Gene IRAK-0_af-1 (S.moellendorffii)

IRAK-0_af-1

Species: S.moellendorffii
Alias: IRAK-0_af-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_af-1.AA Protein None 1020 None Fasta, JSON
IRAK-0_af-1.NA RNA None 3063 None Fasta, JSON
IRAK-0_af-1.kin_dom Protein Kinase Domain None 220 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_af-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-0_af-1.AA LRR_1 137-158 37 0.004463 15.08 Pfam 1-26 (26) Show / Hide 
Range on Protein: 137-158
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLVTLDLNN-N--NLQGPIPR--CIGI
.| .|||.. |  ||.| ||   . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 162-185 32 42.757904 0.96 Pfam 1-26 (26) Show / Hide 
Range on Protein: 162-185
Range on HMM: 1-26/26
Sequence Identity: 32% (9 aa)

RLKKLGMAGGA--GNL-GTIPEE-LGSL
.|..| . |     || |.||.. . .|
NLQHLDLSG-CNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 187-209 40 0.000431 18.68 Pfam 1-26 (26) Show / Hide 
Range on Protein: 187-209
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLEQLYLDN-T--NLTGPIPSS-FGGM
.|. |.|.. .  |||| ||.| | ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 211-233 37 0.000315 19.16 Pfam 1-26 (26) Show / Hide 
Range on Protein: 211-233
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQQLDIRY-N--RLSGRIPLE-LGRL
.|| ||... |  .|.| || . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 235-256 29 55.053107 0.57 Pfam 1-26 (26) Show / Hide 
Range on Protein: 235-256
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

NLVELGIQV-N--SLEGGIEA--VASL
|| .| ..  |  .|.| |      .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 258-281 29 0.030704 12.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 258-281
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLETLRAFN-N--HFSGNLSLSIFRNL
.|..|   . |  ...|... |.| ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 283-304 33 0.520988 7.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 283-304
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRVLNLKL-N--NFTGGIPE--LDER
.|..|.|   |  |.|| ||.  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 307-329 48 0.00016 20.21 Pfam 1-26 (26) Show / Hide 
Range on Protein: 307-329
Range on HMM: 1-26/26
Sequence Identity: 48% (13 aa)

NLTHLDLSF-N--QFSGGIPGS-LVRL
||.|||||  |  ...| || | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-0_af-1.AA LRR_1 331-349 50 0.03854 11.76 Pfam 1-22 (26) Show / Hide 
Range on Protein: 331-349
Range on HMM: 1-22/26
Sequence Identity: 50% (11 aa)

SLTHLFLGH-N--NLSGAIPSS
.|.|| |.. |  ||.| ||.|
NLQHLDLSGCNCCNLTGHIPPS
LRR_1 IRAK-0_af-1.AA LRR_1 353-375 37 0.003204 15.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 353-375
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

ALQVLDVSH-N--SLSGSLPNL-PQQL
 ||.||.|. |  .|.|..|.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Malectin IRAK-0_af-1.AA Malectin 417-575 26 6.1e-19 74.05 Pfam 1-181 (202) Show / Hide 
Range on Protein: 417-575
Range on HMM: 1-181/202
Sequence Identity: 26% (49 aa)

TSFAVRVGSSED-LTNRDGTLFRSDGFARNSTG--LHYLEADRNWALELSSEFSSTV----TFPATI---SGVP-PEDN--SSLYQTMRWSSSYLAYHGG
.|...  |..|   | .||...  | .    .     |  .. .|.   .  |.       .. ..|   | .. ..|.  . |||| ||| | ..| . 
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYS-TGDFMDDDNNQYYY-GYITTNSSIFYTTDDVDPELYQTERWSPSSFRYYIP

NLAPGTYSVSLYFCETVFTN-------ASYRAMDVVVQGEVIARQLDVVREVGP--RTAYKITRNATVTDGSLS--IEFIFTG
 |. |.|.| |.|.|. |..       .  |  || .||... . .|.. |.|   ..|.|   |.|||.| |.  | |  .|
CLENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYWAG
Kinase IRAK-0_af-1.AA TKL 685-848 24 2.5e-50 173.53 In-house 1-242 (364) Show / Hide 
Range on Protein: 685-848
Range on HMM: 1-242/364
Sequence Identity: 24% (61 aa)

LGQGGFGSVYVGNLQDQT---------LVAVKQLLHQ---------------------------TQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEH-
.|.|||| || |... ..          ||||..  .                           ... |. ...||...|. .| |.|   |||.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PMLVCDYMRNGSLDHFLHGSRGFLTWNQRRKIAIDTAFGLAYLHDES-----KHRIIHCDLKPPNILLDDDLM--------------P
            ...| .|. .||| |.||       |.|| ..|.|.| |..||| .      |  |||.|||..|||.|...               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RIADFGMARLYEEGK-----------------SHVTATKMGGTIGYLAP
 |.||| .|  .. .                 .. |  . .||....||
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAP
Pkinase IRAK-0_af-1.AA Pkinase 679-898 25 6.3e-44 156.39 Pfam 1-209 (293) Show / Hide 
Range on Protein: 679-898
Range on HMM: 1-209/293
Sequence Identity: 25% (60 aa)

FNPTKKLGQGGFGSVYVG-NLQDQTLVAVKQLLHQTQQG--REAFRK--EIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNG----SLDHFLH-GSR
.   .|.|.|.||.|| . .  .. .||||..  ...    ... |.  ||.|. ...| | |  .... .  |. .| .|...|    .| ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GFL--TWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMP----RIADFGMARLYEEGKSHVTATKMGGTIGYLAPGKKKERISRVLDLG
| .  .... ....  .. ||.|.|..   .|||.|||| |||.|..  .    .|.||| |....   . . .|   ||..|.||    | |       
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP----EVIR------

FIDISSLAEYAMHYQLSDKADVYSYGVVLLEIISGR
            .   . |.|..|.|..| | ..||
-----------GGQYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_af-1.AA IRAK 679-848 33 1.3e-43 151.21 In-house 1-191 (317) Show / Hide 
Range on Protein: 679-848
Range on HMM: 1-191/317
Sequence Identity: 33% (64 aa)

FNPTKKLGQGGFGSVYVGNLQDQT-LVAVKQLLH----QTQQGREAFRK---EIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNGSLDHFLHGSRG-
|..  ..|.|||| || | .. .|  .||| |      .. . .. |.    |...... .| |.|.. |||.| . . || .||.||||   |..  | 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-F---LTWNQRRKIAIDTAFGLAYLHDES-KHRIIHCDLKPPNILLDDDLMPRIADFGMARLY----EEGKSHV---TATKMGGTIGYLAP
     |.| || .|.. || |. .||. . .  ||| | |. |||||....| |.|||..|      .  |. .    . .  ||  |..|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPP
Kinase IRAK-0_af-1.AA MLK 679-898 25 2.5e-43 148.19 In-house 1-233 (291) Show / Hide 
Range on Protein: 679-898
Range on HMM: 1-233/291
Sequence Identity: 25% (66 aa)

FNPTKKLGQGGFGSVYVGNLQDQT----LVAVKQLLH------QTQQGREAFRKEIRILSSVQHRN----LVAVRGYCLEAEH-PMLVCDYMRNGSLDHF
..  ...| |.||.|. |. . ..     ||||.  .      .|   ...|..|.|.|. ..|.|     ....| ||. ..   .|  |...||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGSRG-------------FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDD------DLMPRIADFGMAR-LYEEGKSHVTATKMGGTI
||| |.               .  .  ..| . | |..||| . .. ||| |||..|||.|.      ..  .|.||| .| ... . .  . ... || 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-T--NMMSNAGTY

GYLAPGKKKERISRVLDLGFIDISSLAEYAMHYQLSDKADVYSYGVVLLEIISGR
 . ||    | |..               . . . | |.||.|.|||| |.....
AWMAP----EVIQQ---------------FRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_af-1.AA Pkinase_Tyr 679-826 30 8e-34 115.18 Pfam 1-160 (270) Show / Hide 
Range on Protein: 679-826
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

FNPTKKLGQGGFGSVYVGNLQ-----DQTLVAVKQLLHQTQQG---REAFRKEIRILSSV-QHRNLVAVRGYCL-EAEH--PMLVCDYMRNGSLDHFLHG
    ||||.| ||.|| | .      ... |||| | ... .    ||.| .|..|...  .| |.|   | |. . |.  ...|  || .|.|...|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---RGFLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMPRIADFGMARL
    .. ||  .  ..... | |..||..   ...|| ||   |.|.....  .|.|||.||.
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_af-1.AA LRRK 679-848 25 2.1e-33 115.55 In-house 1-248 (351) Show / Hide 
Range on Protein: 679-848
Range on HMM: 1-248/351
Sequence Identity: 25% (65 aa)

FNPTKKLGQGGFG-SVYVGNLQDQ---------------------------TLVAVKQLLHQ-----------------------------------TQQ
.   ...|.|||| .|| .....|                           . ||.|...                                     .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

GREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRNGSLDHFLHGSR--GF------LTWNQRRKIAIDTAFGLAYLHDESKHR--IIHCDLKP
 || ||.|. |.|. .| |.|   |.|.  .....| .|...|.|.|||| ..  ||      ..|. . |||.. | |..|||   .|.  |||.|||.
FRE-FRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH---SHNPPIIHRDLKS

PNILL---D---------DDLMPRIADFGMARLYEEGKSHVTATKMGGTIGYLAP
|||||   .         ..    |||||  |..     .  | ...|..|..||
PNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAP
Kinase IRAK-0_af-1.AA TK 679-837 16 8.3e-33 106.73 In-house 1-319 (486) Show / Hide 
Range on Protein: 679-837
Range on HMM: 1-319/486
Sequence Identity: 16% (54 aa)

FNPTKKLGQGGFG---SVYVGNLQDQ--------------------------TLVAVKQLL---HQTQQGREA--------------FRKEIRILSS--V
    ||||.| ||    || | ....                          | ||||.|    ...|. ...              .  |. ....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVAVRGYCLEA------------EHPMLVCDYMRNGS----LDHFLHGSRG---------------------------------------------
.| |.|   |.|..             |..|.|  || .|.    |...|. .|.                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------FLTWNQRRKIAIDTAFGLAYLHDESKH-----RIIHCDLKPPNILLDDDLM-----------PRIADFG-
                              .||  |.  .. . | |..|||  ||.     ...| ||   |.|.....             .||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH--SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------MARLYEEGKSHVTAT
       .||  ....  ....
SRQGSGVLARDIYSDDDYYRKS
Kinase IRAK-0_af-1.AA Dicty4 679-848 29 3.7e-32 104.67 In-house 1-186 (277) Show / Hide 
Range on Protein: 679-848
Range on HMM: 1-186/277
Sequence Identity: 29% (55 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQL--LHQT--QQGREAFRKEIRILSSVQHRNLVAVRGYCL----EAEHPMLVCDYMRNGSLDHFLHG----
 | ....|.|.||.|| |.   .. |||| |  . |.  .   ..||||. |... .| |..   |.|.    . . .. |  ||  |.|   ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--SRGFLTWNQRRK---IAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMPRIADFGMARLYEEGKSHVT-ATKMGGTIGYLAP
  ..  | |  ...   .|.|.| |...|| ..  .||| |||. |.| |...   ..||| ...  ....| . .. . || .. ||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAP
Kinase IRAK-0_af-1.AA TKL-Unique 681-826 30 3.1e-31 107.48 In-house 1-166 (290) Show / Hide 
Range on Protein: 681-826
Range on HMM: 1-166/290
Sequence Identity: 30% (52 aa)

PTKKLGQGGFGSVYVGNLQDQTLVAVKQLLH---QTQQGREAFRKEIRILSSVQ-HRNLVAVRGYCL----EAEHPMLVCDYMRNGSLDHFLH-------
. .|.|.||.|.|| |    .. ||.||.     .  . .. |..|.....  . | |.|   |||      . .  .|..|.  |||.  ||       
FWNKIGEGGYGQVYKG-KWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--GSRGFLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDD-----LMPRIADFGMARL
   .   |...|| |.||| | |. ||| ...  |||.|||..|.|.| .     .  .|.||| ...
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKF
Kinase IRAK-0_af-1.AA UTK 679-826 30 5.8e-30 99.68 In-house 1-177 (296) Show / Hide 
Range on Protein: 679-826
Range on HMM: 1-177/296
Sequence Identity: 30% (54 aa)

FNPTKKLGQGGFGSVYVGNLQD------QTLVAVKQLL--HQTQQGRE---AFRKEIR---ILSSVQ-HRNLVAVRGYCLEAEHPMLVCDYMRNGSLDHF
  . ..|||| || |... ...      . .||||..   . .|| .|    |..| |   ... .. |.|.. . |.|.  | .|.|  ||.||.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LHGSRG-------FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDD-------LMPRIADFG---MARL
|  .|        .||  || . | | | |..|||    ....|.||   |.|....       .  .|||||   |.|.
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH---SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRR
Kinase IRAK-0_af-1.AA S_TKc 679-953 22 1.5e-29 105.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 679-953
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FNPTKKLGQGGFGSVYVGNLQD-QTLVAVKQLLHQTQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPMLVCDYMRN--GSLDHFLHGSRGF-----
.   .|.|.|.||.|| .   . . .||.|..        | .|.||.||.. .| |.|   ... . .|  .| .|. .  |.| ....  ..      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMPRIADFGMARLYEEGKSHVTATKMGGTIGYLAPGKKKERISRVLDLGFIDISSLA
..  . |...  .. .|.|.|   .|.|||.|||| |||||.     |.|||.||..         | . ||  |.||    | .               
FPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAP----EVL---------------

EYAMHYQLSD-KADVYSYGVVLLEIISGRRAIDSAAPREEVVLVDFAQSLASISTLELVTLLDKKLEGEGGE-ISVAEVVD-------MARV
      . .  |.|..| |..| | ..|.   .     .. .. .         . |.  ...| |. .  . ... |.         .  .
------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_af-1.AA RIPK 685-848 29 1.7e-26 87.29 In-house 1-191 (290) Show / Hide 
Range on Protein: 685-848
Range on HMM: 1-191/290
Sequence Identity: 29% (57 aa)

LGQGGFGSVYVGNLQDQTLVAVKQL---LHQT----QQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEH------PMLVCDYMRNGSLDHFLHGSRGF-
.| |||| |.     ..  ...|     .|      .| |..   |  .. . .... | . | | . |       . .|  || |||| ||||    . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LTWNQRRKIAIDTAFGLAYLHDESKH-RIIHCDLKPPNILLDDDLMPRIADFGMARLYEEGKSHV----------TATKM-GGTIGYLAP
   . |  |  .   .. |  |||  |.   ||| |||| |||.| ..   ||||| |   .  .||           .. |  .||. |..|
HHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPP
Kinase IRAK-0_af-1.AA Src 679-830 36 5.7e-26 85.18 In-house 1-150 (255) Show / Hide 
Range on Protein: 679-830
Range on HMM: 1-150/255
Sequence Identity: 36% (57 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQLLHQTQQGREAFRKEIRILSSVQHRNLVAVRGYCLEAEHPML-VCDYMRNGSLDHFLH-GSRGF-LTWNQ
.   .||||| || |. |  ...| |||| |   |    ||| .|. |. ...| .||.    | . | | . |  ||..|||  .|.  ..|  |  .|
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQ

RRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMPRIADFGMARLYEEG
   .|   | | |||   .. ..|| ||   |.| .....  .|||| ||| .|.
LIDMAAQVAEGMAYL---ESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED
Kinase IRAK-0_af-1.AA TyrKc 679-975 22 1.4e-23 85.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 679-975
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

FNPTKKLGQGGFGSVYVGNLQDQTLVAVKQLLHQTQQGREAFRKEIRILSSV--QHRNLVAVRGYCLEA-------EHPMLVCDYMRNGSLDHFLHGSRG
    |||| | || || | .   . |||| | . .   ||.|..|.||....  .| |.|.  |.|..        | .|.|  || .|.|...|. .|.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FLTWNQRRKIAIDTAFGLAYLHDESKHRIIHCDLKPPNILLDDDLMPRIADFGMARLYEEG------KSHVTA----TKMG-GTIGYLAPGKKKERISRV
 |.. .  ..... | | .|||.    ..|| ||   |.|.....  .|.|||..|  ...      |.  ..     . .   |  .||          
KLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP----------

LDLGFIDISSLAEYAMHYQLSDKADVYSYGVVLLEIISGRRAIDSAAPREE-----VVLVDFAQSLASISTLELVTL----LDKKLEGEGGEISVAEVVD
            |  ...  . | ||.|.||.. || .     . . | ..     .   .  . . .   ..                    .|    .
------------ECINYGKFTTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------FVCCPDE

MARVAVLCTLENPLLRPRMRAVWLML
| ..   |  |.|  ||.....   .
MYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_af-1.AA IRAK 869-975 18 3.3e-10 32.56 In-house 189-317 (317) Show / Hide 
Range on Protein: 869-975
Range on HMM: 189-317/317
Sequence Identity: 18% (25 aa)

LAEYAMH---YQLSDKADVYSYGVVLLEIISGRRAIDSAAPR---EEVVLVDFAQSLAS-ISTLE-------------------LVTLLDKKLEGEGGEI
... ..     ||. | |||| |.||||...|.|| ..  |.       . . ... ..  |..                     . ..|.. .. ..  
MPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPP--

SVAEVVDMARVAVLCTLENPLLRPRMRAVWLML
  ... .|. .|. |...   .|. |. |   |
--NMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_af-1.AA TKL 874-899 46 1e-06 20.17 In-house 262-287 (364) Show / Hide 
Range on Protein: 874-899
Range on HMM: 262-287/364
Sequence Identity: 46% (12 aa)

MHYQLSDKADVYSYGVVLLEIISGRR
.... | |.||||.|.|| ||....|
KGFEYSEKCDVYSFGIVLWEILTRCR
Kinase IRAK-0_af-1.AA LRRK 879-902 32 5.3e-05 13.62 In-house 260-284 (351) Show / Hide 
Range on Protein: 879-902
Range on HMM: 260-284/351
Sequence Identity: 32% (8 aa)

SDKADVYSYGVVLLEIISGR-RAID
..|.|.||.|..| |..... .. |
TEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_af-1.AA TKL-Unique 879-897 57 0.000237 11.46 In-house 206-224 (290) Show / Hide 
Range on Protein: 879-897
Range on HMM: 206-224/290
Sequence Identity: 57% (11 aa)

SDKADVYSYGVVLLEIISG
| |.||||.|.|| ||...
SEKSDVYSFGIVLWEIATR
Kinase IRAK-0_af-1.AA Dicty4 881-894 78 0.000741 8.94 In-house 197-210 (277) Show / Hide 
Range on Protein: 881-894
Range on HMM: 197-210/277
Sequence Identity: 78% (11 aa)

KADVYSYGVVLLEI
||||||.| || ||
KADVYSFGIVLWEI
Kinase IRAK-0_af-1.AA RIPK 879-900 31 0.006982 5.62 In-house 206-227 (290) Show / Hide 
Range on Protein: 879-900
Range on HMM: 206-227/290
Sequence Identity: 31% (7 aa)

SDKADVYSYGVVLLEIISGRRA
. | ||||...|. |. ... .
TPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_af-1.AA TK 881-896 50 0.008496 4.35 In-house 374-389 (486) Show / Hide 
Range on Protein: 881-896
Range on HMM: 374-389/486
Sequence Identity: 50% (8 aa)

KADVYSYGVVLLEIIS
| ||.|.||.. || .
KSDVWSFGVLMWEIFT
Kinase IRAK-0_af-1.AA Src 881-898 52 0.023428 3.76 In-house 180-198 (255) Show / Hide 
Range on Protein: 881-898
Range on HMM: 180-198/255
Sequence Identity: 52% (10 aa)

KADVYSYGVVLLEIIS-GR
|.|| |.|. | ||.. ||
KSDVWSFGILLTEIVTYGR
Kinase IRAK-0_af-1.AA Pkinase_Tyr 874-896 34 0.048662 7.53 Pfam 187-209 (270) Show / Hide 
Range on Protein: 874-896
Range on HMM: 187-209/270
Sequence Identity: 34% (8 aa)

MHYQLSDKADVYSYGVVLLEIIS
...  . | ||.|.||.. ||..
NYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_af-1.AA UTK 883-897 53 0.076573 2.09 In-house 222-236 (296) Show / Hide 
Range on Protein: 883-897
Range on HMM: 222-236/296
Sequence Identity: 53% (8 aa)

DVYSYGVVLLEIISG
||.|.|||. || ..
DVWSFGVVCWEIWTW