Gene IRAK-0_y-1 (S.moellendorffii)

IRAK-0_y-1

Species: S.moellendorffii
Alias: IRAK-0_y-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_y-1.AA Protein None 868 None Fasta, JSON
IRAK-0_y-1.NA RNA None 2607 None Fasta, JSON
IRAK-0_y-1.kin_dom Protein Kinase Domain None 194 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_y-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-0_y-1.AA TKL 554-813 20 4.9e-60 205.77 In-house 1-364 (364) Show / Hide 
Range on Protein: 554-813
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

IGKGAFGMVYKARLPS---------GEILAIKKGKLGKAASFGG------------------------------ELKLLSRLHHTNLVNLIGYCKQEK--
||.|.|| |||...           |.  |.|| |     .|                                |....|||.| |.| ..|||....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------------QLVFEFMANGS-LYDCLFVKNIKLDWSTRLKIAIQAAHGLEYLHLFAD-----PSIIHRDVKSSNILLDEGFN--------------
              .| |.. .|| |.. .        |. |...|...| |..|||         | ||||| ||.|||.|| ..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

AHVADFGAST-LGPTENSTHV---------------TSTSLVGTPGYVDPEYFQTM----------------QLSPKSDVYSFGVVILELFTGRKAVD-L
. ..||| |. . ...|...                |. . .|||..  || .. .                . |.|.||||||.|. |..|...  . .
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

GQSIVGVV----AWVEKVASEFSSLVPA------LDMEPPVDEEKSRILAEVLELGVCCVRPKAIDRPTMTVVASSL
. . . .     .. ..|....  . .       .   . .    . .. .. .|  .|  ... .||... . . |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH---K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-0_y-1.AA IRAK 548-745 37 2.5e-57 196.79 In-house 1-225 (317) Show / Hide 
Range on Protein: 548-745
Range on HMM: 1-225/317
Sequence Identity: 37% (85 aa)

FSSDMVIGKGAFGMVYKARLPSGE-ILAIKKGKLGKAASFGG----------ELKLLSRLHHTNLVNLIGYCKQEKQ--LVFEFMANGSLYDCLFVKNI-
|. | .||.|.|| ||....   . | |.|| | ..  |...          |||...|..| |.| | ||| .. .  ||...|.|||| | |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

-K---LDWSTRLKIAIQAAHGLEYLHLFA-DPSIIHRDVKSSNILLDEGFNAHVADFGASTLG-PTENSTHVTS----TSLV-GTPGYVDPEYFQ--TMQ
     | | .|..|.. .| |...|| .    .|||.|.||.|||||. |..  .|||.   | |.... . |.    ||.| ||  |  ||.    . |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSPKSDVYSFGVVILELFTGRKAVD
|..|.||||||.|.||..||..||.
LTKKTDVYSFGIVLLEVLTGCRAVY
Kinase IRAK-0_y-1.AA TKL-Unique 553-740 33 1.3e-43 151.2 In-house 4-224 (290) Show / Hide 
Range on Protein: 553-740
Range on HMM: 4-224/290
Sequence Identity: 33% (75 aa)

VIGKGAFGMVYKARLPSGEILAIKKGKL--GKAAS----FGGELKLLSRLH-HTNLVNLIGYCK----QEK--QLVFEFMANGSLYDCLF---------V
.|| |..| |||.  . |.. |||. ..  ..  .    |  |......|| | |.| ..|||.    ...   .| |..  ||||| |           
KIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNN

KNIKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEG-----FNAHVADFGASTLGPTENSTHVT------STSLVGTPGYVDPEYFQT-
.|.||... |.|.||..| |..|||    | ||||| ||||.|.|..     .|. ..||| |..  ..| . ..       .. .|.. .. || .   
NNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMN

-MQLSPKSDVYSFGVVILELFTG
  | | ||||||||.|  |..|.
FCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-0_y-1.AA MLK 548-741 28 2.9e-42 144.42 In-house 1-233 (291) Show / Hide 
Range on Protein: 548-741
Range on HMM: 1-233/291
Sequence Identity: 28% (67 aa)

FSSDMVIGKGAFGMVYKARLPSGE----ILAIKKGKLGK---------AASFGGELKLLSRLHHTN----LVNLIGYCKQE-KQ--LVFEFMANGSLYDC
.    .||.|.|| |.|.|    .    |.|.|. .  .         .  |  | ..|..| | |     . . | |.|. ..  .| |....||||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LFVKN-------------IKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDE------GFNAHVADFGASTLGPTENSTH-VTSTSLVGT
|  ..             .  | .  ...| | |.|..|||  | . ||||| ||.|||.||      . .. ..|||.|.    . ...  . .|  ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMCTNMMSNAGT

PGYVDPEYF---QTMQLSPKSDVYSFGVVILELFTGR
. .  || .   .  . | |.||.|.|||. |..|..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-0_y-1.AA Pkinase 548-741 26 4e-41 146.48 Pfam 1-209 (293) Show / Hide 
Range on Protein: 548-741
Range on HMM: 1-209/293
Sequence Identity: 26% (57 aa)

FSSDMVIGKGAFGMVYKARLPSGEI-LAIKKGKLGKAASFGG-------ELKLLSRLHHTNLVNLIGYCKQEKQLV--FEFMANG----SLYDCLF-VKN
.    .||.|.|| |||..  . ..  |.|. |. .. |          |.... ||.| | | |....  .. .   .|.. .|    .|.| .   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IKL--DWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNA----HVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQ-TMQLSPKS
 ..  .. .  ... | . ||||.|     .|||||.|..|||.|.  .     ...||| . .    .   .  |...|||.|. ||  .     .||.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVVILELFTGR
|..|.|... |...||
DMWSCGCILYEMLCGR
Kinase IRAK-0_y-1.AA LRRK 548-745 26 5.2e-38 132.06 In-house 1-284 (351) Show / Hide 
Range on Protein: 548-745
Range on HMM: 1-284/351
Sequence Identity: 26% (76 aa)

FSSDMVIGKGAFG-MVYKARLPS---------------------------GEILAIKKGKLG-------------------------------------K
. .   ||.|.||  ||.|.. .                           ..  |||| ...                                     .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AASFGGELKLLSRLHHTNLVNLIGYCKQEKQLVFEFMANGSLYDCLFVKN--------IKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILL
  .|  |. ..|.|.| |.|.|.|.| .   .| |.. .|.||. |. |         ....|...||||.| | |.||||  ..|.||||| || ||||
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILL

---D---------EGFNAHVADFGASTLGPTENSTHVT-STSLVGTPGYVDPEYFQTM---QLSPKSDVYSFGVVILELFTGR-KAVD
   .         .  .|..|||| |.      ..| .    .||.||.. ||  . .   . . |.|.||||... || |..  . |
WSSPQNHSPNYPNAHVCAKIADFGISR--MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD
Kinase IRAK-0_y-1.AA RIPK 554-743 30 1.8e-36 121.77 In-house 1-227 (290) Show / Hide 
Range on Protein: 554-743
Range on HMM: 1-227/290
Sequence Identity: 30% (70 aa)

IGKGAFGMVYKARLPSGEILAIKKGKLGKA----------ASFGGELKLLSRLHHTNLVNLIGYCKQEKQ--------LVFEFMANGSLYDCLFVKNIK-
.|.|.|| |.|||  .    ..|| | .|                | | . .| . . | . | |..|..        .| |.|.|||| . |  |  . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

---LDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTH--------VTSTSLV--GTPGYVDPEYFQTMQL
   . |. |  .  . . |  |||   .| ||||| | .|||.|  |.. .|||| .|   .  |.           ..|.   ||  | .|| | | . 
HHPDPWPLRCRMIHEISCGMCYLHS-MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

SP------KSDVYSFGVVILELFTGRKA
.|      |.|||||..|. |..|....
KPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-0_y-1.AA Dicty4 548-740 31 6.2e-36 117.45 In-house 1-213 (277) Show / Hide 
Range on Protein: 548-740
Range on HMM: 1-213/277
Sequence Identity: 31% (68 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAA-------SFGGELKLLSRLHHTNLVNLIGYCK----QE--KQLVFEFMANGSLYDCLFV----
   .  ||||.|| |||..   | . |.|| .. .         .|  | .... . | |.. . |.|     .    . | |.|  |.||  |      
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--KNIKLDWSTRLK---IAIQAAHGLEYLHLFA-DPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQLSPK
  ..|||||.....   .|. || |. .||  . .| ||||| ||.|.| |. ... |.||| |..  .. .     .. .|||... ||  .      |
QQQSIKLDWPLIKRAMRMAFDAARGMNWLH--CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEK

SDVYSFGVVILELFTG
.|||||| |  |..|.
ADVYSFGIVLWEILTR
Kinase IRAK-0_y-1.AA HH498 548-741 27 3.3e-34 105.54 In-house 1-223 (284) Show / Hide 
Range on Protein: 548-741
Range on HMM: 1-223/284
Sequence Identity: 27% (62 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAASFGG-----------ELKLLSRLHHTNLVNLIGYC-KQEKQL--VFEFMANGSLYDCL-----
.     || |.|| ||| .   . | |.|  .  .  . .            |  ...|| | . |  .. |   ..|.  | .. .||||.  |     
IEFHEKIGSGSFGKVYKGEW-RNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPI

---------FVKN---IKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYF
          . .   . .|   .. |..  ||| .|||  . . |||||  | |||..|   | ||||| |     .     . |.  | . .  || |
GGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRF--VCDMHDDNMTKQPGNLRWMAPEVF

Q-TMQLSPKSDVYSFGVVILELFTGR
    . | | ||.|.. .| |..|..
SQCQKYSIKVDVFSYAMCIWEMHTRE
Kinase IRAK-0_y-1.AA DRK 589-739 36 5.2e-32 105.71 In-house 47-197 (258) Show / Hide 
Range on Protein: 589-739
Range on HMM: 47-197/258
Sequence Identity: 36% (56 aa)

ELKLLSRLHHTNLVNLIGYCKQ--EKQLVFEFMANGSLYDCLFVKNIKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
|  |...| | | .  .| |    .   . |.|  ||||  |    |..||. ...... .| |. |||   .| ||||| || | | || .   |||||
EINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFG

ASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQLSPKSDVYSFGVVILELFT
 ||      .   . |  .|||. . ||         | |||||..|  |. |
LSTRFKKHKQHKFAMT-MCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase IRAK-0_y-1.AA STE 548-741 25 1.9e-30 104.81 In-house 1-265 (359) Show / Hide 
Range on Protein: 548-741
Range on HMM: 1-265/359
Sequence Identity: 25% (69 aa)

FSSDMVIGKGAFGMVYKARLP----------------SGEILAIKKGKLGK--------------------AASFGGELKLLSRLH--HTNLVNLIGYCK
.    .||||||| ||||.                  .||| |||. .| .                      ..  |.|......  | | |. .|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------QEKQLVFEFMANGSLYDCLF---VKNIKLD----------WSTRLKIAIQAAHG-LEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
         .|  .. |.|..||| | .     ..  |.           |   .|. |  .| |.|||      |||||.|..||||     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

ASTLGPTENS------------THV-TSTSLVGTPGYVDPEYFQTMQ------LSPKSDVYSFGVVILELFTGR
 ..    ...            | .  ....|||| .  ||  | ..       . |.|..|.| .|.|. ||.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-0_y-1.AA S_TKc 548-820 24 7.4e-30 106.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-820
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

FSSDMVIGKGAFGMVYKARLPS-GEILAIKKGKLGKAASFGGELKLLSRLHHTNLVNLIGYCK-QEKQLVFEFMAN--GSLYDCLFVKNIK-----LDWS
.    .||||||| |||.|  . |.| |||. |     ..  |...|.. || |.|.|....  ..  .|.|.. .  |.|.| .  .. .     ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

TRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTENSTHVTSTSLVGTPGYVDPEYFQTMQLSP-KSDVYSFGVVILEL
.  ... | . .|||.|   .  |||||.| .||||||  .  ..||| ...           |...||| |. || .   . .. |.|..|.|... |.
HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FTGRKAVDLGQSIVGVVAWVEKVASEFSSLVPALDMEPPVDEEKSRILAEVLELGVCCVRPKAIDRPTMTVVAS--SLEKVLKHF
..|.   .       . .  .|.                          |....   | .    .|||   .    .. |    |
LCGYPPFP------QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_y-1.AA Pkinase_Tyr 548-686 29 2.6e-26 89.73 Pfam 1-156 (270) Show / Hide 
Range on Protein: 548-686
Range on HMM: 1-156/270
Sequence Identity: 29% (47 aa)

FSSDMVIGKGAFGMVYKARLP-----SGEILAIKKG--KLGKA----ASFGGELKLLSRL-HHTNLVNLIGYCK-QEKQ----LVFEFMANGSLYDCLFV
 . . ..|.||||.|||...       .   |.|.   .  .     ..|  |.|... | || |.|.|.| |  |...    .|.|.|..|.|.| |  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---NIKLDWSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFG
.   . .|. .. |....| | |.|||.      .||||.   |.|..|.. . ..|||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFG
Kinase IRAK-0_y-1.AA TyrKc 548-813 23 4.2e-18 67.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-813
Range on HMM: 1-280/280
Sequence Identity: 23% (72 aa)

FSSDMVIGKGAFGMVYKARLPSGEILAIKKGKLGKAASFGGELKLLSRL--HHTNLVNLIGYCK---------QEKQLVFEFMANGSLYDCLFVKNIKLD
 . . ..| |||| |||...   .  |.|. | .. . |  |......|  || |.|.|.|.|          .   .|.|.|..|.| | |  .  || 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WSTRLKIAIQAAHGLEYLHLFADPSIIHRDVKSSNILLDEGFNAHVADFGASTLGPTE-------NSTHVTSTSLVG-------TPGYVDPEYFQTMQLS
... |....|.| | ||||      .||||    |.|..|.. . ..||| |  .  .          ......          ..    || ...   .
MKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA----PECINYGKFT

PKSDVYSFGVVILELFTGRKAVDLGQSIVGVVAWVE-----KVASEFSSLVPALDMEPPVDE-----EKSRILAEVLELGVCCVRPKAIDRPTMTVVASS
.||||.||||.. |.||            |   . .     . ..|   .| . .. |. ..        .  .|. ..  .| . .. ||||.. . . 
TKSDVWSFGVCMWEIFTY-----------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-0_y-1.AA Pkinase_Tyr 713-742 45 0.000357 14.76 Pfam 183-213 (270) Show / Hide 
Range on Protein: 713-742
Range on HMM: 183-213/270
Sequence Identity: 45% (14 aa)

PEYFQTMQLSPKSDVYSFGVVILELFT-GRK
|| ....  . ||||.||||.. |.|| |..
PECINYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase IRAK-0_y-1.AA IRAK 793-813 33 0.122651 1.78 In-house 297-317 (317) Show / Hide 
Range on Protein: 793-813
Range on HMM: 297-317/317
Sequence Identity: 33% (7 aa)

VCCVRPKAIDRPTMTVVASSL
.||.  .|  |..|. | ..|
CCCGHHRANRRCDMAWVMQQL