Gene IRAK-0_aq-1 (S.moellendorffii)

IRAK-0_aq-1

Species: S.moellendorffii
Alias: IRAK-0_aq-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_aq-1.AA Protein None 514 None Fasta, JSON
IRAK-0_aq-1.NA RNA None 1545 None Fasta, JSON
IRAK-0_aq-1.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_aq-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_aq-1.AA TKL 184-449 22 2.5e-65 223.37 In-house 1-364 (364) Show / Hide 
Range on Protein: 184-449
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

IGEGGYGVVFKGFLPD---------GSVVAVKNLLNNTGQ---------------------------AEKEFRVEVEAIGKVRHKNLVRLLGYCAE----
||.||.|.|.|| .           | .|||| .  .  .                           .......|.  . . || |.|...||| .    
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-SCYR--------MLVYEYVDNGNLEDWLHGFSSQTQAFPWEARMKIALGTAKALTYLHEAL-----EPKVVHRDIKASNILVEGDWN------------
  |..        ..|.||...|.|.. ||          |. |...||..|... |||         |...|||.| .||||  .|.            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKISDFGLAKLL----GSEKSHVTTR--------------VMGTFGYVAPEYAS----------------TGLLNERSDVYSFGVLLMELITGRDPVD
  .||.||||.. .    .....  |..              . ||... |||                    .  .|..||||||..| |..|.. | .
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY

-YSRPPGEVNLVDWLK---VMVANRHSEDVADPRLQV----KPTPRILKKALLVAIRCVDPDSLRRPKMGHVVHML
 |  .| ...  . ..   .||...      .|. |      | | ...     . .| |.|   || .  ... |
DYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_aq-1.AA IRAK 178-449 29 8.2e-59 201.7 In-house 1-317 (317) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-317/317
Sequence Identity: 29% (95 aa)

FCEDSKIGEGGYGVVFKGFLPDGS-VVAVK----NLLNNTGQAEKEFRV---EVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNGNLEDWLHGFS-S
| .| .|||||.|.|..| .     ..|||    .   .... ...|.    |...  . ||.|.| |.|||.|.    |||.|  || ||| |..   .
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

QT-QAFPWEARMKIALGTAKALTYLHEALEPK--VVHRDIKASNILVEGDWNAKISDFGLAKLL----GSEKSHV----TTRVMGTFGYVAPEYAS--TG
 . .. .|  | .|..|||... .||.. .|.  . |.||| .|||   . ..||.||||.       ..||. .    | .| ||  | .||.    .|
CPPKPLSWHQRCSICWGTACGIQFLHQN-HPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQG

LLNERSDVYSFGVLLMELITGRDPVDYSRPPGEVNLVDWLKVMVANRHS--------------------------EDVADPRLQVKPTPRILKKALL-VA
 |  ..||||||. |.|..||. .|.  ||. .  |.| . .    . .                          |.  |.|  . | |. . |... .|
QLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYY-LKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHR--MPPCPPNMEKEMCQCA

IRCVDPDSLRRPKMGHVVHML
..|.     ||..|  |.  |
CCCGHHRANRRCDMAWVMQQL
Kinase IRAK-0_aq-1.AA TKL-Unique 182-376 35 2.5e-45 156.91 In-house 3-224 (290) Show / Hide 
Range on Protein: 182-376
Range on HMM: 3-224/290
Sequence Identity: 35% (79 aa)

SKIGEGGYGVVFKGFLPDGSVVAVKNLL-NNTGQAE--KEFRVEVEAIGKVR-HKNLVRLLGYCA----ESCYRMLVYEYVDNGNLEDWLH---GFS---
.||||||||.|.||  . |. ||.| .  |.    |  .||. ||  . | . |.|.|.. |||.       .. .| ||.. |.| | ||     .   
NKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNN

SQTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGD-----WNAKISDFGLAKLLGSE-KSHVT-------TRVMGTFGYVAPEYAST
..   .... |.|.|.  |... |||  .||.. |||.| ||.||  .     ||.||.||||.|.. .. |. ..       . ..|.| ..|||  . 
NNNCKLNMQQRVKMAIDIAQGMYYLHH-CEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--GLLNERSDVYSFGVLLMELITG
   . .| |||||||. | |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_aq-1.AA Dicty4 181-379 34 6.9e-44 144.35 In-house 4-216 (277) Show / Hide 
Range on Protein: 181-379
Range on HMM: 4-216/277
Sequence Identity: 34% (74 aa)

DSKIGEGGYGVVFKGFLPDGSVVAVKNL-LNNTG--QAE-KEFRVEVEAIGKVRHKNLVRLLGYCA----ESCYRMLVYEYVDNGNLEDWLHG-FSSQTQ
...||.|..| |.||    |. |||| | ..|..  ... .||| ||.  .| || |.. ..|.|     ..   . | ||.  |||.  ||   | | |
EQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

AFPWE----AR-MKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVT--TRVMGTFGYVAPEYASTGLLNERSDVY
  . .     | |..|. .|. ...||.   | ..|||.|..|.||  .|..|..||||...   ...| .  . . || ...|||       || .|||
SIKLDWPLIKRAMRMAFDAARGMNWLHCC-NPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVY

SFGVLLMELITGRDP
||| .| |. |. .|
SFGIVLWEILTRQEP
Kinase IRAK-0_aq-1.AA TK 178-379 17 2e-42 139.58 In-house 1-394 (486) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-394/486
Sequence Identity: 17% (71 aa)

FCEDSKIGEGGYG---VVFKGFLPDGS--------------------------VVAVKNLLNNTGQAEKEFRV--------------EVEAIGKVR----
     |.||| .|   .|.|| . ...                           |||| |   ......||.               |.|.. . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNLVRLLGYCAESCY------------RMLVYEYVDNGN----LEDWLHGFSSQTQA-----------------------------------------
 |.|.|||.|.| ..               |.| ||...|.    | |.|.  .  .|                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FPWEARMKIALGTAKALTYLHEA---LEPKVVHRDIKASNILVEGDWN-----------AKISDFG---
                               .. . .. ...  |... |||.    .....||||. | |.||  . .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKLLGSEKSHVTTRVMGTFG-------------------------YVAPEYAS---------TGLLNERSDVYSFGVLLMELIT-GRDP
     ||. ..|..  ....  || .                         . |||            .|   . |||.|||||. |. | |. |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEP
Kinase IRAK-0_aq-1.AA LISK 183-386 27 2e-42 135.5 In-house 1-247 (296) Show / Hide 
Range on Protein: 183-386
Range on HMM: 1-247/296
Sequence Identity: 27% (70 aa)

KIGEGGYGVVFKGFLP-DGSVVAVKNLLN-----NTGQAEKEFRVEVEAIGKVRHKNLVRLLGYCAE-SCYRMLVYEYVDNGNLEDWLHGFSSQTQAFPW
.||.|..| |.|| .  .|.|.|.| . .     |   ..| .  ||. . . ||.| |.  | | . .   ..| ||.. |.|.. |.  ...   .||
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

EARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVE----GDWNAKISDFGLAKLLGSEK-----------------------------------SHV
. |.||||. |....|||.    ...||| |. |.||     ..|..|. |||.|...  |.                                   .. 
PQRVKIALDIACGMSYLHSM---NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRM

TTRVMGTFGYVAPEYASTGLLNERSDVYSFGVLLMELITGRDPVD--YSRPP
|  . ||   .|||       .|..||.|||..| |.||....    . |.|
T--ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTP
Kinase IRAK-0_aq-1.AA Pkinase 178-377 26 1.8e-41 147.72 Pfam 1-209 (293) Show / Hide 
Range on Protein: 178-377
Range on HMM: 1-209/293
Sequence Identity: 26% (58 aa)

FCEDSKIGEGGYGVVFKGFLPDGSV-VAVKNLLNNTGQAEKEFRV-----EVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNG----NLEDWLHGFS
..  .|||.|..|.|.|.   . .  ||||  ..  .. ... .      |..   ...|.| |||.... .. .  .| ||...|     | |....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK-IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

SQTQAF--PWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNA----KISDFGLAKLL-GSEKSHVTTRVMGTFGYVAPEYASTGLLN--
..  .|  ...   .... ....| |.|.    ...|||.| .|||.  . .     ||.||||||..    .|  ||.. || .|.|||      ..  
WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEV-----IRGG

----ERSDVYSFGVLLMELITGR
     ..|..|.|..| |...||
QYYGPKVDMWSCGCILYEMLCGR
Kinase IRAK-0_aq-1.AA MLK 178-379 25 5.7e-40 136.38 In-house 1-235 (291) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-235/291
Sequence Identity: 25% (61 aa)

FCEDSKIGEGGYGVVFKGFLPDGS----VVAVKNLLNNT---GQAE---KEFRVEVEAIGKVRHKN----LVRLLGYCAES-CYRMLVYEYVDNGNLEDW
. .  .||.|..|.|.||          .||||.   ..   ....   ..|. |..   ...|.|     ....| |... |   .| ||...| | . 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHGFSSQTQ----------AFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVE------GDWNAKISDFGLAKLLGSEKSHV---TTRVMGT
||| .|.              . .  |..||  |... |||. . ....|||.| .|||.       .. ..||.|||...    ....     .  .||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAGT

FGYVAPEY---ASTGLLNERSDVYSFGVLLMELITGRDP
. . |||    .  .  .| .||.|.||.| |..|.. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-0_aq-1.AA Pkinase_Tyr 178-379 29 6e-37 125.77 Pfam 1-214 (270) Show / Hide 
Range on Protein: 178-379
Range on HMM: 1-214/270
Sequence Identity: 29% (64 aa)

FCEDSKIGEGGYGVVFKGFLP-----DGSVVAVKNLLNNTGQAE---KEFRVEVEAIGKV-RHKNLVRLLGYCA-ESCY--RMLVYEYVDNGNLEDWLHG
   . |.||| .|.|.|| .      ..  |||| | ... . .   ..|  |..   .  .|.|.|||.| |  ..     ..| ||. .|.| | |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

FSSQTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLL-GSEKS-HVTTRVMGTFGYVAPEYASTGLLNERSDV
 ... |... .   ....  ||.. ||..    . .|||. | |.||. .  .||.|||||...   .   ....  .      |||  ..|  .. |||
HREDKQPLTMKDLLQMCWQIAKGMEYLESK---NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLLMELIT-GRDP
.|||||. |..| |. |
WSFGVLMWEIFTYGEQP
Kinase IRAK-0_aq-1.AA LRRK 178-381 24 1.9e-36 126.48 In-house 1-284 (351) Show / Hide 
Range on Protein: 178-381
Range on HMM: 1-284/351
Sequence Identity: 24% (70 aa)

FCEDSKIGEGGYG-VVFKGFLPD---------------------------GSVVAVKNLLN-----------NTG-----------------------QA
. . ..||.||.| .|... . .                           .. ||.| ..            ...                        |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

EKEFRVEVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDNGNLEDWLHGFSSQTQ-----AFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNI
  ||| ||  . . .| |.| |.|.| . .  ..| ||...|.| . || ...  .      ..|  . ||||  ||.. ||| .  |...||| |  ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNI

LVEGD------------WNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTG---LLNERSDVYSFGVLLMELITGR-DPVD
|...              .|||.|||.  .  . .. |. .. |..|..|||    .     .| .|.||||..| ||.|.. .| |
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_aq-1.AA Dicty4-Unclassified 181-379 33 1.8e-34 115.46 In-house 4-207 (263) Show / Hide 
Range on Protein: 181-379
Range on HMM: 4-207/263
Sequence Identity: 33% (71 aa)

DSKIGEGGYGVVFKGFLPDGSVVAVKNLLNNTGQAE----KEFRVEVEAIGKVRHKNLVRLLGYCAES----CYRMLVYEYVDNGNLEDWLH-GFSSQTQ
|  ||.|    | ||    |  |||| .  |  ..     ..|. |||  | . | |||.. |||          . | |    |||    |   | | |
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

AFPWEA--RMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTGLLNERSDVYSFGVL
    .    .|.|.  |. . .||      ..|||||.||||.  . |.|| |||..     .     | . ||    .||       | .|||||....
PIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSNILMDKHFNIKIADFGISRVI--DFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LMELITGRDP
| ||.||  |
LYELATGDEP
Kinase IRAK-0_aq-1.AA RIPK 184-379 27 1.3e-33 111.87 In-house 1-227 (290) Show / Hide 
Range on Protein: 184-379
Range on HMM: 1-227/290
Sequence Identity: 27% (63 aa)

IGEGGYGVVFKGFLPDGSVVAVKNLLN-----NT--GQAEKEFRVEVEAIGKVRHKNLVRLLGYCAES-----CY-RMLVYEYVDNGNLEDWLHGFSS-Q
.| || | ||| .  .  ....|   .      .   | ...   |...  | |... |...| | .      |    .| ||  ||.|.. ||  .. |
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

TQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHV-----------TTRVM-GTFGYVAPEYASTGLL
 .  ||  |  .   .. .  |||    | . ||| | .|||| .. ..||.|||||. ..  .||            . .   ||  | .||   |.. 
HHPDPWPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

NE------RSDVYSFGVLLMELITGRDP
.        .|||||.... |. |.. |
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_aq-1.AA S_TKc 178-449 22 3.1e-33 117.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FCEDSKIGEGGYGVVFKGFLPD-GSVVAVKNLLNNTGQAEKEFRVEVEAIGKVRHKNLVRLLGYCAESCYRMLVYEYVDN--GNLEDWLHGFSSQT--QA
.    |||.|..|.|.|.   . | .||.| .        . .| |..   | .|.|.|.|.... .  .  .| ||.|.  |.| | ..   ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSEKSHVTTRVMGTFGYVAPEYASTGLLNE-RSDVYSFGVLLM
||     ...  ...|| |.|.    ...|||.| .|||.    . ||.|||||..|        | . ||  |.|||       .  ..|..|.|..| 
FPE-HARFYMYQICCALEYCHSH---GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELITGRDPVDYSRPPGEVNLVDWLKVMVANRHSEDVADPRLQVKPTPRILKKALLVAIRCVDPDSLRRPKMGHVVH---------ML
|...|. | .        ..   .|...                      . |.    .| . |  .||    . .          .
EMLCGYPPFP--------QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_aq-1.AA TyrKc 178-449 23 3.4e-31 110.88 SMART 1-280 (280) Show / Hide 
Range on Protein: 178-449
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FCEDSKIGEGGYGVVFKGFLPDGSVVAVKNLLNNTGQAEKEFRVEVEAIGKV--RHKNLVRLLGYCAES-------CYRMLVYEYVDNGNLEDWLHGFSS
   . |.||| .|.|.|| .     |||| | ...   ...|. | .   |.  .|.|.|||.|.| ..          |.| ||...|.| | |.    
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

QTQAFPWEARMKIALGTAKALTYLHEALEPKVVHRDIKASNILVEGDWNAKISDFGLAKLLGSE------KSHVTT----RVM--GTFGYVAPEYASTGL
.   ....   ....  |.   |||.    ...|||. | |.||  .  .|||||||.. ....      |.  ..               |||   .| 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LNERSDVYSFGVLLMELITGRDPVDYSRP----PGEVNLVDWLKVMVANRHSEDVADPRLQVKPTPRILKKALLVAIRCVDPDSLRRPKMGHVVHML
 .. |||.||||.. |. |  .   |. .         .. ..|     .  ...  | .     ..  ..   .  .| . |   || .  ... .
FTTKSDVWSFGVCMWEIFTYGQ-QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_aq-1.AA MLK 430-449 30 0.095828 1.99 In-house 272-291 (291) Show / Hide 
Range on Protein: 430-449
Range on HMM: 272-291/291
Sequence Identity: 30% (6 aa)

RCVDPDSLRRPKMGHVVHML
.| ..|. .||.. ..|  |
QCWNQDPHKRPSFRQIVQHL