Gene AqueK678 (A.queenslandica)

AqueK678

Species: A.queenslandica
Alias: AqueK678
External Links:
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
AqueK678.AA Protein None 851 None Fasta, JSON
AqueK678.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of AqueK678.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD AqueK678.AA RBD 103-173 32 2e-19 71.77 SMART 1-76 (76) Show / Hide 
Range on Protein: 103-173
Range on HMM: 1-76/76
Sequence Identity: 32% (25 aa)

VLIRAHLPEGQRTIVPIRQGVTIQDALMKAMKTRNLTPNTCIVYAES-----PRLLIEWDTDTTQLSGKEVFVVVF
.... ||| .|||.| .| |.|..|.|||. |.|.|.| .|.|.. .      .  ..|... . | |.|..|.. 
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
RBD AqueK678.AA RBD 103-170 36 4e-17 62.13 Pfam 1-74 (77) Show / Hide 
Range on Protein: 103-170
Range on HMM: 1-74/77
Sequence Identity: 36% (27 aa)

VLIRAHLPEGQRTIVPIRQGVTIQDALMKAMKTRNLTPNTCIVY-----AESPRLLIEWDTDTTQLSG-KEVFV
 ....||| .||. |. | |.|..|.|||. |...|.|  | ||      |. .  . |.|| . | |  |..|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWV
C1_1 AqueK678.AA C1_1 184-232 30 6.3e-17 65.79 Pfam 1-55 (55) Show / Hide 
Range on Protein: 184-232
Range on HMM: 1-55/55
Sequence Identity: 30% (17 aa)

HFFVRK-TFIALAFCDVCKKLL-----FQGFRCETCGFRYHQRCSPRVPIQCGGV
| .|.. .|   .||..|....     .||..|..|....|.||...||. ||. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 AqueK678.AA C1 184-229 22 2.1e-13 51.77 SMART 1-61 (61) Show / Hide 
Range on Protein: 184-229
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HFFVRKTFIALAFCDVCKKLLFQ---------GFRCETCGFRYHQRCSPRVPI-------QC
| .....|   ..|..|.|....         |.||. |....|..|...||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 AqueK678.AA C1_3 195-222 23 2.9e-05 14.89 Pfam 1-30 (30) Show / Hide 
Range on Protein: 195-222
Range on HMM: 1-30/30
Sequence Identity: 23% (7 aa)

AFCDVCKKLLF--QGFRCETCGFRYHQRCS
 .|..|.. .    ...| .| |  |..| 
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase AqueK678.AA RAF 548-807 59 4.8e-167 545.95 In-house 1-282 (282) Show / Hide 
Range on Protein: 548-807
Range on HMM: 1-282/282
Sequence Identity: 59% (167 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTEQQMQA---FKNEVAVLMKTRHANILLFMGWTSKPR---LTIVTQWCDGSTLFSHIHVLED--RF
..|..|||||||||||.|.|||.||||.|||..|| .||||   |||||||. ||||.|||||||..|||    . ||||||..|.|. |||| |   .|
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

EMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWD--GNEKVRQPTGSILWMAPEVIR-----------MEEPDPYTF
.| ..||| ||..|| ||||||.||||||||||||||.|||||||||||.||||||   ||... |||..||||||||||           | .  ||.|
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

YCDVYSFGVVVYELISGQLPY-PHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNLES
  ||||||.| |||.....||  |...||||.||.|||.|||| |  |.|.||. ..|   | .|....|||| |. . .. 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase AqueK678.AA RAF 548-805 52 1.5e-152 513.14 In-house 1-275 (275) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-275/275
Sequence Identity: 52% (144 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTE-QQMQAFKNEVAVLMKTRHANILLFMGWTSKP---RLTIVTQWCDGSTLFSHIHVLED-RFEMY
...|||||.|.|||||.|.|||.|||| ||.  ||  .|.|||||||... |||| ||.||||...||    . |||||| ||||..|||| .. .|.| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

KIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVK-TRWD--GNEKVRQPTGSILWMAPEVIRME---------EPDPYTFYCDV
..|.| .|..||.|||||| ||||||||.|||||....|.|.||||.||| .||   .. ...||.|.|.|||||||||          .  |..|. ||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YSFGVVVYELISGQLPYPHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
|.||.| |||..|..|| | | ..||..||.|| ||.|.| ||...||. | |   |  .....||.| |. . .
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase AqueK678.AA TKL 554-805 25 1.4e-88 300.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 554-805
Range on HMM: 1-364/364
Sequence Identity: 25% (93 aa)

IGSGSFGTVYKGKWHG-----------PVAVKKLNVS------------------------NPTEQQMQAFKNEVAVLMK-TRHANILLFMG--------
||||.||.||||||.|           .|||||...                         .|. .... |..|....|. .|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-WTSKP-----RLTIVTQWCDGSTLFSHIHVLEDRFEMYKIIDICRQTAQGVDYLHA--------KQIIHRDLKSNNIFLHDDMT--------------V
 .  .|      | ||...|.| .|....|       . .........|.|..|||.        ..||||||||.||......|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVKT------------------RWDGNEKVRQPTGSILWMAPEVIRMEEPDP-------------YTFYCDVYSFGVVVYELISGQLPYPHV
||.||||.....                  . .....   . |.. ||||||.|......             |.  |||||||.| .|......|| . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

QDRDQI------LFMVGRG--FLRPDPS---------SARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
  ...|      .......  .||| .          .  .|.|.|.|.|. .|.. . ..|| | ..   |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK678.AA Pkinase 548-805 25 3.5e-72 250.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

IEVGERIGSGSFGTVYKGKWHGP---VAVKKLNVSNPTEQQMQAFKN--EVAVLMKTRHANILLFMGWT-SKPRLTIVTQWCDGS----TLFSHIH-VLE
...|..|||||||.|||....|    ||||......  ... |.  .  |.... . .| ||. . .|  .|... .|. .|.|      ||..|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRF--EMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTV----KIGDFGLATVKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTFYCDV
 .|  ..  ......|...|..|.|.. |||||||. ||........    ||.||||| ..  .  |.    ..|.. .|||||||  .  .|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YSFGVVVYELISGQLPYPHV---QDRDQILFMVGRGFLRPDPSSARKDTP-------------------KSFKQLCIKCCQFEKDDRPLFHQVYNN--L
.|.|...||...|..|.|.     . .  ..|. |   .| ...  .. .                   ...|... .|...   .|| ..|. .   .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK678.AA TKL-Unique 550-805 30 1.1e-63 217.93 In-house 1-290 (290) Show / Hide 
Range on Protein: 550-805
Range on HMM: 1-290/290
Sequence Identity: 30% (91 aa)

VGERIGSGSFGTVYKGKWHG-PVAVKKLNV-SNPTEQQMQAFKNEVAVLMKTR-HANILLFMGWTSK-----PRLTIVTQWCDGSTLFSHIH--------
... ||.|..|.||||||.| |||.|.... . .  . || |.||| .. | . |.||...||.. .     |.. ||.  |.|..| ...|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VLEDRFEMYKIIDICRQTAQGVDYLHAKQ--IIHRDLKSNNIFLHDD-----MTVKIGDFGLATVKTRWDGNEKVRQ-------PTGSILWMAPEVIRM
   .  . | ..... .. ||| .||| ..  |||||||| |. .  .     . .|| ||||...... . . . .        . ||..||||||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

EEPDPYTFYCDVYSFGVVVYELISGQL------PYPHVQDRDQILFMVGR--GFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
.. . |.  .||||||.|..|......      || .. |..|.. ||      .||  ..   . ||... |  .|.  . ..|| | .... |
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIPN---HCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK678.AA S_TKc 548-808 25 3.7e-63 217.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-808
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

IEVGERIGSGSFGTVYKGKWHG---PVAVKKLNVSNPTEQQMQAFKNEVAVLMKTRHANILLFMGWTSKPRLTIVTQWCDG--STLFSHIHVLEDR----
 |... ||.|.||.|||.....    ||.|...         . ...|...|.| .| ||  . ..    .| .|.  |||   .||..|.    .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTF-YCDVYSFGVV
 |    .  ...|......|.| ..|||||||  ||.| .  ..||.|||||..          .   |.  .|||||.      .|..  ||..|.|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

VYELISGQLPYPHVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYN------NLESL
.||...|. |.|   . .... ..|               ....|..  ||.|.. ..||   .. .      . . .
LYEMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK678.AA KSR 548-805 35 2.8e-61 207.66 In-house 1-272 (272) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-272/272
Sequence Identity: 35% (97 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVS-NPTEQQ-MQAFKNEVAVLMKTRHANILLFMG-WTSKPRLTIVTQWCDG-STLFSHIHVLEDRFEMYK
.. ||.|| | ||.|..| ||| ||.| ..      | . . .|| ||. . .||| || ||||   . | | ||.  | |  ||..||||  ... | .
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

IIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVK---TRWDGNEKVRQPTGSILWMAPEVIRM-----EEPD----PYTFYCDVY
 ..| .| .||. ||||| ||| |||| |||.     | | ||||  ..       .  . . | |    .||| ||      .|.     |.. . |||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

SFGVVVYELISGQLPYPHVQDRDQILFMVGRG-FLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
.|| . ||.| | .|. . |   .|.. ...|  .|.. ..      .  | .   |  .|...|| | .    |
AFGTIWYEMICGEWPF-KYQCAESIIWQMCQGEGMRQVLRNVQ--CGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase AqueK678.AA Dicty4 548-807 35 1.1e-60 201.18 In-house 1-277 (277) Show / Hide 
Range on Protein: 548-807
Range on HMM: 1-277/277
Sequence Identity: 35% (100 aa)

IEVGERIGSGSFGTVYKGKWHG-PVAVKKLNVSNPT--EQQMQAFKNEVAVLMKTRHANILLFMGWTS----KP-RLTIVTQWCDGSTLFSHIHV-----
| ...|||.||||.||||.| |  |||||||  | .  |  ...|..||. . | || ||.||||       .| .. |||  .   .|.| .|      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-LEDRFEMYKIID---ICRQTAQGVDYLHA--KQIIHRDLKSNNIFLHDDMTVKIGDFGLAT-VKTRWDGNEKVRQPTGSILWMAPEVIRMEEPDPYTFY
  ..  .   |.    ... .|.|. .||.    |||||||| |.   ....||..||||..  |.  | . .   . |. .|||||| . .   ||.  
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

CDVYSFGVVVYELISGQLPYP-HVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNN--LES
 |||||| | .|.  .| ||. | .. .|. . |..  |||  ..   ..|.|.|.|  .|   .   || | .. .   ||.
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPD---WCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK678.AA Pkinase_Tyr 548-805 28 7.5e-56 189.77 Pfam 1-270 (270) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-270/270
Sequence Identity: 28% (81 aa)

IEVGERIGSGSFGTVYKGKWH-------GPVAVKKLNVSNPTEQQ--MQAFKNEVAVLMKT-RHANILLFMGWTS---KP-RLTIVTQWCDGSTLFSHIH
|. |. .|.|.||.||||.|.        |||||.|.  . ...|  ...| .|......  .| ||. ..|  .   .| .. ||.  . .  | .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VL---EDRFEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWDGNEKVRQPTGSIL---WMAPEVIRMEEPDPYTFY
     .... |  ....|.| |.| .||..|..|||||   |. ......|||.|||||      |..  .|. .|. |   |||||.|.  .   .|  
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGK---FTTK

CDVYSFGVVVYELIS-GQLP-YPHVQDRDQILFMV-GRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
 ||.||||. .|... |. | || . .  ... ..  .|        . ...|.   .|  .| ... .||| | .... |
SDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK678.AA TK 548-805 16 1.6e-55 184.25 In-house 1-486 (486) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

IEVGERIGSGSFG---TVYKGKWHG----------------------------PVAVKKLNVSNPTEQQ-MQA--------------FKNEVAVLM--KT
|..|. .|.| ||   .||||.|.|                            ||||| |   ....|. ...              . .| ....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHANILLFMGWTSKPR-------------LTIVTQWCDGST----LFSHIHV-LEDRFEMYKIID-----------------------------------
.| ||. . |  ....             . ||. ....      | .. .   ......   .|                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------------------------------------ICRQTAQGVDYLHAK------QIIHRDLKSNNIFLHDDMT-----------VKIGDFGLATV
                                      .|.| |.|  |||.|      ...||||   |. ......           .||.||||. .
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

KT----RWDGNEKVRQPTGS----------------------------ILWMAPEVIRMEE------PDPYTFYCDVYSFGVVVYELIS-GQLPYPHVQD
..    | .....    ..|                            | |||||...  .         .|   ||.||||...|. . || ||.   .
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

R---------DQILFMVGRG--------------FLRPDPSSAR----------KDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
          .... .. ||              . .| |  .              |. . .|. .|.... .||| | |... |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK678.AA MLK 548-805 29 6.6e-52 178.34 In-house 1-291 (291) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-291/291
Sequence Identity: 29% (87 aa)

IEVGERIGSGSFGTVYKGKWHGPV------AVKKLNVSN----PTEQQMQAFKNEVAVLMKTRHAN----ILLFMGWTSKP-R-LTIVTQWCDGSTLFSH
|.. | ||||||| |.||.|..        |||. . .      |. . ..|. |.  | . .| |    |  |.|  ..|   . ||...|.|. |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IHVLED-------------RFEMYKIIDICRQTAQGVDYLHAKQ---IIHRDLKSNNIFLHD------DMTVKIGDFGLATVKTRWDGNEKVRQPTGSIL
.|  ..             .  .  ..... | |.|..|||...   |||||||| || ...      ..|.|| |||... ... .   .  .. |.  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-GTYA

WMAPEVIRMEEPDPYTFYCDVYSFGVVVYELISGQLPYP-HVQDRDQILFMVGRGFLRPDPSSARKDTPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
|||||||   . ..|.  |||.|.||| .|......||  |.     .  ..  |  .| ||.     |...|.|  .| . .  .|| | |.   |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST----CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK678.AA STE 548-796 24 3.2e-49 169.84 In-house 1-346 (359) Show / Hide 
Range on Protein: 548-796
Range on HMM: 1-346/359
Sequence Identity: 24% (85 aa)

IEVGERIGSGSFGTVYKGKWHGP------------------VAVKKLNVSNPT---------------EQQMQAFKNEVAVLMKTR--HANILLFMGWTS
 |  |.||.|.||||||.. | .                  .|.|..|..| .               ...|| ...|. ...| .  | ||  . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KP--------RLTIVTQWCDGSTLFSHIH-VLEDRF-------------EMYKIIDICRQTAQG-VDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLA
|          | |.  ..|| .| . |. . .  .             |   |. ||||. .|  .||| ..|||||.|. ||.|     ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ-IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

TVKTR--------------WDGNEKVRQPTGSILWMAPEVIRMEE---PDPYTFYCDVYSFGVVVYELISGQLPY---PHVQDRDQILFM--VGR-----
.  |                .. .|    .|.  |||||||. ..    ..|.. ||..|.| .. |.. |. |.   .. .   .|.|.  ...     
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----GFLRPDPSSAR---------------KDTPKSFKQLCIKCCQFEKDDRP
    |   | |.                  .   ..||.   ||.| . ..||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase AqueK678.AA CAMK 553-747 18 1.5e-48 154.17 In-house 1-334 (425) Show / Hide 
Range on Protein: 553-747
Range on HMM: 1-334/425
Sequence Identity: 18% (62 aa)

RIGSGSFGTVYKGKWH-GP--------------VAVKKLN-----------------VSNP---------TEQQMQAFKNEVAVLMK-------TRHANI
 .|.||||.|....    .              ||.| ..                 ...          ... .. ...|.....|        .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LLFMGWTSKPR--------------------LTIVT---QWCDGS----TLFSHIHVLED--------------RFEMYKIIDICRQTAQGVDYLHAKQI
. .  .   |.                    . .|.     |.|      ||..|   ..              ||.      . || ...|.|.| . |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKSNNIFLHDDM-----------------TVKIGDFGLATVKTRWDG---------------------NEKVRQPTGSILWMA-PEVIRM------
.|||||  || | |..                 ..|| |||.|..... ..                     ..| . . |.   || |||..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-----EEPDPYTFYCDVYSFGVVVYELISGQLPY
     || ..|.. ||. | ||. | . .| .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
Kinase AqueK678.AA TyrKc 548-805 28 6.6e-40 139.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-805
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

IEVGERIGSGSFGTVYKGKWHGPVAVKKLNVSNPTEQQMQAFKNEVAVLMKT--RHANILLFMGWTSK--------PRLTIVTQWCDGSTLFSHIHVLED
|. |. .|.| ||.||||.|  .||||.|. .      ...| .|  ...|   .| ||. . |  ..        . | ||.  ...  | ....  ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RFEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDMTVKIGDFGLATVKTRWD-----GNEKVR----QPT--GSILWMAPEVIRMEEPDPYTF
.. | . ...| | |.| .||| |..|||||   |. .... ||||.||||.   .  |     .  ..     .      | |||||.|       .|.
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

YCDVYSFGVVVYELIS-GQLPYPHV----QDRDQILFMVGRGFLRPDPSSARKD-----TPKSFKQLCIKCCQFEKDDRPLFHQVYNNL
  ||.||||. .|. . || ||| .     . ....  | .|. .| | ..         |.   |.  .|.... .||| | ...  .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF