Gene LmjF35.4000 (L.major)

LmjF35.4000

Species: L.major
Alias: LmjF35.4000, LmajK182
External Links:
Annotation:

Classification

Group: STE
Family: STE-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF35.4000.AA Protein None 1343 None Fasta, JSON
LmjF35.4000.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of LmjF35.4000.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TPR_1 LmjF35.4000.AA TPR_1 51-77 44 8.5e-07 27.71 Pfam 8-34 (34) Show / Hide 
Range on Protein: 51-77
Range on HMM: 8-34/34
Sequence Identity: 44% (12 aa)

GNEAFKAGRYHEAIRYYTQAIEVDPDS
||  .| |.| ||| .| .|.|..|. 
GNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 LmjF35.4000.AA TPR_2 44-77 35 1e-06 27.5 Pfam 1-34 (34) Show / Hide 
Range on Protein: 44-77
Range on HMM: 1-34/34
Sequence Identity: 35% (12 aa)

GTRLREEGNEAFKAGRYHEAIRYYTQAIEVDPDS
   ..  |. ..|.|.| |||.|| .|.. ||. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR LmjF35.4000.AA TPR 44-77 38 5e-06 27.41 SMART 1-34 (34) Show / Hide 
Range on Protein: 44-77
Range on HMM: 1-34/34
Sequence Identity: 38% (13 aa)

GTRLREEGNEAFKAGRYHEAIRYYTQAIEVDPDS
   .   ||  .| |.| ||| .|..|.|.||. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 LmjF35.4000.AA TPR_1 112-145 26 0.000206 19.39 Pfam 1-34 (34) Show / Hide 
Range on Protein: 112-145
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

FKGHYRLGLAQMSLNDFGHAMESLRKAWALAPSE
 . .|.||.........  | | ..|| .| |. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
TPR_2 LmjF35.4000.AA TPR_2 112-145 29 0.00034 18.93 Pfam 1-34 (34) Show / Hide 
Range on Protein: 112-145
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

FKGHYRLGLAQMSLNDFGHAMESLRKAWALAPSE
....|.||.. . ..|.  | | ..|| .|.|  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR LmjF35.4000.AA TPR 112-145 29 0.000983 19.65 SMART 1-34 (34) Show / Hide 
Range on Protein: 112-145
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

FKGHYRLGLAQMSLNDFGHAMESLRKAWALAPSE
 . .|.||.. ....|.  |.| ..|| .|.|. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_2 LmjF35.4000.AA TPR_2 78-111 14 0.015397 13.07 Pfam 1-34 (34) Show / Hide 
Range on Protein: 78-111
Range on HMM: 1-34/34
Sequence Identity: 14% (5 aa)

EFLYTNRSFAYFNIKEFEKSAADAAKAVEINANF
  .. |.  .|.. ..... ...  ||.... |.
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
TPR LmjF35.4000.AA TPR 78-111 17 0.064795 11.03 SMART 1-34 (34) Show / Hide 
Range on Protein: 78-111
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

EFLYTNRSFAYFNIKEFEKSAADAAKAVEINANF
   . |.  .|.. .....  ..  ||.|.. |.
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN
TPR_1 LmjF35.4000.AA TPR_1 78-111 20 0.088439 10.2 Pfam 1-34 (34) Show / Hide 
Range on Protein: 78-111
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

EFLYTNRSFAYFNIKEFEKSAADAAKAVEINANF
   ..|.  .|.. .....  ..  ||.|.| |.
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN
S_TKc LmjF35.4000.AA S_TKc 647-920 22 1.1e-55 192.17 SMART 1-231 (231) Show / Hide 
Range on Protein: 647-920
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

FQVLSTLSSTVNSKVYHALRRG--EHVAVKEISIDDDAARRRFQREVNIVSTCNHPNIIRIKGVFFDGPFAYILLPYYHR--GSLRALLSKQEP------
...| .. .   .||| .  ..  ..||.|.|.       ....||..| .  .||||.....|| |  . |. . |     |.|. .. |. .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAKDHGALGVADMTLTNTVTNTSNGYNSIVGTIQYMAPEQLLCETGSHTAK
..   .. ...|......|.|.|||.| ||||.|.|. .  .  |.|||.|.                       ....||  ||||| |         .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYMAPEVL---------G

STG-MSDMWALGFTMLEVALENAFFHDASLGKPSLPLLLPEQKRIDVPAKAVGGDEKLAETIASVLVADPANRATAYDLLA-------HPYF
 ..  .|.|..| .. | .     |.        . ...   .           .. . . |   |. ||..| || ..|.       ||.|
YGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase LmjF35.4000.AA Pkinase 647-920 23 3.5e-50 177.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 647-920
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

FQVLSTLSSTVNSKVYHALRRGEH--VAVKEISIDDDAA--RRRFQR--EVNIVSTCNHPNIIRIKGVFFDGPFAYILLPYYHRG----SLRALLS--KQ
....... |   ..||.. ..|.   ||||.|. ...    ...  |  |. |   .|||||.|....| |..  |. ..|   |    .| ...|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EPM--SWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRP----VISDFGIAKDHGALGVADMTLTNTVTNTSNGYNSIVGTIQYMAPEQLLC
 ..  |.  ......|...|..|.|..||.| ||||.|.|| ..| .     |.|||.|| .              .  .  .....||. ||||| .. 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------Y-NNS-MTTFCGTPWYMAPEVIR-

ETGSHTAKSTGMSDMWALGFTMLEVALENAFFHDA-----------SLGKPSLPLLLPEQKRIDVP-----------AKAVGGDEKLAETIASVLVADPA
    .  . .  .|||..| .. |... .  | ..              . . ||  .... ....            . .  .| . . | . |  ||.
----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPK

NRATAYDLLAHPYF
 | || ..| ||.|
KRPTAEQILQHPWF
Kinase LmjF35.4000.AA TKL 653-854 20 6.7e-44 152.16 In-house 1-283 (364) Show / Hide 
Range on Protein: 653-854
Range on HMM: 1-283/364
Sequence Identity: 20% (58 aa)

LSSTVNSKVYHALRRG----------EHVAVKEISI-------------------------DDDAARRRFQREVNIVSTCN--HPNIIRIKGVFFDGPF-
. |   ..||..  ||          . |||| ...                         |..| . ||..|. |..  .  ||||....|. ...|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYILLPYYHRGSLRALLSKQEPMSWVAVQDMLRQLASGVAYLHEHG--------IVHGDLKPSNVLIADDGR--------------PV
             .|   |...|||. .|       |    .. .. |.|..||| ..        |.| |||..|.|. ....              . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGIAKDHGALGVADMTLTNTVT-----NTSNGYNSIVGTIQYMAPEQLLCETGSHTA----------KSTGMSDMWALGFTMLEVA
|.|||.....   |   .| |..       |...  ....||...|||| |  ..    .          . .  .|... |  . |..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL
Kinase LmjF35.4000.AA STE 647-920 19 1.2e-40 141.24 In-house 1-359 (359) Show / Hide 
Range on Protein: 647-920
Range on HMM: 1-359/359
Sequence Identity: 19% (76 aa)

FQVLSTLSSTVNSKVYHALRR-----------------GEHVAVKEISIDDD-----------------AARRRFQREVNIVSTCN--HPNIIRIKGVFF
.. .. . .    .|| |...                 || .|.|.......                   . ....|..| . ||  ||||..  | .|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DG-------PFAYILLPYYHRGSLRALLS------KQ--------EPMSWVAVQDMLRQLASG-VAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAK
..          .| . |   |||. ..       |.         ...   .  ..||.  |  .|||.|.|.| |.||.|.|.       ..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

---DHGA----------LGVADMTLTNTVTNTSN-GYNSIVGTIQYMAPEQLLCETGSHT-AKSTGMSDMWALGFTMLEVALENAFFHD-ASL-------
   |..|                       .|.    |..|||  .|||| ....... .  . .  .|.| || |..| |  .  .||   .       
QLTDSMANIQSNNIIDCI------------ETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP

-----------------GKPSLP-LLLPEQKRIDVPAKAVGGD-----------EKLAETIASVLVADPANRATAYDLLA--HPYF
                 . |.||  | .... |      .              ... . |.  |. || .|.|| .||   || .
FNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM-IS-----Y--GGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase LmjF35.4000.AA CAMK 652-847 18 3e-35 110.52 In-house 1-321 (425) Show / Hide 
Range on Protein: 652-847
Range on HMM: 1-321/425
Sequence Identity: 18% (60 aa)

TLSSTVNSKVYHALRR-G-------------EHVAVKEISID----------------------------DDAARRRFQREVNIVSTCN-------HPNI
|| .   .||. . ..               ..||.| |. .                            ..  |....||..| ....       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRIKGVFFDGPF-------------------AYILL---PYYHRG----SLRALLSKQEP---------------MSWVAVQDMLRQLASGVAYLHEHGI
|..  |. |. .                    |. .    |   |     |   . ....               ..   .. . ||..|.|.|.|.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHGDLKPSNVLIADD-----------------GRPVISDFGIA--KDHGALGV--ADMTLTNTVTNT-------SNGYNSIVGTIQYMA-PEQLLCETGS
|| |||| |.|. |.                 .   |.||| |  .|.|      .|.   . . ..          ..  .||  ||| || |. ....
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

HT--------AKSTGMSDMWALG
             .  .|||..|
NMQNATDEEKPYYGPKCDMWSCG
Kinase LmjF35.4000.AA CAMKL 647-824 25 9.7e-35 108.18 In-house 1-203 (297) Show / Hide 
Range on Protein: 647-824
Range on HMM: 1-203/297
Sequence Identity: 25% (55 aa)

FQVLSTLSSTVNSKVYHALRR---GEHVAVKEISID----DDAARRR-----------FQREVNIVSTCN---HPNIIRIKGVFFDGPF------AYILL
.... ||     .||  |. .   ||.||.| | ..    |. ....            .||..| .  |   |||||..  |. .  .       |. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

PYYHRGS--LRALLSKQ----EPMSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDG--RPVISDFGIA---KDHGALGVADMTLTNTVTNTS
 |   |.  |   . |.    ..|.    . . ||. |.|.|.|.||||| |.|| |.|. ..|     |.||| .   ...             . .. 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-------------IFGPG

NGYNSIVGTIQYMAPE
.  .   |.  |||||
QKLKTFCGSPPYMAPE
Kinase LmjF35.4000.AA Ciliate-E2 689-920 20 3e-32 107.97 In-house 71-365 (365) Show / Hide 
Range on Protein: 689-920
Range on HMM: 71-365/365
Sequence Identity: 20% (63 aa)

REVN----------IVSTCNHPNIIRIKGVFF--DGPFAYILLPYYHRGSLRALLSKQ-----------EPMSWVAVQDMLRQLAS--------------
||.|          | .. ||||||... .|   |    |. . |.  |.|. .. ..           .....  .... .|...              
REINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACII

-GVAYLHEHG-IVHGDLKPSNVLIADDGRPVISDFGIAKDHGAL---GVADMTLTNTVTNTS----------------NGYNSIVGTIQYMAPEQLL-CE
 .. |||. . |.| |.||.|.|.     . |.|||..|.       .   . . .  .. .                | .|.|.||  ||||| |   .
LALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

TG--SHTAKSTGMSDMWALGFTMLEVALENAFFHDASLGKPSLPLLLPEQKRIDVPAK---------------AVGGDEKLAETIAS----VLVADPANR
 .  .     . ..|.|.|| .. |    .  |           .   .|. || | .                   ...    |       |. || .|
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR

AT-AYDLLAHPYF
 | . ..| ||.|
ITGWEQILNHPWF
Kinase LmjF35.4000.AA RSK 689-824 27 2e-27 97.44 In-house 49-178 (278) Show / Hide 
Range on Protein: 689-824
Range on HMM: 49-178/278
Sequence Identity: 27% (40 aa)

REVNIVSTCN-HPNIIRIKGVFFDGPFAYILLPYYHRGSLRALLSKQEP---MSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIAD---DGRPVI
.|.|| ..|. ||.|.. . .| ..   |. . | . | |   |.|..    .|   ... ...... | .||..||.| ||||.|.| .|   .|. ..
TERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKL

SDFGIAKDHGALGVADMTLTNTVTNTSNGYNSIVGTIQYMAPE
.||| .|               . . ..  .. ..||.|||||
TDFGFCKQF-------------RCDHNQWTMTFCYTIEYMAPE
Kinase LmjF35.4000.AA TKL-Unique 649-824 24 6.9e-26 88.37 In-house 1-196 (290) Show / Hide 
Range on Protein: 649-824
Range on HMM: 1-196/290
Sequence Identity: 24% (50 aa)

VLSTLSSTVNSKVYHALRRGEHVAVKEISI-DDDAAR--RRFQREVNIVSTCN-HPNIIRIKGVFF----DGPFAYILLPYYHRGSLRALLS--------
..... . . ..||..  ||. ||.| ...  |   .  . | .|||. .. . |||| .. |. .    . |  .| . |. .|||. .|.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--KQEPMSWVAVQDMLRQLASGVAYLHEHG--IVHGDLKPSNVLIADD-----GRPVISDFGIAKDHGALGVADMTLTNTVTNTSNGYN-SIVGTIQYMA
  .  ....  . .| .. |.|  |||  .  | |.|||.||.|.  .      .  |.|||..|      ...  ...|... ... | . .|....||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK------FNSKINKMTNNEHKGTRNQTRCGSFRWMA

PE
||
PE
Kinase LmjF35.4000.AA CMGC 647-827 15 4e-25 78.7 In-house 1-298 (513) Show / Hide 
Range on Protein: 647-827
Range on HMM: 1-298/513
Sequence Identity: 15% (49 aa)

FQVLSTLSSTVNSKVYHALR----------------RGEHVAVKEISID-DDAARR----------RFQREVNIVSTCN-----------------HPNI
..... . .   ..|| .                   .|.||.| |. . ..   .          | .||. |    |                 |.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IRIKGVFFDGPFA-----------------YILLPYYHRGSLRALLSKQE---------PMSWVA------------VQDML------RQLASGVA--YL
.... .| .   .                 |.   |    .|  .. ..          |.|               .. ..      .|.  |..  |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HEHG--IVHGDLKPSNVLIADDGRP--------------------VISDFGIAK--DHG----------------ALGVADMTLTNTVTNTSNG----YN
| |.  |.| ||||.|.|| ....                      | ||| |.  ..                 .               . .    | 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNK--------------DD-KPNRPYT

SIVGTIQYMAPEQLL
. | |  | ||| ||
HYVVTRWYRAPEILL
Kinase LmjF35.4000.AA PEK 716-847 17 1.2e-24 82.13 In-house 359-581 (655) Show / Hide 
Range on Protein: 716-847
Range on HMM: 359-581/655
Sequence Identity: 17% (40 aa)

YILLPYYHRGSLRALLSKQ--------------------------------------------EPMSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNV
||.  | . ..|| ... .                                            .  ... ... .||...|..|.|..|..| ||||||.
YIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNI

LIADDGR-----PVISDFGIAK-----------------DHGALGVADMTLTNTVTNTSNGYNSI--------------------------VGTIQYMAP
.. .||.       | |||.|.                 ..... ..| . ...  .... . .                           |||  ||.|
FLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSP

EQLLCE---TGSHTAKSTGMSDMWALG
||| ..   .. .. |    .||..||
EQLSGQHYQKSHYNHK----VDMYSLG
Kinase LmjF35.4000.AA STE20 660-852 27 4.4e-23 81.4 In-house 14-219 (288) Show / Hide 
Range on Protein: 660-852
Range on HMM: 14-219/288
Sequence Identity: 27% (61 aa)

KVYHALRR--GEH----VAVKEISIDDD----AARRRFQREVNIVSTCNHPNIIRIKGVFFDGPFA----YILLPYYHRGSLRALLS---KQE------P
||| |  .  ||     ||.| ......      ..  | |..| . |.||||..  | .. .  .    .|. .|   |||. ...   | .      |
KVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHP

MSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAKDHGALGVADMT-LTNTVTNTSNGY-NSIVGTIQYMAPEQLLCET---G
|. . .  ..|..  | .|||...|.| |.|  |.|. .||.  ..||| .        |..| .  . . | ..  |..|||  .|||| ..|..   .
MNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVC--------AQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCMEGPDK

SHTAKSTGMSDMWALGFTMLE
 .. |    .| |.|| | .|
GYDYK----CDIWSLGITAIE
Kinase LmjF35.4000.AA Pkinase_Tyr 660-790 29 7.9e-22 74.55 Pfam 14-161 (270) Show / Hide 
Range on Protein: 660-790
Range on HMM: 14-161/270
Sequence Identity: 29% (44 aa)

KVYHALRR------GEHVAVKEISIDDDAA---RRRFQREVNIVSTC-NHPNIIRIKGVFF--DGP-FAYILLPYYHRGSLRALLSK----QEPMSWVAV
.||..  .      . .|||| .  . .     |. | ||..| ..  .||||.|  ||    ..|   || ..|   |.|.  | |    ..| .    
EVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDL

QDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAKDH
 .| .| |.| .||......| ||   |.|.....   |.||| |.|.
LQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase LmjF35.4000.AA TyrKc 647-920 22 1.2e-14 14.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 647-920
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FQVLSTLSSTVNSKVYHALRRGEHVAVKEISIDDDAARRRFQREVNIVSTC--NHPNIIRIKGVFFDG-------PFAYILLPYYHRGSLRALLSKQEP-
 . . .| .    .||..  . . |||| .  |    |. | || .| .    .||||.|. ||  ..       .  .|.. |   |.|.  | | .| 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

MSWVAVQDMLRQLASGVAYLHEHGIVHGDLKPSNVLIADDGRPVISDFGIAKDHGAL---GVADMTLTNTVTNTSNG-YNSI-VGTIQYMAPEQLLCETG
 ..    ..  | |.| .|||.....| ||   |.|......  ||||| ..|..     |       .. . .. .  ..  .  |  |||| .     
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------ESKDYYRKKEHKGGKTMLPIRWMAPECI-----

SHTAKSTGMSDMWALGFTMLEVALENAFFHDAS----LGKPSLPLLLPEQKRIDVPAK-----AVGGDEKLAETIASVLVADPANRATAYDLLAHPYF
  . | |  || |. | .| |.    .  .       .    .  .. . .| . |.       |.  ... . . .   .||..| |  ..  | .|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase LmjF35.4000.AA CMGC 904-920 58 4.9e-07 18.16 In-house 497-513 (513) Show / Hide 
Range on Protein: 904-920
Range on HMM: 497-513/513
Sequence Identity: 58% (10 aa)

DPANRATAYDLLAHPYF
||..| || . |.||||
DPDKRITAEQALQHPYF
Kinase LmjF35.4000.AA STE20 897-920 41 3e-06 19.39 In-house 265-288 (288) Show / Hide 
Range on Protein: 897-920
Range on HMM: 265-288/288
Sequence Identity: 41% (10 aa)

IASVLVADPANRATAYDLLAHPYF
... |. ||..|.|| .|| ||..
VDKCLQKDPEKRPTASQLLKHPFI
Kinase LmjF35.4000.AA CAMKL 897-920 29 8e-06 14.35 In-house 274-297 (297) Show / Hide 
Range on Protein: 897-920
Range on HMM: 274-297/297
Sequence Identity: 29% (7 aa)

IASVLVADPANRATAYDLLAHPYF
| . |. .|  |.|. ... || .
IRKMLQVNPEKRPTIHQIMNHPWM
Kinase LmjF35.4000.AA CAMK 897-920 37 9e-06 13.8 In-house 402-425 (425) Show / Hide 
Range on Protein: 897-920
Range on HMM: 402-425/425
Sequence Identity: 37% (9 aa)

IASVLVADPANRATAYDLLAHPYF
| . |. || .|.|. . |.|| .
IRKMLQVDPEKRMTIEQCLNHPWM
Kinase LmjF35.4000.AA PEK 668-704 24 1.9e-05 14.09 In-house 25-78 (655) Show / Hide 
Range on Protein: 668-704
Range on HMM: 25-78/655
Sequence Identity: 24% (13 aa)

GEHVAVKEISIDDDA-----------------ARRRFQREVNIVSTCNHPNIIR
|.. |.|.| ...                   .... .|||   . .|||||.|
GCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVR
Kinase LmjF35.4000.AA RSK 904-920 31 0.00116 9.69 In-house 257-278 (278) Show / Hide 
Range on Protein: 904-920
Range on HMM: 257-278/278
Sequence Identity: 31% (7 aa)

DPANRAT-----AYDLLAHPYF
||..| .     | ....||.|
DPHKRLGCGPQDAEEIKQHPWF
Kinase LmjF35.4000.AA RIO1 757-785 51 0.001519 11.52 Pfam 132-160 (200) Show / Hide 
Range on Protein: 757-785
Range on HMM: 132-160/200
Sequence Identity: 51% (15 aa)

HEHGIVHGDLKPSNVLIADDGRPVISDFG
.|.|.|||||   |.|. ||| |.| |..
QECGLVHGDLSEYNILVHDDGKPWIIDWP
Kinase LmjF35.4000.AA PEK 892-920 37 0.009499 4.53 In-house 627-655 (655) Show / Hide 
Range on Protein: 892-920
Range on HMM: 627-655/655
Sequence Identity: 37% (11 aa)

KLAETIASVLVADPANRATAYDLLAHPYF
|.|. |   |  ||..| .| ..| |. |
KQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase LmjF35.4000.AA RIO1 660-674 44 0.251427 4.6 Pfam 1-18 (200) Show / Hide 
Range on Protein: 660-674
Range on HMM: 1-18/200
Sequence Identity: 44% (8 aa)

KVYHA--LRRGE-HVAVK
 ||||    .|. ..|||
NVYHAYSMEDGKDECAVK
HECT LmjF35.4000.AA HECT 1084-1343 26 1.6e-63 218.6 Pfam 52-329 (329) Show / Hide 
Range on Protein: 1084-1343
Range on HMM: 52-329/329
Sequence Identity: 26% (78 aa)

LFVLLGKVLLKSIIENRQIPLQLSSSVLKFLS--GAEPSFVDLEEYDPSIASTLKRLRLLSAAD----LEDA--GLDFSYFTHEF--------------L
.| .||... |.|........... ...|.|   | .... ||||.||.....||.|. ... .    .||   .|.|.  ...               |
WFKFLGRIIGKCIYNGIPLDIPFPPFFWKYLLGNGKPITLEDLEEIDPELYNSLKWLLEMENDGDDESIEDLRFCLTFT-VPWDDGYFGETKTVEEHLIL

KAQ-ADGRYTTDSPLTPESVSDYISLREKFDLVERRRTALEAMRKGFYCEPSLD--HHLKLLSPSDLLLLLCGQLH--VSAQVIVDALEFQ--GFGRNSN
     .|    . | | | . .||.|  .. |... .. .||.|||||   ..   ..|....|..| ||.||. .  .... . . .|..  |.  ||.
-EIFPNG---RNIPVTNENKEEYINLYCDYRLNKQIKKQFEAFRKGFY---EVIPPEWLSMFTPEELELLICGSPEQWIDWEDWKKHTEYDDHGYTKNSP

TPKYLKEVLLDMSQNNLRRFLQLCTATAAVPVSGAMK----KIKVLRCADEGRLPVGHGCTNQLDLPDYNDKQIIKEKLEIALAHASDG-FHVV
| ... |.. ...|  .|.||| .| .  .||.|  .    |...        ||. | | |.|.||.| .|.| .|||..|. |...| |. .
TIQWFWEIVEEFTQEQRRKFLQFVTGCPRLPVGGFKWNLQPKFTI--------LPTAHTCFNYLKLPPYSSKEIMREKLLYAIEHCQEGQFGFS
HECTc LmjF35.4000.AA HECTc 980-1343 19 6.7e-19 70.03 SMART 1-407 (407) Show / Hide 
Range on Protein: 980-1343
Range on HMM: 1-407/407
Sequence Identity: 19% (88 aa)

RLDNDDLLSP----IMVVF------QGEAGIDEGALTTEMLNLFYEQLILVKKALVCAASEEAGAASPHPAGSLVSSSTAAASASAPNEPGIHSVLFSTV
.  .||| ..    ....|      .||.|||.| .| | ..|   ..                                               .| . 
NHNMDDLKKRRQMMLEIEFVVNWHFDGEEGIDYGGPTREWFFLLCKEMFNP----------------------------------------DMYGMFRYS

PY-----------------LPAPDADGIAPD------LFVLLGKVLLKSIIENRQIPLQLSSSVLKFLSGAE----PSFVDLEEYDPSIASTLKRLR---
|.                 |  . . ... .      .| ..|.|. | |..|........ ...| | | .    ... |.|..|| . ..|. |.   
PNDNHNMVKPDYIQYNRYWLWPNPHCCFCNHEHLNQVWFRFIGRVMGKCIYHNCLVDCHFTRHFYKKLLGKPNGTDVTWHDMESFDPEYYQSLVWLIIVQ

---------------LLSAADLEDAG--LDF-SYFTH-EFLKAQAD----GRYTTDSPLTPESVSDYISLREKFDLVERRRTALEAMRKGFYCEPSLDHH
               |    . ..    |.| . ..  ..  .. .    |.   . |.| | .  |. |   . |..| .  .||.|.|||   .... 
QKRNYEQDQHEQSKSLEYDITDVEMDMCLTFTIVDMKDFGQCKMVELKPNGS---NIPVTNENKHEYVHLYCQWRLNKRIEKQMEAFREGFYEVIPENWM

LKLLSPSDLLLLLCGQL-HVSAQVIVDALEFQ-GFGRNSNTP---KYLKEVLLDMSQNNLRRFLQLCTATAAVP--VSG--AMK------KIKVLRCA--
 ... ...| |..||.   .....     |.  |. .|. |    ..  ||.  ...   |||||  | . ..|  | |  |.       |. . .    
RYMFDEEELELMICGMPDEWDMDDWKEHTEYRGGYTHNHQTIRFKQWFWEVVESFTNEERRRFLQFWTGCSRLPASVGGFKALCPSNGPQKFCIHKWGSE

---DEGRLPVGHGCTNQLDLPDYNDKQIIKEKLEIALAH---ASDGFHVV
   |. |||  | | |.|.||.|. |.| .||| .|       ..||. .
TCNDDDRLPTAHTCFNRLCLPPYSSKEILREKLLYAINECRICCEGFGFS