Gene CR4L_e-1 (S.moellendorffii)

CR4L_e-1

Species: S.moellendorffii
Alias: CR4L_e-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: CR4L

Sequence

Name Sequence Type Origin Length Description Download
CR4L_e-1.AA Protein None 847 None Fasta, JSON
CR4L_e-1.NA RNA None 2544 None Fasta, JSON
CR4L_e-1.kin_dom Protein Kinase Domain None 233 None Fasta, JSON

Protein domain

Protein domains of CR4L_e-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CR4L_e-1.AA TKL 507-815 22 1e-63 217.96 In-house 1-364 (364) Show / Hide 
Range on Protein: 507-815
Range on HMM: 1-364/364
Sequence Identity: 22% (93 aa)

IGTGSFGTVYRGVLPD---------GREVAIKRGGVGS------------------SGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDD
|| |.||.||.|..           |..||.|.  . .                    |  .  .. .  .  .  |.  . ||.| ..| ..|.| . .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSD-M-QLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

E-------------RLLVYDFMPNGTVHDHLHGRKEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAV-----PPIIHRDIK
                .|....|.|. ...||                               |. |. .||..|||..|||.        |||||||.|
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK

SSNILID--------------AECSARVSDFGLSL-MGPSDGESHLSLT----------------AAGTVGYMDPEYYRLQ----------------QLT
|.|||.|              |.. . ..|||||  | .| . .. . |                  || ..| ||  | |                . .
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

TKSDVYSFGVVLLEILTGKRAIIVENRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGLPEEA-----DEMEAVLIVAELAEECVRLEGKERPSMG
.|.||||||.|| ||||..|          ...|  |. . |  .  .... .   | | |    .      ..  .   ...|...|   . ..|||. 
EKCDVYSFGIVLWEILTRCR--------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQ

EIVSRL
||..||
EILKRL
Kinase CR4L_e-1.AA IRAK 629-735 45 9.7e-37 127.76 In-house 107-223 (317) Show / Hide 
Range on Protein: 629-735
Range on HMM: 107-223/317
Sequence Identity: 45% (53 aa)

SWQMRIGIALQAARGIEYLHTYA-VPPIIHRDIKSSNILIDAECSARVSDFGLSLMG-PSDGESHLSL------TAAGTVGYMDPEYYR--LQQLTTKSD
||..|. |.. .|.||..||.     ||||.||||.||| |.   .  .||||   | |  .  . ..      .  ||  || ||. |    |||.|.|
SWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTD

VYSFGVVLLEILTGKRA
|||||.||||.||| ||
VYSFGIVLLEVLTGCRA
Pkinase CR4L_e-1.AA Pkinase 501-733 25 4.2e-36 128.73 Pfam 1-209 (293) Show / Hide 
Range on Protein: 501-733
Range on HMM: 1-209/293
Sequence Identity: 25% (62 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE-VAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNG----TVHD
.    .|| ||||.||...  . .. ||.|.  . .  ..    .          ||.. . ||.| . |.| ... ..|.  .| .....|      .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

HLHGRKEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSA----RVSDFGLSLMGPSDGESH
....                    .|  ..   |..  . ...| .||.||.|      |||||.|..||||| ..      ...||||.        ..
YIST--------------------WRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS

LSLTAAGTVGYMDPEYYR-LQQLTTKSDVYSFGVVLLEILTGK
   | .|| .|| ||  |  |  ..|.|..|.|..| | |.|.
-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR
Kinase CR4L_e-1.AA TK 501-731 16 1.9e-34 112.32 In-house 1-389 (486) Show / Hide 
Range on Protein: 501-731
Range on HMM: 1-389/486
Sequence Identity: 16% (65 aa)

FSDDNRIGTGSFG---TVYRGVLPDGR--------------------------EVAIKRGGVGSSGMDAIAKK-KFQDKESA--------FQSELEFLT-
    . .| | ||   .||.| . ...                          .||.|    |..  ..  .   ..|            . .|.. .  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD---RDGGEDFLEEAEEMKMMCH

-RLHHRHLVTLVGFCAEDDE------------RLLVYDFMPNGT----VHDHLHGRKEEEHQERQEGGE-------------------------------
  .|| ..| |.| | ....             ..|  .||.|      .|.|. .......|  ....                               
SLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEE

-------IVPQQQERIFAINLN-------------SWQMRIGIALQAARGIEYLHTYAV---PPIIHRDIKSSNILIDAECS-----------ARVSDFG
       | .. ..  ..  |.             . . .. ...|.|.| ||||   .   . ..|||.   |.|.. .             ....|||
QDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

LSLMGP----SDGESHLSLTAAGTVG----------------------------YMDPEYYRLQQ---------LTTKSDVYSFGVVLLEILT
|| .|      | .|.   ..... |                            .| ||  . ..          ||||||.||||.. ||.|
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
TyrKc CR4L_e-1.AA TyrKc 501-815 21 7.3e-32 113.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 501-815
Range on HMM: 1-280/280
Sequence Identity: 21% (76 aa)

FSDDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRL--HHRHLVTLVGFCAED-------DERLLVYDFMPNG
 . .  .| | ||.||.|..   ..||.|    ..              . .| .|.. ...|  || ..| |.| | ..       .  ..|  .||.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

TVHDHLHGRKEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSD---G
  .|.|. ....                         ...  . ...|.|.| ||||     ..||||.   |.|....  ...||||||  . .|   |
DLKDYLRKHRPK------------------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG

ESHLSLTA----AGT----VGYMDPEYYRLQQLTTKSDVYSFGVVLLEILT-------G-----KRAIIVENRLKLRQNPQLPVNVVDFAVPFILAGQVI
||.   ..     |     .  | ||  .    ||||||.||||.. ||.|       |     . .. | ...| .  .  | |.     | .      
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P-MS-----

SILDPRIGLPEEADEMEAVLIVAELAEECVRLEGKERPSMGEIVSRL
                ..   . .. ..| . . ..||.. ||....
------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CR4L_e-1.AA LRRK 501-735 25 6.8e-31 106.52 In-house 1-282 (351) Show / Hide 
Range on Protein: 501-735
Range on HMM: 1-282/351
Sequence Identity: 25% (78 aa)

FSDDNRIGTGSFG-TVYRGVLPD---------------------------GREVAIKRGGVG----------SSG-----------------MDAIAKKK
.   . || |.|| .|||. . .                           . .||||   ..          |..                  .. . ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTVHDHLHGRKEEE-HQERQEGGEIVPQQQERIFAINLN-SWQMRIGIALQAARG
|.     |. |.  . .|.| ..| |.||| .   . .| ...|.|. ...|| .|. . |  .                   . ||.... |||| |.|
FRE----FRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMK------------------AHISWMLKLKIALQIAKG

IEYLHTYAVPPIIHRDIKSSNILI---D---------AECSARVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQ---QLTTKSDVYSFGVVLLE
.||||  . ||||||| || |||.   .         |.  | ..|||.| |  .   . .  .  |. |.| ||  |     . |.|.|.||||..| |
MEYLHS-HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWE

ILTGK-RA
.||.. ..
LLTRQHHP
Kinase CR4L_e-1.AA RIPK 507-735 25 1.9e-30 100.92 In-house 1-227 (290) Show / Hide 
Range on Protein: 507-735
Range on HMM: 1-227/290
Sequence Identity: 25% (64 aa)

IGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDE------RLLVYDFMPNGTVHDHLHGR
.| |.||.|.. .  . .....|     . .   ...   . .. .   | . . .| ..| | . ||| . .         .|  .|.||   . || .
VGGGGFGEVFKARHRHWGDWVAKKC---KPCKHCHTHM-DDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTK

KEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLS-LMGPS--DG--------E
 .                           |  |  .  . ..|  |||    ||||||| | .|||.|..  . ..||||.  |. |   .         
WPY--------------------QHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVY

SHLSLTAAGTVGYMDPEYYR--LQQL----TTKSDVYSFGVVLLEILTGKRA
|  |.   ||  ||.|| .|  .       |.|.|||||..|. |.||.| .
SMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase CR4L_e-1.AA Dicty4 629-733 44 1.1e-28 92.89 In-house 107-214 (277) Show / Hide 
Range on Protein: 629-733
Range on HMM: 107-214/277
Sequence Identity: 44% (49 aa)

SWQMRIG---IALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSL-MGPSDGESHLS--LTAAGTVGYMDPEYYRLQQLTTKSDVYSF
.|  ..    .|. ||||. .||.   | |||||.||.|.|.|.   . |.|||||  | .  .|.|     ||.||...| ||  . |  . |.|||||
DWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK--HEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSF

GVVLLEILTGK
| || ||||..
GIVLWEILTRQ
Kinase CR4L_e-1.AA TKL-Unique 626-734 37 2.1e-28 97.33 In-house 105-226 (290) Show / Hide 
Range on Protein: 626-734
Range on HMM: 105-226/290
Sequence Identity: 37% (46 aa)

NLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAE-----CSARVSDFGLSLMGPSDGESHLS-------LTAAGTVGYMDPEYYRL--Q
. ...|.|. .|...|.| .|||..  | |||||.||||.|.| .      .....|||||    .. .. ..        |  |.  .| ||  |    
CKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFC

QLTTKSDVYSFGVVLLEILTGKR
| ..||||||||.|| ||.|.|.
QYSEKSDVYSFGIVLWEIATRKI
Kinase CR4L_e-1.AA IRAK 501-601 33 9.9e-28 95.43 In-house 1-98 (317) Show / Hide 
Range on Protein: 501-601
Range on HMM: 1-98/317
Sequence Identity: 33% (36 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE--VAIKRGGVGSSGMDAIAKKKFQDKESAFQS---ELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPNGTVHD
|. ||||| | ||.||||.. .. .  .|.|.         . |. ..  ..  ||.   ||. ..|..| ..| | |.|.| ..  |||..||||. .|
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKK-------LKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLED

HLHGRK
 |....
RLWCQD
Kinase CR4L_e-1.AA MLK 636-733 42 1.5e-27 92.66 In-house 129-233 (291) Show / Hide 
Range on Protein: 636-733
Range on HMM: 129-233/291
Sequence Identity: 42% (46 aa)

IALQAARGIEYLHTYAVPPIIHRDIKSSNILIDA------ECSARVSDFGLSLMGPSDGES-HLSLTAAGTVGYMDPEYY---RLQQLTTKSDVYSFGVV
.||| |||..|||  |..||||||.||.|||||.      .  ....|||.| .  . . . . |  .|||. .| ||     | .. . |.||.|.|||
WALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMS--NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVV

LLEILTGK
| |.||..
LWEMLTRE
Kinase CR4L_e-1.AA Pkinase_Tyr 501-681 22 7.8e-24 81.34 Pfam 1-158 (270) Show / Hide 
Range on Protein: 501-681
Range on HMM: 1-158/270
Sequence Identity: 22% (43 aa)

FSDDNRIGTGSFGTVYRGVLP-----DGREVAIKRGGVGSSGMDAIAKKKFQDKE---SAFQSELEFLTRL-HHRHLVTLVGFCA-EDDE--RLLVYDFM
 . .  .| |.||.||.|..      .. .||.|           . | .  ...    .| .|.. .. | || ..| |.| |  ...    ..|  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK-----------MLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM

PNGTVHDHLHGRKEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLS
|.|  .|.|. ..                        .|.  .  .....| |.| |||.      .||||.   |.|.. .  ....||||.
PHGDLLDYLRKHR--------------------EDKQPLTMKD-LLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLA
Kinase CR4L_e-1.AA DRK 629-731 39 1.4e-22 73.31 In-house 96-197 (258) Show / Hide 
Range on Protein: 629-731
Range on HMM: 96-197/258
Sequence Identity: 39% (41 aa)

SWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDGESHLSLTAAGTVGYMDPEYYRLQQLTTKSDVYSFGVVLLE
.|  .. ... .|.|. |||    | ||||| || | |.|      |.|||||       .     |. || .   ||  | |  | | |||||..|| |
DWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWE

ILT
..|
CVT
Kinase CR4L_e-1.AA S_TKc 501-819 18 3.7e-20 74.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 501-819
Range on HMM: 1-231/231
Sequence Identity: 18% (61 aa)

FSDDNRIGTGSFGTVYRGVLPD-GREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLHHRHLVTLVGFCAEDDERLLVYDFMPN--GTVHDHL
.   . || |.||.||...  . ||.||||.                      ...|.. | . || ..|.| ... . |.  .| .....  |...|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

HGRKEEEHQERQEGGEIVPQQQERIFAINLNSWQMRIGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDGESHLSLTAA
. |. .  . .    ..                     .. | ....||.|      |||||.| .|||.|      ..||||.             |  
KKRGRHGLRFPFPE-HARF-------------------YMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFC

GTVGYMDPEYYRLQQLTT-KSDVYSFGVVLLEILTGKRAIIVENRLKLRQNPQLPVNVVDFAVPFILAGQVISILDPRIGLPEEADEMEAVLIVAELAEE
||  || ||     . .. |.|..|.|..| | |.|.      .  .. ..                                          . .. . 
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------------------------SPEAKDFIRK

CVRLEGKERPSMGEIVS-----RLESAV
| . . ..||.  |.       ..   .
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CR4L_e-1.AA RAF 634-733 30 4e-20 61.66 In-house 106-218 (282) Show / Hide 
Range on Protein: 634-733
Range on HMM: 106-218/282
Sequence Identity: 30% (35 aa)

IGIALQAARGIEYLHTYAVPPIIHRDIKSSNILIDAECSARVSDFGLSLMGPSDG--ESHLSLTAAGTVGYMDPEYYR-----------LQQL---TTKS
| |..| . | .|||      |||||.|| ||. . . . .. ||||  .        ..  .   . . .| ||  |           .|     . .|
IDISRQVCQGMDYLHAKN---IIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSFQS

DVYSFGVVLLEILTGK
||||||.|. |..|..
DVYSFGIVMYELMTRH
Kinase CR4L_e-1.AA TKL-Unique 503-598 26 3.4e-12 39.46 In-house 1-92 (290) Show / Hide 
Range on Protein: 503-598
Range on HMM: 1-92/290
Sequence Identity: 26% (27 aa)

DDNRIGTGSFGTVYRGVLPDGREVAIKRGGVGSSGMDAIAKKKFQDKESAFQSELEFLTRLH-HRHLVTLVGFCA----EDDERLLVYDFMPNGTVHDHL
. | ||.|..|.||.|. . | .||||.  .  ..   . ...       | .|.  . .|| |  .|...|.|.       .. .| ...| |. .|.|
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHP-NEDSSNEMMQE-------FENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVL

H
|
H
Kinase CR4L_e-1.AA MLK 501-618 21 1.2e-08 26.21 In-house 1-125 (291) Show / Hide 
Range on Protein: 501-618
Range on HMM: 1-125/291
Sequence Identity: 21% (29 aa)

FSDDNRIGTGSFGTVYRGVLPDGRE-----VAIKRGGVGSSGMDAIAKKKFQDKESA------FQSELEFLTRLHHRH----LVTLVGFCAEDDE-RLLV
.     || |||| |..|.   ...     ||.||          ..  .| || ..      |. | . | .| |.      . ..| |...    ..|
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKR----------VRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIV

YDFMPNGTVHDHLHG-RKEEE---HQERQEGGEIVPQQ
  ....|  .. ||| |....   |...   . . ...
MEYCEGGSLYNVLHGARSKWMDANHNQK-NDRVYDHDH
Kinase CR4L_e-1.AA RAF 501-518 66 5e-06 15.12 In-house 1-18 (282) Show / Hide 
Range on Protein: 501-518
Range on HMM: 1-18/282
Sequence Identity: 66% (12 aa)

FSDDNRIGTGSFGTVYRG
.   .|||.|||||||||
VMVMTRIGSGSFGTVYRG
Kinase CR4L_e-1.AA ABC1 507-529 45 1.1e-05 21.41 Pfam 19-42 (126) Show / Hide 
Range on Protein: 507-529
Range on HMM: 19-42/126
Sequence Identity: 45% (11 aa)

IGTGSFGTVYRGVLPD-GREVAIK
|...| . |.|..|.| |.|||.|
IAAASIAQVHRARLKDDGEEVAVK
Kinase CR4L_e-1.AA RAF 792-817 30 2e-05 13.2 In-house 257-282 (282) Show / Hide 
Range on Protein: 792-817
Range on HMM: 257-282/282
Sequence Identity: 30% (8 aa)

ELAEECVRLEGKERPSMGEIVSRLES
.|.|.|. .. .|||. ..|..|.. 
RLMEDCWKFQREERPLFQQILKRITV
Kinase CR4L_e-1.AA Pkinase_Tyr 714-731 72 7.4e-05 17.08 Pfam 192-209 (270) Show / Hide 
Range on Protein: 714-731
Range on HMM: 192-209/270
Sequence Identity: 72% (13 aa)

TTKSDVYSFGVVLLEILT
||||||.||||.. ||.|
TTKSDVWSFGVLMWEIFT
Kinase CR4L_e-1.AA DRK 791-817 37 7.6e-05 12.38 In-house 232-258 (258) Show / Hide 
Range on Protein: 791-817
Range on HMM: 232-258/258
Sequence Identity: 37% (10 aa)

AELAEECVRLEGKERPSMGEIVSRLES
. |  .|   .   |||| |.. |||.
IQLMNDCWNEDPQHRPSMQECLERLEA
Kinase CR4L_e-1.AA Dicty4 501-529 51 8.1e-05 12.2 In-house 1-28 (277) Show / Hide 
Range on Protein: 501-529
Range on HMM: 1-28/277
Sequence Identity: 51% (15 aa)

FSDDNRIGTGSFGTVYRGVLPDGREVAIK
   ..|||.||||.||.|    | |||.|
INIEQRIGKGSFGEVYKGTWR-GKEVAVK
Kinase CR4L_e-1.AA TK 782-815 14 8.5e-05 11.18 In-house 453-486 (486) Show / Hide 
Range on Protein: 782-815
Range on HMM: 453-486/486
Sequence Identity: 14% (5 aa)

DEMEAVLIVAELAEECVRLEGKERPSMGEIVSRL
.. ..  ....|  .| ... ..||.. .....|
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CR4L_e-1.AA Dicty4 803-817 47 0.000141 11.38 In-house 261-277 (277) Show / Hide 
Range on Protein: 803-817
Range on HMM: 261-277/277
Sequence Identity: 47% (8 aa)

KERPSMGEIVSR--LES
. |||. ||..|  ||.
QHRPSFEEIIQRRILEH
Kinase CR4L_e-1.AA DRK 504-530 48 0.000691 9.09 In-house 4-29 (258) Show / Hide 
Range on Protein: 504-530
Range on HMM: 4-29/258
Sequence Identity: 48% (13 aa)

DNRIGTGSFGTVYRGVLPDGREVAIKR
 |||| |..| |.||    | .||.|.
GNRIGRGNYGEVFRGTW-RGTQVAVKM
Kinase CR4L_e-1.AA LRRK 803-817 46 0.004271 6.78 In-house 337-351 (351) Show / Hide 
Range on Protein: 803-817
Range on HMM: 337-351/351
Sequence Identity: 46% (7 aa)

KERPSMGEIVSRLES
|.||.. .||.||..
KKRPHFSQIVKRLSQ
Kinase CR4L_e-1.AA MLK 791-815 32 0.005162 6.45 In-house 267-291 (291) Show / Hide 
Range on Protein: 791-815
Range on HMM: 267-291/291
Sequence Identity: 32% (8 aa)

AELAEECVRLEGKERPSMGEIVSRL
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KKLMKQCWNQDPHKRPSFRQIVQHL
Kinase CR4L_e-1.AA TKL-Unique 795-815 38 0.090581 2.24 In-house 270-290 (290) Show / Hide 
Range on Protein: 795-815
Range on HMM: 270-290/290
Sequence Identity: 38% (8 aa)

EECVRLEGKERPSMGEIVSRL
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QQCWHHDPSQRPSFDEIIHRL
Kinase CR4L_e-1.AA IRAK 793-815 21 0.093684 2.2 In-house 295-317 (317) Show / Hide 
Range on Protein: 793-815
Range on HMM: 295-317/317
Sequence Identity: 21% (5 aa)

LAEECVRLEGKERPSMGEIVSRL
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CACCCGHHRANRRCDMAWVMQQL
Kinase CR4L_e-1.AA Pkinase_Tyr 803-815 38 0.491012 4.13 Pfam 258-270 (270) Show / Hide 
Range on Protein: 803-815
Range on HMM: 258-270/270
Sequence Identity: 38% (5 aa)

KERPSMGEIVSRL
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EDRPTFSEIHEQL