Gene AqueK558 (A.queenslandica)

AqueK558

Species: A.queenslandica
Alias: AqueK558
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-B

Sequence

Name Sequence Type Origin Length Description Download
AqueK558.AA Protein None 207 None Fasta, JSON
AqueK558.kin_dom Protein Kinase Domain None 203 None Fasta, JSON

Protein domain

Protein domains of AqueK558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK558.AA TKL 4-202 20 2.1e-36 127.28 In-house 72-364 (364) Show / Hide 
Range on Protein: 4-202
Range on HMM: 72-364/364
Sequence Identity: 20% (60 aa)

FSREMNIASKIRHPNLLQFIGATTEGN--------------PIILTELM-PTSLRKELETGGLAYHTVLNISLDVACALNYLHLFKP-----HPILHRDV
. .|... |..||||..||.|. ....              . | .|..   ||.  |       |  ....||.|...||||  .|      ||.||| 
EEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDL

SSANVLLQPMGGAH--------GGLRAKVSDYGSANLQHLI---------------------IRSINPGGPLYAAPEAANPM----------------EH
 |.|.|.   .  .           ..|..|.| .   .                        ..   | | . |||. . .                | 
KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY

SPSMDVFSYGVLLLEMITRRIPLPEER--------------VGLIDGIRR--------------------ASFRSLVQRCLIVEYRHRPTMNDIITEL
|...||.|.|..| |..||..|  ..               .. .|  .|                     |...| |.|   . . ||....|. .|
SEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK558.AA TK 6-202 13 1.2e-21 68.61 In-house 87-486 (486) Show / Hide 
Range on Protein: 6-202
Range on HMM: 87-486/486
Sequence Identity: 13% (55 aa)

REMNIASKIR-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELETGG--------------------------------
.|...... .     |||.....|. |.|              ..|..|.||  .    ||. | .                                  
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------LAYHTVLNISLDVACALNYLHLFKPHPI----LHRDVSSANVLLQPMGGAHG---
                                             |  |. | .....||.. |||  .         |||.   |.|.   .  ..   
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFD

--GLRAKVSDYGSAN-----LQHLI------IRSINPGGPL-------------------------YAAPEAAN---------PMEHSPSMDVFSYGVLL
  |. .|..|.| .      |   |       |. ..|...                         . |||. |            ...  ||.|.|||.
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

LEMIT--RRIPLP----------------------------------EERVGLI--DGIRR-------------ASFRSLVQRCLIVEYRHRPTMNDIIT
 |. |  .  . .                                  ..|  .   ..                . .  | |.|   . ..|||. ..  
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHE

EL
.|
QL
Kinase AqueK558.AA MLK 4-160 26 4.3e-21 70.0 In-house 52-235 (291) Show / Hide 
Range on Protein: 4-160
Range on HMM: 52-235/291
Sequence Identity: 26% (49 aa)

FSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKELETG---------------GLAYHTVLNISLDVACALNYLHLFKPHPILHR
| .| .......|||      || |. .. ..   |..| ..  ||   | ..                   . ..|..|..| ...|||  .|.|| ||
FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR

DVSSANVLLQP-MGGAHGGLRAKVSDYGSANLQHLI-I-RSINPGGPLYAAPEA---ANPMEHSPSMDVFSYGVLLLEMITRRIP
|  | |.|.    .   ... .|..| | .   | .   .  |.| . . |||.   .     | . ||.|.||.| ||.||..|
DLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase AqueK558.AA CZAK 4-90 44 2.2e-19 67.13 In-house 47-142 (279) Show / Hide 
Range on Protein: 4-90
Range on HMM: 47-142/279
Sequence Identity: 44% (43 aa)

FSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKELETGGLAYHTV-----LNISLDVACALNYLHL-FKPHPILHRDVSSANVLL
| .|  | || .||| .||.|| .|..     | .| |   |||. | |    ||       .|. .|.|   ||||  .|| |||||| || |.||
FQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL-TDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK558.AA TKL-Unique 4-160 24 3e-18 61.12 In-house 42-233 (290) Show / Hide 
Range on Protein: 4-160
Range on HMM: 42-233/290
Sequence Identity: 24% (49 aa)

FSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------TGGLAYHTVLNISLDVACALNYLHLFKPHPILHRDVSS
|..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |               | .  .... .|.| ...|||  .|  |.|||  |
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKS

ANVLLQPMGGAHGG-----LRAKVSDYGSANLQHLIIRSINP-----------GGPLYAAPEAANP--MEHSPSMDVFSYGVLLLEMITRRI------P
 |.|.        .     ...|..| | . ..  |....|            | ....|||  .      | . ||.|.|. | |..|| |      |
SNFLVD------NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK558.AA Pkinase 6-206 17 1.5e-17 63.18 Pfam 47-293 (293) Show / Hide 
Range on Protein: 6-206
Range on HMM: 47-293/293
Sequence Identity: 17% (46 aa)

R--EMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---TGGL--AYHTVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQP
|  |  |  ...||| ......  ..... . .|...      .|   ..    |..   .... .. . ....|.|.|      |.|||. ..|.|.  
RLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDN

MGGAHGGLRAKVSDYGSAN---LQHLIIRSINPGGPLYAAPEAAN-PMEHSPSMDVFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR-------
 |      . |..| |.|    . .    .   | | |.|||  .   ...|. |..|.|..| ||...| | |..          .|. |..       
NGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDW

------------------------ASFRSLVQRCLIVEYRHRPTMNDIITELNDT--I
                         ...... .|| .    |||    ....     .
PWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase AqueK558.AA STE 1-197 17 4.1e-16 53.51 In-house 72-350 (359) Show / Hide 
Range on Protein: 1-197
Range on HMM: 72-350/359
Sequence Identity: 17% (51 aa)

MSLFSREMNIASKIR--HPNLLQFIGATT--------EGNPIILTELMP-TSLRKELE-TGGLA--------------YHTVLNISLDVACA-LNYLHLF
|  . .|..| .| .  |||  ...|.          ...  |  |.|.  ||.. .. ..|                 . .  |  ..  . |.|||  
MQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

KPHPILHRDVSSANVLLQPMGGAHGGLRAKVSDYGSAN-LQHLII-----------------RSINPGGPLYAAPEAANPME------HSPSMDVFSYGV
.   | |||. .||.||           .| .| | .  |.. .                  |    | | . |||  ....      .. . |. | | 
H---IIHRDIKPANILL-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC

LLLEMITRRIPL---PEERVGLIDGIRR-------------------------------------------ASFRSLVQRCLIVEYRHRPTMND
...||.| . |.   .  |. .   .                                              .|.  ...||. ....||| ..
TIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK558.AA LRRK 2-160 26 1.3e-15 51.74 In-house 102-282 (351) Show / Hide 
Range on Protein: 2-160
Range on HMM: 102-282/351
Sequence Identity: 26% (49 aa)

SLFSREMNIASKIRHPNLLQFIGATTEGNPIIL-TELMPT-SLRKELE---TGG-------LAYHTVLNISLDVACALNYLHLFKPHPILHRDVSSANVL
..| .|. | |. .|||... .| .   .|... .|..|  .| . |.     |       .  ...| |.|..| ...||| ..| ||.|||  | |.|
REFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNIL

LQPMGGAH------GGLRAKVSDYGSAN----LQH-LIIRSINPGGPLYAAPEAANPM---EHSPSMDVFSYGVLLLEMITRR-IP
|. .   |          ||..|.|       ... .. ..  .  |.. |||  . .   | .   |..|.|..| | .||. .|
LWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN--PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase AqueK558.AA TK-Unique 4-156 22 3.8e-15 48.8 In-house 50-234 (294) Show / Hide 
Range on Protein: 4-156
Range on HMM: 50-234/294
Sequence Identity: 22% (43 aa)

FSREMNIASKIR-HPNLLQFIGATT-EG-NPIILTELMPTS-LRKELETGG---------------------------LAYHTVLNISLDVACALNYLHL
| .| .. ...  |||..|..|..|  . .. |. | .| . |.. | | .                           . .......  ..||...||. 
FLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS

FKPHPILHRDVSSANVLLQPMGGAHGGLRAKVSDYGSA-----NLQHLIIRSINPGGPLYAAPEAAN--PMEH-SPSMDVFSYGVLLLEMIT
  .. | |||... ||||.       ....|..|.| |     | ..  ..| ..    . |||.       . ..  || |.|||. |. |
Q-RKKIVHRDLCARNVLLTE------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase AqueK558.AA S_TKc 1-207 18 3.7e-14 30.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-207
Range on HMM: 1-231/231
Sequence Identity: 18% (46 aa)

MSL--------------------------------FSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELETGG-------LAYHTVLN
  .                                . ||..| .| .|||. .....  ...  . .|....   .|.. ..  |       .   ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGAHGGLRAKVSDYGSANLQHLIIRSINPGGPLYAAPEAANPMEHSP-SMDVFSYGVLLLEMITR
.   ..|||.|.|  .   |.|||.  .|.||          . |..| |.| .      .   | | | |||      ... . |. | |..| ||...
YMYQICCALEYCHSHG---IIHRDLKPENILLDE--------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

RIPLPEERVGLIDGIRRASFRSLVQRCLIVEYRHRPTMNDIIT----ELNDTIY
. | | .   ... |.  ........|| .. ..|||  .. .      ..   
YPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK558.AA Dicty5 4-160 27 1.3e-13 43.23 In-house 43-202 (260) Show / Hide 
Range on Protein: 4-160
Range on HMM: 43-202/260
Sequence Identity: 27% (47 aa)

FSREMNIASKIR--HPNLLQFIGATTEGNPI--ILTELMPT-SLRKELETGGL------AYHTVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQP
| ||  | | .   |||.  . || .       ..||.    ||.  |           || . | . .|.| .. .||      | |||. | |.|.  
FYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITE

MGGAHGGLRAKVSDYG-SANLQHLIIRSINPGGPLYAAPEAANPMEHSPSMDVFSYGVLLLEMITRRIP
       . .|. |.| | .        .. | . . |.|  |        ||.|.|. | ||.||  |
N------WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP
Kinase AqueK558.AA Pkinase_Tyr 4-108 25 6.7e-12 40.93 Pfam 50-156 (270) Show / Hide 
Range on Protein: 4-108
Range on HMM: 50-156/270
Sequence Identity: 25% (30 aa)

FSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKELETG-----GLAYHTVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQP
| ||..| ... .|||.....|. | .| |   .| .|.||  .|.. | .       |  .. |......|....||.  .   . |||.   |.|.  
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE

MGGAHGGLRAKVSDYG
      .. .|..| |
------NNVVKICDFG
Kinase AqueK558.AA TyrKc 1-202 18 1.2e-10 -50.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-202
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

MSL---------------------------------FSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELETGG--LAYH
 .|                                 | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. |   .  |   
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

TVLNISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGAHGGLRAKVSDYGSANLQHLI------IRSINP----GGP--L---YAAPEAANPMEHS
. |......||  .|||    ... |||    |.|.   .      ..|.|| | .   .           . .    ||   |     |||. |  . .
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PSMDVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRS---------------LVQRCLIVEYRHRPTMNDIITEL
.  ||.|.||.. |. |.  . ...           .  . .| |.    .               . ..|   .   |||...|. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK558.AA Dicty4 4-39 46 2.1e-09 27.73 In-house 45-85 (277) Show / Hide 
Range on Protein: 4-39
Range on HMM: 45-85/277
Sequence Identity: 46% (19 aa)

FSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELMP
| .| .| .||||||...| || |      | . | ||.||
FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMP
Kinase AqueK558.AA Dicty4 143-204 24 9.8e-08 22.06 In-house 199-277 (277) Show / Hide 
Range on Protein: 143-204
Range on HMM: 199-277/277
Sequence Identity: 24% (19 aa)

DVFSYGVLLLEMITRRIPLP---EERVGLIDGIRR------------ASFRSLVQRCLIVEYRHRPTMNDIITE--LND
||.|.| .| |. || .| .    . . ..... .            .|...|.|.|.  .  |||... || .  |. 
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK558.AA TKL-Unique 176-202 33 0.015089 5.02 In-house 264-290 (290) Show / Hide 
Range on Protein: 176-202
Range on HMM: 264-290/290
Sequence Identity: 33% (9 aa)

SFRSLVQRCLIVEYRHRPTMNDIITEL
..| | |.|   .   ||. ..||..|
EYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK558.AA CZAK 127-160 32 0.025005 4.45 In-house 188-221 (279) Show / Hide 
Range on Protein: 127-160
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YAAPEAANPMEHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK558.AA MLK 175-202 21 0.132088 1.5 In-house 264-291 (291) Show / Hide 
Range on Protein: 175-202
Range on HMM: 264-291/291
Sequence Identity: 21% (6 aa)

ASFRSLVQRCLIVEYRHRPTMNDIITEL
... .| ..|   . . ||..  |...|
EHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK558.AA LRRK 192-204 30 0.200746 0.78 In-house 339-351 (351) Show / Hide 
Range on Protein: 192-204
Range on HMM: 339-351/351
Sequence Identity: 30% (4 aa)

RPTMNDIITELND
||....|.  | .
RPHFSQIVKRLSQ
Kinase AqueK558.AA Pkinase_Tyr 143-157 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 143-157
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY
Kinase AqueK558.AA Pkinase_Tyr 191-202 41 3.408398 1.28 Pfam 259-270 (270) Show / Hide 
Range on Protein: 191-202
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

HRPTMNDIITEL
.|||. .|. .|
DRPTFSEIHEQL