Gene HisK_i (S.moellendorffii)
HisK_i
Species: S.moellendorffii
Alias: HisK_i
External Links:
Annotation:
Sequence
Protein domains of HisK_i.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CHASE | HisK_i.AA | CHASE | 154-341 | 22 | 3.1e-27 | 98.56 | Pfam | 1-203 (203) | Show / Hide |
Range on Protein: 154-341 Range on HMM: 1-203/203 Sequence Identity: 22% (47 aa) KQPSVLDQETFAVYTKR---TEFERPLMTGVAYAQRLFHSEREAFERRYG------WEI--KTM--TTKKVQSPQAEYAPAVFTQNSL---SYLESLDML ..|| ....|. |... . . | . |...|.|. |..|.|||.. ..| ... ..... .....|.| .. . .||. ASDSV-SRDEFERYVNSLDQLLRRYPGIQGIGWAPRVPHEQRAAFEQQMRAEGFPDFNIQNWEPDADGQWPAPHRDPYFPITYIYPFDWGNERALGFDMY SGKANCDNILRARSSGKGVLTTPMRLLESNHLGIVVTFTVYKEDLPEDASEEE--RI---AASAGYVGGAFDFELLVTNLLKQLAGSQSIIVNVYDVTNE | . . ..||| .|. ||| | .|. .. |... . || . . ....|. | .| |.| . |. . |. .|| .. . | ...||.|.. SEPVRREAMERARDTGQPVLTGPVTLVQEGQRGFLMYMPVY-RGGMPPTTVEQPPRRPGNQALWGWVYAVFRMDDLMEGLL-NQ---DGIAIRIYDGTDG SKPLLMYGP . . |.|| ADGELFYGS |
|||||||||
| HisKA | HisK_i.AA | HisKA | 428-493 | 35 | 5.7e-27 | 96.84 | SMART | 1-89 (89) | Show / Hide |
Range on Protein: 428-493 Range on HMM: 1-89/89 Sequence Identity: 35% (32 aa) AKSQFLATVSHEIRTPMNGVLGMLQMLMD----------TDLDPTQ-------------RDYAGTAHESGKQLIKLINEVLDQAKIESG ||.||||..|||.|||.....|....| | ||||| | |.| |........ .|||..|| ..||.| AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG |
|||||||||
| HisKA | HisK_i.AA | HisKA | 428-493 | 46 | 3.1e-26 | 94.38 | Pfam | 1-69 (69) | Show / Hide |
Range on Protein: 428-493 Range on HMM: 1-69/69 Sequence Identity: 46% (32 aa) AKSQFLATVSHEIRTPMNGVLGMLQMLMD-TDLDPTQ--RDYAGTAHESGKQLIKLINEVLDQAKIESG ||.||||..|||.|||.....|....| | ||||| | |.| |........ .|||..|| ..||.| AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG |
|||||||||
| HATPase_c | HisK_i.AA | HATPase_c | 540-699 | 30 | 9.3e-35 | 123.19 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 540-699
Range on HMM: 1-120/120
Sequence Identity: 30% (52 aa)
GDPARLHQIITNLVGNSVKFTEQ-GHIFVCVHMEDELTTVSKEEGFDSCNTLSGVKAADLRLSWDSFKSLVGGLEDRNCGELTDVRIVFNVEDTGVGIPL
||| ||||...|||.|..|.|.. ||| | || .| .... |||.|.|||
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-------------------------------------------------DHVRITVEDNGPGIPP
------LAQDRVFTPFMQADS-STSRNYGG--TGIGLSISKCLVELMQGSMDFVSQPGIGATFRFSVVFK
..|.| || ..|. |. |.||| ||.||.|.. .||...|.... |.|| |.||.| . ..
EMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE
|
|||||||||
| HATPase_c | HisK_i.AA | HATPase_c | 540-700 | 25 | 9.8e-35 | 122.63 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 540-700 Range on HMM: 1-130/130 Sequence Identity: 25% (48 aa) GDPARLHQIITNLVGNSVKFTEQ--------------GHIFVCVHMEDELTTVSKEEGFDSCNTLSGVKAADLRLSWDSFKSLVGGLEDRNCGELTDVRI ||| ||.|...||..|..|.|.. |.| | || GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH------------------------------------------------------- VFNVEDTGVGIPL------LAQDRVFTPFMQADS--------STSRNYGG--TGIGLSISKCLVELMQGSMDFVSQPGIGATFRFSVVFKR .. |||.|.||| ..|.| || ..|. |.||.||| ||.||||.| .||...|.. . .||.|.. .| RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER |
|||||||||
| Kinase | HisK_i.AA | HisK | 540-699 | 18 | 7.2e-21 | 71.9 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 540-699
Range on HMM: 1-164/164
Sequence Identity: 18% (38 aa)
GDPARLHQIITNLVGNSVKFTEQG------HIFVCVHMEDELTTVSKEEGFDSCNTLSGVKAADLRLSWDSFKSLVGGLEDRNCGELT------------
|| |. ||. ||..|..|||..| .| . | .. . . . |
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNI----------------------------------KY-N----SIFIQKIQENMVQ
-----DVRIVFNVEDTGVGIPLLAQDRVFTPFMQ----------ADSSTSR--NYGGTGIGLSISKCLVELMQ--------GSMDFVSQPGIGATFRFSV
. | . |.|||.|.| | | .| . .. . | | |.||.|.. |.... .. ..|..|.| || | .
EQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYI
VFK
.
YNN
|
|||||||||
| REC | HisK_i.AA | REC | 875-992 | 24 | 7.1e-36 | 126.42 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 875-992 Range on HMM: 1-150/150 Sequence Identity: 24% (40 aa) KQILVVDDN----KVNRRVAA------GALTKYGAR--------VECVESGK-------AAIARLQPSH------------EFDACFMDVQMP------- . ||.|||. |.|.. . .|.| | . |... .|. .|...|| . ..| ..||..|| MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG EMDGFEATRKIREAEGHDCKCRLPILAMTADLIQATRDECTKCGMDGYVSKPFEEEQLYKAV .|||.|..|.|| ||...|| ..| .. . |.|.|..|||. |.| ... GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
|||||||||
| Response_reg | HisK_i.AA | Response_reg | 877-993 | 30 | 1e-31 | 116.15 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 877-993 Range on HMM: 1-115/115 Sequence Identity: 30% (37 aa) ILVVDDNKVNRRVAAGALT-KYGA-RVECVESGKAAIARLQPSHEFDACFMDVQMPEMDGFEATRKIREAEG-HDCKCRLPILAMTADLIQATRDECTKC .|.|||. ..|.. . .|. |.| .|. ...|..|....| | .| ..||..||.|||.|..|.|| ... .. .||...|| ... |. . VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH-PDLIIMDINMPGMDGLELCRRIRRQHPHPQ----TPIIMCTAHGDEDDAVEALQA GMDGYVSKPFEEEQLYKAVA |...|..||| ...|..|.. GANDYITKPFDPDELHAAIR |
|||||||||