AqueK549

Species: A.queenslandica
Alias: AqueK549
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK549.AA Protein None 1300 None Fasta, JSON
AqueK549.kin_dom Protein Kinase Domain None 165 None Fasta, JSON

Protein domain

Protein domains of AqueK549.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK549.AA TKL 118-248 22 2.7e-24 84.41 In-house 109-288 (364) Show / Hide
Range on Protein: 118-248
Range on HMM: 109-288/364
Sequence Identity: 22% (42 aa)

TEGNPMILTELM-PTSLRKELEIGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-----------PMIGVWRAKVSDYGSANL
..|...| .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.            . .  |..|..|.| .  
PWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

QHSI---------------------IRSVNPGGPLYAAPEAANPK----------------EHSPSMDVFSYGVLLLEMITRRIP
 .                        ..   | | . |||. . .                | |...||.|.|..| |..||..|
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

Kinase AqueK549.AA MLK 147-248 31 3.6e-17 56.21 In-house 126-235 (291) Show / Hide
Range on Protein: 147-248
Range on HMM: 126-235/291
Sequence Identity: 31% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP---MIGVWRAKVSDYGSANLQHSI-I-RSVNPGGPLYAAPEA---ANPKEHSPSMDVFSYGVL
.....|..| ...|||  .|.|| |||  | |.|.      ..   .|..| | .   |..   .  |.| . . |||.   .     | . ||.|.||.
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV

LLEMITRRIP
| ||.||..|
LWEMLTREVP

Kinase AqueK549.AA LRRK 150-248 29 4.4e-16 53.37 In-house 169-282 (351) Show / Hide
Range on Protein: 150-248
Range on HMM: 169-282/351
Sequence Identity: 29% (34 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMI---------GVWRAKVSDYGSAN----LQHS-IIRSVNPGGPLYAAPEAAN---PKEHSPSMDV
|.|..| ...||| ..| ||.|||  | |.||. .              ||..|.|       .... . ..| .  |.. |||  .    .| .   |.
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN--PGWMAPEIMRYNGEEEYTEKVDC

FSYGVLLLEMITRR-IP
.|.|..| | .||. .|
YSFGMILWELLTRQHHP

Kinase AqueK549.AA TKL-Unique 147-248 28 2.1e-14 47.37 In-house 112-233 (290) Show / Hide
Range on Protein: 147-248
Range on HMM: 112-233/290
Sequence Identity: 28% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM--IGVWRAKVSDYGSANLQHSIIRSVNP-----------GGPLYAAPEAANP--KEHSPSMD
.... .|.| ...|||  .|  |.|||  | |.|.     |  |..|..| | . .. .|... |            | ....|||  .   .  | . |
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD

VFSYGVLLLEMITRRI------P
|.|.|. | |..|| |      |
VYSFGIVLWEIATRKITKTYKKP

Kinase AqueK549.AA TK 117-245 14 1.2e-12 37.92 In-house 125-390 (486) Show / Hide
Range on Protein: 117-245
Range on HMM: 125-390/486
Sequence Identity: 14% (39 aa)

TTEGNPMILTELMP-TS----LRKELEIGG----------------------------------------------------------------------
. .. .||..|.||  .    ||. |                                                                          
VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQW

-------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMIGVWR-------AKVSDYGSAN-----LQHSI------IRSVNPG
       .  .  | .....||.. |||  .         |||.   |.|.   ..  |        .|..|.| .      |   |       |. ..|
CLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYG

GPL-------------------------YAAPEAAN---------PKEHSPSMDVFSYGVLLLEMITR
...                         . |||. |          . ...  ||.|.|||. |. |.
TGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTY

Pkinase AqueK549.AA Pkinase 117-252 21 1.4e-12 45.52 Pfam 70-215 (293) Show / Hide
Range on Protein: 117-252
Range on HMM: 70-215/293
Sequence Identity: 21% (33 aa)

TTEGNPMILTELMPT-----SLRKELE---IGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQ--PMIGVWRAKVSDYGSAN---LQ
...... . .|...      .|   ..    |..   .  . .. . ....|.|.|      |.|||. ..|.|.   . |.  . |..| |.|    . 
EDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-

HSIIRSVNPGGPLYAAPEAAN-PKEHSPSMDVFSYGVLLLEMITRRIPLPEE
..   ..  | | |.|||  .  ....|. |..|.|..| ||...| | |..
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGH

Kinase AqueK549.AA CZAK 148-196 36 6.4e-12 39.72 In-house 108-167 (279) Show / Hide
Range on Protein: 148-196
Range on HMM: 108-167/279
Sequence Identity: 36% (22 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMIG----------VWRAKVSDYG
... .|.|   ||||  .|| |||||| || |.||   .              .|..|.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG

Kinase AqueK549.AA STE 157-252 25 4.1e-11 35.61 In-house 163-271 (359) Show / Hide
Range on Protein: 157-252
Range on HMM: 163-271/359
Sequence Identity: 25% (31 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPMIGVWRAKVSDYGSAN-LQHSII-----------------RSVNPGGPLYAAPEAANP------KEHSPSMD
. |.|||  .   | |||. .||.||        .| .| | .  |..|.                  |    | | . |||  ..      |... . |
GLLYYLHSHH---IIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCD

VFSYGVLLLEMITRRIPLPEE
. | | ...||.| . |. ..
IWSLGCTIIEMATGKPPWHDM

S_TKc AqueK549.AA S_TKc 33-296 16 3.1e-10 -26.78 SMART 1-231 (231) Show / Hide
Range on Protein: 33-296
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

SSVLINTGSGPHLLVVGGYNRTSDIW----IFDINNKSWEKLFNLSDIVIERYSHSLSVWSVTPTTNWIIVFGGSTSYTDPAVIELRATTEGNPMILTEL
  .|   |.|    |  .... ..      | .             .|  |.  ..           .|. . ..                ..  . .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-------HHPNIVKLYDVFQD-------------DHLYMVMEY

MPT---SLRKELEIGG-------VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMIGVWRAKVSDYGSANLQHSIIRSVNPGGPLYAAP
...   .|.. ..  |            . ..   ..|||.|.|  .   |.|||.  .|.||       . |..| |.| .      .   | | | ||
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAP

EAANPKEHSP-SMDVFSYGVLLLEMITRRIPLPEERVGLIDDYQPVERSGHSTVRYVGSENVNRRRGDAEAARYC-----LPTL
|      ... . |. | |..| ||.... | | .   ...      ... . .|     . ..| .  || ...      | .
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK549.AA IRAK 148-181 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide
Range on Protein: 148-181
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL

Kinase AqueK549.AA LISK-DD1 229-248 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide
Range on Protein: 229-248
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP

Kinase AqueK549.AA PTB 264-399 19 1.7e-07 32.18 SMART 1-156 (156) Show / Hide
Range on Protein: 264-399
Range on HMM: 1-156/156
Sequence Identity: 19% (32 aa)

ERSGHSTVRYVGSENVNRRR-------GDAEAARYCLPTLRTASKNMRAHKPKAVLGLNLKGVSLYDERSK-SITRVPVDKVTYVTLDP-----------
.   .  |.|.|.  | . |       |.. ... |. ..|     .. |. | .| .  .||.| |. .|  | . |. .....  ||           
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQE-CMRKIR----QHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCC

EDQCYFGVIIQTKESH------TGFRLYCFKAERPIAVTFVNSSRELFDLIMKLRQAKKKM
.| ..||.|.  . ..      . ||...|. | | |   . . ...|.......|.... 
DDDRCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ

Kinase AqueK549.AA LISK 229-250 54 2e-07 20.0 In-house 219-240 (296) Show / Hide
Range on Protein: 229-250
Range on HMM: 219-240/296
Sequence Identity: 54% (12 aa)

SMDVFSYGVLLLEMITRRIPLP
| ||||.|..|.|.|||. . |
SCDVFSFGIVLCEIITRVKADP

Kinase AqueK549.AA LISK 148-196 42 3e-06 15.97 In-house 104-150 (296) Show / Hide
Range on Protein: 148-196
Range on HMM: 104-150/296
Sequence Identity: 42% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-IGVWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.     ..||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG

Kinase AqueK549.AA LISK-DD1 148-196 44 2.5e-05 15.46 In-house 126-172 (290) Show / Hide
Range on Protein: 148-196
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-IGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG

Kinase AqueK549.AA OmpH 393-1030 3 0.000102 18.42 Pfam 36-116 (165) Show / Hide
Range on Protein: 393-1030
Range on HMM: 36-116/165
Sequence Identity: 3% (24 aa)

RQAKKKMKEEREEADKAPQDPDTSNLPAENAPPPSYTSVSKAPDRPPPPMPKQAPAMPPRPQEADIFSFGNEPPPPTFDDVYDVSSGALTSLYGNQPQAP
..|.|....| .. ..                                                                                    
KDAQKQLEKEFKQWQAE-----------------------------------------------------------------------------------

PTFAPPPQPNPFGMAGQPPPPNYPPPPVQEPSITMDLMDAIRNPQQSTTTAYLIGMGMRMPGLGMGPPAGLPADLLLDSNFSQPLLPTNTGGAGPPGGGQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PPQGAGGKIDAFSDLVSIARDKTTSKPEPAPPTIFQSPPTNTETSPPLPYRPPDLDFTDAPPTTSGPAPSGFDNTFGALPPAPGTGGWFWRXKASPPNKM
                                                                                                    
----------------------------------------------------------------------------------------------------

AAKAPDYQPGKRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTGNPPLGVNGYAAAAIGREIFYFGGYCNHGDCYHN
                                                                                                    
----------------------------------------------------------------------------------------------------

SLYSAILFGGYTDNGASNNVYILNFTDTSVNCSKLSNPGGSVQWPKGRRGHSSVLINTSSGPHLLVVGGTGGAYDIWIFDINNKSWKELVNLPVNVTNRC
                                                                                                    
----------------------------------------------------------------------------------------------------

WHSLSVWSVTPTTNWIIVFGGSSSYTDTAVVELRYTSNNDWSTSIIPLDQYQEKLQERRREWEASQPVQPEDRREIDRLTRVLQERERELEEEKR-----
                                                                                  ||... ||..|.      
----------------------------------------------------------------------------------LQKMQKELQKEQQKYQKQ

-EK----EQVRNRLQQQLQGREQQLQQAQQQGQEREREIQQARERERQ
 ..    |. |  .||..| ..|..||.||| |   .|.||... ..|
IRAGTMSEEQRQKKQQEFQQKQQEFQQYQQQYQ-P-QEMQQKQQELMQ

Kinase AqueK549.AA IRAK 197-244 26 0.000369 10.83 In-house 167-219 (317) Show / Hide
Range on Protein: 197-244
Range on HMM: 167-219/317
Sequence Identity: 26% (14 aa)

SANLQHSI---IRSVNPGGPLYAAPEAAN--PKEHSPSMDVFSYGVLLLEMIT
|.......   . |.  |   | .||. .   .. ..  ||.| |. ||| .|
SHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLT

Kelch_1 AqueK549.AA Kelch_1 28-74 16 0.000506 18.19 Pfam 1-45 (45) Show / Hide
Range on Protein: 28-74
Range on HMM: 1-45/45
Sequence Identity: 16% (8 aa)

KRRSHSSVLINTGSGPHLLVVGGYN--RTSDIWIFDINNKSWEKLFNLS
.|..|... .|     .. |.||..  ........|  ...|... ...
PRCGHGVCVHNG----KIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP

Kelch_2 AqueK549.AA Kelch_2 28-74 23 0.000894 18.47 Pfam 1-51 (51) Show / Hide
Range on Protein: 28-74
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

KRRSHSSVLINTGSGPHLLVVGGY--------NRTSDIWIFDINNKSWEKLFNLS
 | .|.|. .    |  ..|.|||         ...|||..| . ..|...  . 
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kinase AqueK549.AA Pkinase_Tyr 117-181 21 0.002298 12.02 Pfam 74-144 (270) Show / Hide
Range on Protein: 117-181
Range on HMM: 74-144/270
Sequence Identity: 21% (16 aa)

T-TEGN--PMILTELMPT-SLRKELEIG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|  ..   ..| .|.||  .|.. |         .  . .|......|....||.  .   . |||.   |.|.
TDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV

Kinase AqueK549.AA Kelch_2 703-759 17 0.00369 16.13 Pfam 1-51 (51) Show / Hide
Range on Protein: 703-759
Range on HMM: 1-51/51
Sequence Identity: 17% (10 aa)

KRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
 |  |... .|. .|..||         ..  . . .... .....| ||.  |  .
PRYCHASCVPGGKIYVFGGYC------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kinase AqueK549.AA Kelch_1 839-885 22 0.008157 13.86 Pfam 1-45 (45) Show / Hide
Range on Protein: 839-885
Range on HMM: 1-45/45
Sequence Identity: 22% (11 aa)

GRRGHSSVLINTSSGPHLLVVGGTGG--AYDIWIFDINNKSWKELVNLP
 |.||... .|     .. |.||  |    .....|  ...|... ..|
PRCGHGVCVHNG----KIYVIGGCDGQYLNSVECYDPETNQWTRCPPMP

Kinase AqueK549.AA CZAK 215-248 32 0.008787 6.12 In-house 188-221 (279) Show / Hide
Range on Protein: 215-248
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YAAPEAANPKEHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP

Kinase AqueK549.AA Kelch_2 839-885 23 0.128622 10.27 Pfam 1-51 (51) Show / Hide
Range on Protein: 839-885
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

GRRGHSSVLINTSSGPHLLVVGGT--------GGAYDIWIFDINNKSWKELVNLP
.| .|.|. .    |  ..|.||             |||..| . ..|...  .|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kinase AqueK549.AA Pkinase_Tyr 231-245 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide
Range on Protein: 231-245
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY

Kinase AqueK549.AA Kelch_1 764-796 21 3.458157 4.44 Pfam 1-30 (45) Show / Hide
Range on Protein: 764-796
Range on HMM: 1-30/45
Sequence Identity: 21% (7 aa)

GVNGYAAAAIGREIFYFGGYCNHGDCYHNSLYS
   |....... .|. .||...    | || ..
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVEC

Kinase AqueK549.AA Kelch_1 703-759 15 3.593993 4.38 Pfam 1-45 (45) Show / Hide
Range on Protein: 703-759
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

KRREHSTVRVGDYLYMWGGGQPDLPAVHNNEKKKSMCSVMEVCHLRTGRWEQKPTTG
.|. |. . .....|  ||  .            .  .  |. ...|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP

Kinase AqueK549.AA Kelch_2 764-795 25 5.781577 3.99 Pfam 1-35 (51) Show / Hide
Range on Protein: 764-795
Range on HMM: 1-35/51
Sequence Identity: 25% (9 aa)

GVNGYAAAAIGREIFYFGGY---CNHGDCYHNSLY
.  . |.. .|  |. ||||     ..||......
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIW

Kinase AqueK549.AA Kelch_2 890-936 27 9.387128 3.19 Pfam 1-32 (51) Show / Hide
Range on Protein: 890-936
Range on HMM: 1-32/51
Sequence Identity: 27% (13 aa)

NRCWHSLSVWSVTPTTNWIIVFGGSSSYTDTAVVELRYTSNNDWSTS
.|. |. .|.      ..|.||||..          |.| |||....
PRYCHASCVP-----GGKIYVFGGYC----------RHTHNNDCWSM

Kelch_2 AqueK549.AA Kelch_2 79-103 36 14.875008 2.43 Pfam 1-20 (51) Show / Hide
Range on Protein: 79-103
Range on HMM: 1-20/51
Sequence Identity: 36% (9 aa)

ERYSHSLSVWSVTPTTNWIIVFGGS
 ||.|. .|.      ..|.||||.
PRYCHASCVP-----GGKIYVFGGY

Kinase AqueK549.AA Kelch_1 800-828 16 56.747322 0.08 Pfam 17-45 (45) Show / Hide
Range on Protein: 800-828
Range on HMM: 17-45/45
Sequence Identity: 16% (5 aa)

FGGYTDNGASNNVYILNFT-DTSVNCSKLS
.||...  ..|.|.... . ..   |. ..
IGGCDG-QYLNSVECYDPETNQWTRCPPMP

Kinase AqueK549.AA TKL 1121-1282 20 2.2e-31 110.25 In-house 1-244 (364) Show / Hide
Range on Protein: 1121-1282
Range on HMM: 1-244/364
Sequence Identity: 20% (52 aa)

LGRGGWGEVRVARFHG----------LEVAAKVLHETIISEYNV-------------------------SLFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  ....|           .|| |.....  .| .                            . .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELEIGGVTYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-----------PMLGVWRAKV
            . | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.            .    |..|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

SDYGSANLQPLIG---------------------RTTNPGNPVYSAPEA
.|.| .      |                     . |  |.| . |||.
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

Kinase AqueK549.AA MLK 1115-1282 21 4e-21 70.1 In-house 1-204 (291) Show / Hide
Range on Protein: 1115-1282
Range on HMM: 1-204/291
Sequence Identity: 21% (44 aa)

RMTERILGRGGWGEVRVARFHGLE-----VAAKVLHETIISEYNVS-----LFSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRK
  .....| |. |.|  .|... .     || |  . .|. .  ..      | .| .......|||      || |. .. ..   |..| ..  ||  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

EL---EI------------GGVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP---MLGVWRAKVSDYGSAN-LQPL-IGRTTNPGNPVY
 |   ..            . ..   .....|..| ...|||  .|.|| |||  | |.|.      ..   .|..| | .  ..     .. |.|.. .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

SAPEA
 |||.
MAPEV

Kinase AqueK549.AA TKL-Unique 1117-1281 25 9e-17 55.82 In-house 1-196 (290) Show / Hide
Range on Protein: 1117-1281
Range on HMM: 1-196/290
Sequence Identity: 25% (50 aa)

TERILGRGGWGEVRVARFHGLEVAAKVLH-ETIISEYNVSLFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE--------
    .|.|| |.|  . ..| .|| |..| .  .|   .  |..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---IGGVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM--LGVWRAKVSDYGSANLQPLIGRTTNP-----------GNPVYSAPE
       ..  .... .|.| ...|||  .|  |.|||  | |.|.        |..|..| | . ..  | ..||            |.. ..|||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

Kinase AqueK549.AA TK 1118-1258 14 3.2e-16 50.14 In-house 4-296 (486) Show / Hide
Range on Protein: 1118-1258
Range on HMM: 4-296/486
Sequence Identity: 14% (43 aa)

ERILGRGG---WGEVRVARFHGL---------------------------EVAAKVLHETIISEYN-VSL--------------FSREMNIAS--KIRHP
.. ||.|    .|||. .. .|.                           .|| |.|.|.  .. .   .              . .|| . .  . .||
GKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHP

NLLQFIGATTEGN-------------PIILTELMP-TS----LRKELEIGG-------------------------------------------------
|.....|. |.|              ..|..|.||  .    ||. |                                                     
NIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD

----------------------------VTYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-PMLGVWR-------AKVSDYG
                            .| .  | .....||.. |||  .         |||.   |.|.   .   |        .|..|.|
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

Pkinase_Tyr AqueK549.AA Pkinase_Tyr 1114-1243 25 3e-15 52.29 Pfam 1-144 (270) Show / Hide
Range on Protein: 1114-1243
Range on HMM: 1-144/270
Sequence Identity: 25% (38 aa)

IRMTERILGRGGWGEVRVARFH------GLEVAAKVLHETIISEY--NVSLFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
|..  . ||.|  |||. .. .      ...|| |.| |.  .|     .... |..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

EIG-----GVTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
         .| . .|......|....||.  .   . |||.   |.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV

Kinase AqueK549.AA Pkinase 1115-1243 18 2.9e-13 47.96 Pfam 1-141 (293) Show / Hide
Range on Protein: 1115-1243
Range on HMM: 1-141/293
Sequence Identity: 18% (27 aa)

RMTERILGRGGWGEVRVARFHGLE--VAAKVLH-ETIISEYNVSLFS-REMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---I
  ..|..|.|. |.|. .. .| .  || |..  ... |. .....  .|  |  ...||| ......  ..... . .|...      .|   ..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--TYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|..  ..  . .. . ....|.|.|      |.|||. ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI

Kinase AqueK549.AA STE 1116-1281 19 3.6e-13 42.95 In-house 1-232 (359) Show / Hide
Range on Protein: 1116-1281
Range on HMM: 1-232/359
Sequence Identity: 19% (47 aa)

MTE-RILGRGGWGEVRVARFH-----------------GLEVAAKVLH----ETIISE------------YNVSLFSREMNIASKIR--HPNLLQFIGAT
 .  ...|.|. |.|  |. |                 |  .| |...    .. . |             ..  . .|..| .| .  |||  ...|. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

T--------EGNPIILTELMP-TSLRKELEIGGVTY---------------PAILSISLDVACA-LNYLHLFKPHPILHRDVSSANVLLQPMLGVWRAKV
         ...  |  |.|.  ||.. ..  . .                . |  |  ..  . |.|||  .   | |||. .||.||        .| 
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL--------VKL

SDYGSAN-LQPLIG-----------------RTTNPGNPVYSAPE
.| | .  |.. .                  |.|  | | . |||
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE

Kinase AqueK549.AA LISK 1120-1178 26 2.1e-12 36.41 In-house 1-64 (296) Show / Hide
Range on Protein: 1120-1178
Range on HMM: 1-64/296
Sequence Identity: 26% (17 aa)

ILGRGGWGEVRVARFH--GLEVAAKVLH---ETIISEYNVSLFSREMNIASKIRHPNLLQFIGA
..|.|. |.|   .    | ..| | .|   .. . . .   . ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV

Kinase AqueK549.AA CZAK 1210-1258 36 8.3e-12 39.3 In-house 108-167 (279) Show / Hide
Range on Protein: 1210-1258
Range on HMM: 108-167/279
Sequence Identity: 36% (22 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMLG----------VWRAKVSDYG
... .|.|   ||||  .|| |||||| || |.||   .              .|..|.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG

Kinase AqueK549.AA LRRK 1115-1281 20 8.5e-12 38.0 In-house 1-249 (351) Show / Hide
Range on Protein: 1115-1281
Range on HMM: 1-249/351
Sequence Identity: 20% (53 aa)

RMTERILGRGGWG-EVRVARFHG----------------------------LEVAAKVLHET-------------------------------IISEYNV
 . |. .|||| | .|  |.. |                             .||.|... .                               ...  ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-SLFSREMNIASKIRHPNLLQFIGATTEGNPIIL-TELMPT-SLRKELE---IGG------V-TYPAILSISLDVACALNYLHLFKPHPILHRDVSSANV
 ..| .|. | |. .|||... .| .   .|... .|..|  .| . |.     |      . .   .| |.|..| ...||| ..| ||.|||  | |.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLQPML---------GVWRAKVSDYGSAN----LQP-LIGRTTNPGNPVYSAPE
||. .              ||..|.|       ... .. . .  |||.. |||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPE

Kinase AqueK549.AA CZAK 1118-1191 33 8.7e-12 39.22 In-house 4-84 (279) Show / Hide
Range on Protein: 1118-1191
Range on HMM: 4-84/279
Sequence Identity: 33% (27 aa)

ERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNV----SLFSREMNIASKIRHPNLLQFIGATTEGN---PIILTELM
..  |.|  |||. |.  |  || | .|     .         | .|  | || .||| .||.|| .|..     | .| |
GQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM

Kinase AqueK549.AA IRAK 1210-1243 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide
Range on Protein: 1210-1243
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL

Kinase AqueK549.AA TyrKc 1115-1290 17 4.1e-08 -91.48 SMART 1-280 (280) Show / Hide
Range on Protein: 1115-1290
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

RMTERILGRGGWGEVRVARFHGLEVAAKVLHETIISEYNVSLFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELEIGG
   ...||.|  |||. ..   ..|| |.|.|       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. |   .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--VTYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMLGVWRAKVSDYG-SANLQPL--------IGRT-----TN----------------
  .. .  ||.....||  .|||    ... |||    |.|.   .   ..|.|| | | ..             |.     ..                
PKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

--------------------------PG-----NPVYSAPEAGIQG------ST------------------------------------LL
                          ||      . . . |   ||                                            ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK549.AA LISK-DD1 1120-1178 31 3.6e-07 22.23 In-house 1-65 (290) Show / Hide
Range on Protein: 1120-1178
Range on HMM: 1-65/290
Sequence Identity: 31% (21 aa)

ILGRGGWGEVRVARFHGLEVAAKVLHE----TIISEYNVSLFSREMNIASK---IRHPNLLQFIGA
. |.|. | |  .   | .|| |..|.     .  .| . .  ||  .      |||||. ||||.
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWK-FMQREIKMLKNLLNIRHPNIVQFIGI

Kinase AqueK549.AA LISK 1210-1258 42 3e-06 16.08 In-house 104-150 (296) Show / Hide
Range on Protein: 1210-1258
Range on HMM: 104-150/296
Sequence Identity: 42% (21 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-LGVWRAKVSDYG
..|.||.||.. |||  .   |.|||  | |.|.     ..||.|| | |
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFG

Kinase AqueK549.AA LISK-DD1 1210-1258 44 2.6e-05 15.44 In-house 126-172 (290) Show / Hide
Range on Protein: 1210-1258
Range on HMM: 126-172/290
Sequence Identity: 44% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPM-LGVWRAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.     . ||.|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQWRIKVCDFG

Kinase AqueK549.AA IRAK 1117-1177 23 0.000123 12.54 In-house 3-70 (317) Show / Hide
Range on Protein: 1117-1177
Range on HMM: 3-70/317
Sequence Identity: 23% (16 aa)

TERILGRGGWGEVRVARFHGLE--VAAKVLHETIISEYN---VSLFS--REMNIASKIRHPNLLQFIG
 .. .| || |.|  .......  .| | |.|.  .. |   ... .   |. . ...||||.. . |
KDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYG