Gene DNAPK (S.moellendorffii)

DNAPK

Species: S.moellendorffii
Alias: DNAPK
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: DNAPK

Sequence

Name Sequence Type Origin Length Description Download
DNAPK.AA Protein None 798 None Fasta, JSON
DNAPK.NA RNA None 2397 None Fasta, JSON

Protein domain

Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DNAPK.AA PIKK 384-677 34 4.1e-90 305.67 In-house 1-290 (290) Show / Hide 
Range on Protein: 384-677
Range on HMM: 1-290/290
Sequence Identity: 34% (102 aa)

TLVGFDETLISLSSKQRPKILTMRGSDEKEYKFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVLDDVIK
   ..|. .. . .||.|| ...||.|.||| . .||.||||.|||..|||  ||  |. | .| ||.|..|||.|||.||.|||.. |||. .| . .|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DGVAQQLAAAKRKEKAGDLLVELRNQYHQWVEKKGGSKSVHDCYKNLYTKVKAGEMEARMNALVAQVPWDALKTGLYKRTSSAESFLAMRSQFARSLSVM
.  ..   ...|.|.  .   ... .|  |. .    | . . . . | .    |.... . ..  .| | .|  .  . ...|.... |. ..||. ||
QWCQK---KHIRHEQEAQMNYQTC-MYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVM

SICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPELIPFRLTPQLTNVLLPLDSLGLLKNDMVRVLSALHKSRQMICAVMDVF
.. ||| | ||||. | .|||||| .| ||||..|. .   |||||..|||||....| . |    |.. . .. |. .. ..|  . .|..||
CMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase DNAPK.AA PI3_PI4_kinase 413-687 19 2.9e-55 194.71 Pfam 1-300 (300) Show / Hide 
Range on Protein: 413-687
Range on HMM: 1-300/300
Sequence Identity: 19% (66 aa)

EYKFIVKGGEDLR--LDQRIEQLF-----------------------AKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVLDDVIKDGVA
.|.||.|||.|||   |.|..|..                         || ... ||.. .|...|..| .|| . .||....|.|.. .. ...  . 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QQLAAA--------KRKEKAGDLLVELRNQYHQWVEKKGGSKSVHDCYKNLYTKVKAGEMEARMNALVAQVPWDALKTGLYKRTSSA-ESFLAMRSQFAR
.  ...         ..... . |.                               . ... . .   ...| ..|   ..|   .| | ... |..|.|
KCKHKHFNKEHKMWMKMWPDWWHLM-------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVR

SLSVMSICGYIAGVGDRHLANTLI--DMQTGSLVPIDFGYSFG-TGVILLPVPELIPFRLTP------QLTNVL------LPLDSLGLLKNDMVRVLSAL
|. .|.. .|| |.||||. | ..  |. || |..||||..|. .    ...||..|||.|.      .. ...       |.   |...  ..... ||
SCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRAL

HKSRQMICAVM-------DVFVREPLVDWKK
 .    . ...       . .|. .|..|..
RRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase DNAPK.AA DNAPK 550-687 36 9.6e-53 181.55 In-house 164-301 (301) Show / Hide 
Range on Protein: 550-687
Range on HMM: 164-301/301
Sequence Identity: 36% (51 aa)

VPWDALKTGLYKRTSSAESFLAMRSQFARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPELIPFRLTPQLTNVLLPLDSL
.| | ..  .    .. | .|..|..|.|.  |  | ..| |.||||| | .. | .|  . ||||.|||     |||||| ||||| . .| ..|.   
IPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKIN

GLLKNDMVRVLSALHKSRQMICAVMDVFVREPLVDWKK
|...  |.  . |. | | .    .|||...|..|||.
GIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN
Kinase DNAPK.AA PI3Kc 415-738 17 4.5e-46 160.3 SMART 1-336 (336) Show / Hide 
Range on Protein: 415-738
Range on HMM: 1-336/336
Sequence Identity: 17% (71 aa)

KFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVLDDVI--------------------------------
 .|.|.|.||| |.|. |.|  || ....| .|..| | ||.|..||....||....| |.  |  .                                 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

---------------------KDGVAQQLAAAKRKEKAGDLLVELRNQYHQWVEKKGGSKSVHDCYKNLYTKVKAGEMEARMNALVAQVPWDALKTGLYK
                     .  ..   .... ..   | ..|   ...                                                  
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN--------------------------------------------------

RTSSAESFLAMRSQFARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVP-----ELIPFRLTPQLTNVLL----PLDSLGLL
     |.. ..|..|.||. .... .|| |.||||. | ..||.|| .. ||||. || |  ..|..     |. |||||... .|      | .  |. 
-----EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYF

KNDMVRVLSALHKSRQMICAVMDVFVREPL-VDWKKEAARTASIRGGEEESHEQ-QHVELKIENA-------QRKLDLWNPAHVTLGELQSSVHA
.  ..|.. |. |..  | ... ..|. |.  .|...     .|.  ..  ... . .|. .. .         . ..    . .  ...   ..
RTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase DNAPK.AA DNAPK 382-481 50 3.6e-39 136.46 In-house 1-100 (301) Show / Hide 
Range on Protein: 382-481
Range on HMM: 1-100/301
Sequence Identity: 50% (50 aa)

HITLVGFDETLISLSSKQRPKILTMRGSDEKEYKFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVLDDV
|. . ||||    . |  ||| . .|| ||.|  |..||.||||.||||||||  || ..  | .|  ||| .||| .||     ||.  |||| || |.
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI
Kinase DNAPK.AA ATR 566-677 33 5.3e-26 85.24 In-house 157-267 (267) Show / Hide 
Range on Protein: 566-677
Range on HMM: 157-267/267
Sequence Identity: 33% (37 aa)

AESFLAMRSQFARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPELIPFRLTPQLTNVLLPLDSLGLLKNDMVRVLSALHK
.... . |. . ||  |... ||| | ||||  | |||  .| .| .|.   |. |  .  |||..|||||  . . . |. . || .  .. ..  . .
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

SRQMICAVMDVF
 |. | .|.| |
HRDDIMSVWDCF
Kinase DNAPK.AA FRAP 553-687 34 2.3e-23 82.77 In-house 117-251 (251) Show / Hide 
Range on Protein: 553-687
Range on HMM: 117-251/251
Sequence Identity: 34% (47 aa)

DALKTGLYKRTSSAESFLAMRSQFARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPELIPFRLTPQLTNVLLPLDSLGLL
. ||  |. .  . |  .  |  . ||| .||. ||| | ||||. | ... .|| .| ||||  |         ||.||||||  |.| .      |  
EDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNY

KNDMVRVLSALHKSRQMICAVMDVFVREPLVDWKK
.|    |.  .   .. . ||.. ||  ||  |. 
RNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase DNAPK.AA ATR 384-478 38 9.4e-21 67.07 In-house 2-96 (267) Show / Hide 
Range on Protein: 384-478
Range on HMM: 2-96/267
Sequence Identity: 38% (37 aa)

TLVGFDETLISLSSKQRPKILTMRGSDEKEYKFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVL
 . |||. .  |.| |.|| ....||| | |  . |  .||| | |  .    .| ..| |    .|.. ||||||||. .||... .|.||  |
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL
Kinase DNAPK.AA ATM 573-636 53 1.9e-18 55.17 In-house 137-199 (304) Show / Hide 
Range on Protein: 573-636
Range on HMM: 137-199/304
Sequence Identity: 53% (34 aa)

RSQFARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPELIPFRLT
|  . ||    || ||| |.||||  | ||  |   || || |  |  | | || || .|||||
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLT
Kinase DNAPK.AA FRAP 413-484 38 3.9e-18 63.3 In-house 1-72 (251) Show / Hide 
Range on Protein: 413-484
Range on HMM: 1-72/251
Sequence Identity: 38% (28 aa)

EYKFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVDNTCVLDDVIKD
|| |. || ||.| | |. |||. .|  |. .    |..||.. |..|| | . ||.  | .   |   |.|
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRD
Kinase DNAPK.AA SMG1 576-629 57 1.2e-15 48.2 In-house 190-242 (242) Show / Hide 
Range on Protein: 576-629
Range on HMM: 190-242/242
Sequence Identity: 57% (31 aa)

FARSLSVMSICGYIAGVGDRHLANTLIDMQTGSLVPIDFGYSFGTGVILLPVPE
.|||  |||. ||| |.||||| | |||| ||  | ||.   |  |  |  |||
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE
Kinase DNAPK.AA SMG1 392-473 36 4.8e-12 36.05 In-house 1-82 (242) Show / Hide 
Range on Protein: 392-473
Range on HMM: 1-82/242
Sequence Identity: 36% (30 aa)

LISLSSKQRPKILTMRGSDEKEYKFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLLQFVD
.  |  | .|| |   ||| | | .. || ||| || || |  . .| .              | |.| |.    ||.|.||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
Kinase DNAPK.AA ATM 415-469 40 4.1e-11 31.35 In-house 1-55 (304) Show / Hide 
Range on Protein: 415-469
Range on HMM: 1-55/304
Sequence Identity: 40% (22 aa)

KFIVKGGEDLRLDQRIEQLFAKMNSVLREDGACAKRELSMRTYAVIPVSQQCGLL
. .||| .||| |  . | |   | .|       || | . || |.|.||  | |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL
FATC DNAPK.AA FATC 766-798 48 9.4e-15 50.29 Pfam 1-33 (33) Show / Hide 
Range on Protein: 766-798
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

ICASVEEQVDCLVDQATDPNLLGRLWVGWQPWM
   |||.|||.|...||||. | ....||.||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW