Gene AqueK536 (A.queenslandica)

AqueK536

Species: A.queenslandica
Alias: AqueK536
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK536.AA Protein None 619 None Fasta, JSON
AqueK536.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of AqueK536.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PDZ AqueK536.AA PDZ 54-131 30 3.8e-20 74.19 SMART 1-80 (80) Show / Hide 
Range on Protein: 54-131
Range on HMM: 1-80/80
Sequence Identity: 30% (27 aa)

PPSLAQFTGRNQHVLDDNGVFVTKIAKGGAADKHGQ-----LEVGDRLLEVNG-QNLAEIDYEDAVAILKATGQ-----EVTLKIEKNS
..   . .|         |.|.... .||.|.|.|      | .|||.||||| |..   ..|.||..||..|.     .|||......
GGLGFSIVG---------GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ AqueK536.AA PDZ 70-128 31 4.9e-19 67.8 Pfam 26-86 (86) Show / Hide 
Range on Protein: 70-128
Range on HMM: 26-86/86
Sequence Identity: 31% (19 aa)

DNGVFVTKIAKG-GAADKHGQLEVGDRLLEVNGQNLAEIDYEDAVAILKATGQ-EVTLKIE
|.|...... .| |||.. | ...||.....|||... .  ..||...| ... ||.|.|.
DQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
PDZ AqueK536.AA PDZ 166-239 36 9.2e-24 86.19 SMART 1-80 (80) Show / Hide 
Range on Protein: 166-239
Range on HMM: 1-80/80
Sequence Identity: 36% (31 aa)

EGLGFNIIGGEEGVGIFISVISKEGVAARNGQ-----LRVGDMILEVNG-NNLEMWSHDIVAQVLKGARD-----TITLKVVYKP
.||||.| |     ||||| . . |.|.. |      ||.||.||||||  ..| ..|. ....||....     ..||.|....
GGLGFSIVG-----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG
PDZ AqueK536.AA PDZ 157-236 32 1.3e-20 73.19 Pfam 1-86 (86) Show / Hide 
Range on Protein: 157-236
Range on HMM: 1-86/86
Sequence Identity: 32% (28 aa)

IITLNRP-EGEGLGFNIIGGEEG---VGIFISVISKE-GVAARNGQLRVGDMILEVNGNNLEMWSHDIVAQVLKGARD-TITLKVV
 .|| .. ...||||.| ||...    ||.|| ...  | |.| | ...||.|...|| ......|| ..|..||... ...|.. 
QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ
Kinase AqueK536.AA TKL 366-616 23 4.2e-57 196.01 In-house 1-364 (364) Show / Hide 
Range on Protein: 366-616
Range on HMM: 1-364/364
Sequence Identity: 23% (88 aa)

LGSGGWGEVIIGKFRG----------QKVAVKRFH----DAIMNQENN-----------------QYYLEMLNREINTMSQLRHPNLLQFIGAVLDHP--
.|||| |||  ||.||          . ||||.|.    |  . ....                 . . . ...||. ||.|||||..||.|.... |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------SGNPMIITEVM-DTSLRSAYEKKELTPDLACRPVILSIMRDVAVGLNYLHC--L----PDPIIHRDVSSANVLLESKGP----------GK
         .|...|..| .   ||.. .            ........|.| |.||||        . ||||||  |.|.|. ...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKTKISDFGSAK----------------------MARFATTKAAGAMVYSAPECLQTVVDFEE----------SKQSPKADVFSYGILLCEVITCRFPEH
|. ||.||| ..                      . | .| .  |   . |||.|.   ...|          .. |.|.||.|.||.|.|..|.. |..
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

HIF----------------------RVLLD---------QVRSSG-SSLHSLVVSCATKDPEKRPTMKQIIEQL
..                       | ...         .  ..   |. .|   |   ||||||....|...|
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK536.AA MLK 360-572 26 4.1e-36 122.81 In-house 1-235 (291) Show / Hide 
Range on Protein: 360-572
Range on HMM: 1-235/291
Sequence Identity: 26% (64 aa)

TLSRHKLGSGGWGEVIIGKFRGQK-----VAVKRFH-DAIMNQENNQYYLEMLNREINTMSQLRHPN----LLQFIGAVLDHPSGNPMIITEVMDT-SLR
 .  ...|||. |.|  |..|..      |||||.. ...          . ...|..  . |.|||      || |. |..|  .  |..| ..  || 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY

SAYEKKELTPD----------LACRPVILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLES--KGPGKWKTKISDFGSAKMARFA---TTKAAGAMV
.    ..  ..               ...... ..| |..|||. .|.||||||  | |.|.    .  .. . ||.||| ...        ...||   
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

YSAPECLQTVVDFEESKQSPKADVFSYGILLCEVITCRFP
. ||| .|    |...| | |.||.|.|..| |..|.. |
WMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK536.AA TK 360-616 16 1.4e-35 116.23 In-house 1-486 (486) Show / Hide 
Range on Protein: 360-616
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)

TLSRHKLGSGG---WGEVIIGKFRG---------------------------QKVAVKRFHDAIMNQENNQYYLEMLN--------REINTMSQLR----
    .|||.|    .|||  |. ||                           ..||||  ..   .... .   ||          .| . |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLLQFIGAVLDHPS----------GNPMIITEVMD-TS----LRSAYEKKE----------------------------------------------
 |||.....|..... .          . .||..| |.  .    ||.   |.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDLACRPVILS-------------------IMRDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGPGKWK-------TKISDFGSAK-
      . |.  .    |.                   .....| |. ||| ..      ..|||.   |.|. .... ||.        ||.||| .. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----MARFAT-----TKAA------------------------GAMV---YSAPECLQTVVDFEE---SKQSPKADVFSYGILLCEVIT---CRFPEHHI
    .||        ...                         |...   . |||||.. |  |     | ..| ||.|.|.|. |. |     ... . 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

F--------------------------------RVLLDQ-VRSSG-------------SSLHSLVVSCATKDPEKRPTMKQIIEQL
                                 |  . | .  .                .. |  .|  .|||.|||..|. |||
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK536.AA Dicty4 363-569 30 1.2e-33 109.69 In-house 4-213 (277) Show / Hide 
Range on Protein: 363-569
Range on HMM: 4-213/277
Sequence Identity: 30% (70 aa)

RHKLGSGGWGEVIIGKFRGQKVAVKRFHDAIM--NQEN-NQYYLEMLNREINTMSQLRHPNLLQFIGAVL--DHPSGNPMIITEVM-DTSLRSAYEK---
  ..|.|. |||  |. ||..||||     ..  ...|  .. |. . .|.. |...||||...| || .     .| ..| || |  ..| |   .   
EQRIGKGSFGEVYKGTWRGKEVAVK-----KLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---KELTPDLACRPVILS---IMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAK------MARFATTKAAGAMVYSAPECLQ
   .. ..|.   | |..   ...|.| |.|.|||  |. |||||  |.| |        |. |..||| ..      .  . .. |.|   . |||...
EQQQSIKLDW---PLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK----NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM

TVVDFEESKQSPKADVFSYGILLCEVITC
    . |     ||||.|.||.| |  |.
HQ-PYNE-----KADVYSFGIVLWEILTR
Kinase AqueK536.AA TKL-Unique 364-568 29 1.9e-32 111.78 In-house 3-223 (290) Show / Hide 
Range on Protein: 364-568
Range on HMM: 3-223/290
Sequence Identity: 29% (69 aa)

HKLGSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQLR-HPNLLQFIGAVLDHPSGNP--MIITEVMDT-SLRSAYE-------
 |.|.|| |.|. ||.|| .||.|.||  . | . .   .. ...|.|.|. |. |||.....|.  ||   .|   |..| ..  ||..          
NKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--KKELTPDLACRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESK-GPGKWKTKISDFGSAKMAR--FATTKA----------AGAMVYSAPE
  .........   ..... .|.| |..||| .  ||||||  | |.|. ..    .|. ||.||| .| .    ..|.            |   ..|||
NNNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

CLQTVVDFEESKQSPKADVFSYGILLCEVIT
 |  .     .. | |.||.|.|| | | .|
VLRMNF----CQYSEKSDVYSFGIVLWEIAT
Kinase AqueK536.AA S_TKc 360-619 22 7.8e-32 113.0 SMART 1-231 (231) Show / Hide 
Range on Protein: 360-619
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

TLSRHKLGSGGWGEVIIGKFRG--QKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVMDT---SLRSAYEKK
     |.|.|. |.|  .. ..  ..||.|. .             |.. |||. ... .|||. .....  |   ..  ...| .|.   .|..  .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKR

EL--TPDLACRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKMARFATTKAAGAMVYSAPECLQTVVDFEESKQSP
    ..      .. ..|. .. .|.|.| .   |||||.  .|.|| .        ||.|||.|.      |   |   | ||| |         . ..
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL---------GYGK

-KADVFSYGILLCEVITCRFPEHHIFRVLLDQVRSSGSSLHSLVVSCATKDPEKRPTMKQIIE------QLDRI
 |.|. | |..| | .. . | .    .......   ... ...  | .||||||||  .. .      .   .
CKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK536.AA Pkinase 365-616 21 2.1e-25 90.92 Pfam 6-293 (293) Show / Hide 
Range on Protein: 365-616
Range on HMM: 6-293/293
Sequence Identity: 21% (68 aa)

KLGSGGWGEVIIGKFRGQK--VAVKRFHDAIMNQENNQYYLEMLNREINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVMDT-----SLRSAYE---KK
|.|||. |.| ... .|    ||||..     . . .|. .    .||  |  |.||| ....... |  .... ...| ..      .| .  .   ..
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHG

EL--TPDLACRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKT----KISDFGSAKMARFATTKAAGAMV------YSAPECLQTV
 .  ... ...     .|. .. ||.|.|     |||||. ..|.|. ..|     .    ||.|||.|| ..  . .   ...      | ||| ..  
CFYFSEWECKF-----YMYQILRGLEYCHSM--GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR--

VDFEESKQSPKADVFSYGILLCEVIT--CRFPEH----------HIFRVLLDQVRSSG------------------------SSLHSLVVSCATKDPEKR
   . .. .||.|..|.|..| |...    ||.|           |.|..  .....                         ... ... .| .|||.||
---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

PTMKQIIEQ--L
|| .|| .   .
PTAEQILQHPWF
Kinase AqueK536.AA STE 361-611 18 5.9e-25 85.12 In-house 1-350 (359) Show / Hide 
Range on Protein: 361-611
Range on HMM: 1-350/359
Sequence Identity: 18% (67 aa)

LSR-HKLGSGGWGEVIIG---K-----FRGQK---------VAVKRFH-----DAIMN-------QENNQYYLEMLNREINTMSQLR--HPNLLQFIGAV
. .  |.|.|. |.|  .   |       |..         .|.|. .       . .       .  |.  .. . .||..|....  |||  ...|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

LDH---PSG--NPMIITEVMD-TSLRSAYE---KKELTPDLAC-------RPVILSIMRDVAVG-LNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKI
..     .   .  |. | ||  ||.. ..   ..  . ..          ..|  | |..  | |.||| .   |||||. .||.||          |.
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKL

SDFGSAKMARF-------------------ATTKAAGAMVYSAPECLQT-VVDFEESKQSPKADVFSYGILLCEVITCRFP--EHHIFRVLLDQVRS---
.||| ..                        ..  .|   . ||| .|    .  ... . |.|. | |....| .| . |  . | .|...   ..   
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----------------SG----------------------SSLHSLVVSCATKDPEKRPTMKQ
                                         ....  .  | .|||.|||| .|
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK536.AA CZAK 467-572 34 2.9e-22 77.74 In-house 108-221 (279) Show / Hide 
Range on Protein: 467-572
Range on HMM: 108-221/279
Sequence Identity: 34% (41 aa)

LSIMRDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGP---------GKWKTKISDFGSA---KMARFATTKAAGAMVYSAPECLQTVVDFEESKQSP
... .|.| | ||||    | ||.||| || |.||..               . ||.|||     .   |  | . | . . ||||      |     ..
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPEC------FKGENYTE

KADVFSYGILLCEVITCRFP
|.||.|.|..| ..|||. |
KVDVYSFGMILWCIITCDQP
Kinase AqueK536.AA TyrKc 360-616 23 3.1e-18 67.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 360-616
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

TLSRHKLGSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQL--RHPNLLQFIGAVLDH-----PSGNPMIITEVMDT-SLRSAY
    .|||.|  |||  |. . ..||||  ..           .|.. ||.. |..|  .|||.....|.....      .. .||..| |.  .|..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

EKKELTPDLACRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKMARFA--------TTKAA---GAM--V---YSA
 |.. .    | .  ||.. ..| | .|||    ..||||    |.|. ...      |||||| ..             . ...   |.   .     |
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PECLQTVVDFEESKQSPKADVFSYGILLCEVIT-CRFPEHH-----------IFRVLLDQVRSSGSS------------LHSLVVSCATKDPEKRPTMKQ
|||.       ..| ..| ||.|.|... |. | .  |              | .|     .    .            ....  .|   |||.|||...
PECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

IIEQL
|.|..
IHECF
Pkinase_Tyr AqueK536.AA Pkinase_Tyr 359-441 30 7.3e-17 57.74 Pfam 1-87 (270) Show / Hide 
Range on Protein: 359-441
Range on HMM: 1-87/270
Sequence Identity: 30% (28 aa)

VTLSRHKLGSGGWGEVIIGKFR------GQKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQL-RHPNLLQFIGAVL--DHPSGNPMIITE
.|.  .|||.|  |||  |. .      ...||||   .  | ..|   ..|.. ||...|.|| .|||.....|...  . |. ...|..|
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVME
Kinase AqueK536.AA DRK 367-443 44 8.4e-16 50.04 In-house 8-79 (258) Show / Hide 
Range on Protein: 367-443
Range on HMM: 8-79/258
Sequence Identity: 44% (34 aa)

GSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQLRHPNLLQFIGAVLDHPSGNPMIITEVM
| |..|||  |  || .||||.      | ||    |  . |||| |.||||||  ||.|. .  |.  . |..| |
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDEN---FLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYM
Kinase AqueK536.AA HH498 363-433 36 5.2e-14 40.41 In-house 4-76 (284) Show / Hide 
Range on Protein: 363-433
Range on HMM: 4-76/284
Sequence Identity: 36% (27 aa)

RHKLGSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENN--QYYLEMLNREINTMSQLRHPNLLQFIGAVLDHPS
  | |||  |.|  |..|.  |||||.            |.   |. ||.  |..| ||.  ||..| .| ||
HEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPS
Kinase AqueK536.AA Dicty4-Unclassified 465-568 32 4.5e-13 41.08 In-house 110-203 (263) Show / Hide 
Range on Protein: 465-568
Range on HMM: 110-203/263
Sequence Identity: 32% (34 aa)

VILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKMARFATTKAAGA--MVYSAPECLQTVVDFEESKQSPKADVFSYGIL
.|. .  |.| |. .||     .||||. |.|.|.          || ||| .    |  .  . |      .||||       ||  . |.||.||...
LIIKYAFDIAQGMQHLHTR--NFIHRDIKSSNILMDK----HFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLM-----HESYNQ-KSDVYSYAMM

LCEVIT
| | .|
LYELAT
Kinase AqueK536.AA HH498 464-515 43 5.3e-13 37.17 In-house 121-169 (284) Show / Hide 
Range on Protein: 464-515
Range on HMM: 121-169/284
Sequence Identity: 43% (23 aa)

PVILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGPGKWKTKISDFG
. .. |  ||| | ||||  |. ||||||  | |.|.   |    . .. |||
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFG
Kinase AqueK536.AA CZAK 364-443 34 1.7e-09 30.8 In-house 5-84 (279) Show / Hide 
Range on Protein: 364-443
Range on HMM: 5-84/279
Sequence Identity: 34% (28 aa)

HKLGSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENNQYYLEMLNREINTMSQLRHPNLLQFIGA-VLDHPSGNPMIITEVM
   | |  |||  .  ||  ||.|  |            ..|  .|.  || |.||| .||.||  .| |     |..| |
QTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGP-NHHCIVMEWM
Kinase AqueK536.AA DRK 464-515 42 3.6e-09 27.26 In-house 98-145 (258) Show / Hide 
Range on Protein: 464-515
Range on HMM: 98-145/258
Sequence Identity: 42% (22 aa)

PVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFG
| ....| |.| |..||||    |||||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDE----HWQVKVADFG
Kinase AqueK536.AA Dicty4-Unclassified 593-616 54 6.1e-09 26.71 In-house 240-263 (263) Show / Hide 
Range on Protein: 593-616
Range on HMM: 240-263/263
Sequence Identity: 54% (13 aa)

SLVVSCATKDPEKRPTMKQIIEQL
.|.. |   || ||||| |||. |
KLIKWCWHNDPNKRPTMNQIIQYL
Kinase AqueK536.AA Dicty4 590-618 32 2.3e-08 24.17 In-house 247-277 (277) Show / Hide 
Range on Protein: 590-618
Range on HMM: 247-277/277
Sequence Identity: 32% (10 aa)

SLHSLVVSCATKDPEKRPTMKQIIEQ--LDR
|. .|.. |  .||..||....||..  |. 
SWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK536.AA Pkinase_Tyr 466-572 28 3.3e-08 28.4 Pfam 113-214 (270) Show / Hide 
Range on Protein: 466-572
Range on HMM: 113-214/270
Sequence Identity: 28% (33 aa)

ILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKISDFGSAKMARFA-----T-TKAAGAMV---YSAPECLQTVVDFEESKQSPKADV
.|.. ...| |..||.  .  .||||.   |.|...   .. . ||.|||   .||         .|. |...     ||||... .       . | ||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG---LARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK------FTTKSDV

FSYGILLCEVIT-CRFP
 |.|.|. |..| .. |
WSFGVLMWEIFTYGEQP
Kinase AqueK536.AA MLK 602-616 53 5e-06 17.0 In-house 277-291 (291) Show / Hide 
Range on Protein: 602-616
Range on HMM: 277-291/291
Sequence Identity: 53% (8 aa)

DPEKRPTMKQIIEQL
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DPHKRPSFRQIVQHL
Kinase AqueK536.AA Dicty4-Unclassified 363-443 23 1.4e-05 15.08 In-house 4-84 (263) Show / Hide 
Range on Protein: 363-443
Range on HMM: 4-84/263
Sequence Identity: 23% (21 aa)

RHKLGSGGWGEVIIGKFRGQKVAVKRFHDAIMNQENNQYY---LEMLNREINTMSQLRHPNLLQFIGAVLDHPSGNP-------MIITEVM
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DQFIGKGHFSKVHKGNWKGKDVAVK-----KFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI-----NPRSHKSTMCIVMEFM
Kinase AqueK536.AA DRK 594-618 36 4.8e-05 13.08 In-house 234-258 (258) Show / Hide 
Range on Protein: 594-618
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LVVSCATKDPEKRPTMKQIIEQLDR
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LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK536.AA TKL-Unique 598-616 42 6.9e-05 13.38 In-house 272-290 (290) Show / Hide 
Range on Protein: 598-616
Range on HMM: 272-290/290
Sequence Identity: 42% (8 aa)

CATKDPEKRPTMKQIIEQL
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CWHHDPSQRPSFDEIIHRL
Kinase AqueK536.AA HH498 551-575 48 0.000107 10.38 In-house 204-228 (284) Show / Hide 
Range on Protein: 551-575
Range on HMM: 204-228/284
Sequence Identity: 48% (12 aa)

SPKADVFSYGILLCEVITCRFPEHH
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SIKVDVFSYAMCIWEMHTREVPFHH
Kinase AqueK536.AA Pkinase_Tyr 591-616 46 0.000143 16.1 Pfam 245-270 (270) Show / Hide 
Range on Protein: 591-616
Range on HMM: 245-270/270
Sequence Identity: 46% (12 aa)

LHSLVVSCATKDPEKRPTMKQIIEQL
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IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK536.AA DRK 553-568 56 0.00023 10.73 In-house 182-197 (258) Show / Hide 
Range on Protein: 553-568
Range on HMM: 182-197/258
Sequence Identity: 56% (9 aa)

KADVFSYGILLCEVIT
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KADVYSFAIVLWECVT
Kinase AqueK536.AA CZAK 594-616 43 0.001245 9.24 In-house 257-279 (279) Show / Hide 
Range on Protein: 594-616
Range on HMM: 257-279/279
Sequence Identity: 43% (10 aa)

LVVSCATKDPEKRPTMKQIIEQL
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LIEMCWNKNPDERPSFKQILQHL
Kinase AqueK536.AA HH498 593-616 37 0.012321 3.73 In-house 261-284 (284) Show / Hide 
Range on Protein: 593-616
Range on HMM: 261-284/284
Sequence Identity: 37% (9 aa)

SLVVSCATKDPEKRPTMKQIIEQL
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NLIQMCWHPCPENRPDFDQIVTIL