Gene AqueK600 (A.queenslandica)

AqueK600

Species: A.queenslandica
Alias: AqueK600
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK600.AA Protein None 799 None Fasta, JSON
AqueK600.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of AqueK600.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK600.AA TKL 554-790 18 5e-47 162.55 In-house 1-364 (364) Show / Hide 
Range on Protein: 554-790
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)

LGRGSYAVVTVGIFRD----------LRVAVKSLHNIIISDYNL-------------------------ALFSREMSIASRVRHPNLVQFIGATKVDN--
.|.|....|  |..|             |||| ..    .  ..                           . .|. . || ||||.|||.|. .  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLILTELM-STSLNQELRRNRLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTG---------AAGFEAKV
            . | .|..   ||   |       .|....|.|.|.|.||||  .|      ||||||  |.|.|..             .|   .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKLVQVDS--------------------TGTVMPGNVAYAAPEARDPD----------------QHSPAMDVYSYSVLLMEMTLGSPPEMTMAER
.|.|... .. ..                    |     |. .. |||. . .                . |...||||. ..| |.  . .|.  . ..
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

EVQ---------AGSV-----------------------SWSDMKSLIQIGINASPRARLTMAQVIESL
...         .. .                        . .||.|.|   .. |..|... .... |
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK600.AA MLK 548-740 26 1.9e-34 116.93 In-house 1-229 (291) Show / Hide 
Range on Protein: 548-740
Range on HMM: 1-229/291
Sequence Identity: 26% (61 aa)

TLTKEELGRGSYAVVTVGIFRDLR-----VAVKSLHNIIISDYNLA-----LFSREMSIASRVRHPN----LVQFIGATKVD-N-PLILTELMST-SLNQ
 ...| .| ||. .|  | .|  .     ||||  .  |. |   .      | .|  ......|||     .|| |. . . .  .|..| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELRRNR---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGAAGFEAKVADYGTAKLVQVD-STGTVMPGNVAY
 |. .|                . ......| ..| |..|||  .|.||||||  |.|.|.   |   ..  .|..| ||.. ..   .. . ..|..|.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

AAPEAR---DPDQHSPAMDVYSYSVLLMEM
 |||..     .. | . ||.|. |.| ||
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEM
Kinase AqueK600.AA TK 548-790 14 2.7e-30 98.15 In-house 1-486 (486) Show / Hide 
Range on Protein: 548-790
Range on HMM: 1-486/486
Sequence Identity: 14% (69 aa)

TLTKEELGRGSYA---VVTVGIFRDL---------------------------RVAVKSLHNIIISDYNLAL---------------FSREMSIAS--RV
    ..||.| .    .|  |. |..                           .|||| |.    .. .  .               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVDN------------PLILTELMS-TS----LNQELRRNR----------------------------------------------
.|||.|...|  |....            ..|..|.|.  .    | . ||..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTGAA------GFEAKVADYG---
                               || .| | .....| |. |||  .    | ..|||.   |.|.      .      |. .|.||.|   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TAKLVQVDSTGTVMPGN---------------------------VAYAAPEARD---------PDQHSPAMDVYSYSVLLMEMT-LG-SPPE--M
      |. .. |.  ... .                            . . |||. .            .... ||.|. ||. |.  .|  |.   |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TM---------------------------------AEREVQAGSVSW------------SDMKSLIQIGINASPRARLTMAQVIESL
.                                   ...  ..  .|             ..  |.|   .. |. | |..|. | |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK600.AA TKL-Unique 550-740 28 4.6e-29 99.7 In-house 1-221 (290) Show / Hide 
Range on Protein: 550-740
Range on HMM: 1-221/290
Sequence Identity: 28% (63 aa)

TKEELGRGSYAVVTVGIFRDLRVAVKSLH-NIIISDYNLALFSREMSIASRVR-HPNLVQFIGATK---VDNP--LILTELMST-SLNQELR--------
  . .|.|.|..|  |..|   ||.|..| |  .|   .  |..| .. .. . |||.|...|...   |..|   | .| ..  ||.  |         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

---RNRLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVM----------PGNVAYAAPEARD
    . |..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   ....|.            |.  ..|||   
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

P--DQHSPAMDVYSYSVLLMEM
   .| |   ||||... | |.
MNFCQYSEKSDVYSFGIVLWEI
Kinase AqueK600.AA S_TKc 548-796 19 1.6e-27 98.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-796
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

TLTKEELGRGSYAVVTVGIFRD--LRVAVKSLHNIIISDYNLALFSREMSIASRVRHPNLVQFIGATKVDNPLILTELMST---SLNQELRRNR------
    ...|.|....|  .. ..   .||.| ..           . ||..| .. .|||.|.....   |.  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVMPGNVAYAAPEARDPDQHSP-AMDVYSYS
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |...      | . |   | |||     .... . |..|  
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VLLMEMTLGSPPEMTMAEREVQAGSVSWSDMKSLIQIGINASPRARLTMAQVIE---SLKRINIF
..| ||  | ||     ..  .      ...|..|.   .  |. |.|  .. .     |    |
CILYEMLCGYPPFP-QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK600.AA CZAK 549-740 29 6.9e-25 87.39 In-house 1-215 (279) Show / Hide 
Range on Protein: 549-740
Range on HMM: 1-215/279
Sequence Identity: 29% (63 aa)

LTKE-ELGRGSYAVVTVGIFRDLRVAVKSLHNIIISDYNL----ALFSREMSIASRVRHPNLVQFIGATKVDN---PLILTELMS-TSLNQELR-RNRLT
|. . . |.| .  |  .  |   ||.| .| .   .         | .| || |  .||| |||.||   |.     | .| |   || . |  .  . 
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH

NQ---QILSIAQDVALGLNYLHL-FKPQPIIHRDVSSPNVLLKPCTG--------AAGFEAKVADYGTAKLVQVDSTG-TVMPGNVAYAAPEARDPDQHS
 |     ...| |.| | ||||  .|| ||.||| || |.||                  .|..|.|  ..     .  |   | ... |||    .  .
KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT

PAMDVYSYSVLLMEM
.  ||||.  .| ..
EKVDVYSFGMILWCI
Kinase AqueK600.AA Dicty4 550-668 32 3.3e-22 71.02 In-house 3-139 (277) Show / Hide 
Range on Protein: 550-668
Range on HMM: 3-139/277
Sequence Identity: 32% (45 aa)

TKEELGRGSYAVVTVGIFRDLRVAVKSL--HNIIISDYNLALFSREMSIASRVRHPNLVQFIGA-T----KVDNPLILTELM-STSLNQELRR------N
. ...|.||.. |  |. |   |||| |  ||.  . . |  | .| .| .  ||||...| || |    .   ..| ||.| ...|   |.        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

RLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK600.AA STE 549-750 17 6.7e-22 74.19 In-house 1-271 (359) Show / Hide 
Range on Protein: 549-750
Range on HMM: 1-271/359
Sequence Identity: 17% (50 aa)

LTK-EELGRGSYAVVTVGIFR-----------------DLRVAVKSLH---------------NIIISDYNLALFSREMSIASRVR--HPNLVQFIGATK
... |..|.|.. .|  .. .                   ..|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VD--------NPLILTELMS-TSLNQELRRN---------------RLTNQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAK
..        .  |  |.|.  || . ....               |.  .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAKLVQ-----------------VDSTGTVMPGNVAYAAPEARDP------DQHSPAMDVYSYSVLLMEMTLGSPPEMTM
 .| |... ..                  ..  . . |   . |||  ..      ....   |..|   ...||  | || ..|
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDM
Pkinase_Tyr AqueK600.AA Pkinase_Tyr 547-740 24 1.4e-21 73.68 Pfam 1-207 (270) Show / Hide 
Range on Protein: 547-740
Range on HMM: 1-207/270
Sequence Identity: 24% (54 aa)

VTLTKEELGRGSYAVVTVGIFR------DLRVAVKSLHNIIISDYN--LALFSREMSIASRV-RHPNLVQFIGATK-VDNP---LILTELMST-SLNQEL
.|.  ..||.|.. .|  |. .      .. ||||.| .   .. .  .. | ||..| .   .|||.|...|.    . |   .| .|.|   .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRN-----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVDSTG-TVMP---GNVAYAAPEARDPDQ
|..     .|| ...|......| |..||.  .   .||||.   |.|..      .. .|..| | |.... |..  ..       .   |||.     
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

HSPAMDVYSYSVLLMEM
 . . ||.|. ||. |.
FTTKSDVWSFGVLMWEI
Kinase AqueK600.AA Dicty5 585-740 28 1.1e-19 64.43 In-house 38-196 (260) Show / Hide 
Range on Protein: 585-740
Range on HMM: 38-196/260
Sequence Identity: 28% (47 aa)

YNLALFSREMSIASRVR--HPNLVQFIGATKVDNPL--ILTELMST-SLNQELR--RN----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPN
...  | ||  | | .   |||.. . || . .     ..||. .  ||   |.  |.     .   |.|..| |.| .. .||      |||||. | |
FDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMN

VLLKPCTGAAGFEAKVADYGTAKLVQVDSTGTVMPGNVAYAAPEARDPDQHSPAMDVYSYSVLLMEM
.|.        ...|. |.||   |      |.  |  .. |.|           ||||. . | ||
FLI-----TENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEM
Kinase AqueK600.AA Pkinase 548-746 24 4.3e-18 65.05 Pfam 1-211 (293) Show / Hide 
Range on Protein: 548-746
Range on HMM: 1-211/293
Sequence Identity: 24% (53 aa)

TLTKEELGRGSYAVVTVGIFRDLR--VAVKSLHNIIISDYNLALFSR--EMSIASRVRHPNLVQFIGATK-VDNPLILTELMST-----SLNQELR---R
  ... .|.||...|  .. .. .  |||| .    ...  .    |  | .|  |..||| |.....    |.. . .|..       .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NRL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKL--VQVDSTGTVMPGNVAYAAPEA-RDPDQHSPAMD
...  . ... ...  .. ||.|.|      |||||. . |.|..  .|  .   |..| | ||.     .|  |.  |   |.|||  |.   ..|. |
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSYSVLLMEMTLGSPP
..|. ..| || .| ||
MWSCGCILYEMLCGRPP
Kinase AqueK600.AA TK-Unique 548-746 22 4.7e-18 58.94 In-house 1-239 (294) Show / Hide 
Range on Protein: 548-746
Range on HMM: 1-239/294
Sequence Identity: 22% (56 aa)

TLTKEELGRGSYAVVTVGIFR--------DLRVAVKSLHNIIISDYNLALFSREMSIASRVR-HPNLVQFIGATK-VD-NPLILTELMSTS-LNQELRRN
   ....|.|..  |  | ..        . .|||| ....  .|   . | .| .. . .  |||.||..|..   | ...|. | .. . |   ||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVK-MLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

R---------------------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQ----VDSTG
|                           .. .. ...| ..| |..||.   .. |.|||... ||||       ....|..|.| |. |.    .....
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ-RKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMC

TVMPGNVAYAAPEA-R--DPDQHSPAMDVYSYSVLLME-MTLGSPP
.  .  ... |||. .  .   |..  ||.|. ||. | .|||..|
SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACP
Kinase AqueK600.AA LRRK 548-737 21 6e-18 60.06 In-house 1-272 (351) Show / Hide 
Range on Protein: 548-737
Range on HMM: 1-272/351
Sequence Identity: 21% (60 aa)

TLTKEELGRGSYA-VVTVGIFRD----------------------------LRVAVKSLHN--------------------------------IIISDYN
    |..|||... .|  ...|.                              ||.|...                                 .. .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LALFSREMSIASRVRHPNLVQFIGATKVDNPLIL-TELMST-SLNQELR---RNR-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNV
. .| .|..| |. .|||.|. .| .   .||.. .|...  .|.. |.   ...       .. . .| || ..| |..||| ..| ||||||  |||.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LL-KPCTGA------AGFEAKVADYGTAKLVQVDSTG--TVMPGNVAYAAPEARDPD---QHSPAMDVYSYSVLL
|| .  ..       |   ||.||.|.  . |.. .|    . ||  . ||| .  .   . .   |.||. ..|
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMIL
Kinase AqueK600.AA TyrKc 548-790 21 3e-17 56.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-790
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

TLTKEELGRGSYAVVTVGIFRDLRVAVKSLHNIIISDYNLALFSREMSIASRV--RHPNLVQFIGATKV--------DNPLILTELMST-SLNQELRRNR
   ...||.| . .|  |. . . ||||.|..       .. | ||..| ...  .|||.|...|.           . ..|..|.|.  .|.. ||..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGAAGFEAKVADYGTAKLVQVD-------STGTV-----MP--GNVAYAAPEARD
  |.... ||.. ..| | .|||     ..||||    |.|..         .|..| | .. .  |       .. ..           .   |||. .
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

PDQHSPAMDVYSYSVLLMEM-TLGSPPE-------MTMAE--REVQAG------SV--------SWSDMKSLIQIGINASPRARLTMAQVIESL
    ... ||.|. |.. |. |.| .|        |. .|  . |..|                  ..| ....   .. |  | |.....| .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK600.AA MLK 765-790 26 0.005621 6.32 In-house 266-291 (291) Show / Hide 
Range on Protein: 765-790
Range on HMM: 266-291/291
Sequence Identity: 26% (7 aa)

MKSLIQIGINASPRARLTMAQVIESL
.|.|...  |. |. | ...|... |
WKKLMKQCWNQDPHKRPSFRQIVQHL