Gene IRAK-0_bg (S.moellendorffii)

IRAK-0_bg

Species: S.moellendorffii
Alias: IRAK-0_bg
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bg.AA Protein None 551 None Fasta, JSON
IRAK-0_bg.NA RNA None 1656 None Fasta, JSON
IRAK-0_bg.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bg.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_bg.AA TKL 191-456 21 1.6e-65 224.03 In-house 1-364 (364) Show / Hide 
Range on Protein: 191-456
Range on HMM: 1-364/364
Sequence Identity: 21% (79 aa)

IGEGGYGVVYRGRLPD---------DTLVAVKNLINNKGQ---------------------------AEREFRVEVEAIGRVRHKNLVRLLGYCVEGNY-
||.||.|.||.|..           .. |||| .  .  .                           .. ....|.  . | || |.|...||| .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYVDNGNLEQWLHGPVALSKTPGWDARMKIVLGTAKALAYLHEAL-----EPKVVHRDIKASNILLDSRWN------------
             ..|.||...|.|.  ||          |. |....|..|....|||         |...|||.| .|||.|. |.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--SKVSDFGLAKLL----GSEKSHVTTR--------------VMGTFGYVAPEYAN----------------TGLLNERSDVYSFGVLLMEVVTGRDPVD
   |..||||.. .    .....  |..              . ||... |||  .                 .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YARPAGEVNLVDWLKMMVGSRRSDEVADPRLEE-------KPSPRALKRALLIALRCVDPDAGKRPRMGHVVHML
 |  .  ...  . ...|   . ..    |. ..        | | ....   .. .| |.|. ||| .  ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_bg.AA IRAK 185-388 37 3.4e-62 212.95 In-house 1-225 (317) Show / Hide 
Range on Protein: 185-388
Range on HMM: 1-225/317
Sequence Identity: 37% (85 aa)

FAPGNVIGEGGYGVVYRGRLPDDT-LVAVKNLINNK----GQAEREFRV---EVEAIGRVRHKNLVRLLGYCVEGNYRMLVYEYVDNGNLEQWLHGPVAL
|...|.|||||.|.||||..   |  .||| |....    .. ...|.    |...  | ||.|.| |.||| |.    |||.|  || ||  |..  . 
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWC-QDG

SKTP---GWDARMKIVLGTAKALAYLHEALEPK--VVHRDIKASNILLDSRWNSKVSDFGLAKLL----GSEKSHV----TTRVMGTFGYVAPEYAN--T
. .|    |  | .| .|||... .||.. .|.  . |.||| .||||| . . | .||||.       ..||. .    | .| ||  | .||. .  .
QCPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

GLLNERSDVYSFGVLLMEVVTGRDPVD
| |  ..||||||. |.||.||. .|.
GQLTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_bg.AA TK 185-456 16 1.4e-46 153.71 In-house 1-486 (486) Show / Hide 
Range on Protein: 185-456
Range on HMM: 1-486/486
Sequence Identity: 16% (81 aa)

FAPGNVIGEGGYG---VVYRGRLPDD--------------------------TLVAVKNLINNKGQAEREFRV--------------EVEAIGRVR----
   |...||| .|   .||.|.. ..                          | |||| |    .....||.               |.|..   .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCVEG------------NYRMLVYEYVDNGN----LEQWLHGPVALSKT-----------------------------------------
 |.|.|||.|.|..|               |.| ||...|.    | ..|.      ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PGWDARMKIVLGTAKALAYLHEA---LEPKVVHRDIKASNILLDSRWN-----------SKVSDFG---
                               .    .. . .  |....|||.    .....||||. | |.|.... .            |..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGSEKSHVTTRVMGTFG-------------------------YVAPEYAN---------TGLLNERSDVYSFGVLLMEVVT-GRDPVDYAR
     ||. ..|..  ....  || .                         . |||  |         .|   . |||.|||||. |..| |. |     
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PA------GEVNLVDWLKMMVG--------------SRRSD-EVADP----RLEEKPSPRALKRALLIALRCVDPDAGKRPRMGHVVHML
.       | .|     .   |               |.   . . .    |    |.. . .   .. ..| ..|. .||..  ....|
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-0_bg.AA TKL-Unique 187-383 32 1.6e-41 144.25 In-house 1-224 (290) Show / Hide 
Range on Protein: 187-383
Range on HMM: 1-224/290
Sequence Identity: 32% (74 aa)

PGNVIGEGGYGVVYRGRLPDDTLVAVKNLI-NNKGQAE--REFRVEVEAIGRVR-HKNLVRLLGYCV----EGNYRMLVYEYVDNGNLEQWLH------G
..|.|||||||.||.|  . .  ||.| .  |..   |  .||. ||  . . . |.|.|.. |||.      ... .| ||.. |.|   ||       
FWNKIGEGGYGQVYKGKWRGYP-VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

PVALSKTPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSR-----WNSKVSDFGLAKLLGSE-KSHVT-------TRVMGTFGYVAPEYA
  . .... .  |.|...  |... |||  .||.. |||.| ||.|.|..     || |..||||.|.. .. |. ..       . ..|.| ..|||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

NT--GLLNERSDVYSFGVLLMEVVTG
.    . .| |||||||. | | .|.
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_bg.AA Pkinase 185-384 26 1.3e-39 141.15 Pfam 1-209 (293) Show / Hide 
Range on Protein: 185-384
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FAPGNVIGEGGYGVVYRGRLPDD-TLVAVKNLINNKGQAEREFRV-----EVEAIGRVRHKNLVRLLGYCVEGNYRMLVYEYVDNG----NLEQWLHGPV
.  | .||.|..|.||...  ..  .||||  |. ... . . .      |..   |..|.| |||.... ....  .| ||...|     |  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

ALSKTP--GWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNS----KVSDFGLAKLL-GSEKSHVTTRVMGTFGYVAPEYANTGLLN--
  ...    ..   .... ....|.|.|.    ...|||.| .|||.|.. .     |..||||||..    .|  ||.. || .|.|||      ..  
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGG

----ERSDVYSFGVLLMEVVTGR
     ..|..|.|..| |...||
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_bg.AA S_TKc 185-463 23 8.9e-37 129.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 185-463
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

FAPGNVIGEGGYGVVYRGRLPD-DTLVAVKNLINNKGQAEREFRVEVEAIGRVRHKNLVRLLGYCVEGNYRMLVYEYVDN--GNLEQWLHGPVAL---SK
.  ...||.|..|.||..|  . . .||.| .        . .| |..   . .|.|.|.|...... ..  .| ||.|.  |.| . ..        ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

TPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNSKVSDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYANTGLLNE-RSDVYSFGVLL
 |  .|| ...  ...||.|.|.    ...|||.| .|||||.  . |..|||||..|        | . ||  |.|||       .  ..|..|.|..|
FPE-HAR-FYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

MEVVTGRDPVDYARPAGEVNLVDWLKMMVGSRRSDEVADPRLEEKPSPRALKRALLIALRCVDPDAGKRPRMGHVVH--MLEAEEFPF
 | ..|. | .        ..   .|...                      . |. .  .| . |  |||    . .  .. .    |
YEMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_bg.AA LISK 190-393 25 1.3e-35 113.03 In-house 1-247 (296) Show / Hide 
Range on Protein: 190-393
Range on HMM: 1-247/296
Sequence Identity: 25% (65 aa)

VIGEGGYGVVYRGRLP-DDTLVAVKNLIN-----NKGQAEREFRVEVEAIGRVRHKNLVRLLGYCVE-GNYRMLVYEYVDNGNLEQWLH-GPV---ALSK
.||.|..| ||.|..  . . .|.| ...     |.  ... .  ||. . . ||.| |.  | |..     ..| ||.. |.|.| |.  ..    |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLP-

TPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSR----WNSKVSDFGLAKLLGSEK----------------------------------
   |. |.|| |. |....|||.    ...||| |. |.|.. .    |. || |||.|...  |.                                  
---WPQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQR

-SHVTTRVMGTFGYVAPEYANTGLLNERSDVYSFGVLLMEVVTGRDPVD--YARPA
 .. |  . ||   .|||  .    .|..||.|||..| | .|....    . |..
KRRMT--ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTP
Kinase IRAK-0_bg.AA LRRK 185-388 24 1.2e-34 119.98 In-house 1-284 (351) Show / Hide 
Range on Protein: 185-388
Range on HMM: 1-284/351
Sequence Identity: 24% (71 aa)

FAPGNVIGEGGYG-VVYRGRLPD---------------------------DTLVAVKNLIN----------------------------------NKGQA
.  .. ||.||.| .|||... .                           .. ||.| ..                                   ..  |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EREFRVEVEAIGRVRHKNLVRLLGYCVEGNYRMLVYEYVDNGNLEQWLHGPVALS----KTP-GWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNI
 |||| ||  . . .| |.| |.|.|   . ...| ||...|.| . || .   .    |.  .|  . ||.|  ||...||| .  |...||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LL---D---------SRWNSKVSDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYANTG---LLNERSDVYSFGVLLMEVVTGR-DPVD
||   .            . |..|||.  .  . .. |. .. |..|..|||  . .     .| .|.||||..| | .|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_bg.AA Dicty4 185-386 31 9.9e-34 110.0 In-house 1-216 (277) Show / Hide 
Range on Protein: 185-386
Range on HMM: 1-216/277
Sequence Identity: 31% (69 aa)

FAPGNVIGEGGYGVVYRGRLPDDTLVAVKNLINNKGQ--AER--EFRVEVEAIGRVRHKNLVRLLGYCV----EGNYRMLVYEYVDNGNLEQWLHG---P
 . .. ||.|..| ||.|.    . |||| | |..    ...  ||| ||.  .  || |.. ..|.|     .    . | ||.  |||.  ||     
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

VALSKTPGWDARMK---IVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNSKVSDFGLAKLLGSEKSHVT--TRVMGTFGYVAPEYANTGLLNERS
   |... |  . .   . . .|. ...||.   | ..|||.|..|.| |  |. ||.||||...   ...| .  . . || ...|||       || .
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVLLMEVVTGRDP
|||||| .| | .|. .|
DVYSFGIVLWEILTRQEP
Kinase IRAK-0_bg.AA Pkinase_Tyr 185-386 28 2.5e-33 113.49 Pfam 1-214 (270) Show / Hide 
Range on Protein: 185-386
Range on HMM: 1-214/270
Sequence Identity: 28% (62 aa)

FAPGNVIGEGGYGVVYRGRLP-----DDTLVAVKNLINNKGQAE---REFRVEVEAIGRV-RHKNLVRLLGYCV-EGNY--RMLVYEYVDNGNLEQWLHG
   | ..||| .|.||.|..      ... |||| | ..  . .   ..|  |..      .|.|.|||.| |. .|     ..| ||. .|.|   |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

PVALSKTPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNSKVSDFGLAKLL-GSEKS-HVTTRVMGTFGYVAPEYANTGLLNERSDV
.    . .      .. .  ||...||..    . .|||. | |.|...    |..|||||...   .   ....  .      |||  |.|  .. |||
HREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLLMEVVT-GRDP
.|||||. |..| |. |
WSFGVLMWEIFTYGEQP
Kinase IRAK-0_bg.AA MLK 185-386 24 2.6e-33 112.96 In-house 1-235 (291) Show / Hide 
Range on Protein: 185-386
Range on HMM: 1-235/291
Sequence Identity: 24% (59 aa)

FAPGNVIGEGGYGVVYRGRLPDDT----LVAVKNLINNK---GQAE---REFRVEVEAIGRVRHKN----LVRLLGYCVEGNY-RMLVYEYVDNGNLEQW
.    .||.|..|.|..||    .     ||||.   ..   ....   ..|. |..   ...|.|     ....| | . ..   .| ||...| |   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHG-PVALS---------KTPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDS------RWNSKVSDFGLAKLLGSEKSHV---TTRVMGT
||| .   .          .   |  |.. |  |....|||. . ....|||.| .|||.|         . |..|||...    ....     .  .||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAGT

FGYVAPEY---ANTGLLNERSDVYSFGVLLMEVVTGRDP
. . |||    .  .  .| .||.|.||.| |..|.. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_bg.AA TyrKc 185-456 23 4.7e-31 110.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 185-456
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FAPGNVIGEGGYGVVYRGRLPDDTLVAVKNLINNKGQAEREFRVEVEAIGRV--RHKNLVRLLGYCVEG-------NYRMLVYEYVDNGNLEQWL--HGP
   | ..||| .|.||.|..   . |||| | ...   ...|. | .   ..  .|.|.|||.|.|...          |.| ||...|.| . |  |.|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

VALSKTPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNSKVSDFGLAKLLGSE------KSHVTT----RVM--GTFGYVAPEYANT
        ..   .. .  |.  .|||.    ...|||. | |.|....   |.|||||.. ....      |.  ..               |||  |.
K-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

GLLNERSDVYSFGVLLMEVVTGRDPVDYARP----AGEVNLVDWLKMMVGSRRSDEVADPRLEEKPSPRALKRALLIALRCVDPDAGKRPRMGHVVHML
|  .. |||.||||.. |. |  .   |  .         .. ..|     .. ...  | .    .... .    | ..| . |. .||..  ... .
GKFTTKSDVWSFGVCMWEIFTYGQ-QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_bg.AA RIPK 191-386 25 4.3e-30 99.71 In-house 1-227 (290) Show / Hide 
Range on Protein: 191-386
Range on HMM: 1-227/290
Sequence Identity: 25% (58 aa)

IGEGGYGVVYRGRLPDDTLVAVKNLIN--N-----KGQAEREFRVEVEAIGRVRHKNLVRLLGYCVEGNY------RMLVYEYVDNGNLEQWLHGPVA-L
.| || | |.. |  .   ...|   .  .     . | . .   |...  . |... |...| | . .         .| ||  ||.|.  ||     .
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

SKTPGWDARMKIVLGTAKALAYLHEALEPKVVHRDIKASNILLDSRWNSKVSDFGLAKLLGSEKSHV-----------TTRVM-GTFGYVAPEYANTGLL
 .   |. |  ..  .. .  |||    | . ||| | .|||.|.  . |..|||||. ..  .||            . .   ||  | .||  .|.. 
HHPDPWPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

NE------RSDVYSFGVLLMEVVTGRDP
.        .|||||.... || |.. |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_bg.AA CZAK 185-386 28 1.4e-28 100.95 In-house 1-221 (279) Show / Hide 
Range on Protein: 185-386
Range on HMM: 1-221/279
Sequence Identity: 28% (64 aa)

FAPGNVIGEGGYGVVYRGRLPDDTLVAVKNLINNKGQAERE------FRVEVEAIGRVRHKNLVRLLGYCVEGN--YRMLVYEYVDNGNLEQWLHGPVAL
.  | .||.| .| ||...    . ||.| .  |.     |      |  ||  .   .| | |  || | |..   .  | |.   | | . |     .
LKFGQTIGQGFFGEVYKAYW-RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFY

SKT-PGWDARMKIVLGTAKALAYLHEALEP-KVVHRDIKASNILLDSRWN-------------SKVSDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYANT
 |  |    .... .  |.   |||    |  ..|||   .|||||.                 |..|||| ..   |     |  ||   . |||    
HKQNP--HLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREM-MEQPFEMTQTMGCLCWMAPECFKG

GLLNERSDVYSFGVLLMEVVTGRDP
 .  | .|||||| .| ...|...|
ENYTEKVDVYSFGMILWCIITCDQP
Kinase IRAK-0_bg.AA MLK 437-456 35 0.009681 5.49 In-house 272-291 (291) Show / Hide 
Range on Protein: 437-456
Range on HMM: 272-291/291
Sequence Identity: 35% (7 aa)

RCVDPDAGKRPRMGHVVHML
.| ..|..||| . ..|  |
QCWNQDPHKRPSFRQIVQHL
Kinase IRAK-0_bg.AA Pkinase_Tyr 436-456 23 5.301997 0.63 Pfam 250-270 (270) Show / Hide 
Range on Protein: 436-456
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

LRCVDPDAGKRPRMGHVVHML
..| ..|. .||..  ....|
KQCWHYDPEDRPTFSEIHEQL