Gene AqueK552 (A.queenslandica)

AqueK552

Species: A.queenslandica
Alias: AqueK552
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK552.AA Protein None 241 None Fasta, JSON
AqueK552.kin_dom Protein Kinase Domain None 174 None Fasta, JSON

Protein domain

Protein domains of AqueK552.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK552.AA TKL 1-174 18 4.6e-31 109.1 In-house 109-364 (364) Show / Hide 
Range on Protein: 1-174
Range on HMM: 109-364/364
Sequence Identity: 18% (49 aa)

TEGNPIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQ-LMEGG--------NRWRAKVSDYGTVS-
..|.. | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.   ..          . |..|..|.|.   
PWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

LQPLTS--------------------TRNPG-NPVYSAPESFNPR----------------EHSPAMDVFSYGVLLIEMVVCQ--FPDVGKR--------
... ..                    | ... .| . ||| ..                  | |...||.|.|..| |.. ..  . | . .        
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

----VAQIKAIKRPTLK--------------------NLIERCLIENYKDRPTMSDIIKEL
    .  ..  .||...                    .|...|  .. ..||....|.|.|
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK552.AA CZAK 31-132 32 1.4e-15 53.14 In-house 108-221 (279) Show / Hide 
Range on Protein: 31-132
Range on HMM: 108-221/279
Sequence Identity: 32% (37 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLLQLMEG--------GNRWRAKVSDYGTV---SLQPLTSTRNPGNPVYSAPESFNPREHSPAMDVFS
... .|.|   ||||  .|| |||||| || |.||                  .|..|.|       ||   |   |   . ||| |     ..  ||.|
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYS

YGVLLIEMVVCQFP
.| .| ... |  |
FGMILWCIITCDQP
Kinase AqueK552.AA HH498 28-126 38 3.5e-15 44.18 In-house 121-219 (284) Show / Hide 
Range on Protein: 28-126
Range on HMM: 121-219/284
Sequence Identity: 38% (40 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYG----TVSLQPLTSTRNPGNPVYSAPESFN-PREHSPAMDVFSYGVL
. .. ||.|||   ||||   .||| |||  | |.|.   | |   .|.| |.|      ..   . |  |||. . ||| |      |   |||||.  
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH--EDG---HAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMC

LIEM
. ||
IWEM
Kinase AqueK552.AA MLK 30-127 32 6.6e-15 48.25 In-house 126-230 (291) Show / Hide 
Range on Protein: 30-127
Range on HMM: 126-230/291
Sequence Identity: 32% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQL----MEGGNRWRAKVSDYGTVS-LQPL-T-STRNPGNPVYSAPESF---NPREHSPAMDVFSY
.....|..| ...|||  .|.|| |||  | |.|.      |..|    .|..| ||.  ..   |  . |.|.. . ||| .        | . ||.|.
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG---TLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSW

GVLLIEMV
||.| ||.
GVVLWEML
Kinase AqueK552.AA TKL-Unique 30-127 26 6.9e-15 49.09 In-house 112-222 (290) Show / Hide 
Range on Protein: 30-127
Range on HMM: 112-222/290
Sequence Identity: 26% (30 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVSLQP--LTSTRN----------PGNPVYSAPESFNP--REHSPAMD
.... .|.| ...|||  .|  |.|||  | |.|.      . |..|..| |.. ..   ...| |           |.. ..||| ..      |   |
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSD

VFSYGVLLIEMV
|.|.|. |.|..
VYSFGIVLWEIA
Kinase AqueK552.AA Dicty5 25-126 31 9.3e-15 47.22 In-house 101-196 (260) Show / Hide 
Range on Protein: 25-126
Range on HMM: 101-196/260
Sequence Identity: 31% (33 aa)

VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGT---VSLQPLTSTRNPGNPVYSAPESFNPREHSPAMDVFSYGV
.||. .|.. .|.| .. .||      | |||. | |.|.       .| .|. |.||   | .. .  | . | . . |.| || .      ||.|.|.
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLIT-----ENWKIKIIDFGTSRFVDNR-YHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGI

LLIEM
 | ||
VLWEM
Kinase AqueK552.AA TK 2-174 11 1.6e-14 44.39 In-house 127-486 (486) Show / Hide 
Range on Protein: 2-174
Range on HMM: 127-486/486
Sequence Identity: 11% (43 aa)

EGNPIILTELMP-TS----LRKELESGG------------------------------------------------------------------------
.. ..|..|.||  .    ||. | .                                                                          
QEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCL

-----VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQ-LME-----GGNRWRAKVSDYG--------TVSLQPL----TSTRNPGNP
     .  .  | .....||.. |||  .         |||.   |.|.   .      .|.   .|..|.|             .     ......| .
TCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTG

V-------------------------YSAPESFN---------PREHSPAMDVFSYGVLLIEMVV---CQFPDVGKR------------VAQIKAI----
.                         . |||..|          . .... ||.|.|||. |..     ...                 . ....     
RPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLC

-------------KRPTLKN-------------------LIERCLIENYKDRPTMSDIIKEL
             ..| .                     |. .|  .. .||||.|.. ..|
RSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK552.AA LRRK 33-123 30 7.4e-13 41.81 In-house 169-272 (351) Show / Hide 
Range on Protein: 33-123
Range on HMM: 169-272/351
Sequence Identity: 30% (32 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLL-QLMEGG------NRWRAKVSDYGTVS-LQPLTST---RNPGNPVYSAPESFNPR---EHSPAMDVFS
|.|..| ...||| ..| ||.|||  | |.||  ....       .   ||..|.|. .  |.....   .  |||.. |||  .     | .   |..|
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYS

YGVLL
.|..|
FGMIL
Kinase AqueK552.AA STE 40-194 17 9.6e-13 41.44 In-house 163-359 (359) Show / Hide 
Range on Protein: 40-194
Range on HMM: 163-359/359
Sequence Identity: 17% (40 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVS-LQP------------------LTSTRNPGNPVYSAPESFNP------REHSPA
. |.|||  .   | |||. .||.||          .| .| |. . |..                    ..   | | . |||  ..       ...  
GLLYYLHSHH---IIHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

MDVFSYGVLLIEMVVCQFP----DVGKRVAQIKAI--------------------KR----------------------PTLKNLIERCLIENYKDRPTM
 |. | | ..|||.  . |       .   .|                       .                       | .|. |..||. ....||| 
CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

SDIIKELNESIXVSSVRKXGARELKWL
|. .|.                | ...
SQLLKS----------------EHPFI
Kinase AqueK552.AA Pkinase 1-178 17 6e-11 39.79 Pfam 71-293 (293) Show / Hide 
Range on Protein: 1-178
Range on HMM: 71-293/293
Sequence Identity: 17% (40 aa)

TEGNPIILTELMPT-----SLRKELE---SGGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVS---LQP
..... . .|...      .|   ..   .|..   .  . .. . ....|.|.|      |.|||. ..|.|.   .| .  . |..| |      . .
DKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-N

LTSTRNP-GNPVYSAPESFN-PREHSPAMDVFSYGVLLIEMVVCQFPDVGK----------RVAQIKA-------IKR---------------------P
 . .  . | | | |||  .  ....|. |..|.|..|.||.  ..|  |.          ....|.         .                      .
NS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

TLKNLIERCLIENYKDRPTMSDIIKELNES--I
..| .|..||  . |.|||    .... ..  .
ECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase AqueK552.AA S_TKc 1-178 18 1.3e-09 -35.79 SMART 19-231 (231) Show / Hide 
Range on Protein: 1-178
Range on HMM: 19-231/231
Sequence Identity: 18% (42 aa)

TE---------------------------------------GNPIILTELMPT---SLRKELESGG-------VAYPAILSISLDVACALNYLHLFKPHP
..                                       ..  . .|....   .|.. ... |            . ..   ..|||.|.|  .   
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG---

ILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVSLQPLTSTRNPGNPVYSAPESFNPREHSP-AMDVFSYGVLLIEMVVCQFPDVGKRVAQIKAIKRPTLK
|.|||.  .|.||         . |..| |   .     |   | | | ||| .    ... . |. | |..|.||.. . |      . .| |. | .|
IIHRDLKPENILLDE-------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIGSPEAK

NLIERCLIENYKDRPTMSDIIK-----ELNESI
..|..||  . ..|||  .. .      . . .
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK552.AA TK-Unique 31-127 24 1.6e-07 22.13 In-house 134-233 (294) Show / Hide 
Range on Protein: 31-127
Range on HMM: 134-233/294
Sequence Identity: 24% (26 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVS------LQPLTSTRNPGNPVYSAPESFN--PREH-SPAMDVFSYGV
...  ..||...||.   .. | |||... ||||.      . ..|..|.|          .  . ....    . ||||.    . . ..  || |.||
YHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGV

LLIEMV
|. |..
LMWEIF
Kinase AqueK552.AA TyrKc 1-174 16 3.4e-07 -106.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-174
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

TE---------------------------------------------------------------------GNPIILTELMPT-SLRKELESGG--VAYP
 .                                                                     . . |..|.||  .|.. | . .  .  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYGTVSLQPLT--------STRN----PGN---PV-YSAPESFNPREHSP
  ||.....||  .|||    ... |||    |.|.         ..|.|| |                  |      |.   |.   |||..| .. ..
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

AMDVFSYGVLLIEMV-------------------VCQFPDVGKRVAQIKA-------IKRPTLKNLIERCLIENYKDRPTMSDIIKEL
. ||.|.||.. |.                    | .. . |.|  | .        .  . . .....|  |. .||||.|.|....
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK552.AA LRRK 147-176 33 6e-06 17.03 In-house 322-351 (351) Show / Hide 
Range on Protein: 147-176
Range on HMM: 322-351/351
Sequence Identity: 33% (10 aa)

PTLKNLIERCLIENYKDRPTMSDIIKELNE
. ...||. |  .. |.||..|.|.| | .
HMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase AqueK552.AA MLK 147-174 25 8e-06 16.27 In-house 264-291 (291) Show / Hide 
Range on Protein: 147-174
Range on HMM: 264-291/291
Sequence Identity: 25% (7 aa)

PTLKNLIERCLIENYKDRPTMSDIIKEL
. .|.|...|  .. ..||... |...|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK552.AA TKL-Unique 149-174 30 9e-06 16.61 In-house 265-290 (290) Show / Hide 
Range on Protein: 149-174
Range on HMM: 265-290/290
Sequence Identity: 30% (8 aa)

LKNLIERCLIENYKDRPTMSDIIKEL
...||..|   .  .||. ..||..|
YRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK552.AA TK-Unique 146-174 24 0.000133 11.93 In-house 266-294 (294) Show / Hide 
Range on Protein: 146-174
Range on HMM: 266-294/294
Sequence Identity: 24% (7 aa)

RPTLKNLIERCLIENYKDRPTMSDIIKEL
.... ||...|. .. ..||. ..|...|
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK552.AA Pkinase_Tyr 147-174 32 0.001238 12.93 Pfam 243-270 (270) Show / Hide 
Range on Protein: 147-174
Range on HMM: 243-270/270
Sequence Identity: 32% (9 aa)

PTLKNLIERCLIENYKDRPTMSDIIKEL
. . .|. .|  .. .||||.|.|. .|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK552.AA Pkinase_Tyr 16-81 23 0.001739 12.43 Pfam 98-156 (270) Show / Hide 
Range on Protein: 16-81
Range on HMM: 98-156/270
Sequence Identity: 23% (16 aa)

LRKE-LESGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQLMEGGNRWRAKVSDYG
|||   . . .  . .|......|....||.  .   . |||.   |.|.      |.  .|..| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE----NN-VVKICDFG
Kinase AqueK552.AA Dicty5 151-178 32 0.022888 3.95 In-house 233-260 (260) Show / Hide 
Range on Protein: 151-178
Range on HMM: 233-260/260
Sequence Identity: 32% (9 aa)

NLIERCLIENYKDRPTMSDIIKELNESI
|||. |  .  . ||.   |.| ..  |
NLIKKCWQQKPHNRPSFKEICKYFESII
Kinase AqueK552.AA Pkinase_Tyr 101-127 40 0.146394 5.91 Pfam 182-208 (270) Show / Hide 
Range on Protein: 101-127
Range on HMM: 182-208/270
Sequence Identity: 40% (11 aa)

APESFNPREHSPAMDVFSYGVLLIEMV
|||..| .. . . || |.|||. |..
APECINYGKFTTKSDVWSFGVLMWEIF
Kinase AqueK552.AA HH498 151-174 33 0.152047 0.21 In-house 261-284 (284) Show / Hide 
Range on Protein: 151-174
Range on HMM: 261-284/284
Sequence Identity: 33% (8 aa)

NLIERCLIENYKDRPTMSDIIKEL
||| .|   .  .||. ..|.  |
NLIQMCWHPCPENRPDFDQIVTIL
Kinase AqueK552.AA CZAK 149-174 38 0.280333 0.59 In-house 254-279 (279) Show / Hide 
Range on Protein: 149-174
Range on HMM: 254-279/279
Sequence Identity: 38% (10 aa)

LKNLIERCLIENYKDRPTMSDIIKEL
|  |||.|   |   ||. . |.  |
LGELIEMCWNKNPDERPSFKQILQHL