Gene 84891.m00119 (T.vaginalis)

84891.m00119

Species: T.vaginalis
Alias: 84891.m00119, TvagK0653
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
84891.m00119.AA Protein None 468 None Fasta, JSON
84891.m00119.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 84891.m00119.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84891.m00119.AA CMGC 130-456 12 7.7e-17 50.98 In-house 1-513 (513) Show / Hide 
Range on Protein: 130-456
Range on HMM: 1-513/513
Sequence Identity: 12% (69 aa)

YQIKQILGMSDHAITTLSYD--------------HKMRRNFVVKIMSST-----------------SSSFELPALKKLS----------------YSKNI
|.| . .|    ..    .|              |.  .   .|....                  ..  |.  ||.|.                  .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VHLYSSFIFRN-----------------HIIMCLEVLGGNVYSILSAKPDA---------------------------ASLNLARSVGKCLFAALN--DC
|.|| .| ..|                 |. .  | .. . | ..  ...                             .. . |   . .. .|.   |
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HSQK--IYHGKINSRNILVDPA-----------------LIHASFKLADFSSCNLFEKF------------------KKSPKRLIE--------RTPEEI
||..  | |  .   |||...                  .     |..|| ..  ...                   . .| | .         | || .
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL

LVYKAYP---------DKIDIWNAALTLANIALG--------TPLIQGKNP-----------KSIIFEIRRISGEPPPQVASSCE--------KPDLLVM
| .| |           .||.| ..  .| . .|         || .|..               .|.| .. | |. ..... .        . .   |
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

TVEDTKKKQETIVIKEEEIPMNLEQKETEEEEDNYEEEVEEMIEEEEEEEEKQQGEILIPKKRDLMKLFND-----------------------------
.  .. .|. ..                       .  ... . |      .. .    ...... .|| .                             
IKLPWYNKFPKKWN-W-------------------Q-TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNH

--------QNFVDFLLKCFSWKPEERPTASQILAMPFF
        . ..|.| |.. . |..|.||.|.|..|.|
QFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
S_TKc 84891.m00119.AA S_TKc 130-456 17 2.9e-16 61.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 130-456
Range on HMM: 1-231/231
Sequence Identity: 17% (61 aa)

YQIKQILGMSDHAITTLSYDHKMRRNFVVKIMSSTSSSFELPALKKLSYSKNIVHLYSSFIFRNHIIMCLEVLGG---NVYSILSAKPDA-----ASLNL
|.| ...|    .   . ...|  | . .||..  .   |.  |||    .|||.|| .|   .|. |..| ..|   ......  ..        .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

ARSVGKCLFAALNDCHSQKIYHGKINSRNILVDPALIHASFKLADFSSCNLFEKFKKSPKRLIERT---------PEEILVYKAYPD-KIDIWNAALTLA
||.. . .. ||. |||..| |  .   |||.|        |..|| .. ..            .|         || .     |   |.|.|    .|.
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

NIALGTPLIQGKNPKSIIFEIRRISGEPPPQVASSCEKPDLLVMTVEDTKKKQETIVIKEEEIPMNLEQKETEEEEDNYEEEVEEMIEEEEEEEEKQQGE
  . | |. .  ... ..  |.                                                                              
EMLCGYPPFP--QMQMMFKKIG------------------------------------------------------------------------------

ILIPKKRDLMKLFNDQNFVDFLLKCFSWKPEERPTASQILA-------MPFF
              .. . ||. ||. . ||.|||| ..|.       .|.|
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84891.m00119.AA DYRK2 407-456 33 3.7e-14 42.12 In-house 266-318 (318) Show / Hide 
Range on Protein: 407-456
Range on HMM: 266-318/318
Sequence Identity: 33% (18 aa)

KQQGEILIPKKRDLMKLFN---DQNFVDFLLKCFSWKPEERPTASQILAMPFF
. .|.. .|  ... . .    |.||.||...|| |.|.|| |.||.|  |..
NRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 84891.m00119.AA GSK 418-456 24 1.5e-11 30.9 In-house 288-328 (328) Show / Hide 
Range on Protein: 418-456
Range on HMM: 288-328/328
Sequence Identity: 24% (10 aa)

RDLMKLFNDQN--FVDFLLKCFSWKPEERPTASQILAMPFF
. ..| .....   .|.. ||.   |..|... ...|.|||
VYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 84891.m00119.AA DYRK 405-456 35 6.2e-11 37.35 In-house 268-320 (320) Show / Hide 
Range on Protein: 405-456
Range on HMM: 268-320/320
Sequence Identity: 35% (19 aa)

EEKQQGEILIPKKRDLMKLFN--DQNFVDFLLKCFSWKPEERPTASQILAMPFF
..|  |....|..|..  ...  |..|.||..||. | |..|.|.|| |  |.|
PTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 84891.m00119.AA RCK 427-456 36 3e-10 28.4 In-house 269-298 (298) Show / Hide 
Range on Protein: 427-456
Range on HMM: 269-298/298
Sequence Identity: 36% (11 aa)

QNFVDFLLKCFSWKPEERPTASQILAMPFF
|. .. . |.  | |..|.||.|.| .|.|
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 84891.m00119.AA MAK 427-456 32 7.3e-10 27.13 In-house 322-352 (352) Show / Hide 
Range on Protein: 427-456
Range on HMM: 322-352/352
Sequence Identity: 32% (10 aa)

Q-NFVDFLLKCFSWKPEERPTASQILAMPFF
| . .. . ..  | |..||||.| . .|.|
QSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 84891.m00119.AA MST 427-456 50 4e-09 25.05 In-house 225-254 (254) Show / Hide 
Range on Protein: 427-456
Range on HMM: 225-254/254
Sequence Identity: 50% (15 aa)

QNFVDFLLKCFSWKPEERPTASQILAMPFF
|.| ||. ||   .||.|.|| | |  ||.
QEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 84891.m00119.AA DYRK1 181-349 30 4.3e-09 27.55 In-house 62-232 (321) Show / Hide 
Range on Protein: 181-349
Range on HMM: 62-232/321
Sequence Identity: 30% (53 aa)

NIVHLYSSFIFRNHIIMCLEVLGGNVYSIL-SAKPDAASLNLARSVGKCLFAALNDCHSQ--KIYHGKINSRNILVDPALIHASFKLADF-SSCNLFEKF
.||||   |.||||. . .|.|  |.| .|   .    ||||.|   . .  ||    .   .| |  .   |||.  .   |  |. || |||.| .. 
YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSA-IKIIDFGSSCQLGQRI

KKSPKRLIERTPEEILVYKAYPDKIDIWNAALTLANIALGTPLIQGKNPKSIIFEIRRISGEPPPQVASSCEK
 .  .    | | |.|.  .|  .||.|     |  .  | ||  |.|    .  |  . | || ..  .  |
YQYIQSRFYRSP-EVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPK
Kinase 84891.m00119.AA STE 427-456 46 2.8e-08 25.44 In-house 328-359 (359) Show / Hide 
Range on Protein: 427-456
Range on HMM: 328-359/359
Sequence Identity: 46% (15 aa)

QNFVDFLLKCFSWKPEERPTASQILA--MPFF
..| ||. ||.   |..|||||| |    ||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 84891.m00119.AA DYRK2 181-244 30 3.3e-07 19.12 In-house 62-126 (318) Show / Hide 
Range on Protein: 181-244
Range on HMM: 62-126/318
Sequence Identity: 30% (20 aa)

NIVHLYSSFIFRNHIIMCLEVLGGNVYSIL-SAKPDAASLNLARSVGKCLFAALNDCHSQKIYHG
|.||.  .|.||||... .| |. |.|. .   ..   ||.| |  .. .  .|.  |  .| |.
NCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHC
Kinase 84891.m00119.AA Pkinase 431-456 50 1e-06 24.55 Pfam 268-293 (293) Show / Hide 
Range on Protein: 431-456
Range on HMM: 268-293/293
Sequence Identity: 50% (13 aa)

DFLLKCFSWKPEERPTASQILAMPFF
||. .|. ..|..|||| |||  |.|
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 84891.m00119.AA DYRK 178-244 30 3e-06 19.88 In-house 59-128 (320) Show / Hide 
Range on Protein: 178-244
Range on HMM: 59-128/320
Sequence Identity: 30% (21 aa)

YSKNIVHLYSSFIFRNHIIMCLEVLGGNVYSIL-SAKPDAA-SLNLARSVGKCLFAALNDCHSQ-KIYHG
.....||.| .|..|||  .  | |  | |  |   . .   |||| |.... .. .|   |.  .| |.
DKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHC
Kinase 84891.m00119.AA SLK 427-456 33 3e-06 16.83 In-house 230-259 (259) Show / Hide 
Range on Protein: 427-456
Range on HMM: 230-259/259
Sequence Identity: 33% (10 aa)

QNFVDFLLKCFSWKPEERPTASQILAMPFF
..| ||| ||    |. |.|..|..  ...
KEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 84891.m00119.AA SLK 181-267 31 1.6e-05 14.49 In-house 57-141 (259) Show / Hide 
Range on Protein: 181-267
Range on HMM: 57-141/259
Sequence Identity: 31% (28 aa)

NIVHLYSSFIFRNHIIMCLE-VLGGNVYSILSAKPDAASLNLARSVGKCLFAALNDCHSQKIYHGKINSRNILVDPALIHASFKLADF
|||.||... . |.. | .|   || | .|.     .   .  . |.| .  |||  ||.|. |  .   |||.    .    .||||
NIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILM---TMDGDVRLADF
Kinase 84891.m00119.AA Pkinase 153-243 22 7e-05 18.34 Pfam 24-131 (293) Show / Hide 
Range on Protein: 153-243
Range on HMM: 24-131/293
Sequence Identity: 22% (25 aa)

RRNFVVKIMSSTSSSF----------ELPALKKLSYSKNIVHLYSSFIFRNHIIMCLEVLGG-----NVYSILS-AKPDAA--SLNLARSVGKCLFAALN
.. ..|||..  . .           |.  .|.|. ..||| || .|  ..|| |..| ..|       ....|  .  .   | . .... . .. .|.
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLE

DCHSQKIYH
 |||..| |
YCHSMGIIH
Kinase 84891.m00119.AA STE 173-270 20 0.000318 10.96 In-house 82-194 (359) Show / Hide 
Range on Protein: 173-270
Range on HMM: 82-194/359
Sequence Identity: 20% (25 aa)

LKKLSY-SKNIVHLYSSFIF-------RNHIIMCLEVLG-GNVYSILSAKPDAAS-------------LNLARSVGKCLFAA-LNDCHSQKIYHGKINSR
.||..  ..|||. | ...        .... .|.| .. | . .|.  |                   .. . . . .  . |.  ||..| |  | . 
MKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPA

NILVDPALIHASFKLADFSSC
|||.         ||.||  |
NILL--------VKLCDFGVC
Kinase 84891.m00119.AA Pkinase 290-341 26 0.007469 11.17 Pfam 181-236 (293) Show / Hide 
Range on Protein: 290-341
Range on HMM: 181-236/293
Sequence Identity: 26% (15 aa)

EILV-YKAYPDKIDIWNAALTLANIALGTPLIQGK----NPKSIIFEIRRISGEPPP
|..  .. |. |.|.| . ..|.  ..| |. .|.    |  . .. |.|| | |..
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH
Kinase 84891.m00119.AA DYRK1 429-456 28 0.202917 0.16 In-house 294-321 (321) Show / Hide 
Range on Protein: 429-456
Range on HMM: 294-321/321
Sequence Identity: 28% (8 aa)

FVDFLLKCFSWKPEERPTASQILAMPFF
| | ...   . |..| |  ..|  .||
FKDLIKRMLQYDPKQRITPYYALQHSFF