Gene NEK_b (S.moellendorffii)

NEK_b

Species: S.moellendorffii
Alias: NEK_b
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
NEK_b.AA Protein None 967 None Fasta, JSON
NEK_b.NA RNA None 2904 None Fasta, JSON
NEK_b.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of NEK_b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK_b.AA NEK 10-264 37 1.9e-118 399.83 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-286/286
Sequence Identity: 37% (107 aa)

YEIMEQVGRGAFGSAILVNHKIEKKK-----YVLKKIRLARQTDRCRRSAH-QEMALIAGITHPYIVDHKESWVEKG-CYVCIVTGYCE-GGDMAEM---
||| ...|.|.||.. .| .|. .|.     ||.||| . . ... .. |  .|  . . . ||.||  ..|..|..  . |||  ||| |||....   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRRSN--GTFFPEEKLCRWFTQLLLAVEYLHSN-----HVLHRDLKCSNIFLTKDQD----IRLGDFGLAKLLKAD-DLASS-VVGTPNYMCPELLADIP
| .    |..|.||.  .||.|..||. |.|..     ..||||.|..||||||.      ...||||..|.|. . |.|.. .|||| ||.||.. . |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGFKSDIWSLGCCMYEMAAH--RPAFKAF--DMQGLISKINKS-TVGPLPNN--YSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
|..|||||||||. |||..   ...|.|   .| .|. || |  .  |.| .  ||. |...|..||.|.||.||.. ..| .| .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK_b.AA NEK4 10-264 43 4.3e-101 342.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESW-VEKGCYVCIVTGYCEGGDMAEMIRRSNGTFFP
|..| .||.| .|   || |.. ||.||.||. | .   | |. | .|  |     || ||  ||||  | | . .|| |.|||||. .  ..  . | .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLLK-ADDLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHRP
|.    || |  .|  |.|  |.||||||  ||||||   |..||||... |    |.|. ..||| || ||. .  || .||||||||||.|||.  . 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
|| | ||  || .| .    |.| |||  |. ... || | |. || . |... | .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK_b.AA NEK1 10-264 38 3.6e-86 292.59 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGC--YVCIVTGYCEGGDMAEMIRRS--NGT
|..  |.| |.|| |.|| || . . ||.| |.. .. .  |  .  | |. |   || ||  ||| .| ||  .. ||  ||.|||..  | |    | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILY-IVMEYCDGGDLMQKINRQKRKGK

FFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLT--KDQ---------------DIRLGDFGLAKLL-KADDLASSVVGTPNYMCPELLADIPYG
 |.|     ||.|. ||. . |.  .||||.| .|||||  |.                 ..||||| |..|   ...|. ..||| |  ||.    || 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
 |||||||||  ||  .   .| |  .. |. || ..|. |.|. ||. |.| . .|...||.||| | ..|  | .
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK_b.AA S_TKc 10-264 32 3.8e-83 283.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEG--GDMAEMIRRSNGTF-
|||....|.||||.  .. ||  .... .|.|.         ... .|...     ||.||  ......   ....|. ||.|  ||. ..|.. ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLLKADDLASSVVGTPNYMCPELLADIPYGF-KSDIWSLGCCMYEM
   |||   .... |...|.||.||....||||| .||.|..   | ..|||||..|      ....|||.|| ||.|   .||. |.|.||.||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AAHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLR-------HPHL
.. .| |   .|| .. ||            |  .|..|| .|.|.||.|||. ..|.       || .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK_b.AA NEK8 10-264 31 7.7e-77 218.87 In-house 1-278 (278) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-278/278
Sequence Identity: 31% (87 aa)

YEIMEQVGRGAFGSAILVNHKIEK--KKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIRRSNGTFF
||    |||||||...|   |     .. ..| | . | . . |..|  |  . . . || |.   ..  | .    |.  |..||  ..|| .  .. |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNT-LMIEMEYADGGTLYQMIQHQQNKLF

PEEK-----------------LCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKD-QDIRLGDFGLAKLLKADDLAS-S--VVGTPNYMCPELLADIPY
 ||.                     |.| ..|| ..|.. .||||||  |||.|..   . .||||..| .  . ... .  |||||.|| ||.    ||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

GFKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKS-TVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
 .|||.|.|||  |||.  . || |     |. ||  . .  |..  ||| ... ... | . || ||..  ..  | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK_b.AA AGC 10-264 21 2.6e-76 195.95 In-house 1-395 (395) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

YEIMEQVGRGAFGSAILVNHK------IEKKKYVLKKIRLAR--------QTDRCRRS--------AHQEMALIAGIT----------HPYIVD-HKESW
.|.   .|.|.||  .|| .|        .| | .|... ..        . ..  .           .|    . .           ||.||   . |.
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VEKGC-YVCIVTGYCE--------GGDMAEMIRRSN--GTF-FPEEKLCRWFTQ-------LLLAVEYLHS-NHVLHRD-LKCSNIFLTKDQDIRLGDFG
  |   |...|  |..        ||..  ...  .  . . |.||  . .. .       ..||.||||| ... ||| ||  || |..|  |.| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKLLKAD---------------------------------------------------DLASSVVG--TPNYMCPELLADIPYGFKSDIWS--LGCCMY
|.| .. |                                                   |.... .|  ||.|| || |    ||.  |.||  |||.||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMAAHRPAFKAFDMQ----------GLISKINK-----STVGPLP----------NNYSNTLKSIIRSMLRKNPEHRPT----------VGDLLRHPHL
|| . .| | . . |           .  || .     .   ..|           . |. .|..|. .| |.||.|..          . .. .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase NEK_b.AA Pkinase 10-264 27 2e-73 255.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQ--EMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGG----DMAEMIR-RS
|.| ...|.|.||.  .  || . |....|.|.. .. . .....    | .. . . ||.||  .... . . ....|. |||||    | ...|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

NGTF-FPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDI----RLGDFGLAKL--LKADDLASSVVGTPNYMCPELLA-DIPYGFKSDIWS
.|.| |.|. ......|.| ..||.||. ..||||| .||.. .. .|    ...||||||.  .  .  .....|||.|| ||..  . .|| |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCCMYEMAAHRPAFKAF----DMQGLISKINKSTVGPLPNNYS-----------------------NTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
.|| .|||.  || |.      .    . .|..   .||. ...                        ..|..|...|.|.|. |||  ..| || .
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK_b.AA STE 10-264 22 7.4e-65 221.78 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

YEIMEQVGRGAFGSAILVNHK----IE-----------KKKYVLKKIRLARQT---------------DRCRRSAHQEMALIAGIT--HPYIVDHKESWV
.|..|..|.||||.  .  ..    |.           .. .  |...| ...               .  . .  .|. .       ||.||    . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKG------CYVCIVTGYCEGGDMAEMIRRSNGTFFP------------EEKLCRWFTQLLLA-VEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAK
 .|       ...|.  |..||   ..|..  |...|            |. ...   |.| .  .||||.|. |||.|..||.|     . | |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LLKA-----------------DDLASSVVGTPNYMCPELLA------DIPYGFKSDIWSLGCCMYEMAAHRPAFKA-FDMQGLISKINK-----------
 |                   .    ..|||| .| || .       | .|..|.|||||||.. |||  .| .    .|. .  ....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---STVGPLPN-------------------NYSNTLKSIIRSMLRKNPEHRPTVGDLLR--HPHL
    .  |||.                   ..|  .|  |.  |.|.|..|||. .||.  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK_b.AA NEK-Unclassified 10-264 31 1.2e-63 209.47 In-house 1-258 (258) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-258/258
Sequence Identity: 31% (83 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIRRSNGT--FF
|. .  .| |  |   || |.| |.  | .  .  ..  |  .     . ... . || ||   .|. |    .     ||.||.. . |..  .    |
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRKKKKKRQNK-----IIILSQLRHPHIVTYHDSFFEN-AKLFYTQDYCDGGNLDRRIQKHRKKNEPF

PEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLL-KADDLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHR
 |  . .|. |.  || | |.  ..||||| .|||||.|  . .|||| .. .  . | |   |||...| || . | ||  .||.||||| .|||..  
DEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

PAFKAFDMQGLISKINKSTV------GPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
|.| .  |  .  || .          |    ||  |  .|| |||.|.. ||   ...  .  
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK_b.AA CAMK 15-264 19 2.3e-63 202.74 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-264
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

QVGRGAFGSAILVNHKIEK------------KKYVLKKIRLARQT--------------------------DRCRRSAHQEMALIAG-------ITHPYI
. |||.||   |. ||  .            .|.  | |   . .                          .. |..  .|...          . || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDHKESWVEKGC------------------YVCIVT---GYCEGG----DMAEMIRRSNG-------------TFFPEEKLCRWFTQLLLAVEYLHSNHV
.   | .  . .                  ....|.    ||.||    |. ..|..  .               |.|.  .|.| |.. ||.|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKCSNIFLTKDQ-----------------DIRLGDFGLAKLLKA------------------------DDLASSVVGTPNYMC-PELLAD------
 |||||. || |...                  .| . |||.|. ..                         ... . ..||| ||. ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPYGFKSDIWSLGCCMYEMAAHRPAFKAF-------------DMQGLISKINKSTVGPLPNN---------------YSNT--------LKS
         .||.|.|.||.|. .| |   .| | .              ... |  || |      |                  |.          |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IIRSMLRKNPEHRPTVGDLLRHPHL
 ||.||...||.|.|. . |.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK_b.AA NEK2 89-264 31 8.8e-57 189.69 In-house 81-319 (319) Show / Hide 
Range on Protein: 89-264
Range on HMM: 81-319/319
Sequence Identity: 31% (76 aa)

YCEGGDMAEMIR--RSNGTFFPEEKLCRWFTQLLLAVEYLHS-------------------N--HVLHRDLKCSNIFLTKDQD-----------------
|||||| . ||   |.  ....||   | ..||..|    |                    .   .||||.|  ||||  |.                  
YCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSN

----------------------IRLGDFGLAKLLKADDL-ASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMAAHRPAFKAFDMQGLISKINKST
                      . |||||||. |. | . | . |||| || ||.. . .|  ||||||.||  |||.| .| |.|.  . | .|| .  
YYRDHRVNSGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGH

VGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
  ..|  ||  |  || .|.  ...||| .  .|.|| .
FRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase NEK_b.AA NEK11 10-264 39 2.6e-56 193.42 In-house 1-259 (259) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-259/259
Sequence Identity: 39% (102 aa)

YEIMEQVGRGAFGSAILVNHKIEKKK---YVLKKIRLARQTDRCRRSAHQEMALIAGITHPYIVDHKESWVEKGCYVCIVTGYCEGGDMAEMIR--RSNG
| .  ..| |.||   ||  |  |.     ||| |            |  |  |.. . || ||    |..|.  . ||.| |||| |. . |   .  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNF-CIITEYCEGRDLDYRIQEYKQAG

TFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLLKAD-DLASSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMA
  ||| ..  || |||| |.|.|   .||||||  |||| |   ...|||| ..||    |||  . ||| || || |    |  ||||||| | .||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

AHRPAFKAFDMQGLISKINKSTVGPLPNNYSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
    ||   .   .. .|       ||. |   | .|. .|| |||  ||   |.|. | .
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase NEK_b.AA Pkinase_Tyr 82-202 28 2.3e-16 56.02 Pfam 81-207 (270) Show / Hide 
Range on Protein: 82-202
Range on HMM: 81-207/270
Sequence Identity: 28% (36 aa)

YVCIVTGYCEGGDMAEMIRRS--NGTFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLLKADDLASSVVGT-----PN
...||. |...||. .  |.   ..  .. . |. . .|   . |||.|..  |||| . |. .|..  .. .|||||...  ||   .....       
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIK

YMCPELLADIPYGFKSDIWSLGCCMYEM
 | || ...  .  |||.|| | .|.|.
WMAPECINYGKFTTKSDVWSFGVLMWEI
Kinase NEK_b.AA TyrKc 10-264 21 4.7e-15 20.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YEIMEQVGRGAFG---SAILVNHKIEKKKYVLKKIRLARQTDRCRRSAHQEMALIAGI--THPYIVDHKESWVEKG-------CYVCIVTGYCEGGDMAE
 .  .. |.||||    ...        .   |...        |.  ..|. .   .   || ||      . ..         ..||. |...||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIV-RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

MIRRSNGTFFPEEKLCRWFTQLLLAVEYLHSNHVLHRDLKCSNIFLTKDQDIRLGDFGLAKLLKAD-------DLASSVV--GTP-----NYMCPELLAD
 .|.. .. .. ..|. . .|     |||||... |||| . |. ..... .. .||||.. .. |       |  ..    |.        | || . .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

IPYGFKSDIWSLGCCMYEMA--AHRPAFKA----FDMQGLISKINKSTVGPLPNN--------YSNTLKSIIRSMLRKNPEHRPTVGDLLRHPHL
  . .|||.|| | ||.|.      |         . | .| .. .    | | |         .  . .|...  . .|| |||  ..  |  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK_b.AA NEK2 10-41 37 0.000723 8.77 In-house 1-32 (319) Show / Hide 
Range on Protein: 10-41
Range on HMM: 1-32/319
Sequence Identity: 37% (12 aa)

YEIMEQVGRGAFGSAILVNHKIEKKKYVLKKI
||. .  |.| ||.   | .|  .|  | | |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEI
Kinase NEK_b.AA Pkinase_Tyr 10-23 35 5.992044 0.45 Pfam 1-14 (270) Show / Hide 
Range on Protein: 10-23
Range on HMM: 1-14/270
Sequence Identity: 35% (5 aa)

YEIMEQVGRGAFGS
 ..... |.||||.
ITFGKKLGEGAFGE