Gene AqueK689 (A.queenslandica)

AqueK689

Species: A.queenslandica
Alias: AqueK689
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
AqueK689.AA Protein None 424 None Fasta, JSON
AqueK689.kin_dom Protein Kinase Domain None 116 None Fasta, JSON

Protein domain

Protein domains of AqueK689.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK689.AA TKL 197-311 21 7.9e-20 68.09 In-house 1-165 (364) Show / Hide 
Range on Protein: 197-311
Range on HMM: 1-165/364
Sequence Identity: 21% (36 aa)

LGEGGWAEVKVADFRG----------LKVAAKSLYKLIISPYNI-------------------------GTFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| .||  . .||            || | . .   .  ..                          .. .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PIILTELM-PTSLRKELESGGVAYPAILSISLDVACALNYLHLFKP-----HPMLHRD
            . | .|..   ||.  |       . .....||.|...||||  .|      |..|||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD
Kinase AqueK689.AA CZAK 194-311 33 5.8e-14 47.23 In-house 4-134 (279) Show / Hide 
Range on Protein: 194-311
Range on HMM: 4-134/279
Sequence Identity: 33% (44 aa)

EVVLGEGGWAEVKVADFRGLKVAAKSLYKLIISPYNIGT-----FSREMNIASKIRHPNLLQFIGATTEGN---PIILTELMP-TSLRKELE--SGGVAY
. . |.|   ||. |  ||  || | .. ..      ..     | .|  | || .||| .||.|| .|..     | .| |   |||. |   .  .  
GQTIGQGFFGEVYKAYWRGKDVAIKIIH-RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQ

-PAI-LSISLDVACALNYLHL-FKPHPMLHRD
 | . ... .|.|   ||||  .|| | ||||
NPHLQWNMAIDIARGMNYLHDNWKPNPILHRD
Kinase AqueK689.AA Dicty4 193-300 29 1.9e-13 41.39 In-house 3-129 (277) Show / Hide 
Range on Protein: 193-300
Range on HMM: 3-129/277
Sequence Identity: 29% (37 aa)

TEVVLGEGGWAEVKVADFRGLKVAAKSL--YKLIISPYNIGTFSREMNIASKIRHPNLLQFIGATT-----EGNPIILTELM-PTSLRKELES------G
.|. .|.|. .||  .  || .|| | |   .   . . .  | .| .| .||||||...| || |      | . | ||.|  ..| . | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GVAYP--AILS---ISLDVACALNYLH
 .  .   |..   . .|.|  .|.||
SIKLDWPLIKRAMRMAFDAARGMNWLH
Kinase AqueK689.AA TKL-Unique 196-311 25 1.2e-11 37.49 In-house 4-137 (290) Show / Hide 
Range on Protein: 196-311
Range on HMM: 4-137/290
Sequence Identity: 25% (35 aa)

VLGEGGWAEVKVADFRGLKVAAKSLYK-LIISPYNIGTFSREMNIASKIR-HPNLLQFIGATT-----EGNPIILTELMPT-SLRKELE-----------
..|||| ..|. . .|| .|| |.. .   .|.  . .|..| |. .|.. |||.....|...     ..| .| .| .|  ||.. |            
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

SGGVAYPAILSISLDVACALNYLHLFKPHPMLHRD
.    .  .... .|.| ...|||  .|  ..|||
NCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRD
Kinase AqueK689.AA RRM_1 313-362 32 1.2e-11 43.15 Pfam 22-73 (73) Show / Hide 
Range on Protein: 313-362
Range on HMM: 22-73/73
Sequence Identity: 32% (17 aa)

FGKIKKVELAPD--TAPGKHRGWGFIDYENHKSAADAISSMNLFDLGGQFLR
||.|. ... .|   . |..||..|. .|.| .|..||..|| . ..|  .|
FGPIESIRIMRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
Kinase AqueK689.AA DRK 192-311 32 9.2e-11 32.72 In-house 2-125 (258) Show / Hide 
Range on Protein: 192-311
Range on HMM: 2-125/258
Sequence Identity: 32% (41 aa)

MTEVVLGEGGWAEVKVADFRGLKVAAKSLYKLIIS-PYNIGTFSREMNIASKIRHPNLLQFIGATTE-GNPIILTELMPT-SLRKEL--ESGGVAYPAIL
   .  | |...||     || .|| | |  . |     .  | || |. .. ||||  ||.|. ..   . | .| ||  || . |  ||     | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPMLHRD
.. .|.|  ..|||   |   .|||
QMMFDCAKGMIYLHCCNPI-IIHRD
Kinase AqueK689.AA MLK 233-311 22 9.7e-10 30.1 In-house 52-152 (291) Show / Hide 
Range on Protein: 233-311
Range on HMM: 52-152/291
Sequence Identity: 22% (23 aa)

FSREMNIASKIRHPN----LLQFIGATTE-GN-PIILTELMPT-SLRKELESG---------------GVAYPAILSISLDVACALNYLHLFKPHPMLHR
| .| .......|||      || |. .. ..   |..| ..  ||   | ..                .    .....|..| ...|||  .|.|  ||
FEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHR

D
|
D
Kinase AqueK689.AA TK 235-300 12 2.2e-09 26.82 In-house 87-251 (486) Show / Hide 
Range on Protein: 235-300
Range on HMM: 87-251/486
Sequence Identity: 12% (20 aa)

REMNIASKIR-----HPNLLQFIGATTEGN-------------PIILTELMP-TS----LRKELESGG--------------------------------
.|...... .     |||.....|. |.|              ..|..|.||  .    ||. | .                                  
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------VAYPAILSISLDVACALNYLH
                                             .  .  | .....||.. |||
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH
Pkinase_Tyr AqueK689.AA Pkinase_Tyr 190-311 25 7.1e-09 30.69 Pfam 1-136 (270) Show / Hide 
Range on Protein: 190-311
Range on HMM: 1-136/270
Sequence Identity: 25% (36 aa)

IRMTEVVLGEGGWAEVKVADFR------GLKVAAKSLYKLIISPYN--IGTFSREMNIASKI-RHPNLLQFIGATT-EGNP---IILTELMPT-SLRKEL
|.. .. ||||   ||. .  .      ...|| |.| |   .. .  .  | ||..| ... .|||.....|. | .| |   .| .|.||  .|.. |
ITFGKK-LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

ESG-----GVAYPAILSISLDVACALNYLHLFKPHPMLHRD
 .       .  . .|......|....||.  .   . |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRD
Kinase AqueK689.AA Shk 193-268 39 1.1e-08 27.6 In-house 3-80 (269) Show / Hide 
Range on Protein: 193-268
Range on HMM: 3-80/269
Sequence Identity: 39% (31 aa)

TEVVLGEGGWAEVKVADFRGLKVAAKSLYKLIISPYNIGTFSREMNIASKIRHPNLLQFIGATT--EGNPIILTELMP
.|  || |    |  .  || .|| | . |   . .    |  |  | |||.|||.. | || |   |   | |||||
REDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMP
Kinase AqueK689.AA LISK 196-254 26 1.6e-08 23.61 In-house 1-64 (296) Show / Hide 
Range on Protein: 196-254
Range on HMM: 1-64/296
Sequence Identity: 26% (17 aa)

VLGEGGWAEVKVADFR--GLKVAAKSLYKL---IISPYNIGTFSREMNIASKIRHPNLLQFIGA
..|.|. ..|     |  |  .| | . ..    . | .. .. ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK689.AA TKL-ciliate2 192-320 29 2.6e-08 23.24 In-house 2-133 (273) Show / Hide 
Range on Protein: 192-320
Range on HMM: 2-133/273
Sequence Identity: 29% (40 aa)

MTEVVLGEGGWAEVKVADFRGLKVAAKSLYKLIISPY-NIGTFSREMNIASKIRHPNLLQFIGATTEGN--PIILTELMPTSLRKELES--GGVAYPAIL
 ..  . |||.  .  | .| . || |  .|.       |  |  | .    .||||.  |.|| |.     ||.      ||   | .    ...    
EIQNKITEGGYGIIYKAKWREIVVAVKK-FKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

SISLDVACALNYLHLFKPHPMLHRDAFGKIKKVE
 | ||.|    |||  .| |..|||   .||. |
RIALDIARGVHYLHSSNP-PIIHRDLKRQIKHKE
Kinase AqueK689.AA Pkinase 235-300 15 4.1e-07 26.24 Pfam 47-125 (293) Show / Hide 
Range on Protein: 235-300
Range on HMM: 47-125/293
Sequence Identity: 15% (12 aa)

R--EMNIASKIRHPNLLQFIGAT-TEGNPIILTELMPT-----SLRKELE---SGGV--AYPAILSISLDVACALNYLH
|  |  |  ...||| ......  ..... . .|...      .|   ..   .|..   .  . .. . ....|.|.|
RLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH
S_TKc AqueK689.AA S_TKc 191-402 13 7e-07 -75.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 191-402
Range on HMM: 1-231/231
Sequence Identity: 13% (36 aa)

RMTEVVLGEGGWAEVKVADFRG--LKVAAKSLYKLIISPYNIGTFSREMNIASKIRHPNLLQFIGATTEGNPIILTELMPT---SLRKELESGG------
     ..|.|. ..|. .  ..   .|| | .           .. ||..| .| .|||. .....  ...  . .|....   .|.. ... |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VAYPAILSISLDVACALNYLHLFKPHPMLHRD--------------------AFGKIKKVE------LAPDTAPGKHRGWGFIDYENHKS-AAD-----
      . ..   ..|||.|.|  .    .|||                    ..    .        .||                 .   ..|     
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDEHIKICDFGLARQL---TTFCGTPWYMAPEVL-------------GYGKCKCDWWSCG

-----AISSMNLFDLGGQFLRVGREKQGLETDADIIVKIFVVFAK----PTEAES-TVKSLNGRWF
      ..   .|.   |  .. .     .   |.| |....  .      ||    ..  .  ||
CILYEMLCGYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK689.AA TyrKc 190-397 16 7.2e-07 -111.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 190-397
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

IRMTEVVLGEGGWAEVKVADFRGLKVAAKSLYKLIISPYNIGTFSREMNIASKI--RHPNLLQFIGATTE--------GNPIILTELMPT-SLRKELESG
|.. . .||||   ||  .  . ..|| |.| .       .  | ||..| .|.  .|||.....|. |.        . . |..|.||  .|.. | . 
ITLGK-KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

G--VAYPAILSISLDVACALNYLHLFKPHPMLHRD--------AFGKIKKV-------ELAPD---------TAP----GKH--------------RG--
.  .  .  ||.....||  .|||    ..  |||        . ... |.       ..  |           .    |..               |  
RPKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------------------WGFIDYENH----KSAADAISSMNLFDLGGQFLRVG-REKQGLE--------TDADIIVKIFVVFAK-----PTEAESTVKS
                   |   |..     .|....|          .... | | .|  .          ...   .    .      || .|  .. 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVI----------EYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HEC

L
.
F
Kinase AqueK689.AA RRM 293-364 15 7e-06 26.74 SMART 1-121 (121) Show / Hide 
Range on Protein: 293-364
Range on HMM: 1-121/121
Sequence Identity: 15% (19 aa)

ACALNYL--HLFKPHPMLHRDA----------------FGKIKKVELAPDTA---------------------PGKHRGWGFIDYENHKSAADA--ISSM
      |  .      .|..                  ||.|... . .|                        |..|| .|...|.. .|..|  |. |
TIFVGNLNDPWDVTEEDLREFFKDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDAEKAMVIEMM

N---LFDL--GGQF---LRVG
|    ...  .|.    .||.
NASKGHEFRDDGRPTGHIRVK
Kinase AqueK689.AA RRM_1 381-408 39 0.00022 18.03 Pfam 46-73 (73) Show / Hide 
Range on Protein: 381-408
Range on HMM: 46-73/73
Sequence Identity: 39% (11 aa)

FVVFAKPTEAESTVKSLNGRWFGGRVIT
|| |... .||. ....||. |.||.|.
FVEFEDHEDAEKAIQAMNGKEFNGREIR
Kinase AqueK689.AA LISK 286-300 53 0.008858 4.63 In-house 104-118 (296) Show / Hide 
Range on Protein: 286-300
Range on HMM: 104-118/296
Sequence Identity: 53% (8 aa)

LSISLDVACALNYLH
..|.||.||.. |||
VKIALDIACGMSYLH