Gene 94508.m00090 (T.vaginalis)

94508.m00090

Species: T.vaginalis
Alias: TvagK0669, 94508.m00090
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
94508.m00090.AA Protein None 370 None Fasta, JSON
94508.m00090.kin_dom Protein Kinase Domain None 322 None Fasta, JSON

Protein domain

Protein domains of 94508.m00090.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94508.m00090.AA DYRK 47-368 33 9.1e-80 271.31 In-house 1-320 (320) Show / Hide 
Range on Protein: 47-368
Range on HMM: 1-320/320
Sequence Identity: 33% (111 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATNINDDAIGYTATYYGSFEYRNHRCIVLERLGFNLFSVLEQRN
..||. .| |.||||  .     . ..   ||||| .. . |....  | .||||. .. ..|   .   .| .| .||| ||| | |  ||. .| ...
YEILEYIGKGSFGQVVKCW----DHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ-DPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNH

YRGL-PILLVKKVLRSILTVIKGAKDI-GLIHSDIKPENMCISA--DNQKIKIIDFGASRQLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVAF
 .|. .. ||.|....||| .|  .    .|| |.||||  .    ... ||.|||| | . ..    || ||.||||| || .||.|.||.|| ||.  
FQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILA

ETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNS--ERKHLYFDSSGNVLSMSEMSEANGFEPFTFNDYFTFRVFHDTIRNYRRQPRCGS----QEYI
| | | || ||.|| ... .. | ||. |..||...  .||| .||.      | .  . .    ..   |.| .   . . ..|| |   .    ..  
ELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-C

DRENFIDLLDHMLVYEPATRYTVEECLEHPFL
|...|.|... .|...|. | | .. |.||..
DDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 94508.m00090.AA CMGC 47-368 17 1.7e-61 200.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 47-368
Range on HMM: 1-513/513
Sequence Identity: 17% (92 aa)

FRILDRLGNGTFGQVYDAMWLAPQSR----------NEINVAIKISKSYQVFFDSST-------------QEARILEYIATNINDDAI----------GY
. |....| ||.|.|| .     . .          ..  ||||. |. . . .                 | .||...  | .                
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-TATYYGSFEYRN-----------------HRCIVLERLGFNLFSVLEQRN--YRG------------------------LPILLVKKVLRSILTVIK--
   . | .| ..|                 | ..| | .. .|. .... .  |.|                        ..| ...   . ||. .|  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

GAKDIG--LIHSDIKPENMCISADNQK-------------------IKIIDFGASRQLDDM------------------------RNFYIESRYYRAPEL
     .   || |.||||  |. ...                    .||.||| .|....                            |. .|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILHLP----------YDYKIDIWSAGCVAFETFVG--------FPLIPGQNE-----------AHMIHLFNECLGPLPPEMINNSERKHLYFDSSGNVLS
.|  .          |...||.||.||. .| . |         || ||..|            .....  . ||. . .||.... .| .         
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RH-F---------

MSEMSEANGFEPFTF--------NDYFTFRV----------FHDTIRNYRRQ----PRCGSQEYI-----------------------------------
       | | . .          .|..|            . .  |||...    |..  .                                      
-------N-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQ

-----DRENFIDLLDHMLVYEPATRYTVEECLEHPFL
     . . .||||. ||.|.|. | |.|..|.||..
FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 94508.m00090.AA DYRK1 47-368 31 4.3e-55 189.34 In-house 1-321 (321) Show / Hide 
Range on Protein: 47-368
Range on HMM: 1-321/321
Sequence Identity: 31% (103 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATNINDDAIGYTATYYGSFEYRNHRCIVLERLGFNLFSVLEQRN
. |   .| | ||||  |      . ..  ||||| |  . |..    | |.|| .  . ...   |  .  . | .||| |.|.| | .||. .|   .
YEIDSLIGKGSFGQVVKAY----DHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKY-YIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTH

YRGLPILLVKKVLRSILTVI--KGAKDIGLIHSDIKPENMCIS-ADNQKIKIIDFGASRQLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVAFE
.||  . |..|  . ..| .    . .. .|| |.||||. .  .   .|||||||.| ||..    || ||.||.||..| ..|| .||.|| ||.  |
FRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVE

TFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNSERKHLYFDS-SGNVLSMSEMSEANG-FEPFTFNDYFTFRVFHDTIRNYRRQPRCGSQEYIDRENF
  .| ||  |.||   ..   | ||  | .||. . . | ||.    |  ..    .    .. ..          .    . ||.   |     |   |
MHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPG-HSVEDYLKF

IDLLDHMLVYEPATRYTVEECLEHPFL
 ||. .|| |.|..| |  . |.|.|.
KDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 94508.m00090.AA S_TKc 47-368 21 4.8e-53 183.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-368
Range on HMM: 1-231/231
Sequence Identity: 21% (71 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATNINDDAIGYTATYYGSFEYRNHRCIVLERLGF---NLFSVLE
..||. .| |.||.|| . .          ||||| |      ..  .| .||.            .  ..|..|.  .| ..|.| ..    .||....
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

QRNYRG----LPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQKIKIIDFGASRQLDDMRNFYIESRYYRAPELILHLPYDY-KIDIWSAG
.|...|    .|   ...... |.  ..   . | || |.||||  ..     |||.||| .|||    . .. ...|.|||..   .|.. |.|.|| |
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

CVAFETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNSERKHLYFDSSGNVLSMSEMSEANGFEPFTFNDYFTFRVFHDTIRNYRRQPRCGSQEYIDR
|. .| ..| |. |     .|  .|. ..                                                                       
CILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------------------------------------S

ENFIDLLDHMLVYEPATRYTVEECLE-------HPFL
. ..|.....|...|. |.|. |.|.       ||..
PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94508.m00090.AA HIPK 47-291 35 4.6e-48 149.17 In-house 1-243 (329) Show / Hide 
Range on Protein: 47-291
Range on HMM: 1-243/329
Sequence Identity: 35% (88 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATNINDDAIGYTATYYGSFEYRNHRCIVLERLGFNLFSVLEQRN
. .|. || ||||||  . |   .. ||. ||||| |    .      | .||. . .   |..       |  |. .|| |.| | |  ||.  . | .
YEVLEFLGRGTFGQVVKC-WK--RGTNEM-VAIKILKNHPYYARQGQIEVSILHCLSQENADEY--HFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNK

YRGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQ---KIKIIDFG-ASRQLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVAF
.  ||.  .. .|  .|| ..  |..|||| |.||||. .    .   ..|.|||| ||   .   | |. |||||||| || ||.  ..|.|| |||  
FMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIA

ETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNSERKHLYFDSSGNV
| | | || || .|   |  . .  .   . ...   .|| .||   ..
ELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQS
Kinase 94508.m00090.AA DYRK2 120-289 36 1.2e-45 146.2 In-house 69-245 (318) Show / Hide 
Range on Protein: 120-289
Range on HMM: 69-245/318
Sequence Identity: 36% (65 aa)

SFEYRNHRCIVLERLGFNLFSVLEQRNYRGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQ-KIKIIDFGASRQLDDMRNF-YIESRYY
.| .||| ||..| |. || . . .... |.   || .  .|||. ..  .   .|| | ||||      |.  ||.|||| |.  .  | . || ||.|
YFYFRNHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFY

RAPELILHLPYDYKIDIWSAGCVAFETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNS-----ERKHLYFDSSG
|||| || ..|.  ||.|| ||.. | . |.|| || ||.  . .. | ||  |.......      |. ..|.| .
RAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHC
Kinase 94508.m00090.AA YAK 47-285 34 1.5e-41 138.69 In-house 1-239 (347) Show / Hide 
Range on Protein: 47-285
Range on HMM: 1-239/347
Sequence Identity: 34% (84 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATNINDDAIG---YTATYYGSFEYRNHRCIVLERLGFNLFSVLE
. .|| || ||||||     .     ||. .|.|. |. | .|  .  |..||.     .  .           | .| ..|| |.| | |  ||.  | 
YIVLDMLGQGTFGQVVKCQNCD---TNEL-FAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLK

QRNYRGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISA-DNQKIKIIDFGASRQLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVAF
| ...|. . |..  . .||  .  ...  .|| | ||||    . .   ||||||| | |   |   || .|.||.|| |.  .|   || || ||.  
QNKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVA

ETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNSERKHLYF
| | | |. ||  |   |    . ||  | .||.    |  ||
ELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 94508.m00090.AA Pkinase 47-278 24 1.7e-33 119.48 Pfam 1-242 (293) Show / Hide 
Range on Protein: 47-278
Range on HMM: 1-242/293
Sequence Identity: 24% (62 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQ-----EARILEYI-ATNINDDAIGYTATYYGSFEYRNHRCIVLERLGF----
..|. ..| |.||.|| ...   .      ||.|| |      .   .     |..|.  .   ||         ..|..||...| ..|.| ..     
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNI--------VRLYDWFEDKDHIYMVMEYCEGGLYV

-NLFSVLEQRNYRGL--PILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQK---IKIIDFGASRQL---DDMRNFYIESRYYRAPELIL-HL
  ||.... ......  .   .|.... ||  ..   . | || |.||||  |. ...    .||.||| ..|.   .   . .  ...|.|||.|. . 
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQ

PYDYKIDIWSAGCVAFETFVGFPLIPGQ----NEAHMIHLFNECLGPLPPEMINNS
.|..|.|.||.||. .| . | |. ||.    | . ....... .|| ... . ..
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWW
Kinase 94508.m00090.AA PRP4 47-286 31 9.9e-31 108.41 In-house 1-240 (320) Show / Hide 
Range on Protein: 47-286
Range on HMM: 1-240/320
Sequence Identity: 31% (76 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYIATN-INDDAIGYTATYYGSFEYRNHRCIVLERLGFNLFSVLEQR
.|.    | | |. |  .  ..   |   .|||||  .  .  ..   |  ||  .  .    .        . .|..|.| |.| | .  ||  ||   
YRVYGYCGQGVFSNVCRCRDQT---RGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVL--K

NY---RGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQKIKIIDFG-ASRQLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVA
 |    || .  |    . ..   |  |  . .| |||| |. .. ... .|..||| ||.  .     |  ||.||||| |.  |||| ||.||.||  
KYGKDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTL

FETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMINNSERKHLYFD
.| . |  . ||.   ||. || .  | .|  || ... |  .||
YELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFD
Kinase 94508.m00090.AA GSK 176-268 42 1.7e-28 83.65 In-house 139-236 (328) Show / Hide 
Range on Protein: 176-268
Range on HMM: 139-236/328
Sequence Identity: 42% (42 aa)

HSDIKPENMCISADNQKIKIIDFGASRQLDDMR----NFYIESRYYRAPELILHL-PYDYKIDIWSAGCVAFETFVGFPLIPGQNEAHMIHLFNECLG
| ||||.|. . .|. . || ||| ..||..      ..|| ||||||||||.    |. .||.||.||| .| . |.|| ||... ... .  ..||
HRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLG
Kinase 94508.m00090.AA CDKL 137-276 36 4.9e-25 82.53 In-house 83-225 (286) Show / Hide 
Range on Protein: 137-276
Range on HMM: 83-225/286
Sequence Identity: 36% (52 aa)

NLFSVLEQRNYRGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCISADNQKIKIIDFGASRQLD---DMRNFYIESRYYRAPELILH-LPYDYKI
..  .||. . .|..  .|.|..  ||  |.       || ||||||  |.  |  .|. |||  |.|    ..   | . | |||||| .    |   .
TVLHELEE-YPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPV

DIWSAGCVAFETFVGFPLIPGQNEAHMIHLFNECLGPLPPEMIN
|||..|||  | . | || |||..    ..   ||||| |. ..
DIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQE
Kinase 94508.m00090.AA CLK 47-187 24 1.4e-21 60.85 In-house 1-148 (350) Show / Hide 
Range on Protein: 47-187
Range on HMM: 1-148/350
Sequence Identity: 24% (37 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEAR-ILEYIATNINDDAIGY--TATYYGSFEY-RNHRCIVLERLGFNLFSVL
. |.. || |||| |.     .  ..    ||.|| ..   . . .  | . |.. |... . . .        . .|.|  .| ||| |..| ......
YEIVCTLGEGTFGKVVE---CWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFM

EQRN------YRGLPILLVKKVLRSILTVIKGAKDIGLIHSDIKPENMCIS
   |      |...||  ...  . ... .|   |..|.| | |||| |..
KSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFV
Kinase 94508.m00090.AA CLK 190-285 32 2.1e-18 51.1 In-house 183-285 (350) Show / Hide 
Range on Protein: 190-285
Range on HMM: 183-285/350
Sequence Identity: 32% (33 aa)

NQKIKIIDFGASR---QLDDMRNFYIESRYYRAPELILHLPYDYKIDIWSAGCVAFETFVGFPLIPGQNEAHMIHLFNECLG-PLPPEMINNSE---RKH
|  |..||||  .   . .      . .| ||||| || |.. .. |.|| ||. ||  .|| | .. ..     .  . .| |.|  ||  .     | 
NTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQ

LYF
 ||
KYF
Kinase 94508.m00090.AA CLK 339-368 40 4.3e-10 25.72 In-house 321-350 (350) Show / Hide 
Range on Protein: 339-368
Range on HMM: 321-350/350
Sequence Identity: 40% (12 aa)

ENFIDLLDHMLVYEPATRYTVEECLEHPFL
. ..||.  || |.|. | |  . | ||| 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 94508.m00090.AA HIPK 334-368 40 4.5e-09 24.19 In-house 295-329 (329) Show / Hide 
Range on Protein: 334-368
Range on HMM: 295-329/329
Sequence Identity: 40% (14 aa)

EYIDRENFIDLLDHMLVYEPATRYTVEECLEHPFL
| |||..|...|  |.. ..  |.|  | |.||| 
EKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 94508.m00090.AA PRP4 343-368 50 6.1e-08 25.23 In-house 295-320 (320) Show / Hide 
Range on Protein: 343-368
Range on HMM: 295-320/320
Sequence Identity: 50% (13 aa)

DLLDHMLVYEPATRYTVEECLEHPFL
|||| .|.  |. | |..| |.|||.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase 94508.m00090.AA Pkinase 339-368 33 5e-07 25.94 Pfam 264-293 (293) Show / Hide 
Range on Protein: 339-368
Range on HMM: 264-293/293
Sequence Identity: 33% (10 aa)

ENFIDLLDHMLVYEPATRYTVEECLEHPFL
|...|... .| . |. |.| |..|.||..
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 94508.m00090.AA TyrKc 47-368 17 6.4e-07 -110.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-368
Range on HMM: 1-280/280
Sequence Identity: 17% (63 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISKSYQVFFDSSTQEARILEYI---ATNINDDAIGYTATYYGS---FEYRNHRCIVLERLGF-NLF
 . .. ||.| ||.|| ..|        |.||.|  |..        .||||.  .     ||    .   .    .   | |    .||.|     .| 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNI----VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SVLEQRNYRGLPILLVKKVLRSILTVIKGAK---DIGLIHSDIKPENMCISADNQKIKIIDFGASRQLDDM-------RNFYI----ESR-----YYRAP
. |  .  .    | .|. |   . . .|     . ..|| |.   |  .....  .|| ||| || ..|                  ..        ||
DYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

ELILHLPYDYKIDIWSAGCVAFETF-VGFPLIPG-----QNEAHMIHLFNECLGPLPPEM---INNSERKHLYFDSSGNVLSMSEMSEANGFEPFTFNDY
| | .  .  | |.|| | . .| |  | .  ||      . ...|..  .   . .|.    .                                    
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------

FTFRVFHDTIRNYRRQPRCGSQEYIDRENFIDLLDHMLVYEPATRYTVEECLEHPFL
                    .   .  .   ..      ..|. | | .|.  | ..
--------------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 94508.m00090.AA GSK 47-80 31 1e-06 15.58 In-house 1-38 (328) Show / Hide 
Range on Protein: 47-80
Range on HMM: 1-38/328
Sequence Identity: 31% (12 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEIN----VAIK
... .. |.|.|| || |    |   .. .    ||||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIK
Kinase 94508.m00090.AA DYRK2 339-368 36 5e-06 15.32 In-house 289-318 (318) Show / Hide 
Range on Protein: 339-368
Range on HMM: 289-318/318
Sequence Identity: 36% (11 aa)

ENFIDLLDHMLVYEPATRYTVEECLEHPFL
||||| .   .. .|..| | .. |.||..
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 94508.m00090.AA GSK 342-368 44 5e-06 13.88 In-house 302-328 (328) Show / Hide 
Range on Protein: 342-368
Range on HMM: 302-328/328
Sequence Identity: 44% (12 aa)

IDLLDHMLVYEPATRYTVEECLEHPFL
|||.  .|||.|  | .  |.. ||| 
IDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 94508.m00090.AA CDKL 342-368 29 6e-06 16.23 In-house 260-286 (286) Show / Hide 
Range on Protein: 342-368
Range on HMM: 260-286/286
Sequence Identity: 29% (8 aa)

IDLLDHMLVYEPATRYTVEECLEHPFL
.|..  .|   |. |.|.|....||. 
LDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 94508.m00090.AA Pkinase_Tyr 47-83 35 1e-05 20.09 Pfam 1-37 (270) Show / Hide 
Range on Protein: 47-83
Range on HMM: 1-37/270
Sequence Identity: 35% (13 aa)

FRILDRLGNGTFGQVYDAMWLAPQSRNEINVAIKISK
 ...  || | ||.|| . |   .. ..| ||.|. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK
Kinase 94508.m00090.AA YAK 338-368 32 0.000223 10.35 In-house 317-347 (347) Show / Hide 
Range on Protein: 338-368
Range on HMM: 317-347/347
Sequence Identity: 32% (10 aa)

RENFIDLLDHMLVYEPATRYTVEECLEHPFL
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RDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 94508.m00090.AA DYRK2 47-61 53 0.01328 3.91 In-house 1-15 (318) Show / Hide 
Range on Protein: 47-61
Range on HMM: 1-15/318
Sequence Identity: 53% (8 aa)

FRILDRLGNGTFGQV
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YEILEVIGKGSFGQV