Gene CK1y_a-2 (S.moellendorffii)

CK1y_a-2

Species: S.moellendorffii
Alias: CK1y_a-2
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1y

Sequence

Name Sequence Type Origin Length Description Download
CK1y_a-2.AA Protein None 344 None Fasta, JSON
CK1y_a-2.NA RNA None 1035 None Fasta, JSON
CK1y_a-2.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of CK1y_a-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CK1y_a-2.AA CK1 9-267 73 1.4e-206 692.58 In-house 1-271 (271) Show / Hide 
Range on Protein: 9-267
Range on HMM: 1-271/271
Sequence Identity: 73% (199 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEE---VAIKLESVKTKHPQLLYESKLYRILQG------GTGIPNIRWFGIE--GDYNGLVLDLLGPSLEDLFNFCN
||.|||||.||||.||||.|. ||.|   ||||||. |.|||||.||.|.|.||||      . |||...|.| |  |||| .|.|||||||||||||||
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RKFSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGL-GRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDL
||||||||||.|||.| |.||||.|.|.||||||||||||. |....|||||||||||.|||..||||| |||||||||||||||||||||||||||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ESLGYVLMYFLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKS-YPSEFHSYFHYCRSLRFDDKPDYA
|||||||||||| ||||||||| |||||||||.| ||||..| |||  .|.||. |. |||.|.|..||||.
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase CK1y_a-2.AA CK1-Unclassified 9-241 69 7.2e-201 598.52 In-house 1-244 (244) Show / Hide 
Range on Protein: 9-241
Range on HMM: 1-244/244
Sequence Identity: 69% (170 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRILQGGT-------GIPNIRWFGIE--GDYNGLVLDLLGPSLEDLFNFCNRK
||...|||.|||||||...|.|||||||||||. ..|||||.|| |....||.|        |||.. |.| |  |||| .|.||||||||||||.||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDP-STHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDLE
||||||||.|||.| |.||.|.|.|.|||||||||||| ||....|||||||||.|.|.|. .|..|| |||||||||||||||||.|||||||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SLGYVLMYFLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLC
||||||.|||. |||||..|| .||.||||| | ||||..|.||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase CK1y_a-2.AA CK1-D 9-269 79 5.2e-192 644.18 In-house 1-261 (261) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-261/261
Sequence Identity: 79% (207 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRILQGGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNRKFSLKTVLML
||.||||||||||.||.|||||||||||||||..||||||| .|||.|...||| |||.|||.| ||||| .|.||||||||||||.|.|||||||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

ADQLINRVEYVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFLR
|||.| |.||.|...|.||||||||||||||.| | ||||||||||.|||. |||||.|||||||||||||||||||.|||||||||||||||||||| |
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

SSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRFDDKPDYAYL
 ||||||||| ||.||||.|.|.|||| |. ||| |||||  |. |||.|.|||||||.||
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CK1y_a-2.AA CK1-A 9-269 73 2.4e-177 595.48 In-house 1-261 (261) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-261/261
Sequence Identity: 73% (192 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRILQGGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNRKFSLKTVLML
||| |||||||||.|||| ||.  ||||||.|| | .||||.||.|.||||||. |||..||.| | ||| .|.||||||||||||||.|.|..||||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

ADQLINRVEYVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFLR
|||.| |.|||| |.|.||||||||||||.||  |....|||||||||||. |.||| ||| ||||||||||||| |||||||||||.||.|||.||| |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

SSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRFDDKPDYAYL
 .|||||.|| |||||||||||.||||.|| ||| .|.||  |. |||.|||...||| ||
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CK1y_a-2.AA CK1-G 9-269 57 1.6e-155 522.98 In-house 1-266 (266) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-266/266
Sequence Identity: 57% (153 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRILQGGT-GIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNRKFSLKTVLM
|| |.||| |.|||...|.|. .|| ||||.| .|.. |||  | . |.|| |   |||.. .|| .| || .|.|||||||||||..|.||||.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LADQLINRVEYVHSKSFLHRDIKPDNFLMGL--GRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMY
.| |.|.|.|||||.. . ||.|||||| |    .... ..|||||.||.|.|| | |||.||| | ||||||| ||||||| |||||||.|.|| . ||
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKS--YPSEFHSYFHYCRSLRFDDKPDYAYL
||| ||||||||| . |..|.|| ..| .| || ||..  .| .|  |  | |.| |...||| ||
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase CK1y_a-2.AA CK1 9-269 40 2.4e-139 469.24 In-house 1-339 (339) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-339/339
Sequence Identity: 40% (137 aa)

YRLGRKIGSGSFG-EIYLG-----TNIQTN-----EEVAIKLESVKTK--HPQLLYESKLYRILQGG-------------------TGIPNIRWFGIEGD
.....|||.|.|| .||..     .....|     ||.|.|.|..|..  ||||..|...|..||||                    ..| ..|.. |.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--YNGLVLDLLGPSLEDLFN---FCNRKFSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGL------GRRAN--------QVYIIDFGLAK-KY
  || .|..||||.||||..   .||||||.||.||.|.|.....||.|.. |.|||||||||.||.      |.. .        |||.||||.|. ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

RDP-----------STHQHIAYRE---NKNLTG-TARYASINTHLGIEQSRRDDLESLGYVLMYFLRSS--LPWQGLKAGTK-------KQKYEKISERK
||.           .|.||. .||   .|...| ||||.|||.|||.||.|||||.|..|.|...|. .  ||||..|. .|       |.|||.|.| |
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

MSTTIESLCKS-----YPSEFHSYFHYCRSLRFDDKPDYAYL
|||... ||.      .|.||  .. |.|||...|.|||...
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CK1y_a-2.AA TTBK 9-269 37 1.9e-57 197.16 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-257/257
Sequence Identity: 37% (98 aa)

YRLGRKIGSGSFGEIYLGTNIQTN-EEVAIKLESVKTKHPQLLYESKLYRILQGGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNR-KFSLKTVL
 .  .||| | ||||| ....... |.||||.||....   |  |    . |||   .      | . ..| .|..|.| .| ||     | .||| | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MLADQLINRVEYVHSKSFLHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMY
 |  |... .| .||  |||||||| || || .  . ...|..||||| .|   .. .  . ||     ||.|||||| |.  |  |.||| || |.|  
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

FLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRFDDKPDYAYL
|.   |||  .|        ... | |       | |  |.||| . .  .|| . |.|||. .
FVQGQLPWRKIKD------KDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CK1y_a-2.AA TTBKL 9-273 28 1.6e-56 189.35 In-house 1-288 (288) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-288/288
Sequence Identity: 28% (84 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKT-KHPQ--LLYESKLYRILQ--GGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNRK--FS
..  ..||.| ||..|.. .... ...|.. | ...  .    .  | ..   ||  | . .|.. . | ..||| .|. |.||.| || .  ..|  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGLG----RRANQVYIIDFGLAKKYRDPSTHQ----------HIAYRE---NKNLTGTARYASINT
  |.. .. |..  . ..|.. |.|||.|| |. .|.     .|.  ||.||||.|..|....  .          . . |.      . || ||.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGIEQSRRDDLESLGYVLMYFLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKS------YPSEFHSYFHYCRSLRFDDKPDYAYLKRIF
|.. ||.| ||| |. |...... . |||....      . ..| . |.... | |.|        |||| . . . ||||. | ||| ..  .|
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNME------DKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase CK1y_a-2.AA Worm6 9-269 27 1.2e-54 187.83 In-house 1-279 (279) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-279/279
Sequence Identity: 27% (76 aa)

YRLGRKIGSGSFGEIYLGTNIQTNE--EVAIKLES--VKTKHPQLLYESKLYRILQGGT--GIPNIRWFGIEGD--YNGLVLDLLGPSLEDLFNFC-NRK
. ...|||.|.|| .|. .. ....  ..|.|.|.   . |...|  |      .  .   . ..|   |  .   .| .|. |.|..|.||  .. .||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGL-----GRRANQVYIIDFGLAK--KYRDPSTHQHIAYR-ENKNLTGTARYASINTHLGIEQS
||. | | .| | ....| .|.  |.|||.|| ||  |       .   ..|..|||...  ||..  . . .  | ..    || |||... | |.||.
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGN-ELRTPRWTACGFRGTVRYAPLACHKGQEQC

RRDDLESLGYVLMYFLRSSLPWQGLKAGTKKQ-KYEKISERKMSTTIESLCKSYPS-EFHSYFHYCRSLRFDDKPDYAYL
|.||.||  |..  ...  |||...|.   ..  ....  |. ..  . . .  |  ||   . |  .... |.|||...
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CK1y_a-2.AA Pkinase 9-260 21 5.2e-40 142.55 Pfam 1-258 (293) Show / Hide 
Range on Protein: 9-260
Range on HMM: 1-258/293
Sequence Identity: 21% (59 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLY------ESKLYRILQGGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFC------
|..||||||||||. |..... |...||.|  ........ ..      | .. . |.    .  ..||  ....  .|.....  |. ..  .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLY-VMDLFDYISTW

-NRKF--SLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMG-LGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHL-GIEQS
 ...|  | ... . . |..  .|| ||....|||.||.|.|.   |  .  | |.||||||...      .  .. .. ..|| .|..   .. | . .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDLESLGYVLMYFLRSSLPWQGL----KAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRF
.. |  |.| .| ..|   .|..|     .  ...|....| ... .  .. .|  ....  ..   .. ...
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWT
Kinase CK1y_a-2.AA VRK 80-213 37 8.1e-27 83.26 In-house 106-240 (284) Show / Hide 
Range on Protein: 80-213
Range on HMM: 106-240/284
Sequence Identity: 37% (51 aa)

LVLDLLGPSLEDLFN-FCNRKFSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLT--GT
.|.. .| .|. .    .. .|| |||| || ....  || |..   | |||  | | |.   ..||| .|.||| .| .     | .| |..     ||
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP--NGKHRQYKEDPRRCHNGT

ARYASINTHLGIEQSRRDDLESLGYVLMYFLRSSLPW
  . |.  |.|   ||| |||.||| .|. |  .|||
CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPW
Kinase CK1y_a-2.AA S_TKc 9-287 18 3.3e-15 46.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-287
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRILQGGTGIPNIRWFGIEGDYNGLVLDLLGPSLEDLFNFCNRK--------F
|...||||.|.||. |..... |...||||  .      ... | .. .   .   | ..  .  . |.  .|..... .| ||| .  ..        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDPSTHQHIAYRENKNLTGTARYASINTHLGIEQSR-RDDLESL
.  ..  .. |... .|| ||. ..|||.||.| |.       .. |.|||||...              . . ||  | .         .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVLMYFLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRFDDKPDYAYLKRIFR-D----LFIREGFQ-------FDYV
| .|  .|    |..     . .. ..||                                 ...    ...... |    . . | .|         ..
GCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CK1y_a-2.AA Pkinase_Tyr 9-38 41 4.2e-07 24.67 Pfam 1-34 (270) Show / Hide 
Range on Protein: 9-38
Range on HMM: 1-34/270
Sequence Identity: 41% (14 aa)

YRLGRKIGSGSFGEIYLGTNI----QTNEEVAIK
 ..|.|.|.|.|||.|.||      .|. .||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase CK1y_a-2.AA VRK 9-25 64 6.7e-07 18.61 In-house 1-17 (284) Show / Hide 
Range on Protein: 9-25
Range on HMM: 1-17/284
Sequence Identity: 64% (11 aa)

YRLGRKIGSGSFGEIYL
.|||..||.| ||.|||
WRLGKPIGQGGFGCIYL
Kinase CK1y_a-2.AA TyrKc 9-273 19 4e-06 -123.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-273
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

YRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLESVKTKHPQLLYESKLYRIL--QGGTGIPNI-RWFGIEGD--------YNGLVLDLLGP--SLEDLFNF
 .||.|.|.| |||.|.|| .   ..||.|     . .  .. | .. . |  .     ||| | .|.  .           ...  . |  .| |    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHH----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

CNRKFSLKTVLMLADQLINRVEYVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDP---STHQHIAYRENK--NLT--GTARYA---SINTH
. .|...|. |  . |  .  || ||| . |||.   | | | ..   .| | ||||...  |        .  ||  .  .       |     .||..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYG

--------------------LGIEQSRR-----DDLESLGYVLMYFLRSSLPWQGLKAGTKKQKYEKISERKMSTTIESLCKSYPSEFHSYFHYCRSLRF
                    .| .          . . .   ..   |   |  ..         . .|         .     |.| ..    |     
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---------P-MS---------F--VCCPDEMYQIMKQCWHEDP

DDKPDYAYLKRIF
.| |  . ....|
EDRPTFSEIHECF