AqueK671

Species: A.queenslandica
Alias: AqueK671
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: TAK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK671.AA Protein None 689 None Fasta, JSON
AqueK671.kin_dom Protein Kinase Domain None 215 None Fasta, JSON

Protein domain

Protein domains of AqueK671.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK671.AA IRAK 397-627 35 3e-73 249.68 In-house 1-236 (317) Show / Hide
Range on Protein: 397-627
Range on HMM: 1-236/317
Sequence Identity: 35% (87 aa)

FTEGLV-GHGAFGSVFRANIRGCG-PYAIKKLHNRSEMQSEMEGTLFFEPLHQESFML---ELQSLVKYKHRNVLSLIAISDDGPRPCLVYEYMENGSLA
| .... | |.|| |.|. ... . .||.|||..  .|. ..         | ..|     ||... .. | |...| . . ... .||||.|| |||| 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNE---------HWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLE

DCLLGKKN-VH---LDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARES---LNRPTHVTTVSANSRVAMGTVAYMA
| | . .. .    | |  |..|..  | ...||| .    ..||||.||.||||| |.|||..||||.|..    ..  .. |.   |.|  || .||.
DRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHV-RGTTWYMP

PEFLR--NSKPSSKTDVYAFGVVILELFTGQ-AADDPSRDIRTLHD
|||.|    . . ||||| ||.|.||..||. |..| ..  ..| |
PEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKD

Kinase AqueK671.AA TKL 402-613 23 5.5e-55 188.98 In-house 1-286 (364) Show / Hide
Range on Protein: 402-613
Range on HMM: 1-286/364
Sequence Identity: 23% (68 aa)

VGHGAFGSVFRANIRG---------CGPYAIKKLHNRSEMQSEM-------------EGTLFFEPLHQESFMLELQSLVKYK--HRNVLSLIAISDDGPR
.| |.|| |.... ||         . . |.||.. .... ...                |  . .... | .| . ... .  | |........ ..| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDM-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------PCLVYEYMENGSLADCLLGKKNVHLDWKLRLEIASQVADALNFLHRVNE----PQSLIHGDVKSSNILLDRHLT-------------
             .|.|.||...||| . |.        | .|. .| ..| ..|.||  |     .  .|| | ||.|||.|...|             
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PKLSDFGLARES----LNRPTHVT--------TVSANSRVAMGTVAYMAPEFLRNS----------------KPSSKTDVYAFGVVILELFTGQ
 .|..||||.|.      .  |  |        . . ..    || ..|||| ||..                . | |.|||.||.|. |..|..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

Pkinase AqueK671.AA Pkinase 396-613 22 2.2e-41 147.4 Pfam 1-209 (293) Show / Hide
Range on Protein: 396-613
Range on HMM: 1-209/293
Sequence Identity: 22% (53 aa)

IFTEGLVGHGAFGSVFRA-NIRGCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYKHRNVLSLIAISDDGPRPCLVYEYMENG----SL
. ... .| |.||.|... ..  .  .|.|..  | .  |... |..           |.| . . .| |.. |. .  |......| ||.|.|    .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL--------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

ADCLLGKKNVHL--DWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTP----KLSDFGLARE-SLNRPTHVTTVSANSRVAMGTVAYM
.| . ....  .  ...    .. |.. .|...|.     . || |.|..|||.|.. ..    |..|||||.  .       .  .    .  ||  ||
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYM

APEFLR-NSKPSSKTDVYAFGVVILELFTGQ
||| .| ... ..| |....|... |...|.
APEVIRGGQYYGPKVDMWSCGCILYEMLCGR

Kinase AqueK671.AA TK 396-611 16 7.6e-40 130.74 In-house 1-389 (486) Show / Hide
Range on Protein: 396-611
Range on HMM: 1-389/486
Sequence Identity: 16% (66 aa)

IFTEGLVGHGAFG---SVFRANIRG--------------------------CGPYAIKKLHNRSEMQSEM----------EGTLFFEPLHQESFMLELQS
|  .   |.|.||    |...  ||                          . | |.| |.  ..|..|.          . ..         |. |.. 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDG-GE--------DFLEEAEE

LVKYK-----HRNVLSLIAISDDG------------PRPCLVYEYMENGS----LADCLL--GKKNVH--------------------------------
. . .     | |...|.... .|            . ...| |||..|.    | | |    .|  |                                
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

----------------------------------------LDWKLRLEIASQVADALNFLHRVN---EPQSLIHGDVKSSNILLDRHLT-----------
                                        |. . .| .. |.|... .||. |   . | ..|.|.   |.|......           
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPV

PKLSDFG--------LARESLNRPTHVTTVSANSRVAMGT--------------------VAYMAPEFLR---------NSKPSSKTDVYAFGVVILELF
 |..|||        |||.  ..   ... |   .. |                      . .|||| |.         . | ..|.||..|||.. |.|
CKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF

T
|
T

Kinase AqueK671.AA MLK 396-613 27 6.1e-38 129.24 In-house 1-233 (291) Show / Hide
Range on Protein: 396-613
Range on HMM: 1-233/291
Sequence Identity: 27% (68 aa)

IFTEGLVGHGAFGSVFRANIRGCG----PYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYKHRN-----VLSLIAISDDGPRPCLVYEYME
| ..  .|.|.||.|.... |.        |.|. . | .  .  ...       |. |  |   | . .|.|     .  . .......  |.| ||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYC------EQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCE

NGSLADCLLGKKN------------VHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDR------HLTPKLSDFGLARESLNRPTHVTT
.|||.. | |...            .  |  . . .| |.| ....||  ..|. .|| | ||.|||.|.      |.| | .|||..|.       ...
GGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS-MAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD-------WHQ

VSANSRVAMGTVAYMAPEFL---RNSKPSSKTDVYAFGVVILELFTGQ
  .|   ..||.|.|||| .   |..| | | ||. .|||. |..|..
MCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE

Kinase AqueK671.AA RIPK 402-612 29 3.9e-35 117.18 In-house 1-224 (290) Show / Hide
Range on Protein: 402-612
Range on HMM: 1-224/290
Sequence Identity: 29% (68 aa)

VGHGAFGSVFRANIRGCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYKHRNVLSLIAISDDG-----PR-PCLVYEYMENGSLADCLL
|| |.|| ||.|  |  |  ..||  .  ... .|.         ..    | . . | ........  .  .      .  . .| ||||||||.. | 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQE------RMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLH

GKKN---VHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARESLNRPTHVTT--------VSANSRVAMGTVAYMA
 |       . |.||  .  ... . ..||  | |  .|| | | .|||.|...  |..|||||  . ..  |...         |  |.   || .||.
TKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPP--IIHRDLKPENILVDNNFHVKIADFGLA--TWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMP

PEFLR--NSKP----SSKTDVYAFGVVILELFTG
|| .|  |.||    . | ||| |..|. |..|.
PEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQ

Kinase AqueK671.AA UTK 403-612 26 9.6e-35 116.29 In-house 8-236 (296) Show / Hide
Range on Protein: 403-612
Range on HMM: 8-236/296
Sequence Identity: 26% (64 aa)

GHGAFGSVFRANIRGCG------PYAIKKLHNRSEMQSEMEGTLFFEPLHQE-SFMLELQ---SLVKYK-HRNVLSLIAISDDGPRPCLVYEYMENGSLA
|.|||| |..|  . |         |.|.. ...  | |.|.            ||.| .    . . . |.||| |...  ..  ...|.||||||.|.
GQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEP---------YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

DCLLGKKN------VHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRH-------LTPKLSDFG---LARESLNRPTHVTTVSANSRV
..|   .       ..|.   ||. |...|.....||. .    ..|.|.   |.|...|       .. |..|||   ..|. .|. .  .. ...|  
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG----FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR-VNTFH-FSNRYWESYY

AMGT------VAYMAPEFLRNS-KPSSKTDVYAFGVVILELFTG
 | .      .. |||| | .  ....|.||..||||  |..|.
YMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW

Kinase AqueK671.AA TK-Unique 396-611 20 6.3e-34 114.43 In-house 1-234 (294) Show / Hide
Range on Protein: 396-611
Range on HMM: 1-234/294
Sequence Identity: 20% (52 aa)

IFTEGLVGHGAFGSVFRANIRGCG-------PYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYK-HRNVLSLIAISDDGP-RPCLVYEYME
.. . ..| |||| |.|. ..|           |.|.|. ..  .....            |. |.| . . . | |..... .. .   ......||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQD------------FLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCP

NGSLADCLLGKKNVH------------------------LDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARESLNR
.|.| ..|  .. ..                        .. |. . .| |.| ....|..   ..  .|.|. ..|.|| .... |..|||.||.  . 
CGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQ--RKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-

PTHVTTVSANS-RVAMGTVAYMAPEFLR--NSKP-SSKTDVYAFGVVILELFT
    ..| ... .  .  ...|||| |.       ..|.||..|||.. |.||
----NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase AqueK671.AA TKL-Unique 401-613 28 7.4e-34 116.84 In-house 4-225 (290) Show / Hide
Range on Protein: 401-613
Range on HMM: 4-225/290
Sequence Identity: 28% (68 aa)

LVGHGAFGSVFRANIRGCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYK-HRNVLSLIAISD----DGPRPCLVYEYMENGSLADCLL
..| |..|.|...  ||  |.|||..|. ..  .||.          . |  |.  . | . | |.. .....     . |. |.| ||.. ||| | | 
KIGEGGYGQVYKGKWRGY-PVAIKQFHPNEDSSNEMM----------QEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLH

G--------KKNVHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRH-----LTPKLSDFGLARESLNRPTHVTTVSANSR--VAMGTV
         ..|  |....|. .| ..|.....||. . |   ||.| ||||.|.|..     .  |..||||.. . .. .  .. . ..|  . .|. 
QNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP--IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSF

AYMAPEFLRN--SKPSSKTDVYAFGVVILELFTGQ
 .|||| ||.  .. | | |||.||.|  |..|..
RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK

Kinase AqueK671.AA Pkinase_Tyr 403-611 27 6.7e-33 112.04 Pfam 8-209 (270) Show / Hide
Range on Protein: 403-611
Range on HMM: 8-209/270
Sequence Identity: 27% (61 aa)

GHGAFGSVFRANIR-----GCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKY-KHRNVLSLIAISD--DGP-RPCLVYEYMENGSLADC
|.||||.|...  .     .. | |.|.| . . |...           .|.|| |.. . .. .| |...|...    ..| ....| |||..|.| | 
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN---------CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LLGK--KNVHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARESLNRPTHVTTVSANSRVAMGTVAYMAPEFLRNS
|  .   . .|. |  |... |.|.....|.. |    .|| |.   |.|... .. | .||||||   |  .  .... ....    .  |||| ....
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN----CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLP---IKWMAPECINYG

KPSSKTDVYAFGVVILELFT
| ..|.||..|||.. |.||
KFTTKSDVWSFGVLMWEIFT

Kinase AqueK671.AA S_TKc 396-675 22 6.5e-31 109.94 SMART 1-231 (231) Show / Hide
Range on Protein: 396-675
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

IFTEGLVGHGAFGSVFRANIRG-CGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKYKHRNVLSLIAISDDGPRPCLVYEYMEN--GSLAD
     ..|.||||.|...  ..    .|||...                    |... |.| | | .| |.  |. . .|  . ..| ||...  |.| |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD

CLLGKKNVH----LDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARESLNRPTHVTTVSANSRVAMGTVAYMAPEFL
 .  ..       ..      .. |...||...|. .     || |.| .|||||.  . |..||||||.               .   ||  ||||| |
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG----IIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL

RNSKPSS-KTDVYAFGVVILELFTGQAADDPSRDIRTLHDSNMKLIFAKIVTIELPPLVFACILLELKLGLRSNGNDAIG---IVLCLFYA
   . .  | |....|... |...|.   .           .|...| ||.    . . | . .|.     |    .|      . |  . 
---GYGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK671.AA LRRK 396-613 24 1.2e-27 94.91 In-house 1-279 (351) Show / Hide
Range on Protein: 396-613
Range on HMM: 1-279/351
Sequence Identity: 24% (73 aa)

IFTEGLVGHGAFG-SVFRANIRG---------------------------CGPYAIKKLHNRS------------------------EMQSEMEGTLFFE
.  | ..| |.|| .|.||. ||                           | . ||||..  .                        |  .. ... . .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

PLHQESFMLELQSLVKYKHRNVLSLIAISDDGPRPCLVYEYMENGSLADCLLGKKNV-------HLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVK
 ..  .|  |.  . . .| |..||. .. . |. |.| ||. .|.| . |  ||.        |..| |.|.|| |.|.....||. | |  .|| | |
AFR--EFRHEVWIMSHLNHPNIVSLKGFCIH-PL-CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPP--IIHRDLK

SSNILLDRHLTP------------KLSDFGLAR--ESLNRPTHVTTVSANSRVAMGTVAYMAPEFLR---NSKPSSKTDVYAFGVVILELFTGQ
| |||| .. ..            |..|||. |   ..         ..  .   |.  .|||| .|   ..  . |.|.|.||... || |.|
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFH--------MGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ

Kinase AqueK671.AA Ciliate-E2-Unclassified 403-613 19 1.5e-27 92.63 In-house 8-267 (352) Show / Hide
Range on Protein: 403-613
Range on HMM: 8-267/352
Sequence Identity: 19% (52 aa)

GHGAFGSVFRA--NIRGCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQ-------------SLVKYKHRNVLSLIAISDDGPRPCLVYEYMEN
|.|.||.|...  .  .   ||.| ..   .  .    .   | . ..  | ...             .|.  .| ... .. .  |   ...|.||.|.
GQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEG

GSLADCLLGKKN---------------VHLDWKLRL-----EIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHL---TPKLSDFGLARESLNRPT
|.| ...  .|.                ... .  .      .. |. ..|..||. |     || | | .|||.|       .|..|||..... . . 
GDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN---NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNN

HVTTV---------SANSRVAMGTVAYM----APEFLRNSKPS----SKTDVYAFGVVILELFTGQ
   |          . ..   .||  ||    ||| |.. ...     | |....||.. |. .|.
CD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

Kinase AqueK671.AA TyrKc 396-658 20 1.1e-23 85.95 SMART 1-280 (280) Show / Hide
Range on Protein: 396-658
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

IFTEGLVGHGAFGSVFRANIRGCGPYAIKKLHNRSEMQSEMEGTLFFEPLHQESFMLELQSLVKY--KHRNVLSLIAISDDG-------PRPCLVYEYME
|  .   |.|||| |...  .   . |.|.|.. .                .| || |.. . |.  .| |.. |...  ..       . ...| |||.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

NGSLADCLLGKKNVHLDWKLRLEIASQVADALNFLHRVNEPQSLIHGDVKSSNILLDRHLTPKLSDFGLARESLNR----PTHVTTVSANSRVAM--GTV
.|.| | |  ...  | .|  |... |.|.  ..||.      .|| |    |.|... .| | |||||.|.  .       . . ... .. .     .
HGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

AYMAPEFLRNSKPSSKTDVYAFGVVILELFTG---QAAD-----DPSRDIRTLHDSNMKLIFAKI--------VTIELPPLVFACILL---------ELK
  |||| .. .| ..|.||..|||.. |.||       .      . .... . .. . .   .          . |.  .   |            |..
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

LGL
  .
ECF