Gene 86498.m00569 (T.vaginalis)

86498.m00569

Species: T.vaginalis
Alias: 86498.m00569, TvagK0588
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
86498.m00569.AA Protein None 341 None Fasta, JSON
86498.m00569.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of 86498.m00569.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86498.m00569.AA CMGC 12-296 20 4.3e-78 256.01 In-house 1-513 (513) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-513/513
Sequence Identity: 20% (106 aa)

FDFVEKIGKGSNSTVFKVIE--------------KRTKKVLALKKLK-PRVKTKDEP------------DFEIAAHCVLK-----------------DEN
.. ..|||.|. ..|.| .               ..|... |.||.| |  .. ..               ||     |.                 ..|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLNGKFVCKRDS---------------STYLIFDYYDYDLFSVIHDNSS-------KQLSKDL------------IKSLS------FQLLKAVD--CC
||||   |. | .                . ||.|.| |.||. .|..|.        . ||               ||...      .|.|....   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKHN--VLHRDIKPENIMITRD--------------------GVLKLGDFGYAF-KGDPSLK---------------------KSTNVITPSYRPPEILL
|.|.  ..|||.|||||.|. .                    |.||..||| |   ...| .                      ...| |  ||.|||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GD---------QYYLFPSDIWSVGCVIYELLTG--------KALFRPENFTV---------ESQLDKILSIIGTPS--------------NEE-------
|.         ..|  | |.|||||...|..||        | || ...              ||.||  ..|||.              .||       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------IKTKFSVAVPTNINHYDSCLHNYLINEISD-----------------------------------EFSEFRELLEKILIFNP
                  ....|      . | .  .  . . | . .                                   . .....||.|.|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

ENRLTASQLLQLPIF
..|.||.| || | |
DKRITAEQALQHPYF
S_TKc 86498.m00569.AA S_TKc 12-296 26 3.4e-77 263.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-231/231
Sequence Identity: 26% (78 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLKPRVKTKDEPDFEIAAHCVLKDENIVKLNGKFVCKRDSSTYLIFDYYDY---DLFSVIHDNSS----K
.....|||||. ..|.|...|.|... |.|..|      .    ||. .   . .||||| . |.    .. |....| |    |||..|... .    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

QLSKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYAFKGDPSLKKSTNVITPSYRPPEILLGDQYYLF-PSDIWSVGCVIYELL
...   ....  |...|.. ||.|...|||.|||||....  ..|..||| | .       .| . || |..||.|     | . ..|.||.||..||.|
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TGKALFRPENFTVESQLDKILSIIGTPSNEEIKTKFSVAVPTNINHYDSCLHNYLINEISDEFSEFRELLEKILIFNPENRLTASQLLQ-------LPIF
.|. .|.        |..... .||                                      .|......|.| ..||.|.|| ..||        | |
CGYPPFP--------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86498.m00569.AA CDK 12-296 29 4.2e-69 220.18 In-house 1-284 (284) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-284/284
Sequence Identity: 29% (98 aa)

FDFVEKIGKGSNSTVFKVIEKRTK-----KVLALKKL-----KPRVKTKDEPD----FEIAAHCVLKDENIVKLNGKFVCKR---------DSSTYLIFD
.. .|||| |.  .|.| . |.|.     .. ||||.     . | . |.        ||.    |  .|||||   .. |          ... |..|.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YYDYDLFSVIHDNSSKQLSKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGV-----LKLGDFGYA-FKGD------PSLKKSTNVITPSYRP
| |.|| ....           ||.. .|||.... ||.....|||.|| ||.|...|.     ||..||| |  .|       |. . . .|.|  ||.
YMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEILLGDQYYL--FPSDIWSVGCVIYELLT---GKALFRPENFTVESQLDKILSIIGTPSNEEIK--TKFSVAVPTNINHYDSCLHNYLINEISDEFSEF
||.|||.. |    | |.|||||...|..|   .|.||  ..     ||.||  |.|||. .     ||.                              
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE--IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

RELLEKILIFNPENRLTASQLLQLPIF
 .||.| | ..|..|..|.| || | |
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 86498.m00569.AA Pkinase 12-296 27 1.9e-65 228.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-293/293
Sequence Identity: 27% (86 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLKPRVKTKDEPDF-----EIAAHCVLKDENIVKLNGKFVCKRDSSTYLIFDYYDY-----DLFSVIHDN
. ...|||.|| ..|.| ..| | |. |.|..| | . ....       ||. .  |. .|||.| .  .. .... |....| .      |||..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYD--WFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

SSKQL--SKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVL----KLGDFGYAFK--GDPSLKKSTNVITPSYRPPEILLGDQYYLFPSDIW
... .  | . .|.   |.|.... ||.....|||.|||||.| ..|..    |..||| | .    ..   .| . || |..||...|.|||  ..|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SVGCVIYELLTGKALFRPE--NFTVESQLDKILSIIGTPSNEEIKTKFSVAVPTNINHYDSCLHNYLINEISDEF-----SEFRELLEKILIFNPENRLT
|.||..||.|.|. .|. .    .  .|. .|  | |.|  ... .. |.   . ..| . .        .  ..     .|........| ..|. |.|
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTFHNWSEECKDFIKWCLCKDPKKRPT

ASQLLQLPIF
| |.|| | |
AEQILQHPWF
Kinase 86498.m00569.AA CDC2 12-209 35 2.6e-58 177.58 In-house 1-209 (301) Show / Hide 
Range on Protein: 12-209
Range on HMM: 1-209/301
Sequence Identity: 35% (77 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLKPRVKTKDEPD-------FEIAAHCVLK-DENIVKLNGKFVCKRDSSTYLIFDYYDYDLFSVIH-DNS
.  .||||.|.   |.| ....|... ||||   |... || |        ||     || ..|||||   ...   .. |..|.|.|.||       ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKI--RLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIP

S-KQLSKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYAFKGDPSLKKST---NVITPSYRPPEILLGDQYYLFPSDIWSVGCV
. |... .|.||. .|.|..|. || . ..|||.|| || | ..|..|..||| |      ... |   .|.|  ||.||||||...| .| |.||.||.
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

IYEL---LTGKALF
..|.    | |.||
FAEMFMDVTKKPLF
Kinase 86498.m00569.AA CDK5 12-234 39 1e-52 164.66 In-house 1-223 (287) Show / Hide 
Range on Protein: 12-234
Range on HMM: 1-223/287
Sequence Identity: 39% (91 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLKPRVKTKDE--PDFEIAAHCVLKD---ENIVKLNGKFVCKRDSSTYLIFDYYDYDLFSVIHDNSSKQL
.. .|||| |   ||.|  .| |. . |||.   |    ||  |   |   |.||    .||| |    |   .    |.| . | ||   . |.   ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHD--VIHSEKKLTLVFEFCDQDLKKYM-DSCNGEM

SKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYA-FKGDPSLKKSTNVITPSYRPPEILLGDQYYLFPSDIWSVGCVIYELL-T
....|||. .|||| .  ||.|.||||| || | .| . | |||.||| |   | |    |  |.|  |||| .|.| . |  . |.||.||.. |.  .
DMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANA

GKALFRPENFTVESQLDKILSIIGTPSNEE
|. || | |  || || .|  |.|||. ..
GRPLF-PGN-DVEDQLKRIFKIMGTPCEDK
Kinase 86498.m00569.AA Ciliate-E2 12-296 22 2.8e-52 177.74 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

FDFVEKIGKGSNSTVFKVIEKRTK-----------------------KVLALKKLKPR--VKTKDEPDFEIAAHC------------VLKDENIVKLNGK
..|..|||.|. ..|.|.  ....                       |  |.| .|..    .| | .     .|             |.  ||.|.   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FVCKRDSSTYLIFDYYDY-DLFSVIHDN----------SSKQLSKDLIKSLSFQLLK---------------AVDCCHKHN-VLHRDIKPENIMITRDGV
|  | |.. ||...|... |||. | .|            |...   || .. |.|.               |.  .|. | ..|||||||||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKLGDFGYAFKGDPS-----------LKKSTN----------------------VITPSYRPPEILLGDQY--------YLFPSDIWSVGCVIYELLTGK
.|. |||.. | |..           ...  .                      . || | .|||| | .|        | . .||||.|...||.|.||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

ALFRPENFTVESQLDKILSIIGTPSNEEIKT-KFSVAVPTNINHYDSCLHNYLINE-ISDEFSEF-RELLEK----ILIFNPENRLT-ASQLLQLPIF
  |                       ..||  |..   | .... .  .    ... . .. |.    |. |    .|  .||.|.| ..|.|. |.|
PPF----------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86498.m00569.AA Ciliate-E2-Unclassified 12-296 21 7.7e-51 174.57 In-house 1-352 (352) Show / Hide 
Range on Protein: 12-296
Range on HMM: 1-352/352
Sequence Identity: 21% (80 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLK-------PRVKTKDEPDFEIAAHCVLK-----------------DENIVKLNGKFVCKRDSSTYLIF
. ....||.|....|.|...| .|.. |.| .|         ...|||  .|. . . .|                   ......  .. . .   |.. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYYDY-DLFSVIHDNSS---------------KQLSKDLIK-----SLSFQLLKAV-DCCHKHNVLHRDIKPENIMITRDG---VLKLGDFGYA-FKGDP
.| .. ||.  | ....               |...   .|      .  |.|..   ..||.|..|||||||||... .|    .|. ||| . . ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

SLKKSTN----------------VITPSYR----PPEILLGDQYYL---FPSDIWSVGCVIYELLTGKALFRPENFTV---------------ESQLDKI
. .. ||                . ||.|     .||.| | .|.    . .||||.|...||.|.|.  |  .| .                . . ...
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

LSIIGTPSNEE--IKTKFSVAVPTNINHYDSCLHNYLINEISDEFSEFRELLEKILIFNPENRLTASQLLQLPIF
  .|  |. ..  |  . |  .   ||                      .|| |.|  ||..|.|..|.|. |.|
QKNIQFPKFPWQQIPKHWSPEAKDFIN----------------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 86498.m00569.AA CAMK 17-206 19 4.6e-42 132.87 In-house 1-331 (425) Show / Hide 
Range on Protein: 17-206
Range on HMM: 1-331/425
Sequence Identity: 19% (63 aa)

KIGKGSNSTVFKVIEKRTK------------KVLALKKLKPR-----------------------------VKTKDEPDFEIAAHCV-------LKDENI
..|.|| ..|...|.|.|.            .  | | .. .                              |....   ||. .         |. .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLNGKFVCKR-----------------DSSTYLIF---DYYDY-----DLFSVIHDNSS-------------KQLSKDLIKSLSFQLLKAVDCCHKHNV
.||   .  ..                 |.  |...   .| .      |||. | ....             . .. .  . .  |.. ||. ||.||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKPENIMITRD-----------------GVLKLGDFGYA--FKGDP----------------------SLKKSTNVITPSYRP-PEILLG------
 |||.|||||... .                 . .|. ||| |  |...                         | .| . ||.| . ||.|.|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------DQYYLFPSDIWSVGCVIYELLTGK
        .|| ...|.||.|.. | .|.|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGY
Kinase 86498.m00569.AA STE 12-206 23 1.5e-39 137.38 In-house 1-265 (359) Show / Hide 
Range on Protein: 12-206
Range on HMM: 1-265/359
Sequence Identity: 23% (64 aa)

FDFVEKIGKGSNSTVFKVIEK------RTKKV---------LALKKLKPRVKTKDEPD-------------------FEIAAHCVLK--DENIVKLNGKF
....||||||.  ||.| . .      .|..|          | |... . ... . .                    ||  .  ..   .||||  | .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

V-----CKRDSSTYLIFDYYD-YDLFSVIHDNSSKQLS------------KDLIKSLSFQLLKA-VDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYA
.     .| |.. ...  | |   | ..|. . ... .             ..|.   .|.||.  .  |.|.. |||||| ||..      || ||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

FKGDPSLK----------------KSTNVI-TPSYRPPEILLG-----DQYYLFPSDIWSVGCVIYELLTGK
 . ..|.                 |.. .. || .  ||....     |. | . .||||.||.| |..|||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase 86498.m00569.AA ERK7 66-296 33 1.7e-38 129.06 In-house 59-292 (292) Show / Hide 
Range on Protein: 66-296
Range on HMM: 59-292/292
Sequence Identity: 33% (80 aa)

ENIVKLNGKFVCKRDSSTYLIFDYYDYDLFSVIH-DNSSKQLSKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYA--FKGDPS
.||..|   .  . |   ||.|.. . ||  ||   |  |   |  |    .|||.|.   |  ||.|||.|| ||..  . ..|. ||| |      ..
PNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYI---MYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEE

LKKSTNVITPS-----YRPPEILLGDQYYLFPSDIWSVGCVIYELLTGKALFRPENFTVESQLDKILSIIGTPSNEEIKTKFSVAVPTNINHYDSCLHNY
..... ..|       || |||||| . |    | ||.||.. |.|.||..| | . |.. |..||| .|. |..|.|.   |    . ...  .  .  
YDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMF-PGTSTMN-QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKT

LINEISDEFSEFRELLEKILIFNPENRLTASQLLQLPIF
| . . .   .  .|| ..|.|||..|||| | || |  
LDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 86498.m00569.AA MAPK 63-236 30 6.8e-34 114.46 In-house 61-260 (328) Show / Hide 
Range on Protein: 63-236
Range on HMM: 61-260/328
Sequence Identity: 30% (63 aa)

L-KDENIVKLNGKFVCK-----RD----SSTYLIFDYYDYDLFSVIH-DNSSKQLSKDLIKSLSFQLLKA--VDCCHKHNVLHRDIKPENIMITRDGVLK
. ..|||.||.  |  .     ..       |..... . ||  .|. ..   .|| | |... .|.|..  .   |  ||.|||.||.|| .. .. ||
FHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ---PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLK

LGDFGYAFKGDPS---------------LKKSTNVITPSYRPPEILLGD--QYYLFPSDIWSVGCVIYELLT-GKALFRPENFTVESQLDKILSIIGTPS
..||| | . ||.                  . .| |  || |||.|.   . |    |.|||||   |.|| .| ||. ..     |. .|....||||
ICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKD--YIDQWNLIMEVLGTPS

NEEIK
 | |.
EEFIQ
Kinase 86498.m00569.AA TyrKc 12-294 18 8.4e-11 -48.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-294
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKKLKPRVKTKDEPDFEIAAHCVL--KDENIVKLNGKFVCKRD-------SSTYLIFDYYDY-DLFSVIHDN
  . .|.| |   .|.| . |      | |.||.    . .   |.   | |  . .|||.| |  ||  .          .... | .. || . ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SSKQLSKDLIKSLSFQLLKAVDCCHKHNVLHRDIKPENIMITRDGVLKLGDFGYAFKGDPS---LKKSTNVITP----SYR--------PPEILLGDQYY
  | |. .   | ..|  .  .  |..|. |||.   |........ | .||| . ...        |. ....    . .        .|| .    . 
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

LFPSDIWSVGCVIYELLTGKALFRPE-------NFTVESQLDKILSIIGTPSNEEIKTKFSVAVPTNINHYDSCLHNYLINEISDEFSEFRELLEKILIF
   ||.|| | ...|..|  .   |.       |. |  ....       |.....                               .|  .. ..   .
TK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCWHE

NPENRLTASQLLQLP
.||.| | |.. .. 
DPEDRPTFSEIHECF
Kinase 86498.m00569.AA ERK7 12-42 45 2.1e-08 24.52 In-house 1-31 (292) Show / Hide 
Range on Protein: 12-42
Range on HMM: 1-31/292
Sequence Identity: 45% (14 aa)

FDFVEKIGKGSNSTVFKVIEKRTKKVLALKK
..  ...|||    | |.. ||||.|.||||
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKK
Kinase 86498.m00569.AA STE 267-296 40 2.6e-07 22.01 In-house 328-359 (359) Show / Hide 
Range on Protein: 267-296
Range on HMM: 328-359/359
Sequence Identity: 40% (13 aa)

SEFRELLEKILIFNPENRLTASQLLQ--LPIF
.||.. ..| |. .|..| ||||||.   | .
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 86498.m00569.AA MAPK 267-296 43 3.6e-07 20.59 In-house 299-328 (328) Show / Hide 
Range on Protein: 267-296
Range on HMM: 299-328/328
Sequence Identity: 43% (13 aa)

SEFRELLEKILIFNPENRLTASQLLQLPIF
.. . |||| | |.|. |.|. . || | |
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 86498.m00569.AA CDK5 270-296 40 9.9e-07 16.78 In-house 261-287 (287) Show / Hide 
Range on Protein: 270-296
Range on HMM: 261-287/287
Sequence Identity: 40% (11 aa)

RELLEKILIFNPENRLTASQLLQLPIF
..||.|.|..||. |..| . |. | |
MDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 86498.m00569.AA MAPK 12-43 28 1e-06 18.8 In-house 1-38 (328) Show / Hide 
Range on Protein: 12-43
Range on HMM: 1-38/328
Sequence Identity: 28% (11 aa)

FDFVEKIGKGSNSTVFKVIEKR------TKKVLALKKL
.. ...||.|.  .|...| ||      ..|  |.||.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKI
Kinase 86498.m00569.AA CAMK 261-296 35 6e-06 14.45 In-house 385-425 (425) Show / Hide 
Range on Protein: 261-296
Range on HMM: 385-425/425
Sequence Identity: 35% (15 aa)

EISDEFSE------FRELLEKILIFNPENRLTASQLLQLPIF
.||||| .       . |. |.|  .||.|.|..| |. | .
DISDEF-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 86498.m00569.AA CDC2 270-296 37 1.3e-05 12.66 In-house 275-301 (301) Show / Hide 
Range on Protein: 270-296
Range on HMM: 275-301/301
Sequence Identity: 37% (10 aa)

RELLEKILIFNPENRLTASQLLQLPIF
..||...|. .|..|..| . || | |
IDLLMQMLQYDPQKRISAKEALQHPYF