NEK_d

Species: S.moellendorffii
Alias: NEK_d
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
NEK_d.AA Protein None 626 None Fasta, JSON
NEK_d.NA RNA None 1881 None Fasta, JSON
NEK_d.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of NEK_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK_d.AA NEK 9-263 38 9.90000000001e-118 397.43 In-house 1-286 (286) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-286/286
Sequence Identity: 38% (111 aa)

YEIIGQVGKGAFGSAILVNHKLEKKK-----YVLKKIRLARQSDRCRRSAH-QEMALVSRVKHPHIVEYKEAWVEKG-CYVCIVTGYCE-GGDMADI---
|||| ..|.|.||.. .| .|  .|.     ||.||| . . |.. .. |  .|  . .. |||.||.|.....|..  . |||  ||| |||...    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRKAN--GTYFPEERLCRWFVQLLLGVEYLHAN-----HILHRDVKCSNIFLTKDHD----IRLGDFGLAKMLKSD-DLACS-VVGTPNYMCPELLADIP
| |    |.||.||   .||.|..|.. |.| .     .||||| |..||||||..     ...||||..|.|... |.|.. .|||| ||.||.. . |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGFKSDIWSLGCCMYEMSAH--RPAFKAF--DIQGLINKINKS-SIGPLPTC--YSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
|..|||||||||. ||| .   ...|.|   .. .|..|| |     |.|    ||.  ..||..||.|.||.||.. ..| .| .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI

Kinase NEK_d.AA NEK4 9-263 43 3.6e-99 335.78 In-house 1-257 (257) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-257/257
Sequence Identity: 43% (112 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAW-VEKGCYVCIVTGYCEGGDMADIIRKANGTYFP
|... .|||| .|   || |.  ||.||.||. | . | | |. | .|  | |. ||| |||||| |  | | . .|| |.|||||.    ..  .   .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLK-SDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMSAHRP
|.    ||||  ..  |.|  |||||| |  ||||||   |..||||... |  . |.|  ..||| || ||. .  || .||||||||||.|||   . 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
|| | |.  || .| .    |.|  ||   . |.. || | |. ||   .... | .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI

Kinase NEK_d.AA NEK1 9-263 38 1.8e-88 300.25 In-house 1-276 (276) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGC--YVCIVTGYCEGGDMADIIRKA--NGT
|..| |.|.|.|| |.|| || . . ||.| |.. ....  |  .  | |. .. ||| ||.|||. .| ||  .. ||  ||.|||..  | ..   | 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILY-IVMEYCDGGDLMQKINRQKRKGK

YFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLT--KDH---------------DIRLGDFGLAKMLKS-DDLACSVVGTPNYMCPELLADIPYG
 |.|     ||.|. |.. . |   ||||| | .|||||  |.                 ..||||| |.|| . ...|| ..||| |  ||.    || 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FKSDIWSLGCCMYEMSAHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 |||||||||  ||  .   .| |   . |..|| .... |.|  ||   .||. .|...||.||| .  .|  | .
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI

Kinase NEK_d.AA S_TKc 9-263 33 5.4e-88 299.56 SMART 1-231 (231) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEG--GDMADIIRKANG---
|||. ..||||||.  .. ||  .... .|.|.         ... .|... .. .||.|| .......   ....|. ||.|  ||. |.|.| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-TYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLKSDDLACSVVGTPNYMCPELLADIPYGF-KSDIWSLGCCMYEM
  .||| . .... |.....||.| ..|.|||.| .||.|..   | ..|||||. |       ...|||.|| ||.|   .||. |.|.||.||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

SAHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLR-------HPHL
 . .| |   ..| ...||            |...|..|| .|.|.||.|||| |.|.       || .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase NEK_d.AA NEK8 9-263 32 6.8e-80 227.76 In-house 1-278 (278) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-278/278
Sequence Identity: 32% (90 aa)

YEIIGQVGKGAFGSAILVNHKLEK--KKYVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIRKANGTYF
|| |  ||.||||...|   |     .. ..| | . | | . |..|  |  . |.. || |..| .   | .    |.  |..||  ...| .  .. |
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNT-LMIEMEYADGGTLYQMIQHQQNKLF

PEER-----------------LCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKD-HDIRLGDFGLAKMLKSDDLAC-S--VVGTPNYMCPELLADIPY
 |||                     |.| ...| ..| . ||||| |  |||.|..   . .||||..| . .. ..  .  |||||.|| ||.    ||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

GFKSDIWSLGCCMYEMSAHRPAFKAFDIQGLINKINKS-SIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 .|||.|.|||  |||   . || |     |..||  .    |..  ||.  ..|... | . || ||.|....  | .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC

Kinase NEK_d.AA AGC 9-263 22 2.9e-78 201.11 In-house 1-395 (395) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-395/395
Sequence Identity: 22% (89 aa)

YEIIGQVGKGAFGSAILVNHK------LEKKKYVLKKIRLAR--------QSDRCRRS--------AHQEMALVSRVK----------HPHIVE-YKEAW
.|..  .|||.||  .|| .|        .| | .|... ..        . ..  .           .|    ....          || ||   . ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VEKGC-YVCIVTGYCE---------GG-DMADIIRKA-NGTYFPEERLCRWFVQ-------LLLGVEYLHA-NHILHRD-VKCSNIFLTKDHDIRLGDFG
  |   |...|  |..         || ..  ....  .  .|.||| . .. .       ..|..||||  ..| ||| .|  || |..|  |.| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKMLKSD---------------------------------------------------DLACSVVG--TPNYMCPELLADIPYGFKSDIWS--LGCCMY
|.|....|                                                   |.. . .|  ||.|| || |    ||.  |.||  |||.||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMSAHRPAFKAFDIQ----------GLINKINK-----SSIGPLP----------TCYSSSFKSLIRSMLRKNPEHRPT----------AAELLRHPHL
|| . .| | . . |           . .|| .     .   ..|             |.  |.||. .| |.||.|..          | |. .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase NEK_d.AA Pkinase 9-263 29 3.4e-75 260.91 Pfam 1-293 (293) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQ--EMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGG----DMADIIR-KA
|.|....|.|.||.  .  || . |....|.|.. .... .....    | ..  |..||.||...... . . ....|. |||||    | .|.|. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

NGTY-FPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDI----RLGDFGLAKM--LKSDDLACSVVGTPNYMCPELLA-DIPYGFKSDIWS
.|.. |.|. ..... |.| |.||.|.. |.|||.| .||.. .. .|    ...||||||   . ..  . ...|||.|| ||..  . .|| |.|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCCMYEMSAHRPAFKAF------DIQGLINKINK---SSIGPLPTCYS-----------------SSFKSLIRSMLRKNPEHRPTAAELLRHPHL
.|| .|||   || |.        | . .|..| .   ..  | . . |                 ...|..|...|.|.|. ||||...| || .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase NEK_d.AA CAMK 14-263 19 4.1e-68 218.33 In-house 1-425 (425) Show / Hide
Range on Protein: 14-263
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

QVGKGAFGSAILVNHKLEK------------KKYVLKKIRLARQS--------------------------DRCRRSAHQEMALVSR-------VKHPHI
. |.|.||   |. ||. .            .|.  | |   . .                          .. |..  .|... ..       ..||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VEYKEAWVEKGC------------------YVCIVT---GYCEGG----DMADIIRKANG-------------TYFPEERLCRWFVQLLLGVEYLHANHI
.   |..  . .                  ....|.    ||.||    |. | |..  .              .|.|.  .|.| |.. .|.|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDVKCSNIFLTKDH-----------------DIRLGDFGLAKMLKS------------------------DDLACSVVGTPNYMC-PELLAD------
 ||| |. || |....                 .| . |||.|.....                        ...   ..||| ||. ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------IPYGFKSDIWSLGCCMYEMSAHRPAFKAF-------------DIQGLINKINKSSIGPLPTCYSS-----------------------SFKS
         .||.|.|.||.|. .| |   .| | .              ... |  || |      |   |                        . |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRSMLRKNPEHRPTAAELLRHPHL
|||.||...||.|.|... |.|| .
LIRKMLQVDPEKRMTIEQCLNHPWM

Kinase NEK_d.AA STE 9-263 23 2.7e-67 229.9 In-house 1-359 (359) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YEIIGQVGKGAFGSAILVNHK----LE-----------KKKYVLKKIRLARQS---------------DRCRRSAHQEMALVSRVK--HPHIVEYKEAWV
.|.|...||||||.  .  ..    ..           .. .  |...| ...               .  . .  .|. . .. .  ||.||.|  . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EKG------CYVCIVTGYCEGGDMADIIR---KANG---------TYFPEERLCRWFVQLLLG-VEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAK
 .|       ...|.  |..||   |||.   . ..         ..|||. ...  .|.| |  .||| .|| |||.|..||.|     . | |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MLKSD----------------DLAC-SVVGTPNYMCPELLA------DIPYGFKSDIWSLGCCMYEMSAHRPAFKA-FDIQGLINKINK-----------
 | ..                .  . ..|||| .| || .       | .|..|.|||||||.. ||   .| .    . . . .....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---SSIGPLPTC-------------------YSSSFKSLIRSMLRKNPEHRPTAAELLR--HPHL
     . |||.                    .|..||  |.  |.|.|..|||| .||.  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase NEK_d.AA NEK-Unclassified 9-263 33 2.2e-64 212.0 In-house 1-258 (258) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-258/258
Sequence Identity: 33% (89 aa)

YEIIGQVGKGAFGSAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQE-MALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIRKANGT--Y
|. |  .|.|  |   || |.. |.  | ..|     | | ..   |  . ..| ..||||| | ... |    .     ||.||..   |.|  .    
YDKITTLGQGGGGAVYLVRHQISKRHLV-QQI-----SKRKKKKKRQNKIIILSQLRHPHIVTYHDSFFEN-AKLFYTQDYCDGGNLDRRIQKHRKKNEP

FPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKML-KSDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMSAH
| | |. .|..|.   | | |   |.||| | .|||||.|  . .|||| .. .    | |   |||...| || . | ||  .||.||||| .||| . 
FDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

RPAFKAFDIQGLINKINKSSI------GPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
 |.| .  .  .  || .          |    ||     .|| |||.|.. || | |..  .  
EPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI

Kinase NEK_d.AA Ciliate-E2 9-263 23 1.9e-61 209.67 In-house 1-365 (365) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

YEIIGQVGKGAFG-----SAILVNH------------------KLEKKKYVLKKI-----RLARQSDRCRRSAH------QEMALVSRVKHPHIVEYKEA
|..| . |.|.||     . ..|..                  |  .|.| .| .     .   | ..  |  .      .|. . ....||.|....|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WVE-KGCYVCIVTGYCEGGDMADIIR-----------KANGTYFPEERLCRWFVQLLL---------------GVEYLHANH-ILHRDVKCSNIFLTKDH
. | .  .. .|. ||.|||. |.|.           |    || |.  .. . |.|                ..|||| .. |.||| | .||..    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

DIRLGDFGLAKMLKSD--------------------------------DLACSVVGTPNYMCPELLADIP---------YGFKSDIWSLGCCMYEMSAHR
 | . ||||.| .. |                                ... ...|||.||.|| |   .         |..|.||||||...|||   .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PAFKAFDIQGLINKINKSSIGPLPTC-----------------YSSSFKSLIRS----MLRKNPEHRPT-AAELLRHPHL
| |        ...| .  |   . .                  | . | ||.     || |.|| |.| . ..| || .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase NEK_d.AA NEK11 9-263 39 3e-59 203.16 In-house 1-259 (259) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-259/259
Sequence Identity: 39% (103 aa)

YEIIGQVGKGAFGSAILVNHKLEKKK---YVLKKIRLARQSDRCRRSAHQEMALVSRVKHPHIVEYKEAWVEKGCYVCIVTGYCEGGDMADIIR--KANG
| .  ..| |.||   ||  |  |.     ||| |            |  |  |.||..|| || .  ...|.  . ||.| |||| |. . |   |  |
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNF-CIITEYCEGRDLDYRIQEYKQAG

TYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLK-SDDLACSVVGTPNYMCPELLADIPYGFKSDIWSLGCCMYEMS
  |||  .  ||.||||||.|.|   |||||.|  |||| |   ...|||| ...|  | |||  . ||| || || |    |  ||||||| | .||| 
KIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMC

AHRPAFKAFDIQGLINKINKSSIGPLPTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
    ||   .   .. .|       ||  |     ... .|| |||  || |...|. | .
CMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM

Kinase NEK_d.AA Pkinase_Tyr 55-201 27 1.2e-16 57.02 Pfam 52-207 (270) Show / Hide
Range on Protein: 55-201
Range on HMM: 52-207/270
Sequence Identity: 27% (43 aa)

QEMALVSRV-KHPHIVEYKEAWVEKGCY--VCIVTGYCEGGDMADIIRKA--NGTYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIR
.|... .   .||.|| .  . ...|    ..||. |...||. |  ||   ..  .. ..|. . .|   | |||..... |||. . |. .|... ..
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

LGDFGLAKMLKSDDLACSVVGT-----PNYMCPELLADIPYGFKSDIWSLGCCMYEM
 .|||||. . .||   .....        | || ...  .  |||.|| | .|.|.
ICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI

Kinase NEK_d.AA TyrKc 9-263 20 8.8e-16 32.46 SMART 1-280 (280) Show / Hide
Range on Protein: 9-263
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YEIIGQVGKGAFG---SAILVNHKLEKKKYVLKKIRLARQSDRCRRSAHQEMALVSRV--KHPHIVEYKEAWVEKG-------CYVCIVTGYCEGGDMAD
 . . . | ||||    ...        .   |...        |.  ..|. . ...  .||.||    . . ..         ..||. |...||  |
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

IIRKANGTYFPEERLCRWFVQLLLGVEYLHANHILHRDVKCSNIFLTKDHDIRLGDFGLAKMLKSD--------DLACSV-VGTP-----NYMCPELLAD
 .||  .. .. . |. . .|   | |||| ... |||  . |. ....| .. .||||.. ...|            .   |.        | || . .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

IPYGFKSDIWSLGCCMYEM--SAHRPA-------FKAFDIQGLINKINKSSIGPL------PTCYSSSFKSLIRSMLRKNPEHRPTAAELLRHPHL
  . .|||.|| | ||.|.      |         .....  .. . .   . |       ..| .  .. ....  . .|| ||| .|.  |  .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF