Gene LmjF29.2150 (L.major)

LmjF29.2150

Species: L.major
Alias: LmajK047, LmjF29.2150
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
LmjF29.2150.AA Protein None 428 None Fasta, JSON
LmjF29.2150.kin_dom Protein Kinase Domain None 319 None Fasta, JSON

Protein domain

Protein domains of LmjF29.2150.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF29.2150.AA CDC2 182-416 27 3.4e-55 167.84 In-house 112-301 (301) Show / Hide 
Range on Protein: 182-416
Range on HMM: 112-301/301
Sequence Identity: 27% (67 aa)

LILALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLEGIPYKKYV--HEAVTLWYRSPDVLLGNT
.. .. |.|.. | ||||||||. . |  .                              .|..||||.|  ||| ..|   || ||||||.| .|||  
ILQGVHFCHQRRIMHRDLKPQNILIDKKGN------------------------------IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCK

NYTYSADAWSLGCILVEM---ASGSVLFKGKDEADELRHIFTRGCRPSPSIFPRMRDYHYCERYAEVLNRYQEADTENMTSEELMQMQLERISRHLRAFL
 |. . | ||.|||. ||   ..   || |. | |.|  ||     |. ...| . .. .   | .   |... |....   .. .              
RYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPD---YKNTFPRWKPQDLSKICPNNQKK--------------

RDRHALELLGDAGVDLVARLLILDPEHRLTVLDAMNHRFF
  ..  . | . |.||  ..|..||..|... .|..|..|
--KNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Pkinase LmjF29.2150.AA Pkinase 120-416 19 2e-46 165.22 Pfam 61-293 (293) Show / Hide 
Range on Protein: 120-416
Range on HMM: 61-293/293
Sequence Identity: 19% (61 aa)

HLIGLRDAILRPREQLAYVVMDYCEGG----DLWHFMRDLKVSMRSSSGKFGDIM--STRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKRTDAI
. . |.|.  .  ..  |.||.|||||    ||.....           . .  .  | .. ...  ... .| ..||..| ||||||.|...  ... |
NIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST----------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHI

LSSFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLE-GIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGSVLFKGK----D
 .                         ..|..||||...    ..  . . ..|.||..| |..|.. |....| ||.|||| ||..|  .|.|.    .
DA-------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN

EADELRHIFTRGCRPSPSIFPRMRDYHYCERYAEVLNRYQEADTENMTSEELMQMQLERISRHLRAFLRDRHALELLGDAGVDLVARLLILDPEHRLTVL
 .|..  |. ....|    ... ... ....| . ... . .                            .    .. ... |.. ..| .||. |.|  
-HDQMQMICRIMGPP----LHFDWPWWCSISYFF-FRH-W-H-------------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

DAMNHRFF
....| .|
QILQHPWF
Kinase LmjF29.2150.AA CDK 241-416 27 4.3e-46 145.38 In-house 151-284 (284) Show / Hide 
Range on Protein: 241-416
Range on HMM: 151-284/284
Sequence Identity: 27% (51 aa)

TLKVGDFGLSRLEGI------PYKKYVHEAVTLWYRSPDVLLGNTNYT--YSADAWSLGCILVEMAS---GSVLFKGKDEADELRHIFTRGCRPSPSIFP
.||..||||.|. ||      | ..| || ||||||.|..||| ..|.   . | ||.|||..||.    .  || |. | | | .||     |.... |
RLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWP

RMRDYHYCERYAEVLNRYQEADTENMTSEELMQMQLERISRHLRAFLRDRHALELLGDAGVDLVARLLILDPEHRLTVLDAMNHRFF
 . .. .                                                      ||  ..| .||..|..  .|..| .|
GVTKLPDY-----------------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase LmjF29.2150.AA CMGC 176-317 23 9.2e-43 137.76 In-house 184-367 (513) Show / Hide 
Range on Protein: 176-317
Range on HMM: 184-367/513
Sequence Identity: 23% (50 aa)

RRWSVELILALG--FLHSHN--IAHRDLKPQNLMLAKRTD--------AILSSFFAVDSANSSELCDIAGAPAGEL--------YTLKVGDFGLSRLEGI
| ..  .. .|   ..|||.  | ||||||.|... ....                                            ..||..||||.| ...
R-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS--------------------------EDWNPCQKNGRLKICDFGLARWYHP

PYKK---------------------YVHEAVTLWYRSPDVLLGN---------TNYTYSADAWSLGCILVEMASG--------SVLFKGKDE--------
. ..                     | |. ||.|||.| .|||          ..||.. | ||.|||. ||  |          ||.|..|        
HSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNG

---ADELRHIF
    | | .||
KSHIDQLFKIF
Kinase LmjF29.2150.AA CDK5 241-317 56 5.9e-36 110.74 In-house 136-213 (287) Show / Hide 
Range on Protein: 241-317
Range on HMM: 136-213/287
Sequence Identity: 56% (44 aa)

TLKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMA-SGSVLFKGKDEADELRHIF
.|| .|||| |  ||| . | || |||||| ||||.|   |. | | || |||. ||| .|  || | |. |.|  ||
ELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIF
S_TKc LmjF29.2150.AA S_TKc 92-416 18 5.5e-31 110.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 92-416
Range on HMM: 1-231/231
Sequence Identity: 18% (66 aa)

SSSSGPLRKGAF-DALSAQQRR------------------RISR-GRQHLIGLRDAILRPREQLAYVVMDYCEG--GDLWHFMRDLKVSMRSSSGKFGDI
     .. ||||     .. ..                  .| . .  ... | |..     .  |.||.||.|  ||| ..... .       .. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR------HGLRFP

MSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLEGIPYKKYVHEAVTLWY
..  . |..  ....|| ..|||.| ||||||.|..| .                                ..|..||||.|.         .  .|.||
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------------------------HIKICDFGLARQL-------TTFCGTPWY

RSPDVLLGNTNYTY-SADAWSLGCILVEMASGSVLFKGKDEADELRHIFTRGCRPSPSIFPRMRDYHYCERYAEVLNRYQEADTENMTSEELMQMQLERI
..| ||     |.. ..| ||.|||| ||..|  .|       ..  .| . .                                               
MAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------------------------------------

SRHLRAFLRDRHALELLGDAGVDLVARLLILDPEHRLTVLDAMN-------HRFF
                  . . |.. ..|  |||.|.|. .|..       | .|
-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF29.2150.AA Ciliate-E2 133-416 17 7e-30 99.74 In-house 106-365 (365) Show / Hide 
Range on Protein: 133-416
Range on HMM: 106-365/365
Sequence Identity: 17% (62 aa)

EQLAYVVMDYCEGGDLWHFMRDLKVSM-----RSSSGKFGDIMSTRVFRRWSV-----------ELILALGFLHSHN-IAHRDLKPQNLMLAKRTDAILS
..  | ||.||.||||...... | .          ..| .    ....               ..|||| .||| | | |||.||.|...         
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------

SFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLEGIP-----------YKKYVHE---------------------AVTLWYRSPDVLLGNTN---
                          .|. |||||.   ..            ... .                      . |. | .| .| |  .   
--------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ

-----YTYSADAWSLGCILVEMASGSVLFKGKDEADELRHIFTRGCRPSPSIFPRMRDYHYCERYAEVLN---RYQEA--------------DTENMTSE
     |.|..| ||||.|| || .|   |                                   . . ..   .....              .... . |
QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE

--ELMQM--QLERISRHLRAFLRDRHALELLGDAGVDLVARLLILDPEHRLT-VLDAMNHRFF
   |..   .                              |.|  ||| |.|   ...|| .|
CKDLIKKFGK------------------------------RMLQKDPEKRITGWEQILNHPWF
Kinase LmjF29.2150.AA PFTAIRE 242-317 53 2.4e-26 89.75 In-house 136-212 (287) Show / Hide 
Range on Protein: 242-317
Range on HMM: 136-212/287
Sequence Identity: 53% (41 aa)

LKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGSVLFKGK-DEADELRHIF
||  |||| |   .| . | || |||||| |||||| |.|  . | |  |||.|||  |  .| |  |  | |  ||
LKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPGMKDITDQLEKIF
Kinase LmjF29.2150.AA PCTAIRE 242-317 48 4.2e-25 85.62 In-house 136-217 (291) Show / Hide 
Range on Protein: 242-317
Range on HMM: 136-217/291
Sequence Identity: 48% (40 aa)

LKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGSVLFKGKD------EADELRHIF
||  |||| |   .| | | || ||||||.||||.|.|.|  . | |  |||. ||..|  || |          |.|  ||
LKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPGSTDSHYPGVKDQLHMIF
Kinase LmjF29.2150.AA PITSLRE 242-317 48 4.6e-25 88.27 In-house 145-220 (295) Show / Hide 
Range on Protein: 242-317
Range on HMM: 145-220/295
Sequence Identity: 48% (37 aa)

LKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGSVLFKGKDEADELRHIF
||..|||| |  | | |.|    ||||||.| .|||   |.   | || |||. |. .. .||.|| | |..  ||
LKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIF
Kinase LmjF29.2150.AA p38 185-316 31 5.8e-24 78.57 In-house 118-216 (289) Show / Hide 
Range on Protein: 185-316
Range on HMM: 118-216/289
Sequence Identity: 31% (41 aa)

ALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYS
.| . || .| |||||| |. .  . .                               .. ||||.|        ||   .| |||.| ..|    ||  
GLKYIHSAGIIHRDLKPSNIAVNEDCEL------------------------------RILDFGLARHCDDEMTGYV---ATRWYRAPEIMLNWMHYTQT

ADAWSLGCILVEMASGSVLFKGKDEADELRHI
.| ||.|||. |. .| .||.|.|  | |. |
VDIWSVGCIMAELITGRTLFPGDDHIDQLQRI
Kinase LmjF29.2150.AA CDK4 241-317 42 2.2e-15 49.05 In-house 148-222 (290) Show / Hide 
Range on Protein: 241-317
Range on HMM: 148-222/290
Sequence Identity: 42% (33 aa)

TLKVGDFGLSRLEGIPYKKYVHEAVTLWYRSPDVLLGNTNYTYSADAWSLGCILVEMASGSVLFKGKDEADELRHIF
..|  ||||.|  .    .     ||||||.| |||  . |    | ||.|||  ||     || |. |.| |  ||
HVKLADFGLARIYSF-QMALTPVVVTLWYRAPEVLLQSY-YNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIF
Kinase LmjF29.2150.AA CDK 139-209 25 4.1e-12 34.88 In-house 96-144 (284) Show / Hide 
Range on Protein: 139-209
Range on HMM: 96-144/284
Sequence Identity: 25% (18 aa)

VMDYCEGGDLWHFMRDLKVSMRSSSGKFGDIMSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKR
|..|..  ||...|.                      . .   |. .| ..||..| ||||||||... ..
VFEYMDH-DLKKYMD---------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNN
Kinase LmjF29.2150.AA CDK4 170-207 42 2.9e-11 34.7 In-house 107-144 (290) Show / Hide 
Range on Protein: 170-207
Range on HMM: 107-144/290
Sequence Identity: 42% (16 aa)

MSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLA
|..   .. . .|. .. ||||| | ||||||||. ..
MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT
Kinase LmjF29.2150.AA CMGC 389-416 35 1e-09 27.18 In-house 486-513 (513) Show / Hide 
Range on Protein: 389-416
Range on HMM: 486-513/513
Sequence Identity: 35% (10 aa)

GVDLVARLLILDPEHRLTVLDAMNHRFF
..||. ..|..||. |.|. .|..| .|
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase LmjF29.2150.AA CDK5 154-209 39 1.9e-09 25.52 In-house 83-134 (287) Show / Hide 
Range on Protein: 154-209
Range on HMM: 83-134/287
Sequence Identity: 39% (22 aa)

DLKVSMRSSSGKFGDIMSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKR
|||  | |  |     |. .. .     |   |.| |.|.. |||||||||.  |.
DLKKYMDSCNG----EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKN
Kinase LmjF29.2150.AA p38 390-416 44 1.2e-08 25.37 In-house 263-289 (289) Show / Hide 
Range on Protein: 390-416
Range on HMM: 263-289/289
Sequence Identity: 44% (12 aa)

VDLVARLLILDPEHRLTVLDAMNHRFF
.||  ..|.|||. |.|. .|| | .|
IDLLEKMLELDPDKRITAEEAMQHPYF
Kinase LmjF29.2150.AA CDK5 385-416 31 6e-08 20.68 In-house 256-287 (287) Show / Hide 
Range on Protein: 385-416
Range on HMM: 256-287/287
Sequence Identity: 31% (10 aa)

LGDAGVDLVARLLILDPEHRLTVLDAMNHRFF
|   | ||  ..|...|..|..  .|..| .|
LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase LmjF29.2150.AA PITSLRE 383-416 35 2.5e-07 22.98 In-house 262-295 (295) Show / Hide 
Range on Protein: 383-416
Range on HMM: 262-295/295
Sequence Identity: 35% (12 aa)

ELLGDAGVDLVARLLILDPEHRLTVLDAMNHRFF
... | | ||  ..| ..|. |.|  ||. | .|
NHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
TyrKc LmjF29.2150.AA TyrKc 92-347 14 3e-06 -122.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 92-347
Range on HMM: 1-280/280
Sequence Identity: 14% (49 aa)

SSSSGPLRKGAF-------------------DALSAQQRRRISR--------G-R-QHLIGLRDAILRPRE-----QLAYVVMDYCEGGDLWHFMRDLKV
 .    |  |||                   ||     |. . |        | . .... |  ... . .     .  ..|| |...||| .. |. . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

SMRSSSGKFGDIMSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSFFAVDSANSSELCDIAGAPAGELYTLKVGDFGLSRLEGIP-
             ... .  ...       .|||.|. ||||   | .....                               | |..||||||  .   
K-----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------------------------TVKISDFGLSRDIYDDD

-------YKKY----VHEA-VTLWYRSPDVLLGNTN-YTYSADAWSLGCILVEMASGSVLFKGK-----DEADELRHIFTRG----CRPS----------
       |..        . . .   .| ..  |.. .|   | || |  . |. .              ...|...   .|    . |.          
QQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCP

PSIFPRMR---DYHYCER--YAEVLNRY
. ..  |.   ..   .|   .|.  . 
DEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF29.2150.AA CDK4 389-416 25 4e-06 16.66 In-house 263-290 (290) Show / Hide 
Range on Protein: 389-416
Range on HMM: 263-290/290
Sequence Identity: 25% (7 aa)

GVDLVARLLILDPEHRLTVLDAMNHRFF
| ||. . |  ....|.. . . .| .|
GDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase LmjF29.2150.AA PFTAIRE 186-208 47 1.8e-05 15.22 In-house 110-132 (287) Show / Hide 
Range on Protein: 186-208
Range on HMM: 110-132/287
Sequence Identity: 47% (11 aa)

LGFLHSHNIAHRDLKPQNLMLAK
| . |   . |||||||||.. .
LSYCHQRRVLHRDLKPQNLLISH
Kinase LmjF29.2150.AA PCTAIRE 389-416 32 2.7e-05 14.54 In-house 264-291 (291) Show / Hide 
Range on Protein: 389-416
Range on HMM: 264-291/291
Sequence Identity: 32% (9 aa)

GVDLVARLLILDPEHRLTVLDAMNHRFF
. ||.  || . .. |.   .||.| .|
CQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase LmjF29.2150.AA PCTAIRE 186-206 57 7.2e-05 13.02 In-house 110-130 (291) Show / Hide 
Range on Protein: 186-206
Range on HMM: 110-130/291
Sequence Identity: 57% (12 aa)

LGFLHSHNIAHRDLKPQNLML
| . |   | |||||||||..
LAYCHRRKILHRDLKPQNLLI
Kinase LmjF29.2150.AA PFTAIRE 389-416 32 9.4e-05 12.64 In-house 260-287 (287) Show / Hide 
Range on Protein: 389-416
Range on HMM: 260-287/287
Sequence Identity: 32% (9 aa)

GVDLVARLLILDPEHRLTVLDAMNHRFF
. ||.  .| . |. |.   .|| | .|
AEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase LmjF29.2150.AA Pkinase_Tyr 137-252 18 0.000377 14.68 Pfam 83-160 (270) Show / Hide 
Range on Protein: 137-252
Range on HMM: 83-160/270
Sequence Identity: 18% (22 aa)

YVVMDYCEGGDLWHFMRDLKVSMRSSSGKFGDIMSTRVFRRWSVELILALGFLHSHNIAHRDLKPQNLMLAKRTDAILSSFFAVDSANSSELCDIAGAPA
|.|| |...||| .. |. .          ..  ..     ....   .. .|.|.|. ||||   | ....                            
YIVMEYMPHGDLLDYLRKHR--------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----------------------------

GELYTLKVGDFGLSRL
 .. . |..||||.|.
-NN-VVKICDFGLARD
Kinase LmjF29.2150.AA PITSLRE 182-206 40 0.004035 7.46 In-house 115-139 (295) Show / Hide 
Range on Protein: 182-206
Range on HMM: 115-139/295
Sequence Identity: 40% (10 aa)

LILALGFLHSHNIAHRDLKPQNLML
| ..  ..|.. | |||||  || .
LLRGVEHMHDNWIMHRDLKTSNLLY