Gene AqueK627 (A.queenslandica)

AqueK627

Species: A.queenslandica
Alias: AqueK627
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK627.AA Protein None 784 None Fasta, JSON
AqueK627.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of AqueK627.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_2 AqueK627.AA Kelch_2 12-68 20 0.000185 21.07 Pfam 1-51 (51) Show / Hide 
Range on Protein: 12-68
Range on HMM: 1-51/51
Sequence Identity: 20% (12 aa)

KRNSHSTVRVGDYLYMWGGRQPGLPEVHNNEEKKSMCSLMEV--CHLRTGRWEQKPTTG
 | .|... .|. .|..||.          ..   .|..| .  ....| ||.  |  .
PRYCHASCVPGGKIYVFGGYC--------RHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK627.AA Kelch_1 12-68 15 0.804922 6.71 Pfam 1-45 (45) Show / Hide 
Range on Protein: 12-68
Range on HMM: 1-45/45
Sequence Identity: 15% (9 aa)

KRNSHSTVRVGDYLYMWGGRQPGLPEVHNNEEKKSMCSLMEVCHLRTGRWEQKPTTG
.| .|. . .....|  ||. .            .  .  |. ...|..|.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK627.AA Kelch_1 73-120 18 5e-06 25.36 Pfam 1-45 (45) Show / Hide 
Range on Protein: 73-120
Range on HMM: 1-45/45
Sequence Identity: 18% (9 aa)

GVRGYAAAAIGREIFYFGGHCNHDNCCHNSLYSFNVDTFNWKELSPTT
  .|....... .|. .||...    . || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK627.AA Kelch_2 73-120 17 0.092164 10.82 Pfam 1-51 (51) Show / Hide 
Range on Protein: 73-120
Range on HMM: 1-51/51
Sequence Identity: 17% (9 aa)

GVRGYAAAAIGREIFYFGGH---CNHDNCCHNSLYSFNVDTFNWKELSPTT
.  . |.. .|  |. |||.     ...| ..... .. .|  |.....  
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_1 AqueK627.AA Kelch_1 265-303 17 0.007174 14.06 Pfam 8-45 (45) Show / Hide 
Range on Protein: 265-303
Range on HMM: 8-45/45
Sequence Identity: 17% (7 aa)

TSSGPHLLVVGGADIFVSIPDIWIFDINNKSWKELVNIP
.. . .. |.|| |   .  .....|  ...|... . |
CVHNGKIYVIGGCDG-QYLNSVECYDPETNQWTRCPPMP
Kelch_2 AqueK627.AA Kelch_2 254-303 23 0.064458 11.41 Pfam 1-51 (51) Show / Hide 
Range on Protein: 254-303
Range on HMM: 1-51/51
Sequence Identity: 23% (13 aa)

ERRAHSSVLINTSSGPHLLVVGGA----DIFVSIP-DIWIFDINNKSWKELVNIP
 |  |.|. .    |  ..|.||.    ..... . |||..| . ..|...  .|
PRYCHASCVP----GGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP
Kelch_2 AqueK627.AA Kelch_2 308-331 33 64.338879 0.01 Pfam 1-19 (51) Show / Hide 
Range on Protein: 308-331
Range on HMM: 1-19/51
Sequence Identity: 33% (8 aa)

KRCYHSLSVWSVTPTTNWIIVFGG
 |. |. .|.      ..|.||||
PRYCHASCVP-----GGKIYVFGG
Kinase AqueK627.AA TKL 535-649 22 1.8e-21 74.07 In-house 1-165 (364) Show / Hide 
Range on Protein: 535-649
Range on HMM: 1-165/364
Sequence Identity: 22% (38 aa)

LGKGGWGEVKVAGFRG----------LKVAAKCLYEVIISPYNI-------------------------GTFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||  . .||            || | . .   .  ..                          .. .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRD
            . | .|..   ||.  |       . .....||.|...||||  .|      ||.|||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD
Kinase AqueK627.AA CZAK 532-649 35 1.4e-16 56.9 In-house 4-134 (279) Show / Hide 
Range on Protein: 532-649
Range on HMM: 4-134/279
Sequence Identity: 35% (47 aa)

EVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIISPYNIGT------FSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKELE--SGGVA
. . |.|  |||. |  ||  || | ..   ..  |         | .|  | || .||| .||.|| .|..     | .| |   |||. |   .  . 
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHK

Y-PAI-LSISLDVACALNYLHL-FKPHPILHRD
  | . ... .|.|   ||||  .|| ||||||
QNPHLQWNMAIDIARGMNYLHDNWKPNPILHRD
Kinase AqueK627.AA Dicty4 531-649 31 2.5e-14 44.35 In-house 3-139 (277) Show / Hide 
Range on Protein: 531-649
Range on HMM: 3-139/277
Sequence Identity: 31% (44 aa)

TEVVLGKGGWGEVKVAGFRGLKVAAKCL--YEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELES------G
.|. .|||. |||  .  || .|| | |    .  . . .  | .| .| .||||||...| || |      | . | ||.|  ..| . | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GVAYP--AILS---ISLDVACALNYLHLFKPHPILHRD
 .  .   |..   . .|.|  .|.||   |  |.|||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK627.AA DRK 530-649 34 1.2e-12 39.21 In-house 2-125 (258) Show / Hide 
Range on Protein: 530-649
Range on HMM: 2-125/258
Sequence Identity: 34% (43 aa)

MTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIIS-PYNIGTFSREMNIASKIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ESGGVAYPAIL
   .  |.|..|||     || .|| | |    |     .  | || |. .. ||||  ||.|. ..   . | .| ||  || . |  ||     | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPILHRD
.. .|.|  ..|||   |  |.|||
QMMFDCAKGMIYLHCCNPI-IIHRD
Kinase AqueK627.AA MLK 529-649 21 1.4e-11 36.55 In-house 1-152 (291) Show / Hide 
Range on Protein: 529-649
Range on HMM: 1-152/291
Sequence Identity: 21% (32 aa)

TMTEVVLGKGGWGEVKVAGFRGLKVAAKC--LYEVIISPYNIGT-------FSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKE
  .. ..|.|. |.|  . .|.  . ||   ...| .... ..        | .| .......|||      || |. .. ..   |..| ..  ||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LESG---------------GVAYPAILSISLDVACALNYLHLFKPHPILHRD
| ..                .    .....|..| ...|||  .|.|| |||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRD
Kinase AqueK627.AA TKL-Unique 534-649 26 5.9e-11 35.04 In-house 4-137 (290) Show / Hide 
Range on Protein: 534-649
Range on HMM: 4-137/290
Sequence Identity: 26% (36 aa)

VLGKGGWGEVKVAGFRGLKVAAKCLY-EVIISPYNIGTFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------
..| || |.|. . .|| .|| | .  .  .|.  . .|..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

SGGVAYPAILSISLDVACALNYLHLFKPHPILHRD
.    .  .... .|.| ...|||  .|  |.|||
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRD
Kinase AqueK627.AA LISK 534-592 29 4.5e-10 28.71 In-house 1-64 (296) Show / Hide 
Range on Protein: 534-592
Range on HMM: 1-64/296
Sequence Identity: 29% (19 aa)

VLGKGGWGEVKVAGFR--GLKVAAKCLY---EVIISPYNIGTFSREMNIASKIRHPNLLQFIGA
..|||. |.|     |  |  .| | .    .. . | .. .. ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK627.AA Shk 531-606 39 1.2e-09 31.09 In-house 3-80 (269) Show / Hide 
Range on Protein: 531-606
Range on HMM: 3-80/269
Sequence Identity: 39% (31 aa)

TEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATT--EGNPIILTELMP
.|  || |  | |  .  || .|| | .     . .    |  |  | |||.|||.. | || |   |   | |||||
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP
Kinase AqueK627.AA TK 573-638 12 2.2e-09 26.82 In-house 87-251 (486) Show / Hide 
Range on Protein: 573-638
Range on HMM: 87-251/486
Sequence Identity: 12% (20 aa)

REMNIASKIR-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELESGG--------------------------------
.|...... .     |||.....|. |.|              ..|..|.||  .    ||. | .                                  
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------VAYPAILSISLDVACALNYLH
                                             .  .  | .....||.. |||
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Pkinase_Tyr AqueK627.AA Pkinase_Tyr 528-649 25 3.3e-09 31.83 Pfam 1-136 (270) Show / Hide 
Range on Protein: 528-649
Range on HMM: 1-136/270
Sequence Identity: 25% (36 aa)

ITMTEVVLGKGGWGEVKVAGFR------GLKVAAKCLYEVIISPYN--IGTFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
||. .. ||.|  |||. .  .      ...|| |.|     .. .  .  | ||..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ESG-----GVAYPAILSISLDVACALNYLHLFKPHPILHRD
 .       .  . .|......|....||.  .   . |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRD
Kinase AqueK627.AA Pkinase 529-649 18 4.4e-09 33.19 Pfam 1-133 (293) Show / Hide 
Range on Protein: 529-649
Range on HMM: 1-133/293
Sequence Identity: 18% (25 aa)

TMTEVVLGKGGWGEVKVAGFRGLK--VAAKCLYEVIISPYNIGTFSR--EMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---S
  .. ..|.|. |.|. .  .|    || |..  . ...    |  |  |  |  ...||| ......  ..... . .|...      .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--AYPAILSISLDVACALNYLHLFKPHPILHRD
|..   .  . .. . ....|.|.|      |.|||
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRD
Kinase AqueK627.AA RRM_1 651-700 30 6.8e-09 33.63 Pfam 22-73 (73) Show / Hide 
Range on Protein: 651-700
Range on HMM: 22-73/73
Sequence Identity: 30% (16 aa)

FGKIKKVELAPD--TAPGKHRGWGFIDYENHKSAADGISSMNLFDLGGQFLR
||.|. ... .|   . |..||..|. .|.| .|.. |..|| . ..|  .|
FGPIESIRIMRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
Kinase AqueK627.AA TKL-ciliate2 530-658 30 7.9e-09 25.0 In-house 2-133 (273) Show / Hide 
Range on Protein: 530-658
Range on HMM: 2-133/273
Sequence Identity: 30% (40 aa)

MTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATTEGN--PIILTELMPTSLRKELES--GGVAYPAILS
 ..  .  ||.| .  | .| . || |    .      |  |  | .    .||||.  |.|| |.     ||.      ||   | .    ...     
EIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRR

ISLDVACALNYLHLFKPHPILHRDAFGKIKKVE
| ||.|    |||  .| ||.|||   .||. |
IALDIARGVHYLHSSNP-PIIHRDLKRQIKHKE
TyrKc AqueK627.AA TyrKc 528-780 16 4.8e-07 -108.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 528-780
Range on HMM: 1-280/280
Sequence Identity: 16% (55 aa)

ITMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELESG
||. . .|| |  |||  .  . ..|| |.| |       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. | . 
ITLGK-KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

G--VAYPAILSISLDVACALNYLHLFKPHPILHRD--------AFGKIKKV-------ELAPD---------TAP----GKH--------------RG--
.  .  .  ||.....||  .|||    ... |||        . ... |.       ..  |           .    |..               |  
RPKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------------------WGFIDYEN-HKSAADGISSMNLFDLGGQFLRVLTPPLPLFPPNAAPVLPSLLTSAALGYSSSQNKDPNLCIVDGDDNGNKKS
                   |   |..  .     .|   .. .  |  |   || ..  |  .                                     
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY--P-MS-------------------------------------

MVSILGSSARMMIMQK-LSRKSED-----ILVIMI
  .   ...  .||..   .. ||      ..  .
--FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK627.AA S_TKc 529-780 11 1e-06 -78.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 529-780
Range on HMM: 1-231/231
Sequence Identity: 11% (36 aa)

TMTEVVLGKGGWGEVKVAGFRG--LKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELESGG------
     ..|||. |.|. .  ..   .|| |..           .. ||..| .| .|||. .....  ...  . .|....   .|.. ... |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VAYPAILSISLDVACALNYLHLFKPHPILHRD--------------------AFGKIKKVE------LAPDTAPGKHRGWGFIDYENHKS-AAD----G
      . ..   ..|||.|.|  .   |.|||                    ..    .        .||                 .   ..|    |
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDEHIKICDFGLARQL---TTFCGTPWYMAPEVL-------------GYGKCKCDWWSCG

ISSMNLFD------LGGQFLRVLTPPLPLFPPNAAPVLPSLLTSAALGYSSSQNKDPNLCIVDGDDNGNKKSMVSILGSSARMMIMQKLSRKSE-----D
.    ..          . ....                                                       ..|. .|.. | .  |     .
CILYEMLCGYPPFPQMQMMFKKIG-----------------------------------------------------SPEAKDFIRKCLQKDPEKRPTAE

ILV--------IMI
.|           .
ALQDEWDIKCHPWF
Kinase AqueK627.AA RRM 631-702 14 0.000314 14.29 SMART 1-121 (121) Show / Hide 
Range on Protein: 631-702
Range on HMM: 1-121/121
Sequence Identity: 14% (18 aa)

ACALNYL--HLFKPHPILHRDA----------------FGKIKKVELAPDTA---------------------PGKHRGWGFIDYENHKSAADG--ISSM
      |  .       |..                  ||.|... . .|                        |..|| .|...|.. .|..   |. |
TIFVGNLNDPWDVTEEDLREFFKDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDAEKAMVIEMM

N---LFDL--GGQF---LRVL
|    ...  .|.    .|| 
NASKGHEFRDDGRPTGHIRVK
Kinase AqueK627.AA LISK 624-638 53 0.008858 4.63 In-house 104-118 (296) Show / Hide 
Range on Protein: 624-638
Range on HMM: 104-118/296
Sequence Identity: 53% (8 aa)

LSISLDVACALNYLH
..|.||.||.. |||
VKIALDIACGMSYLH