Gene AqueK580 (A.queenslandica)

AqueK580

Species: A.queenslandica
Alias: AqueK580
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK580.AA Protein None 1000 None Fasta, JSON
AqueK580.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of AqueK580.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK580.AA TKL 310-433 25 3.6e-28 98.53 In-house 1-174 (364) Show / Hide 
Range on Protein: 310-433
Range on HMM: 1-174/364
Sequence Identity: 25% (45 aa)

LGRGSYAVVTVGIFRG----------LRVAVKSLHNIIISDYNL-------------------------GIFSREMNIASRVRHPNLVQFIGATK-----
.|.|....|  |..||            |||| ..    .  ..                           . .|... || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLILTELM-STS-LNQEIRRNRLSNEQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLK
          |.. | .|..   | |.. .       .|....|.|.|.|.||||  .|      ||||||  |.|.|..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD
Kinase AqueK580.AA Dicty4 306-424 33 9.4e-25 79.62 In-house 3-139 (277) Show / Hide 
Range on Protein: 306-424
Range on HMM: 3-139/277
Sequence Identity: 33% (46 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSL--HNIIISDYNLGIFSREMNIASRVRHPNLVQFIGA-T----KVGNPLILTELM-STSLNQEIRR------N
. ...|.||.. |  |. ||  |||| |  ||.  . . |  | .| .| .  ||||...| || |    . | ..| ||.| ...|   ..        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

RLSNE--QILS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK580.AA MLK 304-432 26 1.2e-24 82.56 In-house 1-160 (291) Show / Hide 
Range on Protein: 304-432
Range on HMM: 1-160/291
Sequence Identity: 26% (42 aa)

TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHNIIISDYNL-----GIFSREMNIASRVRHPN----LVQFIGA-TKVGN-PLILTELMST-SLNQ
 ...| .| ||. .|  | .|. .     ||||  .  |. |          | .| .......|||     .|| |. .. ..  .|..| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

EIRRNR---------------LSNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
 .. .|                . ......| ..| |..|||  .|.||||||  |.|.|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK580.AA TKL-Unique 306-432 30 5.5e-22 74.44 In-house 1-145 (290) Show / Hide 
Range on Protein: 306-432
Range on HMM: 1-145/290
Sequence Identity: 30% (45 aa)

TKEELGRGSYAVVTVGIFRGLRVAVKSLH-NIIISDYNLGIFSREMNIASRVR-HPNLVQFIGATK---VGNP--LILTE------LMSTSL------NQ
  . .|.|.|..|  |..||  ||.|..| |  .|   .  |..| |. .. . |||.|...|...   | .|   | .|      |.. .       | 
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

EIRRNRLSNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLL
 .. . |...|....|.|.|.|..|||  .|  |||||  |.|.|.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV
Kinase AqueK580.AA TK 304-432 14 7.5e-20 62.54 In-house 1-273 (486) Show / Hide 
Range on Protein: 304-432
Range on HMM: 1-273/486
Sequence Identity: 14% (39 aa)

TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLH---NIIISDYNLGIFS---------REMNIASRVR----
    ..||.| .    .|  |. ||.                           .|||| |.   .    .  . ..          .|.....  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVQFIG-ATKVGN------------PLILTELMS-TS----LNQEIRRNR----------------------------------------------
 |||.|...|  |....            ..|..|.|.  .    | .  |..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSNEQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLL
                               |. .| | .....| |. |||  .    | ..|||.   |.|.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV
Kinase AqueK580.AA STE 305-444 19 1.6e-17 58.51 In-house 1-187 (359) Show / Hide 
Range on Protein: 305-444
Range on HMM: 1-187/359
Sequence Identity: 19% (38 aa)

LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------NIIISDYNLGIFSREMNIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                 | ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLILTELMS-TSLNQEIRRN---------------RLSNEQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCSGAAGYEAK
..        .  |  |.|.  || . |...               |.. .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK
Kinase AqueK580.AA DRK 311-431 38 8.4e-17 53.47 In-house 8-132 (258) Show / Hide 
Range on Protein: 311-431
Range on HMM: 8-132/258
Sequence Identity: 38% (50 aa)

GRGSYAVVTVGIFRGLRVAVKSLHNIIISDYN-LGIFSREMNIASRVRHPNLVQFIGA-TKVGNPLILTELMST-SL-----NQEIRRNRLSNEQILSIA
|||.|. |  |  ||  |||| | |  | | | |  | || |. .. |||| .||.|. .    ..| .| |.  ||     .. |    ..   .....
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESI---EMDWPLMKQMM

QDVALGLNYLHLFKPQPIIHRDVSSPNVL
 |.| |..|||   |  |||||  | | |
FDCAKGMIYLHCCNPI-IIHRDLKSHNLL
Pkinase_Tyr AqueK580.AA Pkinase_Tyr 303-433 26 4e-16 55.24 Pfam 1-145 (270) Show / Hide 
Range on Protein: 303-433
Range on HMM: 1-145/270
Sequence Identity: 26% (39 aa)

VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHNIIISDYN--LGIFSREMNIASRV-RHPNLVQFIGATK-VGNP---LILTELMST-SLNQEI
.|.  ..||.|.. .|  |. .      .. ||||.| .   .. .  .  | ||..| .   .|||.|...|.    | |   .| .|.|   .|    
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRN-----RLSNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
|..     .|. ...|......| |..||.  .   .||||.   |.|..
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVT
Kinase AqueK580.AA LISK 309-433 32 6.9e-15 44.61 In-house 1-135 (296) Show / Hide 
Range on Protein: 309-433
Range on HMM: 1-135/296
Sequence Identity: 32% (45 aa)

ELGRGSYAVVTVGIFR--GLRVAVKSLH---NIIISDYNLGIFSREMNIASRVRHPNLVQFIGATKV-GNPL-ILTELMST-SLNQEIRRN-----RLSN
|.|.|... |  |  |  |  .|.| .|   |  . . ..  . ||. .  . |||| |||.|. .     | |.||...   | | ....      |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK
.| ..|| |.|.|. |||    . |||||  | |.|..
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVR
Kinase AqueK580.AA Shk 305-424 34 1.9e-14 48.44 In-house 1-128 (269) Show / Hide 
Range on Protein: 305-424
Range on HMM: 1-128/269
Sequence Identity: 34% (44 aa)

LTKEE-LGRGSYAVVTVGIFRGLRVAVKSLHNIIISDYNLGIFSREMNIASRVRHPNLVQFIGA-T-KVGNPLILTELM-STSLNQEIRRNRLSNE--QI
 ..|. || ||.  |  |. ||  |||| .|    . . .  |  |  | |...|||.. | || | . |   | ||||  ..|   ..  .   .   .
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

LS---IAQDVALGLNYLHLFKPQPIIHRD
.    .. | ||| | ||   .  |||||
KRAMRMCRDAALGMNWLHGSNCN-IIHRD
Kinase AqueK580.AA CZAK 399-432 57 6.6e-13 43.35 In-house 108-142 (279) Show / Hide 
Range on Protein: 399-432
Range on HMM: 108-142/279
Sequence Identity: 57% (20 aa)

LSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLL
...| |.| | ||||  .|| ||.||| || |.||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK580.AA Pkinase 304-425 21 3e-12 44.41 Pfam 1-134 (293) Show / Hide 
Range on Protein: 304-425
Range on HMM: 1-134/293
Sequence Identity: 21% (30 aa)

TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHNIIISDYNLGIFSR--EMNIASRVRHPNLVQFIGATK-VGNPLILTELMST-----SLNQEIR---R
  ... .|.||...|  .. .| .  |||| .    ...  . .  |  |  |  |..||| |.....    ... . .|..       .|   |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NRL--SNEQILSIAQDVALGLNYLHLFKPQPIIHRDV
...  | ... ...  .. ||.|.|      |||||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK580.AA S_TKc 304-540 14 1.8e-10 -23.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 304-540
Range on HMM: 1-231/231
Sequence Identity: 14% (40 aa)

TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHNIIISDYNLGIFSREMNIASRVRHPNLVQFIGATKVGNPLILTELMST---SLNQEIRRNR------
    ...|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....   ..  . .|....   .| . |....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCS------GAAGYEAKYPTLFSRG------VDLVKQFPLSY-----YTLGLTVAHLL
 ..  .. .... ....|.|.|  .   |||||.   |.||          | |     .    ..       .      . ..     . .| ... .|
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEML

GLKNVTPFSTVANGKSHHLESKYPEAVDLDCSTNSSESVTLCEECDQSKAEYLCQKCDCKL------CDKCF
     .||.   .   ...               |.|   . . | |   |      ..        |.  |
C--GYPPFP-QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK580.AA TyrKc 304-493 15 7.3e-09 -79.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 304-493
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHNIIISDYNLGIFSREMNIASRV--RHPNLVQFIGATKV--------GNPLILTELMST-SLNQEIRRNR
   ...||.| . .|  |. . . ||||.|..       .  | ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. .|..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LSNEQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCS------------GAAG---------YEAKY---PT-------------------
  |.... ||.. ..| | .|||     ..||||    |.|..               .  .         | .|                         
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

--------------LFSRGVDLVKQ-----FPLSYYTLGLTVAHLLGLKNV----------------------------TPFSTVANGKSHHL
              .|..|            . .     .   . .                                   ||..     . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase AqueK580.AA BBOX 511-558 21 6.9e-08 33.44 SMART 1-51 (51) Show / Hide 
Range on Protein: 511-558
Range on HMM: 1-51/51
Sequence Identity: 21% (11 aa)

ESVTLCEECD-QSKAEYLC-QKCDCKLCDKCFDQ-IHSVSKVLKTHSKVII
.....|....  ..|.. | . |.  ||. |  . .|.. |  . |  | .
HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL
Kinase AqueK580.AA CZAK 305-380 29 1.6e-07 23.59 In-house 1-84 (279) Show / Hide 
Range on Protein: 305-380
Range on HMM: 1-84/279
Sequence Identity: 29% (25 aa)

LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHNIIISDYNL----GIFSREMNIASRVRHPNLVQFIGATKVGN---PLILTELM
|. . . |.| .  |  .  ||  ||.| .| .   .        .| .|  | |  .||| |||.||   ..     | .| |
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK580.AA zf-B_box 512-558 29 6.1e-07 32.13 Pfam 1-45 (45) Show / Hide 
Range on Protein: 512-558
Range on HMM: 1-45/45
Sequence Identity: 29% (14 aa)

SVTLCEECDQSKAEYLCQKCDCKLCDKCFDQIHSVSKVLKTHSKVII
.. .|.|... ..|| ||.|.. .|..|. ..|. .. .|.|. | |
QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI
TUDOR AqueK580.AA TUDOR 851-958 25 1.8e-20 77.55 Pfam 9-128 (128) Show / Hide 
Range on Protein: 851-958
Range on HMM: 9-128/128
Sequence Identity: 25% (31 aa)

VIVSHINSPSEFYI--QYTSDLPSLDHFHSELKGESLQRIS-------GLQKNLVCVVVREDSYRRCQV--ESSDDHSYPSVQLLDYGNSEIVNVHSLFY
|.|.||.||..|.|  | ..| ..|.. ..|..   ..           . .. .||.  .. ..|...    ..|.   .|...||||.|.|... .  
VYVTHIESPCHFWIHQQPHEDDHKLEKMMEEMQEYYNCKPPDYECYPPKPGDGCCCVFSCDGCWYRAMIVVTCCVDDQCVEVFYIDYGNTEYVPFSDIRQ

LP-SKFKETPLFAHKCRLEG
.| . | . | .|.||.| |
IPPPEFMHLPFQAFKCCLAG
TUDOR AqueK580.AA TUDOR 889-945 21 1.1e-05 26.07 SMART 1-60 (60) Show / Hide 
Range on Protein: 889-945
Range on HMM: 1-60/60
Sequence Identity: 21% (13 aa)

SGLQKNLVCVVVR--EDSYRRCQVESSDDH-SYPSVQLLDYGNSEIVNVHSLFYLPSKFK
. .. . .|...   .  . ||.... |.  .   |...||||.| |.. ..  .|.|..
PKWKVGQMCCARWSEDGCWYRCRIIKVDPDNQWYEVFFIDYGNCEWVPWWDIRQMPCKHM