Gene RSK-p3_b (S.moellendorffii)

RSK-p3_b

Species: S.moellendorffii
Alias: RSK-p3_b
External Links:
Annotation:

Classification

Group: AGC
Family: RSK
Subfamily: RSK-p3

Sequence

Name Sequence Type Origin Length Description Download
RSK-p3_b.AA Protein None 991 None Fasta, JSON
RSK-p3_b.NA RNA None 2976 None Fasta, JSON
RSK-p3_b.kin_dom Protein Kinase Domain None 312 None Fasta, JSON

Protein domain

Protein domains of RSK-p3_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PAC RSK-p3_b.AA PAC 233-275 23 4e-08 34.25 SMART 1-43 (43) Show / Hide 
Range on Protein: 233-275
Range on HMM: 1-43/43
Sequence Identity: 23% (10 aa)

CGRLLNYKKDGTPFWNLLTIAPIKDENGKILKYIGMQVEVSKS
 . . .|.|||...| .... || |..|... .|...  ..  
TWEYRFYRKDGSWIWVQVSWTPIRDWQGQPQYWICVHRDITER
PAS RSK-p3_b.AA PAS 158-272 16 0.000591 15.65 Pfam 1-120 (120) Show / Hide 
Range on Protein: 158-272
Range on HMM: 1-120/120
Sequence Identity: 16% (21 aa)

KELREALST-FQQTFVVSDATKADYPILYASAGFYNMTGYTSKEVIGRNCR-FLQGSGTDP--IDVSKIRDALREGQSFCGRLLNYKK-----DGTPFWN
...|  . .      .| |   .|  |||... .  |.|.. .||.|..   ..     ..  ....... ....|.. ..   . ..     ||.|.| 
EHYRRIIENNLPDPIFVWD---EDGWILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWC

LLTIAPIKDENGKILKYIGMQVEV
... .|. |. |.|. ....   .
EVRWCPYRDPGGEIHGFCCFMHDI
PAS_3 RSK-p3_b.AA PAS_3 183-205 39 0.010426 11.47 Pfam 1-23 (94) Show / Hide 
Range on Protein: 183-205
Range on HMM: 1-23/94
Sequence Identity: 39% (9 aa)

ILYASAGFYNMTGYTSKEVIGRN
|.|.| ... |.|||. |..|..
IIYWSPRWEEMFGYTPEEFHGKS
PAS_3 RSK-p3_b.AA PAS_3 220-269 26 0.018747 10.61 Pfam 42-94 (94) Show / Hide 
Range on Protein: 220-269
Range on HMM: 42-94/94
Sequence Identity: 26% (14 aa)

SKIRD--ALREGQSFCGRLLNYKKDGTPFWNLLTIAPIK-DENGKILKYIGMQ
.....  .|..||.. .     .|||.  |   .  .|. ||||.....||  
QAHQEHWKLKKGQPYECEYRIRHKDGEWRWVRDRGRVIRWDENGQPVRMIGVH
PAS_3 RSK-p3_b.AA PAS_3 444-466 39 0.027471 10.05 Pfam 1-23 (94) Show / Hide 
Range on Protein: 444-466
Range on HMM: 1-23/94
Sequence Identity: 39% (9 aa)

IIFASDSFLELTEYTREEILGRN
||..|....|.. ||.||..|..
IIYWSPRWEEMFGYTPEEFHGKS
PAC RSK-p3_b.AA PAC 494-537 13 0.139327 7.19 SMART 1-43 (43) Show / Hide 
Range on Protein: 494-537
Range on HMM: 1-43/43
Sequence Identity: 13% (6 aa)

TVQLLNYTKSGKPFWNLFHLQAMKDNKASFKVFFFFLIYVSDVL
|... .|.| | ..| ... ... | ..   ...   ...    
TWEYRFYRKDGSWIWVQVSWTPIRD-WQGQPQYWICVHRDITER
PAS RSK-p3_b.AA PAS 444-533 13 0.778051 5.13 Pfam 24-120 (120) Show / Hide 
Range on Protein: 444-533
Range on HMM: 24-120/120
Sequence Identity: 13% (13 aa)

IIFASDSFLELTEYTREEILGRNCRFLQGAGTDV---ETVKKIRDAIREQRDITVQLLNYTK-----SGKPFWNLFHLQAMKDNKASFKVFFFFLIYV
| ...... ... ..|||..|..   |    ...   |...... ....... . .  . ..      |.|.| . .   . | .   . |..|.. .
ILYWNRAAERMFGWSREEVMGKMLYDLIHHDDHRCCLEFHDQLWQCMQQGEE-RMFEITFRTPGQHRDGRPRWCEVRWCPYRDPGGEIHGFCCFMHDI
Kinase RSK-p3_b.AA AGC 639-950 27 6.1e-142 369.58 In-house 1-395 (395) Show / Hide 
Range on Protein: 639-950
Range on HMM: 1-395/395
Sequence Identity: 27% (118 aa)

FRPVKSLGFGDTGSVHLVELK------GSSQYFAMKSMDKSV---MINRNKVHRACAE------------REILGLMD----------HPFLPT-LYASF
|. .| .| |  | |.||. |      .. .|.||| ..|..   ....|.|... .|            |.|| ...          |||.   |. ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTATH--VCLVTDFCP---------GG-ELFLQMEKQ-PLKCFAEEVVRFYAAE-------VLVALEYLHC-LGVVYRD-LKPENVLVQANGHLCLTDFD
|. .|  ...| ...|         || ||||.. ..   ..| ||..||||||       .. ||||||  .|...|| |||||.|  ..||..|||| 
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSLL------------------------------------STTKPQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLARSN------SFVG--TEEYIAPE
|.                                      .. . .. ..                        . .| .      .|.|  | ||.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNN-MS-------------------Q-E-DDTTR-KKRDRTWTFCGPCTPEYMAPE

IIKGSGHGSAVDWWA--FGILVYEMLFGRTPFRGKNRQ----------KTFENVL------QKDLVFP---SSKPVRVFSFPSFFSRKHKVFSMQVSLQA
|.    .| |.|||.  .|.| ||||.|..||.|.|.|          ..|....      .... ||   ..               .     ..| .|
IL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP---------------QFPEDRWFSPEA

KQLIRSLLQRDPSKRLGGLN------GAYEIKRHPFF
| ||. ||..||.|||| ..      || |||.||.|
KDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK-p3_b.AA S_TKc 639-950 26 8.8e-89 302.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 639-950
Range on HMM: 1-231/231
Sequence Identity: 26% (85 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPG--GELFLQMEKQPL---
.. .. .| |  |.|...  |.. ...|.| ..           ... |..||   .||.. .|| .||. .|...|...|.|  |.||  ..|..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-KCFAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLSLLSTTKPQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLARSNSFVG
 . | | ..|||..... ||||.| .|...|||||||.|.    |. ..|| |. .                                       ..|.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------TTFCG

TEEYIAPEIIKGSGHGS-AVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKDLVFPSSKPVRVFSFPSFFSRKHKVFSMQVSLQAKQLIRSLLQRDP
| .|.|||..   |.|  ..|||..|...|||| |..||.  . |..|....                                | .||..|| .||.||
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDP

SKRLGGLNGAY---EIKRHPFF
.||..         .|| ||.|
EKRPTA-EALQDEWDIKCHPWF
Kinase RSK-p3_b.AA RSK 642-892 32 3.8e-88 299.16 In-house 1-241 (278) Show / Hide 
Range on Protein: 642-892
Range on HMM: 1-241/278
Sequence Identity: 32% (88 aa)

VKSLGFGDTGSVHLVELK---GSSQYFAMKSMDKSVMINRNK-VHRACAEREILGLMD-HPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLK-C
.| || |. |.| |.  .    . |..|||  .|.....|.| . .. .||.|| .   |||. ||. .||| ... |....|.|||||   .|.  . |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQA---NGHLCLTDFDLSLLSTTKPQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLARSNSFVG
| |. ..||.||. .|.|.|| .|...|||||||.|      .||. ||||... ..                              ...   . ..|..
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF------------------------------RCDHNQWTMTFCY

TEEYIAPEIIK----GSGHGSAVDWWAFGILVYEMLFGRTPFRG---KNRQKTFENVLQKD--LVFP--SS
| ||.|||..|    ..||. |.||| .|.| ||||.|..||.|   .||...........  | .|  ..
TIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQY
Kinase RSK-p3_b.AA Pkinase 639-950 26 1.4e-78 272.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 639-950
Range on HMM: 1-293/293
Sequence Identity: 26% (89 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRAC-AEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPGG----ELF--LQ-MEK
.. .. .| |  |.| .   ||... .|.| ..|.      .....  .| .|.  ..||.  .|| .|.. .|...|...|.||    .||  .. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QPLKCFAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHL----CLTDFDLS-LLSTTKPQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLA
 ..  | |....||. ..| .|||.|  |...|||||||.|.  |||.    ...|| |. ...                                 .  
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------Y-NNS

RSNSFVGTEEYIAPEIIK-GSGHGSAVDWWAFGILVYEMLFGRTPFRGK------NRQKTFENVLQKDLVFPSSKPVRVFSFPSFFS--RKHKVFSMQVS
  ..|.|| .|.|||.|. |...|..||.|..|...||||.||.||.|.      . .. ........| |..... ..  |. |.   . |..|   .|
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHF-HWTF-HNWS

LQAKQLIRSLLQRDPSKRLGGLNGAYEIKRHPFF
  .|..|...|..||.||..    | .|. ||.|
EECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase RSK-p3_b.AA AktR 639-895 38 1.2e-74 254.35 In-house 1-231 (268) Show / Hide 
Range on Protein: 639-895
Range on HMM: 1-231/268
Sequence Identity: 38% (100 aa)

FRPVKSLGFGDTGSVHLVELK-GSSQYFAMKSMDKSVMINRNKVHRACAEREILG-LMDHPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLKCF
|.  | || |  | | ||. |  . ...|||. .|. .|.||. |..  || |.  ...|||.  |. .||| ..  .. ..|||||||    |.  | |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK--KKF

AEEVVRFYAAEVLVALEYLHCL-GVVYRDLKPENVLVQANGHLCLTDFDLSLLSTTKPQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLARSNSFVGTEE
 ||..|||.|..| ||||||    ..|||||||| |   .||...||| ||                                |. .   . .||.|| |
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-----------------------------LQFMMHYDEKAYSFCGTPE

YIAPEIIKG-SGHGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKD-LVFPSSKPV
|.|||.|.   ||. .||||||||..|||..| .||  ||..  |.. . |. . || ....
YMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYF
Kinase RSK-p3_b.AA RSK-Unclassified 639-786 45 9.7e-68 211.68 In-house 1-148 (283) Show / Hide 
Range on Protein: 639-786
Range on HMM: 1-148/283
Sequence Identity: 45% (68 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLKCFAE
|   . .| || | | ||. |.. | .||| . |. || .||. ..  |..|. . .|||  ||| ||||     |. ..|.||..|  .     |||.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLS
. |||||.|| .|||||| ....||||||.|..    ||  |||||||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS
Kinase RSK-p3_b.AA Akt 639-783 43 2.1e-53 169.0 In-house 1-145 (264) Show / Hide 
Range on Protein: 639-783
Range on HMM: 1-145/264
Sequence Identity: 43% (64 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYF-AMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLKCFA
|. .| || |  | | ||. | . ... |||.  |.. |..|.|  . .|| ||  ..|||.  |. ||||... ..|.|.|.|||||  . ..  . | 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRK--RRFS

EEVVRFYAAEVLVALEYLHCLGVVYRD-LKPENVLVQANGHLCLTDF
|.  |||.||.  |.|.||  ...||| |||||.|. ..||.|||||
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDF
Kinase RSK-p3_b.AA SGK 639-786 36 1.3e-47 144.85 In-house 1-172 (283) Show / Hide 
Range on Protein: 639-786
Range on HMM: 1-172/283
Sequence Identity: 36% (64 aa)

FRPVKSLGFGDTGSVHLVELKGS------------------SQYFAMKSMDKSVMI-------NRNKVHRACAER-EILGLMDHPFLPTLYASFQTATHV
|.  | .| |  | | .|. |.                    . .|||   |   |       .....    |||  || .| |||.  |  .|||..  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVTDFCPGGELFLQMEKQPLKCFAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLS
 .| |.  |||.|  . .   |.| | ..||||||.  |||||| . ..||||||||.|  . ||.||||| |.
YFVMDYVNGGEMFYHLQRE--KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase RSK-p3_b.AA PKA 639-783 38 1.3e-45 157.89 In-house 1-145 (263) Show / Hide 
Range on Protein: 639-783
Range on HMM: 1-145/263
Sequence Identity: 38% (57 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPT-LYASFQTATHVCLVTDFCPGGELFLQMEKQPLKCFA
|  ...|| |  | |.|.  |.| .|.||| ..|.  . .. |.. . |. || ...|||. . .|..||....  .| ...||||.|  . |   ..| 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKS--GRFS

EEVVRFYAA-EVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDF
. . .|||| ..  |||||| .  .|||||||| |   |||. .|||
NPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDF
Kinase RSK-p3_b.AA RSK 639-786 34 2.9e-43 150.05 In-house 1-152 (271) Show / Hide 
Range on Protein: 639-786
Range on HMM: 1-152/271
Sequence Identity: 34% (54 aa)

FRPVKSLGFGDTG---SVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLKC
.   . .| |  .    .. .. | . |..|||  .|..  .. .  .. .|| ||   .|||  .|. .||....| ...||. ||.||  . ||  |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQ--KM

FAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQAN----GHLCLTDFDLS
| |. |.||.||.. |.||||..|.|.|||||||.|. .     ||. ..|| ..
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFA
Kinase RSK-p3_b.AA p70 639-786 32 6.7e-40 138.87 In-house 1-175 (299) Show / Hide 
Range on Protein: 639-786
Range on HMM: 1-175/299
Sequence Identity: 32% (57 aa)

FRPVKSLGFGDTGSVHLVELKG---SSQYFAMKSMDK-SVMINRNKVHRAC-------------------------AEREILGLMDHPFLPTLYASFQTA
| ..| || |  | | .|       .....||| . | .. .|      .                          ||| ||    |||.  |  .||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

THVCLVTDFCPGGELFLQMEKQPLKCFAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLS
    |. .. .||||| . |..    . |....||..|. .|||.|| .|..||||||||..  . ||. |||| |.
GKLYLILEYLHGGELFMHLERHGI--WMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLC
Kinase RSK-p3_b.AA MAST 831-950 37 3.3e-39 123.82 In-house 225-334 (334) Show / Hide 
Range on Protein: 831-950
Range on HMM: 225-334/334
Sequence Identity: 37% (49 aa)

VGTEEYIAPEIIKGSG-HGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKDLVFPSSKPVRVFSFPSFFSRK-HKV-FS------MQVSLQAKQ
.|| .|||||.|.| | || .||||. || .|| | | .|| .......|.|.|...                       .  .          |  |. 
CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNC-------------------NEIEWPEGGDINDDEAMSPEAQD

LIRSLLQRDPSKRLGGLNGAYEIKRHPFF
||. ||| ||.||||  |||.|.|.||||
LIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase RSK-p3_b.AA MAST 639-786 41 4.4e-39 123.4 In-house 1-146 (334) Show / Hide 
Range on Protein: 639-786
Range on HMM: 1-146/334
Sequence Identity: 41% (61 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLMDHPFLPTLYASFQTATHVCLVTDFCPGGELFLQMEKQPLKCFAE
|  .| .. |  | | ||. | . . |||| ..|| |||.| |.   .|| || . . ||   .. ||||....|.| ..  || ..  ..     .| |
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG--YFDE

EVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLS
. ...| ||.  .|||||  | | |||||.|.|  .|||  |||| ||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS
Kinase RSK-p3_b.AA RSK-Unclassified 826-890 55 2.2e-38 117.84 In-house 178-242 (283) Show / Hide 
Range on Protein: 826-890
Range on HMM: 178-242/283
Sequence Identity: 55% (36 aa)

RSNSFVGTEEYIAPEIIKGSGHGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKDLVFP
| |||.|||||.|||.|.. ||. |||||  ||..|||||| .|..| |.  ||.|...... ||
RTNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFP
Kinase RSK-p3_b.AA Akt 828-890 43 8.1e-29 89.18 In-house 160-223 (264) Show / Hide 
Range on Protein: 828-890
Range on HMM: 160-223/264
Sequence Identity: 43% (28 aa)

NSFVGTEEYIAPEIIKGSGHGSAVDWWA-FGILVYEMLFGRTPFRGKNRQKTFENVLQKDLVFP
..| || ||.||||..| ||. |||||. .|.. |||..|| ||  ..... |.. ..... ||
KTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFP
Kinase RSK-p3_b.AA PKA 832-892 46 4.3e-26 93.01 In-house 160-223 (263) Show / Hide 
Range on Protein: 832-892
Range on HMM: 160-223/263
Sequence Identity: 46% (30 aa)

GTEEYIAPEIIKGS-GHGSAVDWWAFGILVYEMLFGRTPFRGK--NRQKTFENVLQKDLVFPSS
|| ||.|||||... ||| .|||||.|||.||||.| .||. .  .  ...|  .. .. ||..
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH
Kinase RSK-p3_b.AA SGK 829-892 39 6.7e-24 70.29 In-house 184-247 (283) Show / Hide 
Range on Protein: 829-892
Range on HMM: 184-247/283
Sequence Identity: 39% (25 aa)

SFVGTEEYIAPEIIKGSGHGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKDLVFPSS
.| || || |||.... .|. .||||  |.. |||..|  ||  .|.|  ..| . ..| .| .
TFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ
Kinase RSK-p3_b.AA p70 829-884 53 8.4e-23 79.46 In-house 197-252 (299) Show / Hide 
Range on Protein: 829-884
Range on HMM: 197-252/299
Sequence Identity: 53% (30 aa)

SFVGTEEYIAPEIIKGSGHGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQ
.|.|| || ||||. ..||. |||||. |.| | || |  || | ||.|| . .|.
TFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILK
Kinase RSK-p3_b.AA RSK 829-888 45 1.4e-19 66.68 In-house 164-223 (271) Show / Hide 
Range on Protein: 829-888
Range on HMM: 164-223/271
Sequence Identity: 45% (27 aa)

SFVGTEEYIAPEIIKGSGHGSAVDWWAFGILVYEMLFGRTPFRGKNRQKTFENVLQKDLV
.| .| .|.|||..|  ||. |.||| ||.| |||| |.||| .|.|. .... .  .|.
TFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLG
Kinase RSK-p3_b.AA Akt 914-950 57 3.6e-19 57.84 In-house 227-264 (264) Show / Hide 
Range on Protein: 914-950
Range on HMM: 227-264/264
Sequence Identity: 57% (22 aa)

QVSLQAKQLIRSLLQRDPSKRLG-GLNGAYEIKRHPFF
..| ..| ||..||..||.|||| | |.| ||||||.|
WISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK-p3_b.AA SGK 914-950 56 4.6e-18 51.95 In-house 247-283 (283) Show / Hide 
Range on Protein: 914-950
Range on HMM: 247-283/283
Sequence Identity: 56% (21 aa)

QVSLQAKQLIRSLLQRDPSKRLGGLNGAYEIKRHPFF
|.| .|. ||  |||.||.||||  ... |||.||||
QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase RSK-p3_b.AA RSK-Unclassified 915-950 56 1e-16 48.51 In-house 247-283 (283) Show / Hide 
Range on Protein: 915-950
Range on HMM: 247-283/283
Sequence Identity: 56% (21 aa)

VSLQAKQLIRSLLQRDPSKRLGGLNG-AYEIKRHPFF
.| ... ||. |||| |.||||   | | .|||||||
ISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase RSK-p3_b.AA RSK 915-950 59 6.6e-14 47.54 In-house 242-278 (278) Show / Hide 
Range on Protein: 915-950
Range on HMM: 242-278/278
Sequence Identity: 59% (22 aa)

VSLQAKQLIRSLLQRDPSKRLG-GLNGAYEIKRHPFF
.|  || ||| .|.|||.|||| | ..| |||.||.|
LSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK-p3_b.AA AktR 911-950 47 9.6e-14 49.55 In-house 227-268 (268) Show / Hide 
Range on Protein: 911-950
Range on HMM: 227-268/268
Sequence Identity: 47% (20 aa)

FSMQVSLQAKQLIR-SLLQRDPSKRLG-GLNGAYEIKRHPFF
.....| |.| ||   ||...| |||| . ||. |||.||.|
YPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK-p3_b.AA RSK 915-950 51 2.4e-12 40.58 In-house 235-271 (271) Show / Hide 
Range on Protein: 915-950
Range on HMM: 235-271/271
Sequence Identity: 51% (19 aa)

VSLQAKQLIRSLLQRDPSKRLGG-LNGAYEIKRHPFF
.|  || |.| .| ||| .|||   ||. .||.||.|
ISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK-p3_b.AA p70 916-950 41 4.2e-10 32.92 In-house 264-299 (299) Show / Hide 
Range on Protein: 916-950
Range on HMM: 264-299/299
Sequence Identity: 41% (15 aa)

SLQAKQLIRSLLQRDPSKRLG-GLNGAYEIKRHPFF
.  .. ||. || |.|..|.| |.. | .|..||||
THEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK-p3_b.AA PKA 914-950 39 1.4e-09 38.13 In-house 223-263 (263) Show / Hide 
Range on Protein: 914-950
Range on HMM: 223-263/263
Sequence Identity: 39% (16 aa)

QVSLQA---KQLIRSLLQRDPSKRLGGLN-GAYEIKRHPFF
... .|   | ||..|||.|..||.| .  |.  ||.|..|
HFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase RSK-p3_b.AA TyrKc 639-910 18 1.3e-08 -83.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 639-910
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FRPVKSLGFGDTGSVHLVELKGSSQYFAMKSMDKSVMINRNKVHRACAEREILGLM--DHPFLPTLYASFQTA-------THVCLVTDFCPGGEL--FLQ
 .  | || |  | |.. ..|   .  | |.. ..       .   . | .|.     .|| .  ||.   .          ...|. ..|.| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

MEKQPLKCFAEEVVRFYAAEVLVALEYLHCLGVVYRDLKPENVLVQANGHLCLTDFDLSLLSTTK-PQRCFQLIRPVLPSGKRKPKIPPPPAFVAEPLAR
  .     .  .    ..  .    ||||  ... |||   |.|| .|..   .|| ||   . .  |                         ...   |
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------------------ESKDYYR

SNSFVGTEE-----YIAPEIIKGSGHGSAVDWWAFGILVYEML-FGRTPFRG-----KNRQKTFENVLQKDLVFPSSK---------PVRVFSF------
. .  |.         ||| |. .   .. | |.||.. .|.. .| .|  |     .. |  .|.| | .   .            |  ...       
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

------PSFFSRKHKV
      |.|   ... 
EDPEDRPTFSEIHECF