Gene IRAK-0_t-2 (S.moellendorffii)

IRAK-0_t-2

Species: S.moellendorffii
Alias: IRAK-0_t-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_t-2.AA Protein None 843 None Fasta, JSON
IRAK-0_t-2.NA RNA None 2532 None Fasta, JSON
IRAK-0_t-2.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_t-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-0_t-2.AA B_lectin 113-201 25 1.6e-09 34.32 Pfam 22-137 (137) Show / Hide 
Range on Protein: 113-201
Range on HMM: 22-137/137
Sequence Identity: 25% (30 aa)

VGENATLQFTT-DEGLKVEEDG-----DVVWST--KTANRG---VRWLCISNRATIMLL-DESG--SNVIWQS--SDEPSDTVLLQRALTP------GQK
...|.||.... |  | . . |     ..||||   |...|      . . .     |. | ..  .||.|||   | |.||.|    |.       ...
NNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDD-NNDSNNVLWQSNTFDHPTDTWLPGMKLGWDNNVTIYMN

----LVSWNTSE--DSS
    |.|| ...  | |
WIGYLTSWKSNTNYDPS
B_lectin IRAK-0_t-2.AA B_lectin 63-175 19 0.000795 -7.64 SMART 1-126 (126) Show / Hide 
Range on Protein: 63-175
Range on HMM: 1-126/126
Sequence Identity: 19% (25 aa)

SRYISYEVWMLSYNADT---PRSFFLALVAIRNPTSWELT---RPVILWKARQ--TRLVGE---NATLQFTTDEGLKVEEDGDVVWSTKTA-NRGVRWLC
. ..|      | |  .     .| .      | .. .        ..| |.   ...| .   ...| ...|  | ..  . .|||..|. |.|.  . 
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ-WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSSNTTRNNGNYVAV

ISNRATIMLLDES---GSNVIWQSSDEP
        . |..    .|.|||| | |
LQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase IRAK-0_t-2.AA TKL 526-782 21 1.8e-66 227.17 In-house 1-364 (364) Show / Hide 
Range on Protein: 526-782
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGNGGFGNVFKGLLAD---------GTEVAVKKLEGSN---------------------------QKSKDFFAEVG-ILARTHHWNLVKLLGFCAQGPR-
.| |||| |.|| .           |..|||||.   |                           .. ..|. |.  .. |..| |.|...|.| ..|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KRLLVYEYMKNGSLERWIFEDDRIPGNISWKLRFNIAIGTARGLNYLHDDCV-----ERIIHLDLKPENVLLDDGFQ------------
           .  .|.||...|||.  .           | .|...|...|||.|||| .         ||| |||..|.|.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKIADFGLSKLMDRKESQL-----------------QLTITRGTPGYVAPECIQ----------------EGTVTEKTDVFGFGVLLLEIITGCKNRN
  .||.|||||. |......                  ..   .|||.. |||...                ... .||.||. ||..| ||.|.|.   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

LSGDYLKDY--------------LLVS--NRNGSAAAHLSE------EENEKERLKNVAALCVRDDPNLRPSISKVIQMM
    | ..                .|.  ..      . ..      ...  ...|. .  |   ||. ||| ..... .
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_t-2.AA IRAK 523-734 37 3.2e-49 169.84 In-house 4-238 (317) Show / Hide 
Range on Protein: 523-734
Range on HMM: 4-238/317
Sequence Identity: 37% (89 aa)

SNCLGNGGFGNVFKGLLADGTE--VAVKKLEGS-----NQKSKDFFA---EVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLE-RWIFED-DR
.| .| |||| |..| . ..|.  .|||||        |.. . | .   |. ...| .| |.| |.|.|.... .  |||.||.||||| |    | . 
DNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ-CHCLVYPYMPNGSLEDRLWCQDGQC

IPGNISWKLRFNIAIGTARGLNYLHDDC-VERIIHLDLKPENVLLDDGFQPKIADFGLSKLM----DRKESQL---QLTITRGTPGYVAPECIQ--EGTV
 |   ||  |. |..|||.|...||..     ||| | |. |.|||. |.|||.||||        ... . .      ..|||  | .|| |    |  
PPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL

TEKTDVFGFGVLLLEIITGC---KNRNLSGDYLKDYL
| ||||. ||. |||..|||   ....    ||||..
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLC
Pkinase IRAK-0_t-2.AA Pkinase 520-719 29 1.2e-46 165.98 Pfam 1-208 (293) Show / Hide 
Range on Protein: 520-719
Range on HMM: 1-208/293
Sequence Identity: 29% (65 aa)

GKFSNCLGNGGFGNVFKGLLADGTE-VAVKKLEGSNQKSKDFFA-----EVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNG----SLERWIF--E
 ..  ..| |.|| |.|.   .  . ||||... ...||.   .     |. |..| .| | |.|....   ...  .| ||. .|    .| ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

DDRIPGNISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDGFQP----KIADFGLSKLMDRKESQLQLTITRGTPGYVAPECIQ-EGTVTE
. ..    |..   ...  ..|||.|.|.    .||| ||||||.|.|.  ..    ||.||||.|..|   ..  .|   |||.|.||| |.     . 
HGCFY--FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KTDVFGFGVLLLEIITG
| |....|..| | ..|
KVDMWSCGCILYEMLCG
Kinase IRAK-0_t-2.AA Dicty4 521-719 35 3.8e-46 152.0 In-house 2-213 (277) Show / Hide 
Range on Protein: 521-719
Range on HMM: 2-213/277
Sequence Identity: 35% (78 aa)

KFSNCLGNGGFGNVFKGLLADGTEVAVKKLEGSNQKS-----KDFFAEVGILARTHHWNLVKLLGFCA---QGPRKRLLVYEYMKNGSLERWIFED----
.. . .| |.|| |.||    |.|||||||   ||..     ..| .|| |..   | |.....| |      | | . | |||  |.|.. .  |    
NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYS-LLHDKPSE

--DRIPGNISWKLRFN---IAIGTARGLNYLHD-DCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMDRKESQLQ-LTITRGTPGYVAPECIQEGTVT
  ..|.  ..| |.     .|. .|||.|.||  ..|  |||.|||. | | |. .. |..|||||..| . |.. . .. . |||...|||. ..   .
QQQSIK--LDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYN

EKTDVFGFGVLLLEIITG
|| ||. || .| || |.
EKADVYSFGIVLWEILTR
Kinase IRAK-0_t-2.AA MLK 520-719 28 3.2e-42 144.3 In-house 1-232 (291) Show / Hide 
Range on Protein: 520-719
Range on HMM: 1-232/291
Sequence Identity: 28% (66 aa)

GKFSNCLGNGGFGNVFKGLLADGTE-----VAVKKLE-------GSNQKSKDFFAEVGILARTHHWN----LVKLLGFCAQGPRKRLLVYEYMKNGSLER
 .|.  .|.|.|| |.||    ...     ||||. .        .   ..||  |. .|..  | |     ....| |.| | . ..| ||. .||| .
IQFHEWIGSGSFGKVWKGRW-RNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

WIFE-DDRIP---------GNISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDD------GFQPKIADFGLSKLMDRKESQLQLTITRGTP
 . . .. .          ....  . .|.|   |||..||| . .  ||| |||. |.|.|.      . . ||.|||.|. . ...     . ..||.
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC--TNMMSNAGTY

GYVAPECI---QEGTVTEKTDVFGFGVLLLEIITG
 . ||| |   ......|| ||. .||.| |..|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-0_t-2.AA TKL-Unique 522-720 30 1.6e-38 133.49 In-house 1-225 (290) Show / Hide 
Range on Protein: 522-720
Range on HMM: 1-225/290
Sequence Identity: 30% (70 aa)

FSNCLGNGGFGNVFKGLLADGTEVAVKKLE----GSNQKSKDFFAEVGILARTH-HWNLVKLLGFCAQ---GPRKRLLVYEYMKNGSLERWIF------E
|.| .| ||.|.|.||  . |..||.|...     ||.....|  || .. . | | |.|.. |.|.     | .. .| ||.  |||   .        
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

DDRIPGNISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDG-----FQPKIADFGLSKLMDRK-ESQLQ-L-----TITRGTPGYVAPECI
  .   ......| ..||  |.|..|||      |||.|||. |.|.| .     .. ||.||||||. ..  .. .  .     .   |.. ..||| .
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

QE--GTVTEKTDVFGFGVLLLEIITGC
     . .|| ||. ||. | ||.|..
RMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase IRAK-0_t-2.AA DRK 521-718 35 1.4e-37 124.89 In-house 2-197 (258) Show / Hide 
Range on Protein: 521-718
Range on HMM: 2-197/258
Sequence Identity: 35% (72 aa)

KFSNCLGNGGFGNVFKGLLADGTEVAVKKLEGSNQK----SKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLERWIFEDDRIPGNIS
|  |  | |..| || |    ||.||||.|   |       ..|  |. .. .  | | .  .| |   |   . . |||  ||| . |  |. |   ..
KIGNRIGRGNYGEVFRGTWR-GTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPP-DICICMEYMPRGSLYN-ILHDESI--EMD

WKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMDRKESQLQLTITRGTPGYVAPECIQEGTVTEKTDVFGFGVLLLEI
| |.  ...  |.|..|||  |   ||| |||  | | |. .| |.||||||    . ...       |||. .|||   .   ||| ||. |.. | |.
WPLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

IT
.|
VT
Kinase IRAK-0_t-2.AA S_TKc 520-782 24 1.2e-36 128.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 520-782
Range on HMM: 1-231/231
Sequence Identity: 24% (69 aa)

GKFSNCLGNGGFGNVFKGLLAD-GTEVAVKKLEGSNQKSKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKN--GSLERWIFEDDRIPGN--
 .. . .| |.|| |.|.   . | .||.|..       ...  |. || . || |.|||....     .  .| ||. .  |.| . | .  | ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMDRKESQLQLTITRGTPGYVAPECIQEGTVTE-KTDVFGFGVLL
..      ..  ....|.|.|.    .||| ||||||.|||.  . ||.||||....         |   ||| |.||| .     .  | |.  .|..|
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

LEIITGCKNRNLSGDYLKDYLLVSNRNGSAAAHLSEEENEKERLKNVAALCVRDDPNLRPSISKVIQ---------MM
 | ..|.           .. .. .. |             . .|.    | . ||. ||.. .. |          .
YEMLCGYPPFP-------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_t-2.AA TK 520-782 16 8.1e-36 117.0 In-house 1-486 (486) Show / Hide 
Range on Protein: 520-782
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

GKFSNCLGNGGFG---NVFKGLLADG--------------------------TEVAVKKLE-GSNQKSKDFFA--------------EVGILARTH----
 .. . || | ||    |.||.. ..                          |.|||| |  |... ...||.              |. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HWNLVKLLGFCAQGPRK-----------RLLVYEYMKNGS----LERWIFEDDRIPGN-----------------------------------------
 | |.|.|.| | ||  |            ..| |||..|.    |  .  . ..   .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------ISWKLRFNIAIGTARGLNYLHDDCVE---RIIHLDLKPENVLLDDGFQ-----------PKIADFGLSK
                               .. . .  ..   |.|. |||.  .|   ...| ||   |.|.... .            ||||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

L----MDRKESQLQLTITRGTPG----------------------------YVAPECIQ---------EGTVTEKTDVFGFGVLLLEIITGCK---NRNL
     . |.  . .   .....|                            . ||||..         .|. |.|.||. ||||. || | ..     ..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

S-------------GDYLKD---------------YLLVSNRNGSA----AAHLSEEENEKERLKNVAALCVRDDPNLRPSISKVIQMM
|              .||..               . .    . .     .  . ... . | .  .   | . ||. ||. | . ...
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_t-2.AA Pkinase_Tyr 521-721 32 3.3e-35 119.88 Pfam 2-212 (270) Show / Hide 
Range on Protein: 521-721
Range on HMM: 2-212/270
Sequence Identity: 32% (70 aa)

KFSNCLGNGGFGNVFKGLLA-----DGTEVAVKKL-EGSNQK---SKDFFAEVGILART-HHWNLVKLLGFCA-QGPR-KRLLVYEYMKNGSLERWIFED
.|   || | ||.|.|| .      ....||||.| ||. ..   ..||..|. |.    || |.|.|.| |  ||   . ..| |||..|.|       
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL---

DRI----PGNISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMDRKESQ-LQLTITRGTPGYVAPECIQEGTVTEK
 |     ..... |   ....  |.|..||..     .|| ||   |.|...... ||.||||....  ..    . . ..      |||||..|  |.|
-RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

TDVFGFGVLLLEIITGCK
.||  ||||. ||.| ..
SDVWSFGVLMWEIFTYGE
Kinase IRAK-0_t-2.AA RIPK 526-719 29 9e-35 115.91 In-house 1-224 (290) Show / Hide 
Range on Protein: 526-719
Range on HMM: 1-224/290
Sequence Identity: 29% (67 aa)

LGNGGFGNVFKGLLADGTEVAVKKL-EGSN-------QKSKDFFAEVGILARTHHWNLVKLLGFCAQG----PRK-RLLVYEYMKNGSLERWIFEDDR-I
.| |||| |||   ..  ....||   . .       |.... . |. ....  . . |...||| .     . |   .| |||.||||.       .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

PGNISWKLRFNIAIGTARGLNYLHDDCVER--IIHLDLKPENVLLDDGFQPKIADFGLSKLMDRKESQLQL--------TI----TR-GTPGYVAPECIQ
.  . |.||. .   ...| .|||.       |||.||||||.|.|  |  |||||||.. |    |...          .     | ||  | .|| . 
HHPDPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLATWM--MWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

---EGT---VTEKTDVFGFGVLLLEIITG
         ||.| ||  |.... |. |.
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-0_t-2.AA CZAK 521-719 36 5.8e-32 112.5 In-house 2-218 (279) Show / Hide 
Range on Protein: 521-719
Range on HMM: 2-218/279
Sequence Identity: 36% (81 aa)

KFSNCLGNGGFGNVFKGLLADGTEVAVKKLEGSNQKSKD-------FFAEVGILARTHHWNLVKLLGFC-AQGPRKRLLVYEYMKNGSLERWIFEDDRIP
||    | | || | |.    |. ||.|..     . ||       |  ||.|.    | | |  || | . ||  .  | |.|  ||| |    .|.  
KFGQTIGQGFFGEVYKAYWR-GKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL--TDHYF

GNIS-WKLRFNIAIGTARGLNYLHDDCVE-RIIHLDLKPENVLLDDGFQ-------------PKIADFGLSKLMDRKESQLQLTITRGTPGYVAPECIQE
       |. |.||  ||| |||||   .  |.| ||   |.|||.                 ||.|||||..|  .|   . | | |   . ||||   
YHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREM--MEQPFEMTQTMGCLCWMAPECFKG

GTVTEKTDVFGFGVLLLEIITG
   ||| ||. || .| .|||.
ENYTEKVDVYSFGMILWCIITC
Kinase IRAK-0_t-2.AA TyrKc 520-782 26 1.1e-31 112.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 520-782
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

GKFSNCLGNGGFGNVFKGLLADGTEVAVKKLEGSNQKSKDFFAEVGILART--HHWNLVKLLGFCAQGP------RKRLLVYEYMKNGSLERWI-FEDDR
 ..   ||.| || |.|| .   ..||||.|  .    .||  |  |. .   || |.|.|.| | |.          ..| |||..|.|   .    ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

IPGNISWKLRFNIAIGTARGLNYLHDDCVERIIHLDLKPENVLLDDGFQPKIADFGLSKLMDRK----ESQLQLTITR--GTPG-----YVAPECIQEGT
    ...|   ....  |.| .|||.    ..|| ||   |.|...... ||.|||||.  . .    ||.   . .   |. .       |||||..|.
----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

VTEKTDVFGFGVLLLEIITGCKNRN-------LSGDYLKDYLLVSNRNGSAAAHLSEEE-----NEKERLKNVAALCVRDDPNLRPSISKVIQMM
 |.|.||. |||.. || | ..          .| . .  |.   .|    . ..   .       .|  . .   | . ||. ||. | ... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_t-2.AA LRRK 520-719 25 5.2e-31 106.93 In-house 1-278 (351) Show / Hide 
Range on Protein: 520-719
Range on HMM: 1-278/351
Sequence Identity: 25% (73 aa)

GKFSNCLGNGGFG-NVFKGLLAD---------------------------GTEVAVKKLEG------------SN-----------------------QK
 |. . .| |||| .|... . .                           ...||.||..             .|                        .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

SKDFFAEVGILARTHHWNLVKLLGFCAQGPRKRLLVYEYMKNGSLERWIF---EDDR--IPGNISWKLRFNIAIGTARGLNYLHDDCVER--IIHLDLKP
   |  || |. . .| |.|.|.||| . ..   .| ||. .|.| . ..   .| .  .. .||| |.  ||.  |.|..|||.    .  ||| |||.
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC---MVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS---HNPPIIHRDLKS

ENVLLDDGFQP------------KIADFGLSKLMDRKESQLQ-LTITRGTPGYVAPECIQEG---TVTEKTDVFGFGVLLLEIITG
.|.||    |.            ||||||.|  |  .  .   .    |.||..|||.....   . |||.|.. ||..| |..|.
PNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase IRAK-0_t-2.AA LRRK 751-784 15 0.04036 3.28 In-house 312-351 (351) Show / Hide 
Range on Protein: 751-784
Range on HMM: 312-351/351
Sequence Identity: 15% (6 aa)

EN-EKE-----RLKNVAALCVRDDPNLRPSISKVIQMMEG
.. ...     ....   .|   ||. ||. |.... .. 
QHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_t-2.AA DRK 764-784 33 0.060778 2.41 In-house 238-258 (258) Show / Hide 
Range on Protein: 764-784
Range on HMM: 238-258/258
Sequence Identity: 33% (7 aa)

CVRDDPNLRPSISKVIQMMEG
|   ||  |||   ... .| 
CWNEDPQHRPSMQECLERLEA
Kinase IRAK-0_t-2.AA TKL-Unique 764-782 36 0.179391 1.18 In-house 272-290 (290) Show / Hide 
Range on Protein: 764-782
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CVRDDPNLRPSISKVIQMM
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CWHHDPSQRPSFDEIIHRL
Kinase IRAK-0_t-2.AA CZAK 769-782 35 0.196199 1.16 In-house 266-279 (279) Show / Hide 
Range on Protein: 769-782
Range on HMM: 266-279/279
Sequence Identity: 35% (5 aa)

PNLRPSISKVIQMM
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PDERPSFKQILQHL
Kinase IRAK-0_t-2.AA Dicty4 768-784 42 0.233143 0.49 In-house 259-277 (277) Show / Hide 
Range on Protein: 768-784
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

DPNLRPSISKVIQM--MEG
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DPQHRPSFEEIIQRRILEH