FRAP

Species: S.moellendorffii
Alias: FRAP
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
FRAP.AA Protein None 2318 None Fasta, JSON
FRAP.NA RNA None 6957 None Fasta, JSON

Protein domain

Protein domains of FRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT FRAP.AA HEAT 182-212 22 0.027706 11.77 Pfam 1-31 (31) Show / Hide
Range on Protein: 182-212
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

FVDAIWIALRDPRQAIREHAVEALRACLTVI
.....  .|.||   .|| |...| . . ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT FRAP.AA HEAT 269-299 19 25.415683 1.51 Pfam 1-31 (31) Show / Hide
Range on Protein: 269-299
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

VLDIAFKFRDHRDRLVRRSITSLLPRIAHFL
.|.. .|  .. |  ||..  . | ... ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT FRAP.AA HEAT 509-539 32 0.000582 17.58 Pfam 1-31 (31) Show / Hide
Range on Protein: 509-539
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

AREAVVMHLEDDDAGVRRHAARCCCRLVEHS
  .... .|.|.|. ||. |..| ..|.||.
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

HEAT FRAP.AA HEAT 570-596 40 20.277145 1.85 Pfam 1-26 (31) Show / Hide
Range on Protein: 570-596
Range on HMM: 1-26/31
Sequence Identity: 40% (11 aa)

ILEKLLVAAVSDTDASVREDVFVSLGT
||. ||  . .|.|..||| .. .||.
ILPHLL-KCLNDPDWEVREAACWCLGQ

HEAT FRAP.AA HEAT 609-626 33 49.697725 0.5 Pfam 1-18 (31) Show / Hide
Range on Protein: 609-626
Range on HMM: 1-18/31
Sequence Identity: 33% (6 aa)

CLKAIFIAFNDQSFEVRK
 | ... ..||.. |||.
ILPHLLKCLNDPDWEVRE

HEAT FRAP.AA HEAT 738-769 28 0.001051 16.69 Pfam 1-31 (31) Show / Hide
Range on Protein: 738-769
Range on HMM: 1-31/31
Sequence Identity: 28% (9 aa)

LMPLIVDALRDTSAASKRDVAVRTLGQLVQNT
..|... .|.|.  .. |. |...||||... 
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC

DUF3385 FRAP.AA DUF3385 772-932 34 4.1e-47 167.53 Pfam 1-181 (181) Show / Hide
Range on Protein: 772-932
Range on HMM: 1-181/181
Sequence Identity: 34% (65 aa)

VVTPYTEFPHLLGLLLRILLNGELEWSTRNEVLKVLGVIGALDPHVNKRNELRLHPS----DGNRSSLSETVHGQTNDESLMEAWPTGGISA-ATEDYYS
|..||...|.|||.|..|| ... .|..| |..|..|..|||||.. | ||. .| .       | ....  ... .|..||      |.|  . ..||.
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKF-RDDQHQNQNNPCTDIMLM----MQGYSPLSNDEYYP

TVKVAINALMR-TLRDPSSSIYHQ-SVVKSL----MYIC---------------KVMPDLLLTIRNCED-NLREFIFCQLADLVAIVR
|  |.||.|||  |.||| | .|. .|| .     |||.               ...| .| ..| |.. .||||.| ||..|| ||.
T--VVINSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK

HEAT FRAP.AA HEAT 871-902 18 0.806729 6.7 Pfam 1-31 (31) Show / Hide
Range on Protein: 871-902
Range on HMM: 1-31/31
Sequence Identity: 18% (6 aa)

AINALMRTLRDPSSSIYHQSVVKSLMYICKVM
 ...|.. |.|| ..   ......|  .|...
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC

HEAT FRAP.AA HEAT 1044-1060 11 45.288347 0.64 Pfam 15-31 (31) Show / Hide
Range on Protein: 1044-1060
Range on HMM: 15-31/31
Sequence Identity: 11% (2 aa)

DIRRSTIKTFSRLLPCM
..|.........|....
EVREAACWCLGQLCEHC

HEAT FRAP.AA HEAT 1069-1099 25 0.933811 6.48 Pfam 1-31 (31) Show / Hide
Range on Protein: 1069-1099
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LLHPLLSVLDGTKDELRNDAVDAICVLATVL
.| .||. |. . .| |  |. ....|. ..
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

FAT FRAP.AA FAT 1365-1590 35 4.6e-81 271.65 Pfam 1-264 (408) Show / Hide
Range on Protein: 1365-1590
Range on HMM: 1-264/408
Sequence Identity: 35% (97 aa)

APMAASAAWNMGEWDE--MEEYVSQMD----NGDEMNVPTRGQDGT-GTGFAGAFFRAVLCI--RRSKYD--EAGIYAERARKCLATELAA-LVLESYDR
||.|| |||..|.|||  |.||.|.|.    . |  .    ..| . .... ..||.|.||.  .....|  ||  | ..||..| ||..| |. ||| |
APLAAEAAWRLGQWDETYMDEYISVMKKLLGE-DQ-L-TFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNR

AYSNMVRVQQLAELEEVIEYCTLQTGN-----PASEARASLIRRMWRDRIRGA-KRNVEVWQRLLSVRTLVLP--------------PTEDAETWLKFAS
.|. |||||.||||||.|.|..    |     . |...   .|..|..| .|   ||||||||.|..|..|..              |.||...|.|||.
HYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFAN

LCYKSGR-------------YDPEQSDPPPGYVVNPPVMLAYLKYLWSFGEESKRQTAYRRLQYLAL-DLAN
|| |.||             |||...|..|     |... |||||.|. |   ..| |...|.  ..  ...
LCRKHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATG---QQQEAFQHLREFTSCHMQH

FAT FRAP.AA FAT 1617-1680 38 6.1e-21 70.35 Pfam 342-408 (408) Show / Hide
Range on Protein: 1617-1680
Range on HMM: 342-408/408
Sequence Identity: 38% (27 aa)

WGK-AWHRWALFNTAALSHYSMKGDSVKA------AHHVVSAVSGYFKSIANASTNKGGDDSLQDILRLLT
| | |||.|||.| ....||  . .....       .||| ||...|.|||  .     . |.||.||||.
WYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQG----SNSRQDTLRLLW

HEAT FRAP.AA HEAT 1710-1740 19 0.023619 12.01 Pfam 1-31 (31) Show / Hide
Range on Protein: 1710-1740
Range on HMM: 1-31/31
Sequence Identity: 19% (6 aa)

VLPQIIARIHSHIPAVRELIQQLLVRIGQIH
.|| ..  ...  . |||   . |... ...
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC

Rapamycin_bind FRAP.AA Rapamycin_bind 1787-1885 67 8.6e-65 206.45 Pfam 1-100 (100) Show / Hide
Range on Protein: 1787-1885
Range on HMM: 1-100/100
Sequence Identity: 67% (68 aa)

ELIRVAILWHEMWYEALEEASRLYFGEHNKEGMLNVLEPLHRKLEEEGAVTLKEIAF--AYGRELQEAHEWCMEYRRTGNEAELTQAWDLYYHVFKRINK
|||||||||||||.|.||||||.|||.||.|.|.|.||||| .||  |  |..||.|  ..||.||||||||. |.|||.|..| ||||.||.||.||.|
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEK-GPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRK

Q
|
Q

Kinase FRAP.AA FRAP 1954-2204 66 2.6e-176 592.04 In-house 1-251 (251) Show / Hide
Range on Protein: 1954-2204
Range on HMM: 1-251/251
Sequence Identity: 66% (167 aa)

DYTFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHLIREYRDARKVPVNAEHRAMVSFAPDLDHLTL
.| ||||||||.||||||||||||.|.|| |   |  |.|||||| ..||| |.||||||..||||| |||.||.. ..  |.|.. | . ..| |||.|
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPL

IAKVEVFQHALEATDGDDLAKVFWLKSKTSEVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYSGKILHIDFGDCFEAAMTREKFPEKVPFRLT
. |||.|..... | |.||.|. ||||  ||.|.|||||||||||.|||.||.||||||||||.||.||.|||.||||||||| ||.|||||||.|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMLVKAMEVSGIEGNFRSICEDVMHVLRSNKDSVMAMMEAFVHDPLINWRL
|||| |||. |||||.| .|| || |.| .|.|||| .|||| |||..|||
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL

Kinase FRAP.AA PIKK 1925-2194 44 1e-144 487.04 In-house 1-290 (290) Show / Hide
Range on Protein: 1925-2194
Range on HMM: 1-290/290
Sequence Identity: 44% (129 aa)

TIQSFDPQLIVMPSKQRPRKCTIKGSDGQDYTFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHLIR
 |...|. ..||..||.|.| .|.|.||  | .|.|||||||||.||||||.|.||.| .   .  ..|.|..| |.|.|...|||.||.||.||. ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRDARKVPVNAE--------------------HRAMVSFAPDLDHLTLIAKVEVFQHALEATDGDDLAKVFWLKSKTSEVWLERRTNYTRSLAVMSMVG
..... .   . |                    .. | . .....|..|  ||||| .....| .|...| ||.|. ..| |.|||.|||||.|||.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YLLGLGDRHPSNLMLNRYSGKILHIDFGDCFEAAMTREKFPEKVPFRLTRMLVKAMEVSGIEGNFRSICEDVMHVLRSNKDSVMAMMEAF
| ||||||||.|.|.....|.|.|||||.||| ||.|...||||||||||..| ||.. |.||.||..||.||...|......|. .|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase FRAP.AA PI3_PI4_kinase 1954-2204 33 3.2e-104 357.33 Pfam 1-300 (300) Show / Hide
Range on Protein: 1954-2204
Range on HMM: 1-300/300
Sequence Identity: 33% (100 aa)

DYTFLLKGHEDLR--QDERVMQLF-----------------------GLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHLIREYRD
.| |..||..|||  ||.|.||..                       .|.|... . . . ......| | ..|..|..|.|.|||||.|.|...|.|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

ARKVPV-NAEHRAMVSFAPDLDHLTLIAKVEVFQHALEATDGDDLAKVFWLKSKTS-EVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLML--NRYSG
 .| .  | ||. ..  .|| .||... ||||| ...  | ...| ..|| ....  | |.|.|.|..||.|.|..|.|.||.||||..|.|.  .. .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

KILHIDFGDCFE-AAMTREKFPEKVPFRLTR------MLVKAM------EVSGIEGNFRSICEDVMHVLRSNKDSVMAMM-------EAFVHDPLINWRL
.. |||||.||. ..| ....||.||||.|.      ..|.||      ..|| .| ||..|.... .||......|...       |..|||.|..|| 
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase FRAP.AA PI3Kc 1956-2271 26 1e-101 345.14 SMART 1-336 (336) Show / Hide
Range on Protein: 1956-2271
Range on HMM: 1-336/336
Sequence Identity: 26% (93 aa)

TFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHLIREYRDARKVPVNAEHRAMVSF-----------
 ...|...|||||.|.||.|.|.|... . . ..  || ...| ..|..|..|.|.|||||.||| . ..|.. .|.| . ... |              
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------APDLDHLTLIAKVEVFQHALEATDGDDLAKVFWLKSKTS-EVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYSGKILHIDFGD
          ... .|.|.. ....| .|. .. ...|.. || ..... |.| |.|.|.|||.|...||.|.||.||||..|.|| . .|...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEAAMTREKFP----EKVPFRLTRMLVKAME----VSGIEGNFRSICEDVMHVLRSNKDSVMAMMEAFVHDPL-INWRLFNINDVPASMATIRAQTATQ
.|. ......|.    |.||||||...| .|.    .|| .|.||..|. .. ..|......|...|..|.||. ..|| .     . . . .|..   .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFRLD

NLEAVGLPSPPQRGAREREMLHAF------NVVGQL-GDANEVLNERAVSVMGR
.               ..| .. |       . . . .  .  ... .  ... 
H-------------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase FRAP.AA ATR 1924-2194 30 2.5e-52 176.43 In-house 1-267 (267) Show / Hide
Range on Protein: 1924-2194
Range on HMM: 1-267/267
Sequence Identity: 30% (83 aa)

VTIQSFDPQLIVMPSKQRPRKCTIKGSDGQDYTFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHLI
  |  ||  . .. | |.|.| ..|||||. |  . | ..|||.| | |.   |.| ..    .   . . .. | |.||  ....| || |  ||. ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

REYRDARKVPVNAEHRAMVSFAPDLDHLTLIAKVEVFQHALEATDGDDLAKVFWLKSKTSEVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYS
 .    .|.     .  . .   |     .  |  ||.  |           |  .   .. |   | || || ||..||||..||||||  |.....  
DKLWKEKKQYMQFYQLRQCM---DKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GKILHIDFGDCFEAAMTREKFPEKVPFRLTRMLVKAMEVSGIEGNFRSICEDVMHVLRSNKDSVMAMMEAF
| . |.|.   |    . |  || ||||||. .| .|   . .| ||  ||..| ..| ..| .|.....|
GECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase FRAP.AA ATM 2085-2202 45 1.6e-38 120.48 In-house 132-248 (304) Show / Hide
Range on Protein: 2085-2202
Range on HMM: 132-248/304
Sequence Identity: 45% (54 aa)

VWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYSGKILHIDFGDCFEAAMTREKFPEKVPFRLTRMLVKAMEVSGIEGNFRSICEDVMHVLRSNK
.| |.|  |||| |  |.|||.|||||||  |...|  |  . ||| |  ||        || ||||||| .|  | . |.|| ||  ||  | |.|  .
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

DSVMAMMEAFVHDPLINW
. .. ..|  . |||  |
ETLLTIVEVLLYDPLFDW

Kinase FRAP.AA DNAPK 2080-2204 34 1.4e-21 75.13 In-house 177-301 (301) Show / Hide
Range on Protein: 2080-2204
Range on HMM: 177-301/301
Sequence Identity: 34% (43 aa)

SKTSEVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYSGKILHIDFGDCFEAAMTREKFPEKVPFRLTRMLVKAMEVSGIEGNFRSICEDVMHV
| | | .|  |  . |. ||    .. || ||||  | | |   | |  ||||  | .|      ||  ||||||  .  |   .| | ...|    |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LRSNKDSVMAMMEAFVHDPLINWRL
.|. .   .  .. |. ||.. |  
FRKDRNILTNFCDVFINDPSFDWKN

Kinase FRAP.AA DNAPK 1924-2022 36 2.1e-20 70.83 In-house 2-100 (301) Show / Hide
Range on Protein: 1924-2022
Range on HMM: 2-100/301
Sequence Identity: 36% (36 aa)

VTIQSFDPQLIVMPSKQRPRKCTIKGSDGQDYTFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWVPNCDTLHHL
| |  ||    || |  ||..  |.| |  .  |. || |||||| |. |||   |  .        ..|    | ..|.    ||| || |  .|  .
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI

Kinase FRAP.AA SMG1 1933-2013 40 9.6e-20 61.95 In-house 1-81 (242) Show / Hide
Range on Protein: 1933-2013
Range on HMM: 1-81/242
Sequence Identity: 40% (33 aa)

LIVMPSKQRPRKCTIKGSDGQDYTFLLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGWV
. ..| | .|.|    ||||. | .| || |||  |||.||   .|||.                | | ||   |||| ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV

Kinase FRAP.AA SMG1 2059-2136 44 8.7e-18 55.37 In-house 156-233 (242) Show / Hide
Range on Protein: 2059-2136
Range on HMM: 156-233/242
Sequence Identity: 44% (35 aa)

VFQHALEATDGDDLAKVFWLKSKTSEVWLERRTNYTRSLAVMSMVGYLLGLGDRHPSNLMLNRYSGKILHIDFGDCFE
|    .|||  . |||  |    | . |      | || ||||||||..||||||  | ..    | . |||.  |||
VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE

Kinase FRAP.AA ATM 1958-2012 47 5.1e-14 40.78 In-house 3-57 (304) Show / Hide
Range on Protein: 1958-2012
Range on HMM: 3-57/304
Sequence Identity: 47% (26 aa)

LLKGHEDLRQDERVMQLFGLVNTLLTNARHTAEKDLSIQRYDVVPLSPNSGLIGW
| || .|||||  . | | . ||||     |  . | |  | |||||  || . |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW

FATC FRAP.AA FATC 2286-2318 60 9.2e-21 69.55 Pfam 1-33 (33) Show / Hide
Range on Protein: 2286-2318
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

SVLSVKDQVQKLIDQATSSENLCQSYVGWCPFW
  ||| .||..||..||. ||||| |.||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW