr | 16-205 | 27 | 9.8e-27 | 91.17 | Pfam | 2-204 (270) | Show / Hide |
Range on Protein: 16-205 Range on HMM: 2-204/270 Sequence Identity: 27% (57 aa) ETGKELGRGAYGVATEVIVS------ETTCAAKKLHDAIVQVH-TLKKFGDEVLLHSEQ-RHPNIVQLIGVYYPPHSQL--PMLVMEYLPL-SLTQCLKE . ||.||.||.|. . . ....| |.| . . . ...| |. . .. .|||||.|.|| . .... ...|||| |. .| |.. TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-DQGEPNQIYIVMEYMPHGDLLDYLRK K-----ELPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDLGVSRLVDTFKKNHLTTVPGNAMV----MPPEALKDNPVYDHK . |..... .. ...|||. ||. |. ..|||| | |.|.|.. .||.| | .|.. ... ... |.... |.||..... . .| HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTK LDVFSYGCLI || |.| |. SDVWSFGVLM |
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| Kinase | AqueK509.AA | HH498 | 109-214 | 38 | 9.8e-27 | 81.46 | In-house | 120-225 (284) | Show / Hide |
Range on Protein: 109-214 Range on HMM: 120-225/284 Sequence Identity: 38% (41 aa) LQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDLGVSRLVDTFKKNHLTTVPGNAMVMPPEALKDNPVYDHKLDVFSYGCLILHI || | | .|||.| ||| .. |.||||. |.|. |.. | | || | .| ||| | || . . |. | |||||. | . LQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEM LTGQFP .|. | HTREVP |
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| Kinase | AqueK509.AA | STE | 15-214 | 21 | 1.3e-26 | 91.1 | In-house | 1-267 (359) | Show / Hide |
Range on Protein: 15-214 Range on HMM: 1-267/359 Sequence Identity: 21% (60 aa) KETGKELGRGAYGVATEVIVSETT-----------------CAAKKLH---------------DAIVQVHTLKKFGDEVLLHSEQR--HPNIVQLIGVYY | ...|.||.|. . ... .| |... . ... .... |. .... . |||||. .| |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF ---PP---HSQLPMLVMEYLP-LSLTQCLKEK-----ELP----------LQMKYSILLDVAKG-LCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDL .. ...| ..|||.. ||.. .|.| .|. . |. .. || | ||| .. |.|||. . |.|| .|..| KEGHNHKNDDEL-WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF GVSR-LVDTFKKN--------------HLTTVPGNAMVMPPEALKD-----NPVYDHKLDVFSYGCLILHILTGQFP ||. |.|. .. . .|. | | || .. .. || | |. | ||.|.. .||. | GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP |
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| Kinase | AqueK509.AA | LRRK | 60-214 | 34 | 3.1e-26 | 89.82 | In-house | 107-282 (351) | Show / Hide |
Range on Protein: 60-214 Range on HMM: 107-282/351 Sequence Identity: 34% (62 aa) EVLLHSEQRHPNIVQLIGVYYPPHSQLPMLVMEYLPL-SLTQCLKEKE----------LPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTS || . |. .|||||.|.|. | ...||||.|. .| . |..|. .. ..|. | |..|||. ||| ..|. |.||||. |.|| | EVWIMSHLNHPNIVSLKGFCIHP----LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPP-IIHRDLKSPNILLWS S------------YSAKISDLGVSRLVDTFKKNHLTTVPGNAMVMPPEALKDN--PVYDHKLDVFSYGCLILHILTGQ-FP | . |||.| | ||. .|.. . .. || | || ...| .|. | |..|.| .. ..||.| .| SPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP |
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| Kinase | AqueK509.AA | TK-Unique | 15-205 | 27 | 1.1e-25 | 85.61 | In-house | 1-229 (294) | Show / Hide |
Range on Protein: 15-205 Range on HMM: 1-229/294 Sequence Identity: 27% (64 aa) KETGKELGRGAYGVATEVIVSE-------TTCAAKKLHDAIVQVHTLKKFGDEVLLHSEQR-HPNIVQLIGVYYPPHSQLPMLVMEYLPLS-----LTQC | |...|.||.| |.. ..|.| |.. . .. .. ..| .| ...| ||||||..|. . . .|..|||.| . | .| LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC LKE-----------------------KELPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDLGVSRLVDTFKKNHLTT--VPG .. .. .. |... ..|.|. ||.. | | |||||| | |||||. . .||.|.| .| |.| ... .. . RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQR-KKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI NAMVMPPEALK--DNPVYDHKLDVFSYGCLI . |.||.|| ... . | || |.|.|. PIRWMAPESLKCYHGMYHTTKSDVWSFGVLM |
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| Kinase | AqueK509.AA | MLK | 15-214 | 23 | 1.2e-25 | 86.08 | In-house | 1-235 (291) | Show / Hide |
Range on Protein: 15-214 Range on HMM: 1-235/291 Sequence Identity: 23% (57 aa) KETGKELGRGAYGVATEVIVSETT-----CAAKKLH-DAIVQVHT----LKKFGDEVLLHSEQRHPN----IVQLIGV-YYPPHSQLPMLVMEYLPL-SL .. . .| |..|. .. | |. . ... . ..| |. . . .||| |.|. || || . .||||.. || IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP--CHFCIVMEYCEGGSL TQCLKEKE---------------LPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTS------SYSAKISDLGVSRLVDTFKKNH---LTTV |.... ... . .. |..|.|. ||| . ||.|.|||| |.|.. .||.| |.|| ..... . YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSN PGNAMVMPPEAL--KDNPVYDHKLDVFSYGCLILHILTGQFP .|.. | ||.. . . |. | ||.|.| .. .||.. | AGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP |
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| Kinase | AqueK509.AA | LISK | 20-202 | 27 | 7.6e-25 | 77.48 | In-house | 1-226 (296) | Show / Hide |
Range on Protein: 20-202 Range on HMM: 1-226/296 Sequence Identity: 27% (64 aa) ELGRGAYGVATEVIVS--ETTCAAKKLH---DAIVQVHTLKKFGDEVLLHSEQRHPNIVQLIGVYYPPH-SQLPMLVMEYLP-LSLTQCLKEK-----EL |.|.|..| . . . | |..| . ..|.. || . ..||||||| .||.| | . ..| || |.| || . | EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCY--HNDGQLHIVTEYINGGDLHQYLKDMDKHKIPL PLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSS----YSAKISDLGVSRLVDTFK----------------------------------KN | . . .| ||.|.|. ||| . |.||||...|.|. . ...|. |.| |..| . | PWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKR HLTTVPGNAMVMPPEALKDNPVYDHKLDVFSYG ..| . |.. |.|| |.. || . ||||.| RMTIC-GTPYWMAPEMLLGQS-YDESCDVFSFG |
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| Kinase | AqueK509.AA | Pkinase | 15-214 | 23 | 5.5e-24 | 85.89 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 15-214 Range on HMM: 1-211/293 Sequence Identity: 23% (53 aa) KETGKELGRGAYGVATEVIVSETTC-AAKKLHDAIVQVHTLKKFGD------EVLLHSEQRHPNIVQLIGVYYPPHSQLPMLVMEYLPL-----SLTQCL ..|. .|.|..|. . . | . | | | .|. ... |. .. . .|||||.|..... .. . .||||.. .| . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK---IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYI K-EKELPL--QMKY--SILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSA----KISDLGVSRLVDTFKKNHLTTVPGNAMVMPPEALKDNPVYD . ... .. ... .... ...|| |.| . |.|||| |.|. . . ||.| |.....| .|..||. | |.|| ..... |. STWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYG HKLDVFSYGCLILHILTGQFP .| |..|.||.. |.|..| PKVDMWSCGCILYEMLCGRPP |
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| Kinase | AqueK509.AA | Ciliate-E2 | 15-302 | 15 | 5.6e-24 | 79.18 | In-house | 1-338 (365) | Show / Hide |
Range on Protein: 15-302 Range on HMM: 1-338/365 Sequence Identity: 15% (61 aa) KETGKELGRGAYGVATEVIVSETTC-------------------AAKKLHDAIVQVHT-LKKFGDEVLLHSEQR----------------HPNIVQLIGV . | .|.|..|. .. | .. . ...|. .. . .. . | . | . ||||.... . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YYPPHSQLPMLVMEYLPL-SLTQCLKEK------------ELPLQMKYSILLDVAK---------------GLCYLHGKRPKAIVHRDLTANNVLLTSSY .. . |||||. .| ...|.. . .. | ... .| ||| | . |.|||. .|.|. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF---- SAKISDLGVSRLVDTFKKNHL------------------------------TTVPGNAMVMPPEALKDNPV--------YDHKLDVFSYGCLILHILTGQ ||.|.| |. .|.. .|.. |. |... |.|| |. . ||.| |..| |... |.|. -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK FPQPTNQFVPEPGRVKSFIEVSEWDRRLSYIEDIPKENELLPLARDCLDDAPTGRPEMIESYQFVKQVLSEYPKIK-------------DRLVVEKELKD .| .| || ..|. . . . ...| || PPF----------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD AIQ |. LIK |
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| Kinase | AqueK509.AA | TyrKc | 15-277 | 26 | 1.2e-17 | 62.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-277 Range on HMM: 1-280/280 Sequence Identity: 26% (78 aa) KETGKELGRGAYGVATEVIVSETTCAAKKLHDAIVQVHTLKKFGDEVLLHSEQ--RHPNIVQLIGVYYPP-----HSQLPMLVMEYLPL-SLTQCLKEKE . ||.||.||.|. . . . ...| |.|.. .. | .| . .. .|||||.|.|| . .. .|.|||| |. .| . |.... ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR --LPLQMKYSILLDVAKGLCYLHGKRPKAIVHRDLTANNVLLTSSYSAKISDLGVSRLVDTF------KKNHLTTV--PGNAMV----MPPEALKDNPVY |... . |. ...|.| ||| | ..|||| | |.|... . .|||| | || .. |. .. |..|. |.||..... .. PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG-KF DHKLDVFSYGCLILHILT-GQFPQPTNQFVPEPGRVKSFIEVSEWDRRLSYIEDIPK---------ENELLPLARDCLDDAPTGRPEMIESYQFV .| ||.|.| .. |.| || | | . ..| .|| |. .. . . | |. . ..| . | || . | ... TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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