Gene AqueK628 (A.queenslandica)

AqueK628

Species: A.queenslandica
Alias: AqueK628
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK628.AA Protein None 169 None Fasta, JSON
AqueK628.kin_dom Protein Kinase Domain None 127 None Fasta, JSON

Protein domain

Protein domains of AqueK628.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK628.AA TKL 19-165 19 2.6e-25 88.12 In-house 134-364 (364) Show / Hide 
Range on Protein: 19-165
Range on HMM: 134-364/364
Sequence Identity: 19% (46 aa)

ILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLLQPMGG--------GLGGWKAKVSDYGSANLQHLI---------------------IRSVN
.....||.|...||||  .|      ||.|||  |.|.|.   .             |..|..|.| .   .                        ..  
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

PGGPLYAAPEA--GNP--------------REHSPSMDVFSYGVLLLEMITRRIPLPEER--------------VGLIDGIRR-----------------
 | | . |||.  |..              .| |...||.|.|..| |..||..|  ..               .. .|  .|                 
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCP

---ASFRYLVERCLIVEYRHRPTMNDIITEL
    |.. | ..|   . . ||....|. .|
DCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK628.AA MLK 19-123 31 1.3e-16 54.25 In-house 126-235 (291) Show / Hide 
Range on Protein: 19-123
Range on HMM: 126-235/291
Sequence Identity: 31% (35 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQP-MGGGLGGWKAKVSDYGSANLQHLI-I-RSVNPGGPLYAAPEA---GNPREHSPSMDVFSYGV
.....|..| ...|||  .|.|| |||  | |.|.    .  ... ..|..| | .   | .   .  |.| . . |||.         | . ||.|.||
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGV

LLLEMITRRIP
.| ||.||..|
VLWEMLTREVP
Kinase AqueK628.AA Dicty5 14-123 30 6.4e-14 44.29 In-house 101-202 (260) Show / Hide 
Range on Protein: 14-123
Range on HMM: 101-202/260
Sequence Identity: 30% (34 aa)

LAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG-SANLQHLIIRSVNPGGPLYAAPEAGNPREHSPSMDVFSYGV
.||. .|.. .|.| .. .||      | |||. | |.|.         ||.|. |.| | .        .. | . . |.|  | .      ||.|.|.
IAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITEN------WKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGI

LLLEMITRRIP
 | ||.||  |
VLWEMFTRKEP
Kinase AqueK628.AA LRRK 22-123 29 1.3e-12 40.96 In-house 169-282 (351) Show / Hide 
Range on Protein: 22-123
Range on HMM: 169-282/351
Sequence Identity: 29% (34 aa)

ISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGL------GGWKAKVSDYGSAN----LQH-LIIRSVNPGGPLYAAPEAGNPR---EHSPSMDV
|.|..| ...||| ..| ||.|||  | |.||. .  .          .||..|.|       ... .. ..| .  |.. |||  .     | .   |.
IALQIAKGMEYLHSHNP-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGN--PGWMAPEIMRYNGEEEYTEKVDC

FSYGVLLLEMITRR-IP
.|.|..| | .||. .|
YSFGMILWELLTRQHHP
Pkinase AqueK628.AA Pkinase 10-169 17 2.4e-12 44.74 Pfam 99-293 (293) Show / Hide 
Range on Protein: 10-169
Range on HMM: 99-293/293
Sequence Identity: 17% (37 aa)

ESVGL--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSAN---LQHLIIRSVNPGGPLYAAPEAGN-PREHSP
.. ..   .  . .. . ....|.|.|      |.|||. ..|.|.    | ..  . |..| |.|    . .    ..  | | |.|||  .  ....|
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILID-NNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SMDVFSYGVLLLEMITRRIPLPEE-------RVGLIDGIRR-------------------------------ASFRYLVERCLIVEYRHRPTMNDIITEL
. |..|.|..| ||...| | |..          .|. |..                                ... ....|| .    |||    ....
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQI

NDT--I
     .
LQHPWF
Kinase AqueK628.AA STE 29-160 17 3.3e-12 39.54 In-house 163-350 (359) Show / Hide 
Range on Protein: 29-160
Range on HMM: 163-350/359
Sequence Identity: 17% (36 aa)

A-LNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSAN-LQHLII-----------------RSVNPGGPLYAAPEAGNP------REHSP
. |.|||  .   | |||. .||.||           .| .| | .  |.. .                  |    | | . |||  ..       ... 
GLLYYLHSHH---IIHRDIKPANILL-----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT

SMDVFSYGVLLLEMITRRIPL---PEERVGLIDGIRR-------------------------------------------ASFRYLVERCLIVEYRHRPT
. |. | | ...||.| . |.   .  |. .   .                                              .|.  ...||. ....|||
KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT

MND
 ..
ASQ
Kinase AqueK628.AA CZAK 20-53 54 2.8e-11 37.38 In-house 108-142 (279) Show / Hide 
Range on Protein: 20-53
Range on HMM: 108-142/279
Sequence Identity: 54% (19 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
... .|.|   ||||  .|| |||||| || |.||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK628.AA TKL-Unique 19-123 26 5.7e-11 35.1 In-house 112-233 (290) Show / Hide 
Range on Protein: 19-123
Range on HMM: 112-233/290
Sequence Identity: 26% (34 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGG-----WKAKVSDYGSANLQHLIIRSVNP-----------GGPLYAAPEAGNP--RE
.... .|.| ...|||  .|  |.|||  | |.|.        .     |..|..| | . ..  |... |            | ....|||  .     
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVD------NNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQ

HSPSMDVFSYGVLLLEMITRRI------P
 | . ||.|.|. | |..|| |      |
YSEKSDVYSFGIVLWEIATRKITKTYKKP
Kinase AqueK628.AA HH498 17-71 41 2.4e-10 28.58 In-house 121-169 (284) Show / Hide 
Range on Protein: 17-71
Range on HMM: 121-169/284
Sequence Identity: 41% (23 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG
. .. ||.|||   ||||   .||| |||  | |.|.   |      .|.| |.|
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG------HAVVADFG
Kinase AqueK628.AA IRAK 20-53 45 1.7e-08 26.37 In-house 112-146 (317) Show / Hide 
Range on Protein: 20-53
Range on HMM: 112-146/317
Sequence Identity: 45% (16 aa)

LSISLDVACALNYLHLFKPH-PILHRDVSSANVLL
.||..  ||....|| . |  || |.|..|||.||
CSICWGTACGIQFLHQNHPCTPIIHGDIKSANILL
S_TKc AqueK628.AA S_TKc 1-169 15 2.4e-08 -54.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-169
Range on HMM: 1-231/231
Sequence Identity: 15% (38 aa)

M--------------------------------------------------------------------PT---SLRKELESVG-------LAYPAILSI
                                                                     ..   .|.. ... |       .    . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

SLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYGSANLQHLIIRSVNPGGPLYAAPEAGNPREHSP-SMDVFSYGVLLLEMITRR
   ..|||.|.|  .   |.|||.  .|.||            |..| |.| .      .   | | | |||      ... . |. | |..| ||....
MYQICCALEYCHSHG---IIHRDLKPENILLDE--------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

IPLPEERVGLIDGIRRASFRYLVERCLIVEYRHRPTMNDIIT-----ELNDTI
 | | .   ... |.  ... ....|| .. ..|||  .. .      .   .
PPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK628.AA LISK-DD1 104-123 65 6.9e-08 24.84 In-house 211-230 (290) Show / Hide 
Range on Protein: 104-123
Range on HMM: 211-230/290
Sequence Identity: 65% (13 aa)

SMDVFSYGVLLLEMITRRIP
| ||||.|..|||.|||..|
SCDVFSFGMVLLELITRKKP
TyrKc AqueK628.AA TyrKc 3-165 14 5.2e-05 -141.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-165
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

TSLRKELES-------------------------------------VG------------------------------------------------LAYP
 .| |.| .                                     .|                                                |  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

AILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG-SANLQHL--------IIRS----VNPG-GPL-YAAPEAGNPREHS
  ||.....||  .|||    ... |||    |.|.   .       .|.|| | | .. .          .|.       .  |.   |||. | .. .
DLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PSMDVFSYGVLLLEMITRRIPLPEE-----------RVGLIDGIRRASFRY---------------LVERCLIVEYRHRPTMNDIITEL
.  ||.|.||.. |. |.  . ...           .  . .| |.    .               . ..|   .   |||...|. ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK628.AA HH498 106-123 55 6.6e-05 11.06 In-house 208-225 (284) Show / Hide 
Range on Protein: 106-123
Range on HMM: 208-225/284
Sequence Identity: 55% (10 aa)

DVFSYGVLLLEMITRRIP
|||||.  . || ||..|
DVFSYAMCIWEMHTREVP
Kinase AqueK628.AA LISK-DD1 20-71 42 0.000196 12.22 In-house 126-172 (290) Show / Hide 
Range on Protein: 20-71
Range on HMM: 126-172/290
Sequence Identity: 42% (22 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGGLGGWKAKVSDYG
..|.||.|||  |||  .   |.|||  | | |.   | ..  |..|| | |
VKIALDIACAMAYLHSKN---IIHRDLKSKNILVDENGDSQ--WRIKVCDFG
Kinase AqueK628.AA IRAK 90-119 34 0.000883 9.47 In-house 188-219 (317) Show / Hide 
Range on Protein: 90-119
Range on HMM: 188-219/317
Sequence Identity: 34% (11 aa)

YAAPEAGN--PREHSPSMDVFSYGVLLLEMIT
| .||. .   .. ..  ||.| |. ||| .|
YMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLT
Pkinase_Tyr AqueK628.AA Pkinase_Tyr 5-53 26 0.004415 11.06 Pfam 98-144 (270) Show / Hide 
Range on Protein: 5-53
Range on HMM: 98-144/270
Sequence Identity: 26% (13 aa)

LRKE-LESVGLAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|||   .   |  . .|......|....||.  .   . |||.   |.|.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK628.AA CZAK 90-123 32 0.016853 5.08 In-house 188-221 (279) Show / Hide 
Range on Protein: 90-123
Range on HMM: 188-221/279
Sequence Identity: 32% (11 aa)

YAAPEAGNPREHSPSMDVFSYGVLLLEMITRRIP
. |||       ..  ||.|.| .| ..|| . |
WMAPECFKGENYTEKVDVYSFGMILWCIITCDQP
Kinase AqueK628.AA TKL-Unique 155-165 45 0.031064 3.9 In-house 280-290 (290) Show / Hide 
Range on Protein: 155-165
Range on HMM: 280-290/290
Sequence Identity: 45% (5 aa)

RPTMNDIITEL
||. ..||..|
RPSFDEIIHRL
Kinase AqueK628.AA LRRK 155-167 30 0.200746 0.78 In-house 339-351 (351) Show / Hide 
Range on Protein: 155-167
Range on HMM: 339-351/351
Sequence Identity: 30% (4 aa)

RPTMNDIITELND
||....|.  | .
RPHFSQIVKRLSQ
Kinase AqueK628.AA MLK 155-165 36 0.313517 0.18 In-house 281-291 (291) Show / Hide 
Range on Protein: 155-165
Range on HMM: 281-291/291
Sequence Identity: 36% (4 aa)

RPTMNDIITEL
||..  |...|
RPSFRQIVQHL
Kinase AqueK628.AA Pkinase_Tyr 106-120 53 0.602102 3.83 Pfam 196-210 (270) Show / Hide 
Range on Protein: 106-120
Range on HMM: 196-210/270
Sequence Identity: 53% (8 aa)

DVFSYGVLLLEMITR
|| |.|||. |..|.
DVWSFGVLMWEIFTY
Kinase AqueK628.AA Pkinase_Tyr 154-165 41 3.408398 1.28 Pfam 259-270 (270) Show / Hide 
Range on Protein: 154-165
Range on HMM: 259-270/270
Sequence Identity: 41% (5 aa)

HRPTMNDIITEL
.|||. .|. .|
DRPTFSEIHEQL