Gene AqueK539 (A.queenslandica)

AqueK539

Species: A.queenslandica
Alias: AqueK539
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK539.AA Protein None 940 None Fasta, JSON
AqueK539.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of AqueK539.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ubiquitin AqueK539.AA ubiquitin 2-62 31 1.4e-08 34.68 Pfam 12-73 (73) Show / Hide 
Range on Protein: 2-62
Range on HMM: 12-73/73
Sequence Identity: 31% (20 aa)

IEVEPSDTVKKVKKKIAEKESLLADKLQILTIDNKEL-QDSDVLQDHSIENEA-TVICTVSQS
.||.|.|||...|.||..|.   .   | |  . |.| .|   |.|. |. .. |... ..|.
FEVDPDDTVEQLKQKIQQKQG-IPPDQQRLIYKGKQLREDHRTLSDYNIQDGSFTIHMVLRQR
UBQ AqueK539.AA UBQ 1-60 34 0.000119 22.7 SMART 15-72 (72) Show / Hide 
Range on Protein: 1-60
Range on HMM: 15-72/72
Sequence Identity: 34% (21 aa)

AIEVEPSD-TVKKVKKKIAEKESLLADKLQILTIDNKELQDSDVLQDHSIENEATVICTVS
..||.||| ||...|..|..||   ... | |. . | |.|   |.|. |....|. . |.
TFEVKPSDWTVSELKQHIEDKEGIPPEQ-QRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR
Rad60-SLD AqueK539.AA Rad60-SLD 2-55 20 0.011607 13.84 Pfam 16-69 (73) Show / Hide 
Range on Protein: 2-55
Range on HMM: 16-69/73
Sequence Identity: 20% (11 aa)

IEVEPSDTVKKVKKKIAEKESLLADKLQILTIDNKELQDSDVLQDHSIENEATV
..|.|..|..|.... ..|... ... . |  | ..|.. |...|  .| . ..
FKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTVEDYDMEDGDMI
UBQ AqueK539.AA UBQ 152-223 36 2.8e-09 38.09 SMART 1-72 (72) Show / Hide 
Range on Protein: 152-223
Range on HMM: 1-72/72
Sequence Identity: 36% (27 aa)

IQIVVKTDSG-RTISLDVLPID-NVGRVKTIIEDKLVIPFKKQEVLFDGTLLEDNDTLFRCGINKGGQLQLHYL
.|| ||.  | .|. ..| | | .|  .|  ||||. ||  .| ....|  |||. ||  ..| .|  . |.  
MQIFVKWQNGWKTFTFEVKPSDWTVSELKQHIEDKEGIPPEQQRLIYQGK-LEDD-TLADYNIQPGSTIHLMVR
Ubiquitin AqueK539.AA ubiquitin 157-221 33 1.2e-08 34.85 Pfam 1-67 (73) Show / Hide 
Range on Protein: 157-221
Range on HMM: 1-67/73
Sequence Identity: 33% (23 aa)

KTDSGR--TISLDVLPIDNVGRVKTIIEDKLVIPFKKQEVLFDGTLL-EDNDTLFRCGINKGGQLQLH
|| .|.  |....| | | |  .|  |..|  ||  .| ....| .| ||. ||. ..| .|  ...|
KTLDGKGSTFTFEVDPDDTVEQLKQKIQQKQGIPPDQQRLIYKGKQLREDHRTLSDYNIQDGS-FTIH
Rad60-SLD AqueK539.AA Rad60-SLD 152-207 27 0.004446 15.41 Pfam 1-58 (73) Show / Hide 
Range on Protein: 152-207
Range on HMM: 1-58/73
Sequence Identity: 27% (16 aa)

IQIVVKTDSGR-TISLDVLPIDNVGRVKTIIEDKLVIPF-KKQEVLFDGTLLEDNDTL
|.|..|.  |  .... | | . .  .. .  .|. ||. ...  .|||  |..|||.
INIKLKCQDGKKEVFFKVKPTTTFSKLMNAYCKKRGIPEHQQVRLIFDGERLDPNDTV
Ubiquitin AqueK539.AA ubiquitin 128-152 33 10.815946 2.3 Pfam 47-73 (73) Show / Hide 
Range on Protein: 128-152
Range on HMM: 47-73/73
Sequence Identity: 33% (9 aa)

L-DDLQSLSHYNIEYGA-TLKLEWSSI
| .| ..||.|||. |. |. .  .  
LREDHRTLSDYNIQDGSFTIHMVLRQR
RING AqueK539.AA RING 301-342 23 0.000199 20.42 SMART 1-23 (23) Show / Hide 
Range on Protein: 301-342
Range on HMM: 1-23/23
Sequence Identity: 23% (10 aa)

CTQCNEAIEVGDGAVLANCSHLLCRLCMDKSVKIKDGECISC
|. | |       .|. .| |  |. |.          |  |
CPICLE-------PVVLPCGH-FCY-CI----------CPIC
Kinase AqueK539.AA TKL 678-933 20 3.4e-48 166.44 In-house 1-364 (364) Show / Hide 
Range on Protein: 678-933
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

LGRGAFGTVRIGKFRG----------QSVAVKQLYAELQSPENI-------------------------SRMNREIDILSQLRHPNIVQFIGAILDHP--
.|.|.||.|  ||.||          . ||||..  .  . ...                          . ..|| ..|.|||||||||.|. .. |  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------DGNPRIMTEVM-DTSLRKAYESKKLTPDSGCRPVILSIMHDVAVGLNYLHTLPI-----DNIVHRDVSSANVLLESKGP----------GK
         .|.. | .| .   ||.  .            ........|.| |.||||.         .|.|||  |.|.|. ...             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

WKTKISDFGSANIVRR----------------------AVSRAPGAEVYSAPECFQGVSNQYSAV----------QTPKMDVYSYGVLFCEALTCKFPDR
|. ||.||| .  . .                      . ..  |   . |||...|  |  ..|           ..|.||||.|....| ||.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-SSFQDML------QQVWSSTKSVGLITRS------------LHH-----ELIKSCTKDNPYKRPTMNEVISKL
   . .|.      .  .   .     ..              .      .|.. | . .| |||...|....|
DYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK539.AA TK 672-933 16 1.1e-33 109.76 In-house 1-486 (486) Show / Hide 
Range on Protein: 672-933
Range on HMM: 1-486/486
Sequence Identity: 16% (78 aa)

TLSQQELGRGAFG---TVRIGKFRG---------------------------QSVAVKQLYAE-LQSPENISR--MN---------REIDILSQLR----
    ..||.|.||   .|. |. ||                           . ||||.| ..  .|.|      |.         .|  ......    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVQFIGAILDHPD----------GNPRIMTEVMD-TS----LRKAYESKK----------------------------------------------
 |||||...|.....            . . |..| |.  .    ||.   ...                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------LTPDSGCRPVILS-------------------IMHDVAVGLNYLHTLPI---DNIVHRDVSSANVLLESKGPGKWK-------TKISDFGSA--
      . |.. .    |.                   .....| |. ||| ...    |.||||.   |.|. .... ||.        ||.||| .  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

-------------NIVRRA-VSRAPGAEV----------------------YSAPECFQ-GVSNQY--SAVQTPKMDVYSYGVLFCEALT---CKFPDRS
             . .|.   ... ..                        . ||||.. .|  .     . |.| ||.|.|||  | .|     ..   
GSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SFQD-----MLQQVWSSTKSV-------------GLITR--------------------SLHHELIKSCTKDNPYKRPTMNEVISKL
| ||      .|.|    ..              ..                        ....|...| . .| .|||. .. ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc AqueK539.AA S_TKc 672-937 22 1.5e-32 115.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 672-937
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

TLSQQELGRGAFGTVRIGKFRG--QSVAVKQLYAELQSPENISRMNREIDILSQLRHPNIVQFIGAILDHPDGNPRIMTEVMDT---SLRKAYESKKL--
    ...|.||||.|. .. ..  . ||.|..           .. |||.||.. .|||||...... |   ..  . .| .|.   .|..  ....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TPDSGCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFGSANIVRRAVSRAPGAEVYSAPECFQGVSNQYSAVQTPKMD
..      .. ..|. .. .|.|.| .   .|.|||.  .|.|| .        ||.|||.| ..    .   |   | ||| .           ..| |
LRFPFPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL--------GYGKCKCD

VYSYGVLFCEALTCKFPDRSSFQDMLQQVWSSTKSVGLITRSLHHELIKSCTKDNPYKRPTMNEVIS-----KLDQLL
..| |... | |. . | .   | |....          .... . .|. | . .| ||||  |.       |... .
WWSCGCILYEMLCGYPPFP-QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK539.AA MLK 672-881 25 8.3e-27 90.09 In-house 1-235 (291) Show / Hide 
Range on Protein: 672-881
Range on HMM: 1-235/291
Sequence Identity: 25% (62 aa)

TLSQQELGRGAFGTVRIGKFRGQS-----VAVKQLYAEL----QSPENISRMNREIDILSQLRHPN----IVQFIGAILDHPDGNPRIMTEVMDT-SLRK
 . .. .| |.|| |  |..|..      ||||.  |.     .. . .  ...|. .|. |.|||    |.|| |..|..|  .  | .| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLYN

AYESKKLTPD----------SGCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLES--KGPGKWKTKISDFGSANIVRRA---VSRAPGAEVY
   ...  ..               .........| |..||| .  . |.|||  | |.|.    .  .. . ||.||| .  . .       ..|   .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPECFQG-VSNQYSAVQTPKMDVYSYGVLFCEALTCKFP
 ||| .|   ...||     | ||.|.||.. | ||.. |
MAPEVIQQFRCEKYSE----KCDVWSWGVVLWEMLTREVP
Kinase AqueK539.AA TKL-Unique 674-881 27 5.8e-26 88.64 In-house 1-233 (290) Show / Hide 
Range on Protein: 674-881
Range on HMM: 1-233/290
Sequence Identity: 27% (66 aa)

SQQELGRGAFGTVRIGKFRGQSVAVKQLYA-ELQSPENISRMNREIDILSQLR-HPNIVQFIGAILDHPDGNP--RIMTEVMDT-SLRKAYE--------
    .|.|..|.|  ||.|| .||.||.   |..|.| .   ..|. ... |. |||||...|.  ||   .|   | .| ..  ||..           
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-SKKLTPDSGCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESK-GPGKWKTKISDFG----SANIVRRAVSRA-----PGAE---VYSAPE
 .......     ..... .|.| |..|||..    | |||  | |.|. ..    .|. ||.|||    ...| .  ...      .. .    ..|||
NNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

CFQGVSNQYSAVQTPKMDVYSYGVLFCEALTCKF------P
 . .. .|||     | ||||.|.   | .| |       |
VLRMNFCQYSE----KSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK539.AA Dicty4 675-824 33 1.7e-25 82.15 In-house 4-159 (277) Show / Hide 
Range on Protein: 675-824
Range on HMM: 4-159/277
Sequence Identity: 33% (55 aa)

QQELGRGAFGTVRIGKFRGQSVAVKQLYAELQS--PENISRMNREIDILSQLRHPNIVQFIGAIL---DHPDGNPRIMTEVM-DTSLRKAYES------K
.|..|.|.||.|  |. ||. |||| | .  |    . ..   .|..|....|||||..| || .    || | . | || |  ..| .   .      .
EQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHP-GKMCIVTEYMPKGNLYSLLHDKPSEQQQ

KLTPDSGCRPVILS---IMHDVAVGLNYLHT-LPIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
. ..|.   | |..   .. |.| |.|.||.  |.  |.|||  |.| |        |. |..|||
SIKLDW---PLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDK----NWRVKVCDFG
Kinase AqueK539.AA STE 672-826 23 2.3e-25 86.59 In-house 1-194 (359) Show / Hide 
Range on Protein: 672-826
Range on HMM: 1-194/359
Sequence Identity: 23% (49 aa)

TLSQQELGRGAFGTVRIGKFR-----------------GQSVAVKQLYAELQSP---------------ENISRMNREIDILSQLR--HPNIVQFIGAIL
   ....|.||||||  .. .                 |. .|.||.  | ...               |.. .  .||.|.....  |||||...|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DHP-----DGNPRIMTEVMD-TSLRKAYESKKLTPDSGC----------RPVILSIMHDVAVG-LNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKI
.       |..  |  | ||  ||.. ...|. ....             ..|  | ...  | |.||| .    |.|||. .||.||          |.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL---------VKL

SDFGSA
.||| .
CDFGVC
Kinase AqueK539.AA Pkinase 672-881 22 3.5e-23 83.03 Pfam 1-211 (293) Show / Hide 
Range on Protein: 672-881
Range on HMM: 1-211/293
Sequence Identity: 22% (53 aa)

TLSQQELGRGAFGTVRIGKFRGQS--VAVKQLYAELQSP-ENISRMN-REIDILSQLRHPNIVQFIGAILDHPDGNPRIMTEVMDT-----SLRKAYE--
    . .|.|.||.|.... .| .  ||||..  . ... ..... . .|| |.  |.|||||.....  |  .... . .| ..      .|    .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-SKKL--TPDSGCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKT----KISDFGSA----NIVRRAVSRAPGAEVYSAPECFQ
 ....  ...     .. ..|  .. ||.|.|     .|.|||. ..|.|. ..|     .    ||.|||.|    .   .  .   |   | |||  .
RHGCFYFSEW-----ECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR

GVSNQYSAVQTPKMDVYSYGVLFCEALTCKFP
      .   .|| |..|.|... | |. ..|
-----GGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase AqueK539.AA DRK 675-751 42 6.7e-18 57.24 In-house 4-79 (258) Show / Hide 
Range on Protein: 675-751
Range on HMM: 4-79/258
Sequence Identity: 42% (33 aa)

QQELGRGAFGTVRIGKFRGQSVAVKQLYAELQSPENI-SRMNREIDILSQLRHPNIVQFIGAILDHPDGNPRIMTEVM
.   ||| .| |  |  ||  |||| | .     ||. . . |||....|||||||.||.|. .  ||  . | .| |
GNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYM
Kinase AqueK539.AA TyrKc 672-933 24 5.6e-17 51.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 672-933
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

TLSQQELGRGAFGTVRIGKFRGQSVAVKQLYAELQSPENISRMNREIDILSQL--RHPNIVQFIGAILDH-----PDGNPRIMTEVMDT-SLRKAYESKK
    ..||.||||.|. |. . . |||| | ..      .  . ||. |...|  .|||||...|.....      .. . | .| |.  .|..   ...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

LTPDSGCRPVILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFGSANIVRRA--------VSRA---PGAE--V---YSAPEC
 .    | .  ||.....| | .|||     |..|||    |.|. ...      |||||| .  .           . |.    |.   .     ||||
PK---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

FQGVSNQYSAVQTPKMDVYSYGVLFCEALTCKFPDRSS-FQ--DMLQQVWSSTKSVGLITRSLH-------------HELIKSCTKDNPYKRPTMNEVIS
.    . .    |.| ||.|.||.  | .|   .  .   |     |.|    |. .   .  .             ....|.| . .| .|||..|...
I--NYGKF----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

KL
..
CF
Pkinase_Tyr AqueK539.AA Pkinase_Tyr 671-739 35 1.4e-16 56.78 Pfam 1-76 (270) Show / Hide 
Range on Protein: 671-739
Range on HMM: 1-76/270
Sequence Identity: 35% (28 aa)

VTLSQQELGRGAFGTVRIGKFR------GQSVAVKQLYAELQSPEN--ISRMNREIDILSQL-RHPNIVQFIGAILDH
.|.  ..||.||||.|. |. .      .. |||| |  |  ..|.  .  . ||. |..|| .|||||...|...|.
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQ
Kinase AqueK539.AA CZAK 775-881 31 9.5e-15 50.12 In-house 108-221 (279) Show / Hide 
Range on Protein: 775-881
Range on HMM: 108-221/279
Sequence Identity: 31% (38 aa)

LSIMHDVAVGLNYLHT-LPIDNIVHRDVSSANVLLESKGP---------GKWKTKISDFGSANIVRRAVS---RAPGAEVYSAPECFQGVSNQYSAVQTP
...  |.| | ||||.      |.||| || |.||..               . ||.|||     .   .    . |   . ||||| | ..      |.
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENY------TE

KMDVYSYGVLFCEALTCKFP
| ||||.| .  . .||  |
KVDVYSFGMILWCIITCDQP
Kinase AqueK539.AA CZAK 675-735 35 2.6e-13 44.82 In-house 4-68 (279) Show / Hide 
Range on Protein: 675-735
Range on HMM: 4-68/279
Sequence Identity: 35% (24 aa)

QQELGRGAFGTVRIGKFRGQSVAVKQLYAELQSPENISR------MNREIDILSQLRHPNIVQFIGA
 |. |.| || |. .  || .||.| ..  . .  | .         .|. |.| |.|||.|||.||
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGA
Kinase AqueK539.AA LRRK 672-740 17 1e-11 37.68 In-house 1-130 (351) Show / Hide 
Range on Protein: 672-740
Range on HMM: 1-130/351
Sequence Identity: 17% (23 aa)

TLSQQELGRGAFG-TVRIGKFRG----------------------------QSVAVKQLYA--------------------------------ELQSPEN
  .....|||.|| .|  .|.||                            |.||.|..                                  .  ....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

ISRMNREIDILSQLRHPNIVQFIGAILDHP
 .   .|. |.| |.|||||. .|  ....
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL
Kinase AqueK539.AA TK-Unique 775-871 29 1.1e-11 36.64 In-house 134-228 (294) Show / Hide 
Range on Protein: 775-871
Range on HMM: 134-228/294
Sequence Identity: 29% (31 aa)

LSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFGSA------NIVRRAVSRAPGAEVYSAPECFQGVSNQYSAVQ-TPKMDVYS
.... ..| |..||. .. ..|||||... |||| .    . . ||.||| |      . . .  |. .    . ||| ..        .  |.| ||.|
YHFAWQIACGMEYLASQR-KKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWS

YGVL
.|||
FGVL
Kinase AqueK539.AA TK-Unique 672-735 31 7.6e-11 33.75 In-house 1-72 (294) Show / Hide 
Range on Protein: 672-735
Range on HMM: 1-72/294
Sequence Identity: 31% (23 aa)

TLSQQELGRGAFGTVRIGKFRG--------QSVAVKQLYAELQSPENISRMNREIDILSQLR-HPNIVQFIGA
   ....|.||||.|  |...|        ..||||.| ... ...  . . .|| ....|  ||||||..|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNA-TDTDKQDFLKEIQMMKELGDHPNIVQCLGC
Kinase AqueK539.AA LRRK 773-871 28 2.9e-09 28.93 In-house 165-271 (351) Show / Hide 
Range on Protein: 773-871
Range on HMM: 165-271/351
Sequence Identity: 28% (33 aa)

VILSIMHDVAVGLNYLHTLPIDN--IVHRDVSSANVLL-ESKGP-------GKWKTKISDFGSAN---IVRRA-VSRAPGAEVYSAPECFQGV-SNQYSA
..| |. ..| |..|||     |  |.|||  | |.|| .|. .          . ||.|||      ... . ...  | ... |||. ..    .|  
LKLKIALQIAKGMEYLHS---HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--

VQTPKMDVYSYGVL
  | | |.||.|..
--TEKVDCYSFGMI
Kinase AqueK539.AA LRRK 910-935 34 5.2e-08 24.41 In-house 326-351 (351) Show / Hide 
Range on Protein: 910-935
Range on HMM: 326-351/351
Sequence Identity: 34% (9 aa)

ELIKSCTKDNPYKRPTMNEVISKLDQ
.||..| . .| |||........| |
DLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK539.AA Dicty4 910-935 32 3.4e-07 20.25 In-house 250-277 (277) Show / Hide 
Range on Protein: 910-935
Range on HMM: 250-277/277
Sequence Identity: 32% (9 aa)

ELIKSCTKDNPYKRPTMNEVISK--LDQ
.||. |   .| .||...|.|..  |. 
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK539.AA DRK 772-824 40 4.2e-07 20.15 In-house 98-145 (258) Show / Hide 
Range on Protein: 772-824
Range on HMM: 98-145/258
Sequence Identity: 40% (22 aa)

PVILSIMHDVAVGLNYLHTL-PIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
| ....| |.| |..|||   ||  |.|||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPI--IIHRDLKSHNLLVDE----HWQVKVADFG
Kinase AqueK539.AA Pkinase_Tyr 774-824 29 2e-06 22.24 Pfam 113-156 (270) Show / Hide 
Range on Protein: 774-824
Range on HMM: 113-156/270
Sequence Identity: 29% (15 aa)

ILSIMHDVAVGLNYLHTLPIDNIVHRDVSSANVLLESKGPGKWKTKISDFG
.|.. ...| |..||.  .   ..|||.   |.|...   .. . ||.|||
LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK539.AA TKL-Unique 910-933 37 5e-06 17.54 In-house 267-290 (290) Show / Hide 
Range on Protein: 910-933
Range on HMM: 267-290/290
Sequence Identity: 37% (9 aa)

ELIKSCTKDNPYKRPTMNEVISKL
.||. | ...| .||. .|.|..|
DLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK539.AA TK-Unique 909-933 32 1e-05 15.82 In-house 270-294 (294) Show / Hide 
Range on Protein: 909-933
Range on HMM: 270-294/294
Sequence Identity: 32% (8 aa)

HELIKSCTKDNPYKRPTMNEVISKL
..|.|||....| .||.  .....|
YNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK539.AA DRK 911-935 32 5e-05 13.01 In-house 234-258 (258) Show / Hide 
Range on Protein: 911-935
Range on HMM: 234-258/258
Sequence Identity: 32% (8 aa)

LIKSCTKDNPYKRPTMNEVISKLDQ
|.. |   .|  ||.| |..  |. 
LMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK539.AA MLK 910-933 33 5.3e-05 13.44 In-house 268-291 (291) Show / Hide 
Range on Protein: 910-933
Range on HMM: 268-291/291
Sequence Identity: 33% (8 aa)

ELIKSCTKDNPYKRPTMNEVISKL
.|.| | ...| |||.. .....|
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK539.AA CZAK 910-933 37 0.007374 6.4 In-house 256-279 (279) Show / Hide 
Range on Protein: 910-933
Range on HMM: 256-279/279
Sequence Identity: 37% (9 aa)

ELIKSCTKDNPYKRPTMNEVISKL
|||  | . ||  ||.  ...  |
ELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK539.AA Pkinase_Tyr 909-933 36 0.00939 9.95 Pfam 246-270 (270) Show / Hide 
Range on Protein: 909-933
Range on HMM: 246-270/270
Sequence Identity: 36% (9 aa)

HELIKSCTKDNPYKRPTMNEVISKL
..|.|.| . .| .|||. |....|
YDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK539.AA Pkinase 910-933 30 1.376061 3.16 Pfam 268-293 (293) Show / Hide 
Range on Protein: 910-933
Range on HMM: 268-293/293
Sequence Identity: 30% (8 aa)

ELIKSCTKDNPYKRPTMNEVISK--L
..||.| . .|.||||  ..     .
DFIKWCLCKDPKKRPTAEQILQHPWF