Gene 95836.m00094 (T.vaginalis)

95836.m00094

Species: T.vaginalis
Alias: 95836.m00094, TvagK0671
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
95836.m00094.AA Protein None 479 None Fasta, JSON
95836.m00094.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of 95836.m00094.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95836.m00094.AA DYRK2 163-458 40 2.9e-115 376.39 In-house 1-318 (318) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-318/318
Sequence Identity: 40% (128 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRFNPFS
.||... ||| || |. |.||||.. ||.|.| | .   .|  .|. ||.|.   |.|  . .|   |.|.|| |.| ||| |. ||||| .   |. ||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

ARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGY-AKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTGRP
 . .   |..|| ||.| |.. .|||||||||.        .  . |||| ||      . ||||||||||||  |..|| . |.||| ||..|..|| |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPAANESELVEMMFEVLGIPDKELIDNS-----SRGHVYFD---------------ENMKPIHKNPKKKKRTPKSVSLRSMLR-VFDHDLLDLLEKCFS
|||  || .   .| ||||.|.|...|..     .|  ..|.               . .... || ..|.|.| | |. |.|.   | ...| . .|| 
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

YDPSKRITAQEALQHPYF
 |||.|.|...||.||..
WDPSERMTPSQALKHPWI
Kinase 95836.m00094.AA DYRK 163-458 39 6.30000000001e-114 384.79 In-house 1-320 (320) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-320/320
Sequence Identity: 39% (127 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRFNPF-
.|| .. ||| || |. | ||||.. ||.|.| | . ...|.  |..||..|| .|||.|. .|.  |.|..| |.| .|| |  ||||. .  .|..| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SARQIKLVAKKILSCLDFCHQH-GVIHCDLKPENVAFIPG-STVNSRILDFGSGCFNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTG
| . .. .|..|| ||.| |..   |||||||||.      .  .  . |||| || .   . ||||||||||||  |.||. . |.||. ||..|..||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

RPLFPAANESELVEMMFEVLGIPDKELIDNS--SRGHVYFDE--------------------NMKPIHKNPKKKKRTPKSVSLRSMLRVFDHDLLDLLEK
 |||| .|| ..  .. ||||.| |..||..  .| | .||.                    . |.. ..  ...|.|.. .. . ..  ||...|...|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKK

CFSYDPSKRITAQEALQHPYF
|. .||.||||...||||| |
CLQWDPHKRITPSQALQHPWF
Kinase 95836.m00094.AA CMGC 163-458 20 9e-100 328.57 In-house 1-513 (513) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-513/513
Sequence Identity: 20% (108 aa)

FEIKSIFGKGAFGEVICCLD--------------HKTHKQVALKVIVNTQQMQQQGR-------------VEVSILQHLN----------HADPDYKSG-
.|| .  |.|..|.|  | |              |.| ..||.| | | . .. |..              |..||.|||            ||| |   
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-VVQNMDSFMFRD-----------------HVCATFEVLGKNLYEYSRSIRF-------NPFSARQ------------IKLVA------KKILSCLD--F
 .|.  |.|....                 |..  || ....||.| .. .|       .|.|  .            ||         . || .|.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

CHQHG--VIHCDLKPENVAFIPGSTVNS------------------RILDFGSGCFNGYA------------------------KFEYIQSRFYRAPEVV
||.|.  .||.||||||. . .  ....                  .| |||. .. .                            .|...|.|||||. 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGIP----------YGPPMDIWSFACIIVEMLTG--------RPLFPAANE-----------SELVEMMFEVLGIPDKELIDNS---------SR---GH
.| .          |..|.|.||..||. ||.||        .||||  .|            .  ...|.||| |. ..|...         ..   ..
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

VYFDEN---------------MKPIHKNPKKK---KRTPKSVSLRSMLRVFD-----------------------------------HDLLDLLEKCFSY
.  ...               ...  .|....   . ...  .....   ..                                   ....|||.|.. |
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPSKRITAQEALQHPYF
||.|||||..|||||||
DPDKRITAEQALQHPYF
Kinase 95836.m00094.AA S_TKc 163-458 27 6.8e-75 256.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGK---NLYEYSRSIRFN
.||  . ||||||.| .| ..||...||.|.|       .. | |..||..           .|.  |.|   ||..  .| ..    .|..| .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----FSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGYAKFEYIQSRFYRAPEVVFGIPYGP-PMDIWSFACIIV
.    |.  ... ... |.. |..||.||.||.||||||. .      .  | |||. ..       .. ...|.||||.   .||. . |.||. ||. 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGRPLFPAANESELVEMMFEVLGIPDKELIDNSSRGHVYFDENMKPIHKNPKKKKRTPKSVSLRSMLRVFDHDLLDLLEKCFSYDPSKRITAQEALQ
|||.|.|.||       ..|||...|                                               .....|...||. .||.||.|| ||||
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HPYF
       ||.|
DEWDIKCHPWF
Kinase 95836.m00094.AA DYRK1 163-413 38 2.4e-69 236.67 In-house 1-253 (321) Show / Hide 
Range on Protein: 163-413
Range on HMM: 1-253/321
Sequence Identity: 38% (98 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRFNPFS
.|| |  |||.|| |.   ||.....||.|.| | .   .| ..|. .|  .|..|.. |  .|.    ||||.|.|  ||.|  |||.  |   |   |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

ARQIKLVAKKILSCLDF--CHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTGR
   ..  |....  | |       .|||||||||.  .       .|.|||| |  |   ..||||||||.|||. ||.|   .|.||  ||.||| || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPAANESELVEMMFEVLGIPDKELIDNSSRGHVYFDENMKPIHKNPKKKKR
|||  .|| . .. . ||||.| |..|| . . | ||. . . ..   |.. .
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDK
Kinase 95836.m00094.AA Pkinase 163-458 28 4.1e-55 194.2 Pfam 1-293 (293) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-293/293
Sequence Identity: 28% (91 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRV-----EVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGK-----NLYEY
..|... |.|.||.|  | ...| |.||.|.|    .  .. .      |..|...|||        .|.  |.|. .||..  .| ...      |..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN------IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

SR---SIRFNPFSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNS----RILDFGSGCF---NGYAKFEYIQSRFYRAPEVVF-GIPYG
 .   . .|  || ...| ... ||. |..||..|.||.||||||. .|  .. .     .| |||. ..   |.     .  ...|.||||.  | .||
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI-LID-NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

PPMDIWSFACIIVEMLTGRPLFPAA----NESELVEMMFEVLGIPDKELIDNSSRGHVYFDENMKPIHKNPKKKKRTPKSVSLRSMLRVFDHDLLDLLEK
|. |.||. ||. |||.|||.|| .    |  .  .|.....| | .. .......  .|  .  . |              ..      . ...|....
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------F-HWTF-HNWSEECKDFIKW

CFSYDPSKRITAQEALQHPYF
|. .||.||.||...||||.|
CLCKDPKKRPTAEQILQHPWF
Kinase 95836.m00094.AA HIPK 163-399 32 4e-53 165.4 In-house 1-239 (329) Show / Hide 
Range on Protein: 163-399
Range on HMM: 1-239/329
Sequence Identity: 32% (78 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHADPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRFNPFS
.|.  . |.| ||.|. |  . |.  ||.|.. |      ||..|||||. | . ..|    .|  .. |  . |.|  ||.|  |||.. .  .| |  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

ARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSR--ILDFGSGCFNGYA-KFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTG
.. |. . . .|  |    . |.|| ||||||.  .  .    |  ..||||      . .  |.|||.|||||.. |.|.   .|.||  |.| |   |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

RPLFPAANESELVEMMFEVLGIPDKELIDNSSRGHVYFDE
.||.| |.| ...  . .  . | . |.   .. | .||.
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDR
Kinase 95836.m00094.AA YAK 163-388 35 9.3e-52 173.94 In-house 1-230 (347) Show / Hide 
Range on Protein: 163-388
Range on HMM: 1-230/347
Sequence Identity: 35% (82 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNH-ADPDYKS---GVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRF
. .  . |.| || |. |    |   .| ||| | |   ||.. |. ||. ||   ||. |     ..  .|.| .. | |  || |  |||||    .|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

NPFSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLT
  ||   |.   | ||  .       .|||||||||.          .| |||| |        |||.|.||.||.. ...|    | ||  ||..|   
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GRPLFPAANESELVEMMFEVLGIPDKELID
| |.|| . | . .    ..||.|  ..||
GLPIFPGNSEYNQIKRIIDMLGYPPSWMID
Kinase 95836.m00094.AA CLK 306-458 30 8.6e-41 119.55 In-house 187-350 (350) Show / Hide 
Range on Protein: 306-458
Range on HMM: 187-350/350
Sequence Identity: 30% (52 aa)

RILDFGSGC---FNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTGRPLFPAANESELVEMMFEVLG--IP----DKEL----IDNSS-
.. ||||     |    . . ...| ||||||. | ..  | |.||..||..|  ||  ||.  ...|  .||....|  ||     . .    .. .  
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFY

RGHVYFDENMKPIHKNPKKKKRTPKSVSLRSMLRVFDHD---LLDLLEKCFSYDPSKRITAQEALQHPYF
.. ...|. ..      .. .. .|   |..... .| .   | ||..|.. ||||||||...|||||.|
HNRLDWDW-HN---SDGRYVMENCK--PLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 95836.m00094.AA DyrkP 163-363 35 1.5e-40 130.86 In-house 1-205 (323) Show / Hide 
Range on Protein: 163-363
Range on HMM: 1-205/323
Sequence Identity: 35% (74 aa)

FEIKSIFGKGAFGEVICCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHA-DPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYEYSRSIRFNP-
. |    |  ||   | |.| .| . . .|.| | .    |   |. .|. .|   | | |  |..  | |  ..|.    |.|  ||||. .  | |  
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKN-VLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

---FSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEML
   |    .. . ..||  ||. |   .|||||||||.     .  . .|.|||| ||       |.||| ||||||. |  |   .|.||  ||. |. 
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELW

TGRPLF
||  ||
TGNVLF
Kinase 95836.m00094.AA CLK 163-297 31 6.1e-39 113.88 In-house 1-147 (350) Show / Hide 
Range on Protein: 163-297
Range on HMM: 1-147/350
Sequence Identity: 31% (47 aa)

FEIKSIFGKGAFGEVICCLDHKT-HKQVALKVIVNTQQMQQQGRVEVS-ILQHLNHA-DPDYKSG--VVQNMDSFMF-RDHVCATFEVLGKNLYEYSRSI
.||..  | |.|| |  | |||   |.||||.| |  .   . .||.. |....| . ||. |.   ...  |.| .  .|.|  || .|...|.  .| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R------FNPFSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAF
.      . |.  ..|.  |. ... . | |  . .| ||||||  |
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase 95836.m00094.AA CDK 327-458 30 1.8e-34 107.61 In-house 183-284 (284) Show / Hide 
Range on Protein: 327-458
Range on HMM: 183-284/284
Sequence Identity: 30% (42 aa)

RFYRAPEVVF-GIPYG--PPMDIWSFACIIVEMLT---GRPLFPAANESELVEMMFEVLGIPDKELIDNSSRGHVYFDENMKPIHKNPKKKKRTPKSVSL
. |||||. .    |.  .| |.||. ||..||.|   ..||||  .| .  .. |...| |. .   . .    |                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

RSMLRVFDHDLLDLLEKCFSYDPSKRITAQEALQHPYF
            |||.|.. |||.|||.|..|||||||
------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 95836.m00094.AA PRP4 286-401 30 4.4e-15 51.71 In-house 128-243 (320) Show / Hide 
Range on Protein: 286-401
Range on HMM: 128-243/320
Sequence Identity: 30% (36 aa)

IHCDLKPENVAFIPGSTVNSRILDFGS-GCFNGYAKFEYIQSRFYRAPEVVFGIPYGPPMDIWSFACIIVEMLTGRPLFPAANESELVEMMFEVLGIPDK
.| |.|| |.  .  |.    . |||| .  .      | .||||||||.. |.||    |.|| .| . |. ||  .||     .   .. .. |   .
LHADIKPDNI-LVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPN

ELIDNSSRGHVYFDENM
 .| ..     .||.|.
KMIRKGQFKDNHFDQNC
Kinase 95836.m00094.AA PRP4 163-251 33 6.7e-15 51.04 In-house 1-92 (320) Show / Hide 
Range on Protein: 163-251
Range on HMM: 1-92/320
Sequence Identity: 33% (31 aa)

FEIKSIFGKGAFGEVICCL-DHKTHKQVALKVIVNTQQMQQQGRVEVSILQHLNHA--DPDYKSGVVQNMDSFMFRDHVCATFEVLGKNLYE
... .  |.| |. |. |    .. ..|| |.| |   |.. |  |. ||| || |  |.. |. .|.  ..| .| | |  || .  || |
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLRE
Kinase 95836.m00094.AA PRP4 429-458 56 1.1e-11 39.1 In-house 291-320 (320) Show / Hide 
Range on Protein: 429-458
Range on HMM: 291-320/320
Sequence Identity: 56% (17 aa)

HDLLDLLEKCFSYDPSKRITAQEALQHPYF
| . |||.||.  ||.||||  |||.||..
HQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 95836.m00094.AA DyrkP 415-458 47 6.4e-10 28.14 In-house 280-323 (323) Show / Hide 
Range on Protein: 415-458
Range on HMM: 280-323/323
Sequence Identity: 47% (21 aa)

PKSVSLRSMLRVFDHDLLDLLEKCFSYDPSKRITAQEALQHPYF
||   ||  ||  ||  .|   .|   |  .| ||.||||||.|
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 95836.m00094.AA CDK 266-294 41 2.7e-08 22.46 In-house 110-138 (284) Show / Hide 
Range on Protein: 266-294
Range on HMM: 110-138/284
Sequence Identity: 41% (12 aa)

IKLVAKKILSCLDFCHQHGVIHCDLKPEN
||   . .|. |..||.....| |||| |
IKCYMWQLLRGLHYCHSNWIMHRDLKPQN
Kinase 95836.m00094.AA CDK 163-217 25 4.2e-08 21.85 In-house 1-67 (284) Show / Hide 
Range on Protein: 163-217
Range on HMM: 1-67/284
Sequence Identity: 25% (17 aa)

FEIKSIFGKGAFGEVICCLDHKTH-----KQVALKVIVNTQQ--------MQQQGRVEVSILQHLNHA
.|.    | |..|.|  . |..|.     . |||| |   ..        . .    |.|.|..| |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HP
Kinase 95836.m00094.AA DYRK1 433-458 50 2.8e-07 21.09 In-house 296-321 (321) Show / Hide 
Range on Protein: 433-458
Range on HMM: 296-321/321
Sequence Identity: 50% (13 aa)

DLLEKCFSYDPSKRITAQEALQHPYF
||...   ||| .|||  .||||..|
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase 95836.m00094.AA TyrKc 163-458 14 4e-06 -124.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 163-458
Range on HMM: 1-280/280
Sequence Identity: 14% (51 aa)

FEIKSIFGKGAFGEVI-CCLDHKTHKQVALKVIVNTQQMQQQGRVEVSILQHL--NH----------ADP-------DYKSGVVQ-----NMDSFM-FRD
 . . . | ||||||  . ..     ||| |.. .    ..  . | .|. .|  .|           ..       .    |.      . ...   . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

HVCATFEVLGKNLYEYSRSIRFNPFSARQIKLVAKKILSCLDFCHQHGVIHCDLKPENVAFIPGSTVNSRILDFGSGCFNGYA-KF----EYI------Q
.                       .. ..    .  | .  .. |....|| ||   |.  . |.    .| |||   . .   .     .|.      .
PK----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC-LV-GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

SR-----FYRAPEVVFGIPYGPPMDIWSFACIIVEMLT-GRPLFPA-----ANESELVE--MMFEVLGIPDK--ELIDNSSRGHVYFDENMKPIHKNPKK
..        |||. .   . .  |.|||   . |..| | .  |       . .|..|  .  . . .|.   . .                       
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------

KKRTPKSVSLRSMLRVFDHDLLDLLEKCFSYDPSKRITAQEALQHPYF
           .       .. .. ..|  .||..| | .|   | .|
-----------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 95836.m00094.AA YAK 431-458 25 6.2e-05 12.27 In-house 320-347 (347) Show / Hide 
Range on Protein: 431-458
Range on HMM: 320-347/347
Sequence Identity: 25% (7 aa)

LLDLLEKCFSYDPSKRITAQEALQHPYF
..|..      .| .| ... | |||. 
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 95836.m00094.AA HIPK 433-458 46 0.000306 8.71 In-house 304-329 (329) Show / Hide 
Range on Protein: 433-458
Range on HMM: 304-329/329
Sequence Identity: 46% (12 aa)

DLLEKCFSYDPSKRITAQEALQHPYF
..| |  . |. ||||  |||.||. 
HVLKKMCTWDAHKRITPCEALNHPFV