Gene AqueK550 (A.queenslandica)

AqueK550

Species: A.queenslandica
Alias: AqueK550
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK550.AA Protein None 214 None Fasta, JSON
AqueK550.kin_dom Protein Kinase Domain None 166 None Fasta, JSON

Protein domain

Protein domains of AqueK550.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK550.AA TKL 17-166 18 6.6e-29 101.23 In-house 132-364 (364) Show / Hide 
Range on Protein: 17-166
Range on HMM: 132-364/364
Sequence Identity: 18% (44 aa)

PELLRISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPMGG--------GLGGWRAKVSDYGTVS-LQPLA--------------------RTC
. ..|..||.|...||||  .|      ||.|||  |.|.|.   .             |..|..|.|.   ...                      .|.
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

NPG-NPVYSAPES-----PYP-----------RQHSPSMDVFSYGVLLIEMALCEFPEEEKSLR------------EAQIKAIKRPTLK-----------
... .| . |||      .|.           .. |...||.|.|..| |.. .. |...   .            .  ..  .||...           
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

---------NLIERCLIENYKQRPTMSDIIKEL
         .|...|  .. ..||....|.|.|
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK550.AA MLK 19-116 30 8.7e-16 51.35 In-house 126-229 (291) Show / Hide 
Range on Protein: 19-116
Range on HMM: 126-229/291
Sequence Identity: 30% (32 aa)

LLRISLDVACALNYLHLFKPHPILHRDVSSANVLLQP-MGGGLGGWRAKVSDYGTVS-LQPL-A-RTCNPGNPVYSAPESP---YPRQHSPSMDVFSYGV
.....|..| ...|||  .|.|| |||  | |.|.    .  ...  .|..| ||.  ..   . ...|.|.. . |||        . | . ||.|.||
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LLIEM
.| ||
VLWEM
Kinase AqueK550.AA HH498 20-116 37 1.1e-13 39.32 In-house 124-219 (284) Show / Hide 
Range on Protein: 20-116
Range on HMM: 124-219/284
Sequence Identity: 37% (38 aa)

LRISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYG----TVSLQPLARTCNPGNPVYSAPESPY-PRQHSPSMDVFSYGVLLI
..||.|||   ||||   .||| |||  | |.|.   |      .|.| |.|      ..     |  |||. . |||      . |   |||||.  . 
MTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG------HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIW

EM
||
EM
Kinase AqueK550.AA TK 11-166 14 1.8e-12 37.38 In-house 229-486 (486) Show / Hide 
Range on Protein: 11-166
Range on HMM: 229-486/486
Sequence Identity: 14% (38 aa)

TGGLAYPELLRISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQPMGG-----GLGGWRAKVSDYG--------TVSLQPLARTCNPGNPVY----
.. |  ..|| .....||.. |||  .         |||.   |.|.   .      .  |  .|..|.|             .        .. .    
KHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRP

-------------------------SAPESPY---------PRQHSPSMDVFSYGVLLIEMA-LC-EFPEEEKS--------------------------
                          |||.            . ...  ||.|.|||. |.  .. | . .. |                          
MWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRS

--------LREAQIKAIKR-------------PTLKNLIERCLIENYKQRPTMSDIIKEL
        .| .| .                 . .  |. .|  .. ..|||.|.. ..|
GLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK550.AA STE 29-164 19 4.3e-12 39.11 In-house 163-353 (359) Show / Hide 
Range on Protein: 29-164
Range on HMM: 163-353/359
Sequence Identity: 19% (41 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYGTVS-LQPLAR------------TCN------PGNPVYSAPESPYP------RQHSP
. |.|||  .   | |||. .||.||           .| .| |. . |..  .            |.        | | . |||   .       ... 
GLLYYLHSHH---IIHRDIKPANILL-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT

SMDVFSYGVLLIEMALCEFPEEE-KSLREAQIKAIKR-------------------------------------------PTLKNLIERCLIENYKQRPT
. |. | | ..||||  . |  . . .|    ....                                            | .|. |..||. ....|||
KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT

MSDIIK
 |. .|
ASQLLK
Kinase AqueK550.AA CZAK 20-122 31 1.3e-11 38.58 In-house 108-221 (279) Show / Hide 
Range on Protein: 20-122
Range on HMM: 108-221/279
Sequence Identity: 31% (36 aa)

LRISLDVACALNYLHL-FKPHPILHRDVSSANVLLQPMGG-------GLGGWRAKVSDYGTV---SLQPLARTCNPGNPVYSAPESPYPRQHSPSMDVFS
. . .|.|   ||||  .|| |||||| || |.||                  .|..|.|       ||   |   |   . |||       ..  ||.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YGVLLIEMALCEFP
.| .| ..  |. |
FGMILWCIITCDQP
Kinase AqueK550.AA TKL-Unique 20-117 27 2.2e-10 33.02 In-house 113-222 (290) Show / Hide 
Range on Protein: 20-117
Range on HMM: 113-222/290
Sequence Identity: 27% (32 aa)

LRISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGG-----WRAKVSDYGTVSLQP--LARTCN----------PGNPVYSAPESPYP--RQH
... .|.| ...|||  .|  |.|||  | |.|.        .     |..|..| |.. ..   .. | |           |.. ..|||       | 
VKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVD------NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY

SPSMDVFSYGVLLIEMA
| . ||.|.|. |.|.|
SEKSDVYSFGIVLWEIA
Kinase AqueK550.AA LRRK 19-93 33 2.9e-10 32.49 In-house 166-249 (351) Show / Hide 
Range on Protein: 19-93
Range on HMM: 166-249/351
Sequence Identity: 33% (29 aa)

LLRISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGL------GGWRAKVSDYGTVS----LQP-LARTCNPGNPVYSAPE
.|.|.|..| ...||| ..| ||.|||  | |.||. .  .           ||..|.|. .    ... .|..|  |||.. |||
KLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
Kinase AqueK550.AA TK-Unique 14-117 24 2e-09 28.77 In-house 128-233 (294) Show / Hide 
Range on Protein: 14-117
Range on HMM: 128-233/294
Sequence Identity: 24% (28 aa)

LAYPELLRISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYGTVS----LQPLARTC--NPGNPVYSAPESPY--PRQH-SPSM
. .  |...  ..||...||.   .. | |||... ||||.       . ..|..|.|        ......|  ..    . ||||..   ... ..  
ISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKS

DVFSYGVLLIEMA
|| |.|||. |..
DVWSFGVLMWEIF
S_TKc AqueK550.AA S_TKc 1-172 16 2.3e-07 -68.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-172
Range on HMM: 1-231/231
Sequence Identity: 16% (41 aa)

M--------------------------------------------------------------------PT---SLRKELETGG-------LAYPELLRI
                                                                     ..   .|.. ..  |       .   .  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

SLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYGTVSLQPLARTCNPGNPVYSAPESPYPRQHSP-SMDVFSYGVLLIEMALCEF
   ..|||.|.|  .   |.|||.  .|.||          . |..| |   .     |   | | | |||     .... . |. | |..|.||.  . 
MYQICCALEYCHSHG---IIHRDLKPENILLDE--------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PEEEKSLREAQIKAIKRPTLKNLIERCLIENYKQRPTMSDIIK---ELNESIYV
| .     .. .| |. | .|..|..||  . ..|||  .. .   . .   ..
PFP---QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK550.AA TyrKc 3-166 15 2e-06 -119.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-166
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

TSLRKELETG-------------------------------------G------------------------------------------------LAYP
 .| |.|  |                                     |                                                |  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

ELLRISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYGTVSLQPLARTCNPG------NPVYS----------------APESP
.|| .....||  .|||    ... |||    |.|.   .      ..|.|| |      |.|    .        .|.                |||. 
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH------TVKISDFG------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

YPRQHSPSMDVFSYGVLLIEMA-LCEFPEEE-----KSLRE--AQIKAIKRPTLKNL----------------IERCLIENYKQRPTMSDIIKEL
  .  ..  ||.|.||.. |.  ... | ..     .| .|  ...|. .|.                     ...|  |. ..|||.|.|....
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK550.AA TAK1 26-93 35 4e-06 16.58 In-house 111-173 (284) Show / Hide 
Range on Protein: 26-93
Range on HMM: 111-173/284
Sequence Identity: 35% (24 aa)

VACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWRAKVSDYGTVSLQPLARTCNPGNPVYSAPE
.| ...|||  .| |. |||.  .| ||   .  |     |. | ||.       ||| | . . |||
CAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTL-----KICDFGTFCDMHQMMTCNRGTCRWMAPE
Kinase AqueK550.AA LRRK 139-168 33 4e-06 17.56 In-house 322-351 (351) Show / Hide 
Range on Protein: 139-168
Range on HMM: 322-351/351
Sequence Identity: 33% (10 aa)

PTLKNLIERCLIENYKQRPTMSDIIKELNE
. ...||. |  .. |.||..|.|.| | .
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK550.AA TKL-Unique 141-166 34 7e-06 16.89 In-house 265-290 (290) Show / Hide 
Range on Protein: 141-166
Range on HMM: 265-290/290
Sequence Identity: 34% (9 aa)

LKNLIERCLIENYKQRPTMSDIIKEL
...||..|   .  |||. ..||..|
YRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK550.AA TAK1 138-165 21 9e-06 15.35 In-house 257-284 (284) Show / Hide 
Range on Protein: 138-165
Range on HMM: 257-284/284
Sequence Identity: 21% (6 aa)

RPTLKNLIERCLIENYKQRPTMSDIIKE
.. .... ..|  .|  .||.|... | 
PKRIEQFMKCCWDDNPEKRPSMQECVKY
Kinase AqueK550.AA Pkinase 98-172 16 1e-05 21.33 Pfam 187-293 (293) Show / Hide 
Range on Protein: 98-172
Range on HMM: 187-293/293
Sequence Identity: 16% (18 aa)

RQHSPSMDVFSYGVLLIEMALCEFPEEEK------SLREAQIKAIKR-------------------------------PTLKNLIERCLIENYKQRPTMS
. ..|. |..|.|..|.||.. ..|  ..      . ..  |. |..                               ...| .|..||  . |.|||  
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQM-ICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--

DIIKELNESIYV
  .... .. ..
--AEQILQHPWF
Kinase AqueK550.AA MLK 139-166 25 1.2e-05 15.77 In-house 264-291 (291) Show / Hide 
Range on Protein: 139-166
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

PTLKNLIERCLIENYKQRPTMSDIIKEL
. .|.|...|  .. ..||... |...|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Pkinase_Tyr AqueK550.AA Pkinase_Tyr 5-53 28 7.5e-05 17.05 Pfam 98-144 (270) Show / Hide 
Range on Protein: 5-53
Range on HMM: 98-144/270
Sequence Identity: 28% (14 aa)

LRKE-LETGGLAYPELLRISLDVACALNYLHLFKPHPILHRDVSSANVLL
|||   . . |  ..|| .....|....||.  .   . |||.   |.|.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK550.AA TK-Unique 138-166 24 0.000179 11.48 In-house 266-294 (294) Show / Hide 
Range on Protein: 138-166
Range on HMM: 266-294/294
Sequence Identity: 24% (7 aa)

RPTLKNLIERCLIENYKQRPTMSDIIKEL
.... ||...|. .. ..||. ..|...|
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK550.AA Pkinase_Tyr 139-166 28 0.001837 12.35 Pfam 243-270 (270) Show / Hide 
Range on Protein: 139-166
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

PTLKNLIERCLIENYKQRPTMSDIIKEL
. . .|. .|  .. ..|||.|.|. .|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK550.AA Pkinase 12-53 25 0.012015 10.44 Pfam 101-141 (293) Show / Hide 
Range on Protein: 12-53
Range on HMM: 101-141/293
Sequence Identity: 25% (11 aa)

GGL--AYPELLRISLDVACALNYLHLFKPHPILHRDVSSANVLL
|..   . |. .. . ....|.|.|      |.|||. ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
Kinase AqueK550.AA HH498 143-166 33 0.165645 0.09 In-house 261-284 (284) Show / Hide 
Range on Protein: 143-166
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

NLIERCLIENYKQRPTMSDIIKEL
||| .|   .   ||. ..|.  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK550.AA CZAK 141-166 38 0.228009 0.92 In-house 254-279 (279) Show / Hide 
Range on Protein: 141-166
Range on HMM: 254-279/279
Sequence Identity: 38% (10 aa)

LKNLIERCLIENYKQRPTMSDIIKEL
|  |||.|   |   ||. . |.  |
LGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK550.AA Pkinase_Tyr 105-116 58 1.204569 2.81 Pfam 196-207 (270) Show / Hide 
Range on Protein: 105-116
Range on HMM: 196-207/270
Sequence Identity: 58% (7 aa)

DVFSYGVLLIEM
|| |.|||. |.
DVWSFGVLMWEI