AqueK675

Species: A.queenslandica
Alias: AqueK675
External Links:
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: KSR

Sequence

Name Sequence Type Origin Length Description Download
AqueK675.AA Protein None 435 None Fasta, JSON
AqueK675.kin_dom Protein Kinase Domain None 222 None Fasta, JSON

Protein domain

Protein domains of AqueK675.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK675.AA RAF 170-282 41 8.3e-32 106.14 In-house 14-129 (275) Show / Hide
Range on Protein: 170-282
Range on HMM: 14-129/275
Sequence Identity: 41% (48 aa)

TVQKGYWHGNVWVHQRTIKR---QEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGH-NFTTPSKLKILRQISEG
|| .| |||.| |  ...|    ...   |.|||  .  .||||| |||| | .   . ...|...  || ||| |||      | . ....| .||  |
TVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKP-DNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMNWTIQIAQQICQG

MEYLHAKGIQHGGLSSK
| |||||.| |. |.||
MDYLHAKNIIHRDLKSK

Kinase AqueK675.AA KSR 170-282 40 1.6e-29 97.8 In-house 14-128 (272) Show / Hide
Range on Protein: 170-282
Range on HMM: 14-128/272
Sequence Identity: 40% (48 aa)

TVQKGYWHGNVWVHQRTIK----RQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKG-DTLYNHIHKLGHNFTTPSKLKILRQISE
.| .| ||| | .  ....       |.  |  ||  .  .||||| |||| |   |    ..|.||  ||  ||| |||     . . ....| .||  
KVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPH---LAIVMSLCKGSQTLYHHIHVRREKLDMNRTMQIAQQICQ

GMEYLHAKGIQHGGLSSK
|| ||||||| |. |.||
GMGYLHAKGIIHKDLKSK

Kinase AqueK675.AA RAF 170-282 36 2.2e-24 75.7 In-house 14-132 (282) Show / Hide
Range on Protein: 170-282
Range on HMM: 14-132/282
Sequence Identity: 36% (44 aa)

TVQKGYWHGNVWVHQRTIKR--QEDVRS---FANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGH--NFTTPSKLKILRQI
|| .| |||.| |    ..   .|...    | |||  .   || || |||| .   |  .|. |.     . .|| |||      .|     . |.||.
TVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKFDMHWLIDISRQV

SEGMEYLHAKGIQHGGLSSK
. ||.||||| | |  | |.
CQGMDYLHAKNIIHRDLKSN

Kinase AqueK675.AA TKL-Unique 196-282 28 8.9e-15 48.69 In-house 42-141 (290) Show / Hide
Range on Protein: 196-282
Range on HMM: 42-141/290
Sequence Identity: 28% (29 aa)

FANEVNTLCCIR-HENIQLFMGVCLD-LPAGDTFGIIMSEVKGDTLYNHIH---------KLGHNFTTPSKLKILRQISEGMEYLHAKG--IQHGGLSSK
| ||||.. ... |.|| ..||.| |  ..   . |.|. . | .||...|         .  ....   ..|. ..|. ||.||| ..  | |. | |.
FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSS





Kinase AqueK675.AA TKL 170-282 21 3.6e-14 47.43 In-house 8-169 (364) Show / Hide
Range on Protein: 170-282
Range on HMM: 8-169/364
Sequence Identity: 21% (36 aa)

TVQKGYWHG---------NVWVHQRTIKRQE-DVRS--------------------------FANEVNTLCCIR--HENIQLFMGVCLDLPAGD------
.| ||.|.|         . .|   ..|... | ..                          |  |. .....|  |.|| .|||.|.. | |       
EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPV

----TFGIIMSEVKGDTLYNHIHKLGHNFTTPSKLKILRQISEGMEYLHA--------KGIQHGGLSSK
     ..|.|  ..| .|....|        . .... ..|. ||.|||.        ..| |  | ||
GPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSK

Kinase AqueK675.AA TKL 333-408 17 8.1e-11 35.2 In-house 265-364 (364) Show / Hide
Range on Protein: 333-408
Range on HMM: 265-364/364
Sequence Identity: 17% (17 aa)

KPTPSTDIFAFGTIAYELTTLKLPFLNQSLLDLI---------WSVGNNGHQ-SLK---------LLPRSC---FRSVIHRCWSH--TRRTTFKDILSSI
. ....|...|| . .|. | ..|. ..   . |         . |...|..  ..           . .|   ... . .||.|  . | .|..||. .
EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL





S_TKc AqueK675.AA S_TKc 154-414 16 8.9e-11 -18.85 SMART 1-231 (231) Show / Hide
Range on Protein: 154-414
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

SEEIQLYGEAASSCKETVQKGYWHGNVWVHQRTIKRQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKG--DTLYNHIHKLGHN--
 | ... |. | ..   ...         ..  ||.    ... .|.. |   .|.||  . .|. |    | . ..|  . |   .|. .|.| |..  
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTTPSKLKILRQISEGMEYLHAKGIQHG------------------GLSSKLVTINHRVCISLSFHNTNNRQLEGCDLPYLTPEEIRSITQLSNGYL
   |.     ....|| ...||.| .|| |                   ||. .|                         . |. || .           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------TTFCGTPWYMAPEVL-----------

FLPTKPTP-STDIFAFGTIAYELTTLKLPFLNQSLLDLIWSVGNNGHQSLKLLPRSCFRSVIHRCWSH--TRRTTFKDILS---SIQDNTSF
    . .. . |. ..| | ||. . . ||    .  ..  .|            . ... | .|.    ..| |  ..|     |     |
----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK675.AA Pkinase_Tyr 190-274 25 2.4e-09 32.27 Pfam 42-132 (270) Show / Hide
Range on Protein: 190-274
Range on HMM: 42-132/270
Sequence Identity: 25% (24 aa)

QED--VRSFANEVNTLCCI-RHENIQLFMGVCLDLPAGDT--FGIIMSEVKGDTLYNHIHKL---GHNFTTPSKLKILRQISEGMEYLHAKGI
.|.   ..| .|..... . .|.||  ..|||.  . |.     |.|  ...  |... .|    ....|.. .|.. .||..|||||..|..
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT--DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNC

Kinase AqueK675.AA TyrKc 157-408 20 5.7e-08 -93.77 SMART 1-280 (280) Show / Hide
Range on Protein: 157-408
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

IQLYGEAASSCKETVQKGYWHGNVWVHQR----TIKRQEDVRSFANEVNTLCCI--RHENIQLFMGVCLD-----LPAGDTFGIIMSEVKGDTLYNHIHK
|.|  .  . .  .| || |       .     ..|    .. | .| . .| .  .|.||  . |||..     . ..  . .     .|| . ....|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK-DYLRK

LGHNFTTPSKLKILRQISEGMEYLHAKGIQHGGLSSK-----------LVTINHRVCIS------LSFHN-------TNNRQLE--GCD--LPY--LTPE
 ....... .|..  ||..|||||| |         .           ||. ||.| ||         .           |. |  |..  ||.  . ||
HRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

EIRSITQLSNGYLFLPTKPTPSTDIFAFGTIAYELTTL-KLPFLN-----QSLLDLIWSVGNNGHQSLKLL---------PRSCFRSVIHRCWSH--TRR
 |       | . |     |. .|...||   .|. |. . |  .      |  ..|  | . .                |   .. .. .|| .    |
CI-------NYGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDR

TTFKDILSSI
 ||..| . .
PTFSEIHECF

Kinase AqueK675.AA NZAK 155-276 27 7.8e-08 21.86 In-house 2-128 (329) Show / Hide
Range on Protein: 155-276
Range on HMM: 2-128/329
Sequence Identity: 27% (35 aa)

EEIQLYGEAA--SSCKETVQKGYWHGNVWVHQRTIKRQEDVRSFANEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSE-VKGDTLYNHI---HKLGH
|||   |..   |  |    |     |  |    .|       | .|.  |  ||| ||  ..  |.     |..  | .| . |. | . .   .| . 
EEISFIGGCQFFSRVKKCRKKNTEIANEQVDKVHCKIITKCDFFYHETDILEKIRHFNIPRYYSACIKHAEDDNYHCIYMEWMEGGNLTQFLMNDKKQLR

NFTTPSKLKILRQISEGMEYLHAKGIQH
 |      |..  | |.| ||| ..| |
-FKEHRIIKMIADIAETMSYLHKHHIIH

Kinase AqueK675.AA RAF 335-408 26 1.4e-07 22.07 In-house 195-275 (275) Show / Hide
Range on Protein: 335-408
Range on HMM: 195-275/275
Sequence Identity: 26% (22 aa)

TPSTDIFAFGTIAYELTTLKLPFL-NQSLLDLIWSVGNNGHQSLKLL--PRSCFRSV---IHRCWSHTR--RTTFKDILSSI
....| .||||. ||| .  .|.  .|.   .|| |.  |  .....    .| ...   .  ||| ..  | .| .|...|
SFQSDVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVC-RGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI

Kinase AqueK675.AA TK 248-277 36 1e-06 17.57 In-house 230-264 (486) Show / Hide
Range on Protein: 248-277
Range on HMM: 230-264/486
Sequence Identity: 36% (13 aa)

HNFTTPSKLKILRQISEGMEYLHAK------GIQHG
|..|.. .| . .||..||||||.|      .. |.
HQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHR

Kinase AqueK675.AA KSR 335-370 36 2e-06 17.7 In-house 194-229 (272) Show / Hide
Range on Protein: 335-370
Range on HMM: 194-229/272
Sequence Identity: 36% (13 aa)

TPSTDIFAFGTIAYELTTLKLPFLNQSLLDLIWSVG
....| .||||| ||. .  .|| .|    .|| ..
SHHSDVYAFGTIWYEMICGEWPFKYQCAESIIWQMC

Kinase AqueK675.AA Ciliate-E6 238-282 22 3e-06 16.28 In-house 35-82 (154) Show / Hide
Range on Protein: 238-282
Range on HMM: 35-82/154
Sequence Identity: 22% (11 aa)

TLYNHIHKLGHNFTTPSK---LKILRQISEGMEYLHAKGIQHGGLSSK
.|...||..  .    ..   .|.. |.....||||.|.. .. .. |
NLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLK

Kinase AqueK675.AA Ciliate-B1 239-276 42 3e-06 18.04 In-house 104-141 (290) Show / Hide
Range on Protein: 239-276
Range on HMM: 104-141/290
Sequence Identity: 42% (16 aa)

LYNHIHKLGHNFTTPSKLKILRQISEGMEYLHAKGIQH
|||.| . . |||. ..| .. || .| .|||. .| |
LYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICH

Kinase AqueK675.AA Pkinase 182-276 22 3.6e-05 19.37 Pfam 32-131 (293) Show / Hide
Range on Protein: 182-276
Range on HMM: 32-131/293
Sequence Identity: 22% (23 aa)

VHQRTIKRQEDVRSFA-NEVNTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKGD----TLYNHIH-KLGHNF--TTPSKLKILRQISEGMEYLHAKG
.  |..| ..|.. .  .|.  .  ..|.||  . ... |   .|   ..|  . |.     |. .|. . . .|  .     ....|| .|.||.|..|
IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG

IQH
| |
IIH

Kinase AqueK675.AA LZK 339-408 34 0.000119 11.51 In-house 169-241 (241) Show / Hide
Range on Protein: 339-408
Range on HMM: 169-241/241
Sequence Identity: 34% (26 aa)

DIFAFGTIAYELTTLKLPFLNQSLLDLIWSVGNNGHQSLKLL-PRSC---FRSVIHRCWSH-TR-RTTFKDILSSI
||. || .  |. |  .|. .      || ||.|   ||.|. | .|   |.  .  |||  .| |  |. ||. .
DIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSN---SLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW

Kinase AqueK675.AA RAF 311-366 27 0.000784 7.97 In-house 173-231 (282) Show / Hide
Range on Protein: 311-366
Range on HMM: 173-231/282
Sequence Identity: 27% (16 aa)

YLTPEEIR-SITQLSNGYLFLPTKP-TPSTDIFAFGTIAYELTTLKLPF-LNQSLLDLI
.. || ||  . .     |.  . | ..  |...||.. ||| | ..|.  . .  |.|
WMAPEVIRNLMIDWRGDVLMQDENPYSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQI

Kinase AqueK675.AA TKL-Unique 339-408 21 0.003381 7.34 In-house 210-290 (290) Show / Hide
Range on Protein: 339-408
Range on HMM: 210-290/290
Sequence Identity: 21% (18 aa)

DIFAFGTIAYELTTLKL------PFLNQSLLDLIWSVGNNGHQSLKL-LPRSC---FRSVIHRCWSH--TRRTTFKDILSSI
|...||.. .|. | |.      |. . .   ..  |      .. . .| .|   .|  | .|| |  . | .| .|....
DVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase AqueK675.AA LZK 207-281 33 0.010195 4.9 In-house 45-115 (241) Show / Hide
Range on Protein: 207-281
Range on HMM: 45-115/241
Sequence Identity: 33% (25 aa)

RHENIQLFMGVCLDLPAGDTFGIIMSEVKGDTLYNHIHKLGHNFTTPSKLKILRQISEGMEYLHAKGIQHGGLSS
.|.||  | |||   |    . |||       ||. . . . . |        .|| .||.|||   | |  | |
KHPNIIEFKGVCTQSPC---YCIIMEYCPHGQLYE-VLRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKS

Kinase AqueK675.AA Pkinase 335-408 15 0.012494 10.38 Pfam 190-293 (293) Show / Hide
Range on Protein: 335-408
Range on HMM: 190-293/293
Sequence Identity: 15% (16 aa)

TPSTDIFAFGTIAYELTTLKLPFLNQ----SLLDLIWSVGNNGHQSLKLLPR-----------------------SCFRSVIHRCWS--HTRRTTFKDIL
.|. |....| | ||. . ..|| ..    . .| .. . ....  |.                           . ....| .|.    ..| |...||
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

SS--I
 .  .
QHPWF

Kinase AqueK675.AA TK 388-408 21 0.052554 1.65 In-house 464-486 (486) Show / Hide
Range on Protein: 388-408
Range on HMM: 464-486/486
Sequence Identity: 21% (5 aa)

VIHRCWSH--TRRTTFKDILSSI
.. .||..   .| ||..... .
LMQQCWHYDPEDRPTFSQLHEQL