IRAK-0_b-2

Species: S.moellendorffii
Alias: IRAK-0_b-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_b-2.AA Protein None 377 None Fasta, JSON
IRAK-0_b-2.NA RNA None 1134 None Fasta, JSON
IRAK-0_b-2.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_b-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_b-2.AA TKL 104-370 20 4.4e-64 219.2 In-house 1-364 (364) Show / Hide
Range on Protein: 104-370
Range on HMM: 1-364/364
Sequence Identity: 20% (79 aa)

LGTGSFGTVFQGVLDD---------DTPVAIKKANSTTGP---------------------------RIQQFLNEVTILSQVNHRNLVKLLGCCLETEV-
.| |.||.|..|..           ...||.|| .|.                                ... .|. ..|. .| |.|...|.|.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PLLVFEFVPNGTLFEHLQHRRSSILSWERRLQIAIETAEAISYLHSSAA-----QPIYHRDVKSTNILLDEKFT--------------
            . .| |..|.|.|...|.        |..|...|...| ...||||.        || ||| || |||.||..|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AKVADFGISKLVSLEA--THVSTT----------------VHGTPGYIDPQY----------------QQNYQLTDKSDVYSFGVVLLELITGQKPVDFS
.|..|||.|. .| .   .. .||                . |||..  |                  ..... . |.||||||.|| |..|...     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

RNSSDKNLTAFS-LAYIQSS-------RIEDIIDKGLELGDE---------RAKISSIQEVANLAIRCLEFNRENRPAMRSVAEEL
          .. . |..          .. ..|||| .                .  .....|. .| . . |.|| .  . ..|
---------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-0_b-2.AA IRAK 98-299 34 3.8e-58 199.5 In-house 1-225 (317) Show / Hide
Range on Protein: 98-299
Range on HMM: 1-225/317
Sequence Identity: 34% (78 aa)

FKAELMLGTGSFGTVFQGVLDDDT-PVAIK----KANSTTGPRIQQFLN---EVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNGTLFEHLQHRR-S
| ... .| | ||.|..|...  | ..|.|     |.....   |.|.    |. ...   | |.| |.| |.|.. . ||... |||.|.  |. .  .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

SI---LSWERRLQIAIETAEAISYLHSSA-AQPIYHRDVKSTNILLDEKFTAKVADFGISKLV----SLEATHV----STTVHGTPGYIDPQYQQ--NYQ
     ||| .|. |.. || .| .||.   . || |.|.|| |||||. ||.| .|||         ..|.. .      .| ||  |  | .      |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVLLELITGQKPVD
|| |.||||||.||||..||...|.
LTKKTDVYSFGIVLLEVLTGCRAVY

Kinase IRAK-0_b-2.AA TKL-Unique 103-297 29 9.7e-42 144.99 In-house 4-233 (290) Show / Hide
Range on Protein: 103-297
Range on HMM: 4-233/290
Sequence Identity: 29% (68 aa)

MLGTGSFGTVFQGVLDDDTPVAIKKAN--STTGPRIQQ-FLNEVTILSQVN-HRNLVKLLGCCL-ETEVPL---LVFEFVPNGTLFEHLQH--------R
 .|.|..|.|..|.    .|||||. .  .   ... | | |||....  . | |.|.. | |  ..  |    .| |..| |.| ..|.         .
KIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEK-----FTAKVADFGISKLVSLEATHVST--------TVHGTPGYIDPQYQQN-
... |....|...||  | .  |||.. .  |.||| ||.|.|.|..     . .|..|||.||. | . .  ..        |. |.. .. |.   . 
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-YQLTDKSDVYSFGVVLLELITGQK------P
 .| . ||||||||.|| |..|..       |
FCQYSEKSDVYSFGIVLWEIATRKITKTYKKP

Kinase IRAK-0_b-2.AA S_TKc 98-371 22 6.4e-41 143.19 SMART 1-231 (231) Show / Hide
Range on Protein: 98-371
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

FKAELMLGTGSFGTVFQGVLDD-DTPVAIKKANSTTGPRIQQFLNEVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPN--GTLFEHLQHRRS----SI
..    .| |.||.|....  . .  ||||. .       .....|. ||.. .| |.|||.... . .   .|.|....  |.||.....|..    . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTD-KSDVYSFGVVLL
..  .   .. ....|. |.||   . | |||.|  ||||||  . |..|||.....        ||. ||| |. |      . .  |.|..|.|..| 
FPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGQKPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDERAKISSIQEVANLAIRCLEFNRENRPAMRSVAE--------ELM
|...|. | .                      .. ...| .            .|. ..  .||... |.||    . .        . .
EMLCGYPPFP---------------------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-0_b-2.AA Dicty4 98-297 30 1.7e-40 132.88 In-house 1-216 (277) Show / Hide
Range on Protein: 98-297
Range on HMM: 1-216/277
Sequence Identity: 30% (67 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKA--NSTT--GPRIQQFLNEVTILSQVNHRNLVKLLGCCL----ETEVPLLVFEFVPNGTLFEHLQH----
 . |  .|.||||.|. |     . ||.||.  . ..    ... |..||.|...  | |.....| |.    . . .. | |..| |.|.. |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

-RRSSILSWERRLQ---IAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVS--TTVHGTPGYIDPQYQQNYQLTDKS
   |  |.|.....   .|. .|  . .||..    | ||| || |.| |. ...||.|||.|..   . .|    .|. |||..  |   ..   . |.
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVVLLELITGQKP
|||||| || |. |.| |
DVYSFGIVLWEILTRQEP

Kinase IRAK-0_b-2.AA Pkinase_Tyr 98-247 27 4.9e-38 129.43 Pfam 1-161 (270) Show / Hide
Range on Protein: 98-247
Range on HMM: 1-161/270
Sequence Identity: 27% (45 aa)

FKAELMLGTGSFGTVFQGVLD-----DDTPVAIKKANSTTGPR---IQQFLNEVTILSQV-NHRNLVKLLGCCL-ETEV--PLLVFEFVPNGTLFEHLQH
 .   .|| |.||.|..|...     ...|||.|. . .. ..   .. |..|. |..|  .| |.|.|.|.|. . |   ...|.|..|.| | ..|. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R--RSSILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLV
.      |. .. ||.... |.. .||.|   ... |||.   |.|..|....|..||| ....
HREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDFGLARDI

Kinase IRAK-0_b-2.AA Pkinase 104-295 25 5.7e-38 135.33 Pfam 7-209 (293) Show / Hide
Range on Protein: 104-295
Range on HMM: 7-209/293
Sequence Identity: 25% (54 aa)

LGTGSFGTVFQGVLDDD-TPVAIKKANSTTGPRIQQ---FLN--EVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNG----TLFEHLQHRRSSIL--
.| ||||.|....  ..   ||.|. .   . . ..    ..  |. |.  .|| | |.|.... .   . .|.|....|     ||.... .|.  .  
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

SWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTA----KVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQ-NYQLTDKSDVYSFGV
|..    .. ...... |.||     | |||.|. |||.|.. .     |..|||..|....   .  ||. |||.|. |   . .   . |.|..|.|.
SEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

VLLELITGQ
.| |...|.
ILYEMLCGR

Kinase IRAK-0_b-2.AA TK 98-297 16 7.8e-38 123.88 In-house 1-394 (486) Show / Hide
Range on Protein: 98-297
Range on HMM: 1-394/486
Sequence Identity: 16% (66 aa)

FKAELMLGTGSFG---TVFQGVLDDD--------------------------TPVAIKKANSTTGPRIQQ--------------FLNEVTILSQVN----
 . .  || | ||   .|..| . ..                          ||||.|   ....   ..              ||.|. .... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLLGCCLET------------EVPLLVFEFVPNGT----LFEHLQHRRS---------------------------------------------
 | |.|.|.|.|..             | ...| |..|.|     | ..|. .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SILSWERRLQIAIETAEAISYLHSS----AAQPIYHRDVKSTNILLDEKFT-----------AKVADFGIS
                             ..|. ...| ..   |.. .||||       | . |||.   |.|..|. .           .|.|||| |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

--------KLVSLEATHVSTTVHGTPG-------------------------YIDPQYQQ---------NYQLTDKSDVYSFGVVLLELIT-GQKP
        . .  .   .... .||..                         .  |   .         .   | ||||.||||.. |. | ||.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP

Kinase IRAK-0_b-2.AA LRRK 98-299 28 3.8e-37 128.95 In-house 1-284 (351) Show / Hide
Range on Protein: 98-299
Range on HMM: 1-284/351
Sequence Identity: 28% (83 aa)

FKAELMLGTGSFG-TVFQGVLDD---------------------------DTPVAIKKANST-----------TG-----------------------PR
.| | ..| |.|| .|... . .                           ...||||| | .           ..                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQQFLNEVTILSQVNHRNLVKLLGCCLETEVPL-LVFEFVPNGTLFEHLQHRR-SSI------LSWERRLQIAIETAEAISYLHSSAAQ-PIYHRDVKST
 . | .||.|.|  || |.|.|.| |..   || .| |..|.|.| ..|.... ...      .||  .|.||.. |... ||||  .  || ||| || 
FREFRHEVWIMSHLNHPNIVSLKGFCIH---PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS--HNPPIIHRDLKSP

NILL---D---------EKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDP---QYQ--QNYQLTDKSDVYSFGVVLLELITGQ-KPVD
||||   .         .  .||.|||||| . .   . |  .. |.||.  |   .|    .|  |.|.|.||||..| ||.|.|  | |
NILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEY--TEKVDCYSFGMILWELLTRQHHPFD

Kinase IRAK-0_b-2.AA Dicty4-Unclassified 98-297 33 5.6e-37 124.15 In-house 1-207 (263) Show / Hide
Range on Protein: 98-297
Range on HMM: 1-207/263
Sequence Identity: 33% (71 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTT-GPR---IQQFLNEVTILSQVNHRNLVKLLGCCLET----EVPLLVFEFVPNGTLFEHLQ---HR
 .    .| | |  |  |.      ||.|| |.     |   || |. || ||  . | ||||. | |.           | || . |.|||        
IQIDQFIGKGHFSKVHKGNWKGKD-VAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

RSSILSWER--RLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSF
.   .. .    . .|.. |  . .||.     . |||.|| |||.|  | .|.||||||  ..   .   ||. |||    |        . ||||||.
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSY

GVVLLELITGQKP
...| ||.||  |
AMMLYELATGDEP

Kinase IRAK-0_b-2.AA Ciliate-E2 98-361 17 4.5e-36 121.3 In-house 1-353 (365) Show / Hide
Range on Protein: 98-361
Range on HMM: 1-353/365
Sequence Identity: 17% (66 aa)

FKAELMLGTGSFGTVFQGVLDDD---------------------TPVAIKKANSTTGPRIQQFLNEVTILSQVN----------------HRNLVKLLGC
.|   ..|.|.||.|...  . .                     . . |.  ..     |.|...|  |. ..|                | |..|.  |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CL--ETEVPLLVFEFVPNGTLFEHLQHRRSSI---------LSWERRLQIAIETAE---------------AISYLHSSAAQPIYHRDVKSTNILLDEKF
     ..   ||.|..  |.||....... .          .... ...|  . ..               |. ||||     | ||| |  |||.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF----

TAKVADFGISKLVSLE------------------------------ATHVSTTVHGTPGYIDPQYQQ--NYQ-------LTDKSDVYSFGVVLLELITGQ
  |..|||.|| .. .                                ..  |. |||||  |.  .  .|.        . |.|..|.||.| |...|.
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KPVDFSRNSSDKNLTAFSLAYIQSSRIEDIIDKGLELGDER-------------AKISSIQEVANLAIR----CLEFNRENRP
 |                        .. |... ...  .               . .  ||. .|  .    .|. . |.|.
PPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

Kinase IRAK-0_b-2.AA MLK 98-245 28 2e-34 116.86 In-house 1-181 (291) Show / Hide
Range on Protein: 98-245
Range on HMM: 1-181/291
Sequence Identity: 28% (52 aa)

FKAELMLGTGSFGTVFQGVLDDDT----PVAIKKAN------STTGPRIQQFLNEVTILSQVNHRN----LVKLLGCCLETEV-PLLVFEFVPNGTLFEH
.. .  .| |||| |. |.    .     ||.|...      | |.  ...|  |. .|. ..|.|     ....|.||...   ..| |....| |.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LQHRRS------------SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDE------KFTAKVADFGISK
|  .||             . . .  ...|   |....|||| | .|| ||| || |||.||      . |.|..|||.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR

Kinase IRAK-0_b-2.AA DRK 98-297 33 3.5e-32 106.33 In-house 1-201 (258) Show / Hide
Range on Protein: 98-297
Range on HMM: 1-201/258
Sequence Identity: 33% (68 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGP---RIQQFLNEVTILSQVNHRNLVKLLGCCLETEVPLLVFEFVPNGTLFEHLQHRRSSILSWE
 |     | |..| || |     | ||.|..          .. |  |.....|  | | .  .| |..   .. . |. | | |   | |  |  ..| 
IKIGNRIGRGNYGEVFRGTW-RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-HDESIEMDWP

RRLQIAIETAEAISYLHSSAAQP-IYHRDVKSTNILLDEKFTAKVADFGISK-LVSLEATHVSTTVHGTPGYIDPQYQQNYQLTDKSDVYSFGVVLLELI
...|...  |  . |||..   | | ||| || | | || .  |||||| |      .      |  |||. . |    |   | | |||||..|| |..
LMKQMMFDCAKGMIYLHCC--NPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV

TGQKP
| | |
TRQDP

Kinase IRAK-0_b-2.AA TyrKc 98-370 22 4.3e-30 107.2 SMART 1-280 (280) Show / Hide
Range on Protein: 98-370
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FKAELMLGTGSFGTVFQGVLDDDTPVAIKKANSTTGPRIQQFLNEVTILSQV--NHRNLVKLLGCCLET-------EVPLLVFEFVPNGTLFEHLQHRRS
 . . .|| | ||.|..|...  ..||.|. .. .   .. |..|  |....  .| |.|.|.|.|..        | ...|.|..|.| | ..|. .| 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SILSWERRLQIAIETAEAISYLHSSAAQPIYHRDVKSTNILLDEKFTAKVADFGISKLVSLE--------ATHVSTTVHGT---------PGYIDPQYQQ
  |...  |....  |.  .||||    .. |||    |.|..|..|.|..||| |. .  .          ..... .|          |  |     .
K-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

NYQLTDKSDVYSFGVVLLELIT-GQKPVDF---SRNSSDKNLTAFSLAYIQSSRIED---IIDKGLELGDERAKISSIQEVANLAIRCLEFNRENRPAMR
 .  | ||||.||||.. |. | ||.|          |.. . ..  .     . ..   .                 .|. ..  .| ... |.|| ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------F-VCCPDEMYQIMKQCWHEDPEDRPTFS

SVAEEL
 . |..
EIHECF

Kinase IRAK-0_b-2.AA MLK 270-297 41 5.9e-07 20.31 In-house 207-235 (291) Show / Hide
Range on Protein: 270-297
Range on HMM: 207-235/291
Sequence Identity: 41% (12 aa)

Q-QNYQLTDKSDVYSFGVVLLELITGQKP
| .. . . |.||.|.|||| |..|.. |
QFRCEKYSEKCDVWSWGVVLWEMLTREVP

Kinase IRAK-0_b-2.AA Pkinase_Tyr 276-297 56 0.00022 15.47 Pfam 192-214 (270) Show / Hide
Range on Protein: 276-297
Range on HMM: 192-214/270
Sequence Identity: 56% (13 aa)

TDKSDVYSFGVVLLELIT-GQKP
| ||||.||||.. |..| |..|
TTKSDVWSFGVLMWEIFTYGEQP

Kinase IRAK-0_b-2.AA IRAK 343-370 25 0.00253 7.83 In-house 290-317 (317) Show / Hide
Range on Protein: 343-370
Range on HMM: 290-317/317
Sequence Identity: 25% (7 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.| . .|..|..    .|..|. | ..|
KEMCQCACCCGHHRANRRCDMAWVMQQL

Kinase IRAK-0_b-2.AA TK 343-370 28 0.007941 4.45 In-house 459-486 (486) Show / Hide
Range on Protein: 343-370
Range on HMM: 459-486/486
Sequence Identity: 28% (8 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.|.. |  .| ... | || .. . |.|
EEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAK-0_b-2.AA Pkinase_Tyr 343-370 28 0.048005 7.55 Pfam 243-270 (270) Show / Hide
Range on Protein: 343-370
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

QEVANLAIRCLEFNRENRPAMRSVAEEL
.|. .|  .| ... |.|| .. . |.|
DEIYDLMKQCWHYDPEDRPTFSEIHEQL