Gene AqueK599 (A.queenslandica)
AqueK599
Species: A.queenslandica
Alias: AqueK599
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| AqueK599.AA | Protein | None | 230 | None | Fasta, JSON |
| AqueK599.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of AqueK599.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | AqueK599.AA | TKL | 26-218 | 22 | 3e-41 | 143.37 | In-house | 1-288 (364) | Show / Hide |
Range on Protein: 26-218
Range on HMM: 1-288/364
Sequence Identity: 22% (66 aa)
LGRGSYAVVTVGIFRG----------LRVAVKSLHTIIISDYNL-------------------------GMFSREMSIASRLHHPNLVQFIGATK-----
.|.|....| |..|| |||| ... . .. . .|. . |||.|||.|||.|. .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
---------VGNPLILTELI-STSLNQELHRNQLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCIGP---------AGYEAKV
|.. | .|.. || || .|....|.|.|.|.|||| .| |||||| |.|.|.. . | . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
ADYGTAKVVQGTS--------------------TGTVMPGNVAYAAPEAPIPD----------------QHSPAMDVYSYSVLLMEMNLRCPP
.|.|......... | |. .. |||. . . |...||||. ..| |. ||.|
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
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| Kinase | AqueK599.AA | MLK | 20-212 | 26 | 6.1e-32 | 108.13 | In-house | 1-229 (291) | Show / Hide |
Range on Protein: 20-212 Range on HMM: 1-229/291 Sequence Identity: 26% (62 aa) TLTKEELGRGSYAVVTVGIFRGLR-----VAVKSLHTIIISDYNL-----GMFSREMSIASRLHHPN----LVQFIGA-TKVGN-PLILTELIST-SLNQ ...| .| ||. .| | .|. . |||| .. |. | | .| ....| ||| .|| |. .. .. .|..| .. ||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN ELHRNQ---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CIGPAGYEAKVADYGTAKVVQGT-STGTVMPGNVAY || .. . ......| ..| |..||| .|.|||||| |.|.|. | .. .|..| ||.. .. . .. . ..|..|. VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW AAPEAP---IPDQHSPAMDVYSYSVLLMEM |||. .. | . ||.|. |.| || MAPEVIQQFRCEKYSEKCDVWSWGVVLWEM |
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| Kinase | AqueK599.AA | TKL-Unique | 22-212 | 29 | 1.8e-30 | 104.76 | In-house | 1-221 (290) | Show / Hide |
Range on Protein: 22-212
Range on HMM: 1-221/290
Sequence Identity: 29% (66 aa)
TKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLG---MFSREMSIASRLH-HPNLVQFIGATK---VGNP--LILTELIST-SLNQELH------
. .|.|.|..| |..|| ||.|..| .| .. |..| .. ..|| |||.|...|... | .| | .| .. ||. ||
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN
-----RNQLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVM----------PGNVAYAAPEA
. |..||....|.|.|.|..||| .| ||||| |.|.|. | . .|..| |..|. ...|. |. ..|||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV
PIP--DQHSPAMDVYSYSVLLMEM
.| | ||||... | |.
LRMNFCQYSEKSDVYSFGIVLWEI
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| Kinase | AqueK599.AA | TK | 20-212 | 14 | 1.6e-25 | 81.86 | In-house | 1-387 (486) | Show / Hide |
Range on Protein: 20-212
Range on HMM: 1-387/486
Sequence Identity: 14% (56 aa)
TLTKEELGRGSYA---VVTVGIFRGL---------------------------RVAVKSLH---TIIISDYNLGMFS------------REMSIAS--RL
..||.| . .| |. ||. .|||| |. . . . .. .||.. . .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
HHPNLVQFIG-ATKVGN------------PLILTELIS-TS----LNQELHRN-----------------------------------------------
||||.|...| |.... ..|..|. . . | . |...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------------------------------QLTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLK-PCI-----GPAGYEAKVADYG---
||| .| | .....| |. ||| . | ..|||. |.|. . . |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----TAKVVQGTSTGTVMPGN---------------------------VAYAAPEAPI---------PDQHSPAMDVYSYSVLLMEM
|. .. . ... . . . |||. .... ||.|. ||. |.
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
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| Kinase | AqueK599.AA | Dicty4 | 22-140 | 32 | 3e-22 | 71.15 | In-house | 3-139 (277) | Show / Hide |
Range on Protein: 22-140 Range on HMM: 3-139/277 Sequence Identity: 32% (45 aa) TKEELGRGSYAVVTVGIFRGLRVAVKSL--HTIIISDYNLGMFSREMSIASRLHHPNLVQFIGA-T----KVGNPLILTELI-STSLNQELHR------N . ...|.||.. | |. || |||| | | . . . | | .| .| . . |||...| || | . | ..| ||. ...| || IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ QLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD . . |.. .| |.|.|.|.|| | ||||| SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD |
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| Kinase | AqueK599.AA | LRRK | 20-189 | 22 | 2.2e-21 | 72.42 | In-house | 1-249 (351) | Show / Hide |
Range on Protein: 20-189
Range on HMM: 1-249/351
Sequence Identity: 22% (57 aa)
TLTKEELGRGSYA-VVTVGIFRG----------------------------LRVAVKSLHTI----------------------------------IISD
|..|||... .| ...|| ||.|..... .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA
YNLGMFSREMSIASRLHHPNLVQFIGATKVGNPLIL-TELIST-SLNQELH---RNQ-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSP
... | .|..| |.|.|||.|. .| . .||.. .|... .|.. || ... .. . .| || ..| |..||| ..| |||||| ||
FRE--FRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSP
NVLLKPCIGP-------AGYEAKVADYGTAK---VVQGTSTGTVMPGNVAYAAPE
|.||. . | . ||.||.|. ... . . .. || . |||
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPE
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| Kinase | AqueK599.AA | HH498 | 22-212 | 31 | 6.5e-21 | 62.67 | In-house | 3-219 (284) | Show / Hide |
Range on Protein: 22-212
Range on HMM: 3-219/284
Sequence Identity: 31% (71 aa)
TKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNL------GMFSREMSIASRLHHPNLVQFIGATKVGNP---LILTELIST-SLNQEL-------
..| | ||. | | .|. |||| .. || || || .|| ||. |||..|. . | .| |. .. || |
FHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYAC-CDDPSQFAIVTQYCDNGSLFSILNTIPIGG
-------HRNQ-----LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQ--GTSTGTVMPGNVAYAAPEA
| .. . | .. |. ||| | |||| ..|||||| | |.|. . |.|||.| |. . . | ||| . |||
AGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-----EDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEV
PI-PDQHSPAMDVYSYSVLLMEM
. | ||.|| . ||
FSQCQKYSIKVDVFSYAMCIWEM
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| Kinase | AqueK599.AA | STE | 21-189 | 17 | 9.6e-21 | 70.06 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 21-189 Range on HMM: 1-232/359 Sequence Identity: 17% (44 aa) LTK-EELGRGSYAVVTVGIFR-----------------GLRVAVKSLH---------------TIIISDYNLGMFSREMSIASRLH--HPNLVQFIGATK ... |..|.|.. .| .. . | ..|.| .. . .. . .. . .|..| .... ||| |...|. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF VG--------NPLILTELIS-TSLNQELHRN-----QLT----------NQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAK .. . | |... || . .... .|. .|| |.... | |.||| . |||||. . |.|| .| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK VADYGTAKVVQG----------------------TSTGTVMPGNVAYAAPE .| |... .. | .|| . ||| LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP------WMAPE |
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| Kinase | AqueK599.AA | CZAK | 115-212 | 31 | 7.6e-20 | 68.86 | In-house | 108-215 (279) | Show / Hide |
Range on Protein: 115-212 Range on HMM: 108-215/279 Sequence Identity: 31% (35 aa) LSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCIG--------PAGYEAKVADYGTA--KVVQGTS-TGTVMPGNVAYAAPEAPIPDQHSPAMDV ...| |.| | |||| .|| ||.||| || |.|| . .|..|.| . |.. | |. | ... ||| . . .. || WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTM--GCLCWMAPECFKGENYTEKVDV YSYSVLLMEM ||. .| .. YSFGMILWCI |
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| Pkinase_Tyr | AqueK599.AA | Pkinase_Tyr | 19-212 | 24 | 3.8e-19 | 65.45 | Pfam | 1-207 (270) | Show / Hide |
Range on Protein: 19-212 Range on HMM: 1-207/270 Sequence Identity: 24% (54 aa) VTLTKEELGRGSYAVVTVGIFR------GLRVAVKSLHTIIISDYN--LGMFSREMSIASRL-HHPNLVQFIGATK-VGNP---LILTELIST-SLNQEL .|. ..||.|.. .| |. . .. ||||.| .. . . .| ||..| . | ||||.|...|. | | .| .|. .| | ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL HRN-----QLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTG-TVMP---GNVAYAAPEAPIPDQ ... .|| ...|......| |..||. . .||||. |.|.. . .|..| | |. .. ... .. . |||. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK HSPAMDVYSYSVLLMEM . . ||.|. ||. |. FTTKSDVWSFGVLMWEI |
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| Kinase | AqueK599.AA | Dicty4-Unclassified | 23-212 | 26 | 4.1e-19 | 62.09 | In-house | 4-201 (263) | Show / Hide |
Range on Protein: 23-212 Range on HMM: 4-201/263 Sequence Identity: 26% (56 aa) KEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDY--NLGMFSREMSIASRLHHPNLVQFIGATKVGNP-------LILTELI-STSLNQELH-----RN ..|.| . | |. .| |||| . . . | .| | . |||||. |. || | .|.. . | | .. DQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCI--NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ Q---LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVAYAAPEAPIPDQHSPAMDVYS | | |. .| |.| |. .|| .||||. | |.|. . .|.|| | . |. . . | | .. .|| . |||| QPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMD-----KHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYS YSVLLMEM | ..| |. YAMMLYEL |
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| Kinase | AqueK599.AA | Pkinase | 20-218 | 22 | 1.8e-14 | 52.28 | Pfam | 1-211 (293) | Show / Hide |
Range on Protein: 20-218 Range on HMM: 1-211/293 Sequence Identity: 22% (50 aa) TLTKEELGRGSYAVVTVGIFRGLR--VAVKSLHTIIISDYNLGMFSR--EMSIASRLHHPNLVQFIGATK-VGNPLILTELIST-----SLNQELH---R ... .|.||...| .. .| . |||| . ... . | | .| ||.||| |..... ... . .|. .| .. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH NQL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLK-PCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVA---YAAPEAPI-PDQHSPA . . . ... ... .. ||.|.| |||||. . |.|.. . .| |..| | ||... . .. | . . |.||| ..|. GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK MDVYSYSVLLMEMNLRCPP |..|. ..| || .. || VDMWSCGCILYEMLCGRPP |
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| Kinase | AqueK599.AA | S_TKc | 20-229 | 16 | 2.1e-14 | 34.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 20-229
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)
TLTKEELGRGSYAVVTVGIFRG--LRVAVKSLHTIIISDYNLGMFSREMSIASRLHHPNLVQFIGATKVGNPLILTELIST---SLNQELHRNQ------
...|.|....| .. .. .||.| .. .. ||..| .. ||||.|..... .. . .|.... .| . .....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF
-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGTSTGTVMPGNVAYAAPEAPIPDQHSP-AMDVYSYS
.. .. .... ....|.|.| . |||||. |.|| . |..| | |... | . | | ||| .... . |..|
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG
VLLMEMNLRCP--------------------------------PGINDKRE-------KSTI
..| || ..| |.. . . .
CILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | AqueK599.AA | TyrKc | 20-230 | 18 | 1.3e-12 | -18.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 20-230
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)
TLTKEELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNLGMFSREMSIASRL--HHPNLVQFIGATKV--------GNPLILTELIST-SLNQELHRNQ
...||.| . .| |. . . ||||.|. . .| ||..| ..| ||||.|...|. . ..|..|. . .|.. |....
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR
--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCIGPAGYEAKVADYGTAKVVQGT-------STGTV-----MP--GNVAYAAPEAPI
|.... ||.. ..| | .||| ..|||| |.|.. ... .|..| | .. . .. .. . |||.
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVG-----ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN
PDQHSPAMDVYSYSVLLMEM---------N--------------------LRCPPG--------INDKREK-------------------STIW
... ||.|. |.. |. . ...|| |. . ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | AqueK599.AA | CZAK | 21-89 | 35 | 1.8e-08 | 27.08 | In-house | 1-74 (279) | Show / Hide |
Range on Protein: 21-89 Range on HMM: 1-74/279 Sequence Identity: 35% (26 aa) LTKE-ELGRGSYAVVTVGIFRGLRVAVKSLHTIIISDYNL----GMFSREMSIASRLHHPNLVQFIGATKVGNP |. . . |.| . | . || ||.| .| . . || .| || | | ||| |||.|| ..| LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGP |
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