Gene IRAK-0_ar-1 (S.moellendorffii)

IRAK-0_ar-1

Species: S.moellendorffii
Alias: IRAK-0_ar-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_ar-1.AA Protein None 581 None Fasta, JSON
IRAK-0_ar-1.NA RNA None 1746 None Fasta, JSON
IRAK-0_ar-1.kin_dom Protein Kinase Domain None 201 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_ar-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF26 IRAK-0_ar-1.AA DUF26 103-148 22 5.2e-05 17.21 Pfam 12-55 (55) Show / Hide 
Range on Protein: 103-148
Range on HMM: 12-55/55
Sequence Identity: 22% (11 aa)

DQPSCGQCIQNAYTNI-QSVNLYAVGGAIWINQTFQRCRMRYDPSS-F
.  .| .|.. |  .. ..   ...||.||      .| .||. .. |
SPSDCRDCLATAVRQMLPQCCPNRQGGRIW----YDWCYLRYSDYPNF
Kinase IRAK-0_ar-1.AA TKL 276-542 20 1.5e-68 234.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 276-542
Range on HMM: 1-364/364
Sequence Identity: 20% (79 aa)

LGQGGFGTVYKATLNN---------GSQVAVKKLSLQSNQGN---------------------------REFVNEITIITGIQHRNLVRLKGYCVEADE-
.|.||||.|||.....         |  |||||.. .... .                            ....|| ..  ..| |.|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RLLVYEFLNKGS-LDRALFSSGSNVVLDWHSRFQIAIGIARGLAYLHEESH-----VQIIHRDIKASNILLDDKLQ------------
              .|.|.  .|| |.. .          || |...|..||||..||| .        .|||||.| .|||.|....            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKISDFGISKLFDLDKGFGFTSTK----------------VAGTLGYMAPEYAT----------------RGRLTTKADVFSYGILVLEIASGRKCVD
  .||.|||.|. .. ...   |.|.                . ||...||||                    .  ..|.||.|.||.  ||.....   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

PAL-PAEEELLLQ----LSWKLVMANRMSECIDKRLGG----DYAVEEVSRLLRVAMLCTQEHEEARPTMSDVVAML
|   . ... ..|    . ...|  ...   |. .               .. . .. | ..  |.||......  |
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_ar-1.AA IRAK 270-474 35 5.6e-64 218.86 In-house 1-225 (317) Show / Hide 
Range on Protein: 270-474
Range on HMM: 1-225/317
Sequence Identity: 35% (80 aa)

FSVESKLGQGGFGTVYKATLNNGS-QVAVKKL----SLQSNQGNREFVN---EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSGSN
|... ..|.||||.||.. ..|    .|||||    ... |.  ..|     |. . . ..| |.| | ||| | ..  |||...  |||   |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VV---LDWHSRFQIAIGIARGLAYLHEES-HVQIIHRDIKASNILLDDKLQPKISDFGISKLF----DLDKGFG--FTSTKVAGTLGYMAPEYAT--RGR
.    | || |. |..|.|.|. .||. .  . |||.||| .|||||. ..|||.|||         .. |.    .   .| ||. ||.||. .   |.
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTTKADVFSYGILVLEIASGRKCVD
||.| ||.| || .||...|.. |.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_ar-1.AA Pkinase 270-470 29 2.2e-51 181.83 Pfam 1-209 (293) Show / Hide 
Range on Protein: 270-470
Range on HMM: 1-209/293
Sequence Identity: 29% (65 aa)

FSVESKLGQGGFGTVYKATLNNGSQ-VAVKKLSLQSNQG--NREFVN--EITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKG----SLDRALF--SS
. ...|.|.|.||.|||..  . .. ||||.......    ... ..  || |   ..| | |||.... . |.  .| |....|    .| . .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQP----KISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYAT-RGRLTTK
|.   ....    ..  |.|||.|.|..    |||||.| .|||.|.. ..    ||.|||..|.||     .   | ..||..|||||    .   ..|
GCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

ADVFSYGILVLEIASGR
.|..|.|... | ..||
VDMWSCGCILYEMLCGR
Kinase IRAK-0_ar-1.AA Dicty4 270-467 33 3.3e-47 155.57 In-house 1-211 (277) Show / Hide 
Range on Protein: 270-467
Range on HMM: 1-211/277
Sequence Identity: 33% (72 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKL-SLQSN-QGNR--EFVNEITIITGIQHRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALFS----
  .|...|.|.||.|||.|   |..|||||| ... |   |.  || .|..|   |.| |.. ..|.|     .  . . | |.. ||.| . | .    
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

SGSNVVLDWHSRFQ---IAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGF-TSTKVAGTLGYMAPEYATRGRLTTK
  ... |||  . .   .|. .|||...||. . . |||||.|..|.| |. .. |..|||.|...  .. ... ..| ..|| ..||||     . . |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT-ACGTPCWMAPEVMMHQPYNEK

ADVFSYGILVLEIA
|||.|.||.  ||.
ADVYSFGIVLWEIL
Kinase IRAK-0_ar-1.AA MLK 270-470 26 1.2e-43 149.34 In-house 1-233 (291) Show / Hide 
Range on Protein: 270-470
Range on HMM: 1-233/291
Sequence Identity: 26% (62 aa)

FSVESKLGQGGFGTVYKATLNNGS----QVAVKKLSL------QSNQGNREFVNEITIITGIQHRN----LVRLKGYCVEADE-RLLVYEFLNKGSLDRA
. .. ..| |.|| |.|..  |       ||||.         ..    ..|  |. .   ..|.|     ....| | .     ..| |.. .||| . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFS-SG----------SNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDD------KLQPKISDFGISKLFDLDKGFGFTSTKVAGTL
| . ..          . .| | .. ...|  .|||..|||..  ..|||||.| .|||.|.      ... ||.|||.|  .|. .    . .. |||.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS--RDWHQMC-TNMMSNAGTY

GYMAPEY---ATRGRLTTKADVFSYGILVLEIASGR
 .||||    .  .. . |.||.|.|..  |. ...
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_ar-1.AA TKL-Unique 272-469 32 1.5e-43 150.99 In-house 1-224 (290) Show / Hide 
Range on Protein: 272-469
Range on HMM: 1-224/290
Sequence Identity: 32% (73 aa)

VESKLGQGGFGTVYKATLNNGSQVAVKKLSL---QSNQGNREFVNEITIITGIQ-HRNLVRLKGYCV----EADERLLVYEFLNKGSLDRALF----SS-
. .|.|.||.|.|||..  .|..||.|....   .||.  .|| ||....  .. | |.|.. |||.     . .. .| |... |||.  |      . 
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

--GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDK-----LQPKISDFGISKLFD-LDKGFGFTS-----TKVAGTLGYMAPEYA
   .|  |..  | ..|| ||.|. ||| ..   |||||.| ||.|.| .     .. ||.|||.||. .  .|..  ..     . . |.. .||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

TR--GRLTTKADVFSYGILVLEIASG
..     ..|.||.|.|| . |||..
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_ar-1.AA TK 270-468 16 5e-43 141.61 In-house 1-389 (486) Show / Hide 
Range on Protein: 270-468
Range on HMM: 1-389/486
Sequence Identity: 16% (66 aa)

FSVESKLGQGGFG---TVYKATLNNGS--------------------------QVAVKKLSLQSNQGNRE-----------------FVNEITIITG--I
  .. |||.| ||   .|||.......                          .|||| | . ...  .|                 ...|. .      
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHRNLVRLKGYCVEADE------------RLLVYEFLNKGS----LDRALFSSGSNVV------------------------------------------
.| |.||| |.|.. ..             ..| |. ..|.    |.  | ..  .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDWHSRFQIAIGIARGLAYLHEE--SHV--QIIHRDIKASNILLDDKLQ-----------PKISDFGIS
                               |. | .  ..  ||.|..|||.   .    ...|||. | |.|......            ||.||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------KLFDLDKGFGFTSTKVAGTLG-------------------------YMAPEYAT---------RGRLTTKADVFSYGILVLEIAS
         |....   ....  || .                         .||||  .          |. ||| ||.|.|.|. || .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_ar-1.AA STE 270-470 23 3.3e-41 143.24 In-house 1-265 (359) Show / Hide 
Range on Protein: 270-470
Range on HMM: 1-265/359
Sequence Identity: 23% (65 aa)

FSVESKLGQGGFGTVYKATLNN----------------GSQVAVKKLSLQSNQG-----------------NREFVNEITIITGIQ--HRNLVRLKGYCV
.   .|.|.|.|||||||  ..                |  .|.|...|....                    .. .|| |    .  | | |.  |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EA-------DERLLVYEFLNKGSLDRALF---SSGSN--------VVLDWHSRFQIAIGIARG-LAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFG
         ||  .. |... ||||  .    . | .         ... .    |.  | .| |.|||.     |||||||..||||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ISKLFDLDKG-------------FGFTSTKVAGTLGYMAPEYATRGR------LTTKADVFSYGILVLEIASGR
... .. .                .  .. ..||  .||||  ....       .||.|. | |....| | |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_ar-1.AA S_TKc 270-546 24 5.3e-39 136.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 270-546
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FSVESKLGQGGFGTVYKATLNN-GSQVAVKKLSLQSNQGNREFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNK--GSLDRALFSSGSNV----
. .  |.|.|.||.|||.. .. | .||.|...       . . .|| |    .| |.|.|...... |.  .| |...   |.| . . . |..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

VLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYATRGRLTT-KADVFSYGI
    | || ..  |...|.|.|  || .|||||.| .|||||.  . ||.|||.....          | . ||. |||||       .. |.|. | |.
FPE-HARF-YMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LVLEIASGRKCVDPALPAEEELLLQLSWKLVMANRMSECIDKRLGGDYAVEEVSRLLRVAMLCTQEHEEARPTMSDVVA-----MLLGYL
.. | ..|.   .     ........                           . ..   . | |   | |||  .. .     ..  ..
ILYEMLCGYPPFP-----QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_ar-1.AA LRRK 270-470 25 3.3e-38 132.75 In-house 1-279 (351) Show / Hide 
Range on Protein: 270-470
Range on HMM: 1-279/351
Sequence Identity: 25% (74 aa)

FSVESKLGQGGFG-TVYKATLNN---------------------------GSQVAVKKLSLQS--------NQGN-------------------------
.  |...|.|||| .||.|....                           .. ||.||. . .        |  |                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFVNEITIITGIQHRNLVRLKGYCVEADERLLVYEFLNKGSLDRALFSSGSNV------VLDWHSRFQIAIGIARGLAYLHEESHV-QIIHRDIKASN
 ||| .|..|. . .| |.| |||.| .   . .| |..  |.|.. |... ..       ...|. . .||. ||.|..|||  ||   ||||| |  |
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPN

ILL---D---------DKLQPKISDFGISKLFDLDKGFGFT-STKVAGTLGYMAPEYATRG---RLTTKADVFSYGILVLEIASGR
|||   .         .    ||.||||| .|   . |. .   .. |. |.||||    .     |.|.|..|.|..  |. ...
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMF---QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-0_ar-1.AA Dicty4-Unclassified 270-469 33 7.1e-38 127.28 In-house 1-204 (263) Show / Hide 
Range on Protein: 270-469
Range on HMM: 1-204/263
Sequence Identity: 33% (71 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGN----REFVNEITIITGIQHRNLVRLKGYCVEA----DERLLVYEFLNKGSLDRALF--SSG
  .   .|.| |  |.|     |  |||||.   . .       .|  |. |   ||| |||...|||.           | ||. || |        | 
IQIDQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

SNVVLDWHS--RFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVAGTLGYMAPEYATRGRLTTKADVF
 .  .   .     .|. ||.|...||    . .||||||.||||.|     || |||||   |    | |. | .|||    .||       . |.||.
QQQPIKLDDTLIIKYAFDIAQGMQHLHT---RNFIHRDIKSSNILMDKHFNIKIADFGISRVID----FNFNMTTIAGTPKWESPECLMHESYNQKSDVY

SYGILVLEIASG
||...  | | |
SYAMMLYELATG
Kinase IRAK-0_ar-1.AA TyrKc 270-542 26 1.3e-37 132.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 270-542
Range on HMM: 1-280/280
Sequence Identity: 26% (80 aa)

FSVESKLGQGGFGTVYKATLNNGSQVAVKKLSLQSNQGNREFVNEITIITGI--QHRNLVRLKGYCVEA-------DERLLVYEFLNKGSLDRALFSSGS
 . . ||| | ||.|||.|..   |||||.|   .    ..| .|. | . .  .| |.||| |.|..        .  ..| |.  .|.|.  | ... 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLD------KGFGFT----STKVAGTLGYMAPEYATRGRL
.  | .    .... ||.| .|||.    ..||||. | |.|...... |||||| |.  . |      |    .    ..|    .  ||||    |. 
K--LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKADVFSYGILVLEIASGRKCVDPALPAEEE----LLLQLSWKLVMANRMSECIDK-----RLGGDYAVEEVSRLLRVAMLCTQEHEEARPTMSDVVAM
||| ||.|.|..  || .     . . | ...    .  |   ..|.. .. .. .             |.  . . ..   | .|  | |||.|...  
TTKSDVWSFGVCMWEIFT-----YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_ar-1.AA TK-Unique 270-468 24 2.3e-35 119.44 In-house 1-234 (294) Show / Hide 
Range on Protein: 270-468
Range on HMM: 1-234/294
Sequence Identity: 24% (58 aa)

FSVESKLGQGGFGTVYKATLNNGS-------QVAVKKLSLQSNQG-NREFVNEITIITGIQ-HRNLVRLKGYCVEAD-ERLLVYEFLNKGSLDRALFSSG
. |....|.| ||.|..... ...       .||||.|   ...   ..| .|| .   .  | |.|.. |.|.. |   ....|.. .|.|.  | ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SN-----------------------VVLDWHSRFQIAIGIARGLAYLHE--ESHVQIIHRDIKASNILLDDKLQPKISDFGISKLFDLDKGFGFTSTKVA
 .                         .. .. ...|..||.|..||..  .   .|.|||. |.|.|| .... ||.|||...  . ..    . ..  
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

GTLGYMAPEYAT--RGRL-TTKADVFSYGILVLEIAS
  . .||||.    .|   ||| || |.|.|  ||..
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-0_ar-1.AA Pkinase_Tyr 270-419 30 1.2e-33 114.56 Pfam 1-160 (270) Show / Hide 
Range on Protein: 270-419
Range on HMM: 1-160/270
Sequence Identity: 30% (49 aa)

FSVESKLGQGGFGTVYKATLN-----NGSQVAVKKLSLQSNQGN---REFVNEITIITGI-QHRNLVRLKGYCV-EADE--RLLVYEFLNKGSLDRALFS
 .   |||.| ||.|||.|..     .. .||||.|  .. . .   ..| .|. | . . .| |.||| | |. . .    ..| |.  .|.|.  | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S-GSNVVLDWHSRFQIAIGIARGLAYLHEESHVQIIHRDIKASNILLDDKLQPKISDFGISKL
   ..  |. .   |... ||.|..||..     .||||. | |.|...... ||.||| ...
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-0_ar-1.AA Pkinase_Tyr 440-471 48 0.00012 16.36 Pfam 181-213 (270) Show / Hide 
Range on Protein: 440-471
Range on HMM: 181-213/270
Sequence Identity: 48% (16 aa)

MAPEYATRGRLTTKADVFSYGILVLEIAS-GRK
||||    |. ||| || |.|.|  || . |..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_ar-1.AA TK 519-542 29 0.000399 8.88 In-house 463-486 (486) Show / Hide 
Range on Protein: 519-542
Range on HMM: 463-486/486
Sequence Identity: 29% (7 aa)

RVAMLCTQEHEEARPTMSDVVAML
.. . | ..  | |||.|... .|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_ar-1.AA TK-Unique 524-542 31 0.001795 7.98 In-house 276-294 (294) Show / Hide 
Range on Protein: 524-542
Range on HMM: 276-294/294
Sequence Identity: 31% (6 aa)

CTQEHEEARPTMSDVVAML
|.|. .| ||. .... .|
CWQWEPEERPSFRQIKHRL
Kinase IRAK-0_ar-1.AA LRRK 522-544 30 0.17657 0.98 In-house 329-351 (351) Show / Hide 
Range on Protein: 522-544
Range on HMM: 329-351/351
Sequence Identity: 30% (7 aa)

MLCTQEHEEARPTMSDVVAMLLG
..| |.. . ||..|..|  |  
QHCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-0_ar-1.AA Pkinase_Tyr 530-542 46 1.229388 2.78 Pfam 258-270 (270) Show / Hide 
Range on Protein: 530-542
Range on HMM: 258-270/270
Sequence Identity: 46% (6 aa)

EARPTMSDVVAML
| |||.|... .|
EDRPTFSEIHEQL