89154.m00301

Species: T.vaginalis
Alias: 89154.m00301, TvagK0662
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
89154.m00301.AA Protein None 278 None Fasta, JSON
89154.m00301.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of 89154.m00301.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89154.m00301.AA DYRK 1-255 41 6.1e-104 351.62 In-house 38-320 (320) Show / Hide
Range on Protein: 1-255
Range on HMM: 38-320/320
Sequence Identity: 41% (117 aa)

MHEQGQIEAKILAKLNKS---NSPFIVRAYDFFIFRSHICITYEILGKNLYEISQANNYRPL-PVKLVRQYATEMLRGIEQCHRL-GIVHCDLKPENVLV
.| |.||| ||| .||.    ..  .|..||.|..| | ||. | |  ||||    |. ... ...|||..|  .| ..   |..  |.||||||||...
FHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML

CPD-NKVHCKLIDFGSSCFDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQG--KRKN
.   ||   |.|||||||| ... | ||||||||||||..| .|. . |.||.  |..||..|.|||||||| .||..| |||| |.  ....|  .||.
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKH

EFFDE-----------QLH----------LKQSRSVRKRIPGSLPLSRALKSNDPVYEDFIARCLTWDPIARTTATQLLQHPWL
.|||.           | .           . .|   .|.||. ..  ... .|  . ||| .||.|||  | |. | |||||.
KFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF

Kinase 89154.m00301.AA DYRK2 2-255 41 4.5e-101 329.45 In-house 39-318 (318) Show / Hide
Range on Protein: 2-255
Range on HMM: 39-318/318
Sequence Identity: 41% (115 aa)

HEQGQIEAKILAKL---NKSNSPFIVRAYDFFIFRSHICITYEILGKNLYEISQANNYRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPD
|.| ..| .|| ..   .| |.  .|.  |.|.|| |.||| | |. ||||    |..  . ..|||  |  .| ...  |.  |.||||||||.|    
HNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQW

NKVHCKLIDFGSSCFDGH-QKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQG-----KRKN
|.   |.||||||||.   . | |||||||||||| .| ||| . |.|||  |..||. |.|||||||| .|. .. |||| |.. .. .      .|..
NRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRK

EFFD----------------EQLHLKQSRSVRKRIPGSLPLSRALK-SNDPVYEDFIARCLTWDPIARTTATQLLQHPWL
 ||.                |.  ....|  ..|.||| ... .|| ..|. . ||| ||..|||  | |. | |.|||.
YFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI

Kinase 89154.m00301.AA CMGC 1-255 19 3.4e-83 273.07 In-house 51-513 (513) Show / Hide
Range on Protein: 1-255
Range on HMM: 51-513/513
Sequence Identity: 19% (91 aa)

MHEQGQ-------------IEAKILAKLNKS--------------NSPFIVRAYDFFIFRS-----------------HICITYEILGKNLYEISQANN-
..||..              | ||| .|||               . . ||. ||.| ..                  |...  | ....||.. . |. 
YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQF

-YRP------------------------LPVKLVRQYATEMLRGIE--QCHRLG--IVHCDLKPENVLVCPDNKV------------------HCKLIDF
 |..                        ... ..| |.  .|||..   ||. .  |.|.||||||.|.......                  . |..||
DYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF

GSSCFDGHQ------------------------KYEYIQSRFYRAPEVMIGVK----------YGPPMDIWSFALIVVELLLG--------KPLFPGENE
|.... ..                          ..|...|.|||||...| |          |..|.|.||.. |  |...|        ||||||..|
GLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSE

-----------LEQLTMIAEVLGNPNAGLVRQGK-------RKNEFF------------------------DEQLHLKQSRSVRKRIPGSLPLSRALKS-
           ..|| .| .|||.|.  . ..||       ...|..                        .|   .....  |.  .   |...  .  
YPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWH

----------------------------------NDPVYEDFIARCLTWDPIARTTATQLLQHPWL
                                   ||   |.. ..|..||  | || | ||||..
PNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF

Kinase 89154.m00301.AA YAK 4-195 40 3.8e-59 199.45 In-house 41-239 (347) Show / Hide
Range on Protein: 4-195
Range on HMM: 41-239/347
Sequence Identity: 40% (81 aa)

QGQIEAKILAKLNKSNSP-------FIVRAYDFFIFRSHICITYEILGKNLYEISQANNYRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVC
|.  |..||  ||.   |        |.| ||||... | |. .|.|  ||||    |... . . |.||. .  | |.       |.||||||||.. |
QAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLC

PDNKVHCKLIDFGSSCFDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQGKRKNEFF
  ||   |.|||||||      | |||.|.||.||..... |    | ||   ||.|| || |.|||  | .|.. | ..|| |   .. ||. || .|
KPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF

Kinase 89154.m00301.AA Pkinase 8-255 30 1.7e-53 188.87 Pfam 50-293 (293) Show / Hide
Range on Protein: 8-255
Range on HMM: 50-293/293
Sequence Identity: 30% (82 aa)

EAKILAKLNKSNSPFIVRAYDFFIFRSHICITYEILGK-----NLYEISQANNYRPL--PVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPDNK
|..|...||   .|.||| ||.|  ..||..  | ...      |... .. .....  . . .. |....|||.| ||. ||.|.||||||.|.   |.
EIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NN

VHC----KLIDFGSSCF---DGHQKYEYIQSRFYRAPEVMI-GVKYGPPMDIWSFALIVVELLLGKPLFPGE----NELEQLTMIAEVLGNPNAGLVRQG
 |.    |..|||....    ..  . .  ...|.||||   | .|||. |.||. .|. |.|.|.|.|||.    | ..|. ||....| |.     . 
GHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWW

KRKNEFFDEQLHLKQSRSVRKRIPGSLPLSRALKSNDPVYEDFIARCLTWDPIARTTATQLLQHPWL
 ..  ||  .                  ...  .  ..   ||| .||..||  | ||.|.|||||.
CSISYFF-FRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 89154.m00301.AA DYRK1 3-198 40 2.6e-53 183.42 In-house 40-240 (321) Show / Hide
Range on Protein: 3-198
Range on HMM: 40-240/321
Sequence Identity: 40% (81 aa)

EQGQIEAKILAKLNKSNSP---FIVRAYDFFIFRSHICITYEILGKNLYEISQANNYRPLPVKLVRQYATEMLRGI--EQCHRLGIVHCDLKPENVLVCP
.| ||| ..|  .||        ||.    |.|| |.|. .|.|  |||.. .  ..|   . |.|..|  |.. .       | |.||||||||.|.| 
NQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCN

DNKVHCKLIDFGSSCFDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQGKRKNEFFDE
  .   |.|||||||  |.  |.||||||||.|||..|..|   .|.||   |.||.  | ||| | ||..|.. | |||| | . .. |. .   .|. 
PKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK

Q
.
D

Kinase 89154.m00301.AA S_TKc 1-255 24 2.4e-51 177.84 SMART 18-231 (231) Show / Hide
Range on Protein: 1-255
Range on HMM: 18-231/231
Sequence Identity: 24% (70 aa)

MHEQG--------------QIEAKILAKLNKSNSPFIVRAYDFFIFRSHICITYEILGK---NLYEISQANNYRP----LPVKLVRQYATEMLRGIEQCH
 .. .              . | .|| |    . |.||. ||.|   .|...  | ..    .|... . .....    .|   .| |. ......| ||
CRHKKTGRIVAIKIIKEHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCH

RLGIVHCDLKPENVLVCPDNKVHCKLIDFGSSCFDGHQKYEYIQSRFYRAPEVMIGVKYGP-PMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLG
..||.|.||||||.|..     | |..|||....     . .. ...|.||||.   .||. . |.||.  |. |.| |.|.||      |. |. ...|
SHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG

NPNAGLVRQGKRKNEFFDEQLHLKQSRSVRKRIPGSLPLSRALKSNDPVYEDFIARCLTWDPIARTTATQLLQ-------HPWL
                                              .|   ||| .||..||  | || ..||       |||.
----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 89154.m00301.AA HIPK 4-204 36 6.8e-51 158.25 In-house 41-246 (329) Show / Hide
Range on Protein: 4-204
Range on HMM: 41-246/329
Sequence Identity: 36% (75 aa)

QGQIEAKILAKLNKSNSP--FIVRAYDFFIFRSHICITYEILGKNLYEISQANNYRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPDNKV
||||| .||..| . |.    .||||..|  ..|.|. .|.|  |||.    |.. |||.| .|      |. . .   ||..| ||||||..     . 
QGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRC

--HCKLIDFGS-SCFDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQGKRKNEFFDEQ
    | ||||| | .    .  |.|||.|||||...|...   .|.||   .. || || ||.|| .| .|   | .  . |.  |. .. .|. |||..
PYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD

LHLKQS
  .| .
KQSKFR

Kinase 89154.m00301.AA DyrkP 23-161 41 3.6e-33 106.09 In-house 63-205 (323) Show / Hide
Range on Protein: 23-161
Range on HMM: 63-205/323
Sequence Identity: 41% (60 aa)

IVRAYDFFIFRSHICITYEILGKNLYEISQAN----NYRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPDNKVHCKLIDFGSSCFDGHQK
..| ||.|  . |. |  |.|  ||||  . |      |   |  . .    .| ...  | | ..||||||||.|.    | . |.||||||||     
VLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHL

YEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLF
  |.||| ||||||.|| ||   .|.||   |. ||  |  ||
SSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF

Kinase 89154.m00301.AA CDKL 59-179 37 2.5e-30 100.9 In-house 95-218 (286) Show / Hide
Range on Protein: 59-179
Range on HMM: 95-218/286
Sequence Identity: 37% (47 aa)

LPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPDNKVHCKLIDFGSSCFDGHQK--Y-EYIQSRFYRAPEVMIG-VKYGPPMDIWSFALIVVEL
.. ..||.|    |..|..||   ..| | |||| |. | |..  || |||       .   | .|   | ||||| ..| ..||.| |||. . .. |.
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQ-VKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEM

LLGKPLFPGENELEQLTMIAEVLGN
. | ||.||.... || .|  .||.
IDGQPLWPGQSDIDQLYHIQKCLGP

Kinase 89154.m00301.AA CLK 102-255 30 1.1e-29 85.63 In-house 185-350 (350) Show / Hide
Range on Protein: 102-255
Range on HMM: 185-350/350
Sequence Identity: 30% (51 aa)

HCKLIDFGSSC---FDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLG--NPNAGLVRQG--KRKNEF
| ..|||||     ||   ... ...| ||||||  |  .  | |.||.. | .|| .|  ||.. ...| | |. ...|   |..   |    | | ..
HICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKY

F--DEQLHLKQSRSVRKRIPGSLPLSRALKSNDPVYE---DFIARCLTWDPIARTTATQLLQHPWL
|  .  .  ..... |. .    || . ....||  .   | | ..|  || .| |. . ||||. 
FYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF

Kinase 89154.m00301.AA PRP4 1-202 32 6.6e-28 99.04 In-house 39-246 (320) Show / Hide
Range on Protein: 1-202
Range on HMM: 39-246/320
Sequence Identity: 32% (68 aa)

MHEQGQIEAKILAKLNKS-----NSPFIVRAYDFFIFRSHICITYEILGKNLYE-ISQANNYRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVL
||  |  |  || |||           .|| .. | .| |.|. .| .  || | . .      | .| || ||  ..       ...|.| |.|| |.|
MHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL

VCPDNKVHCKLIDFGS-SCFDGHQKYEYIQSRFYRAPEVMIGVKYGPPMDIWSFALIVVELLLGKPLFPGENELEQLTMIAEVLGNPNAGLVRQGKRKNE
|  ....  |..|||| |         | .||||||||..||..|    |.|| .    ||  || .|||    . | .. .. |  .  ..| |. | .
VNESKNT-LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDN

FFDEQLHLK
.||. . ..
HFDQNCNFM

Kinase 89154.m00301.AA CLK 3-96 27 2.8e-23 66.0 In-house 41-148 (350) Show / Hide
Range on Protein: 3-96
Range on HMM: 41-148/350
Sequence Identity: 27% (30 aa)

EQGQIEAK-ILAKLNKS---NSPFI---VRAYDFFIF-RSHICITYEILGKNLYEISQANN------YRPLPVKLVRQYATEMLRGIEQCHRLGIVHCDL
|. ..| . |. |.|.    |. .    .. .| | .   ||||  |..|...|.   .||      |.|.|   .|. |   .. ..  | ....| ||
EAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDL

KPENVLVC
|||| . .
KPENICFV

Kinase 89154.m00301.AA DyrkP 221-255 42 1.4e-07 20.33 In-house 289-323 (323) Show / Hide
Range on Protein: 221-255
Range on HMM: 289-323/323
Sequence Identity: 42% (15 aa)

LKSNDPVYEDFIARCLTWDPIARTTATQLLQHPWL
|. .| .. ||. .||  |   | ||   |||||.
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF

Kinase 89154.m00301.AA TyrKc 1-255 16 1.4e-05 -132.24 SMART 1-280 (280) Show / Hide
Range on Protein: 1-255
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

MHEQGQI--------------------------------EAKILAKL--NKSNSPFIVRAYDFFIFR-------SHICITYEILGK-NLYEISQANNYRP
 .   ..                                ||.|. ||  .    | ||| |   .           ..|  |   . .| .  ...  . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LPVKLVRQYATEMLRGIEQCHRLGIVHCDLKPENVLVCPDNKVHCKLIDFGSSCFDGHQ-------KYEYI----QSR-----FYRAPEVMIGVKYGPPM
|..|   ....   .| |  |. ...| ||   |.||  ..  ..|  ||| | . ..        .|       ...        |||..   |. .  
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSFALIVVELL-LGKPLFPGE-------NELEQLTMIAEVLGNPNA----GLVRQGKRKNEFFDEQLHLKQSRSVRKRIPGSLPLSRALKSNDPVYED
|.|||     |.. .|..  ||.        |. .. .  . .  |                                         .      | .|. 
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F--VCCPDEMYQ-

FIARCLTWDPIARTTATQLLQHPWL
 . .|   ||  | | ...  |  .
IMKQCWHEDPEDRPTFSEI--HECF

Kinase 89154.m00301.AA PRP4 230-255 38 1.5e-05 16.39 In-house 295-320 (320) Show / Hide
Range on Protein: 230-255
Range on HMM: 295-320/320
Sequence Identity: 38% (10 aa)

DFIARCLTWDPIARTTATQLLQHPWL
|.. .||  ||  |.|  . |.|| .
DLLDKCLMLDPKKRITCNEALKHPFI

Kinase 89154.m00301.AA CDKL 230-255 46 1.7e-05 14.75 In-house 261-286 (286) Show / Hide
Range on Protein: 230-255
Range on HMM: 261-286/286
Sequence Identity: 46% (12 aa)

DFIARCLTWDPIARTTATQLLQHPWL
||.  ||  ||  |.|..||..||  
DFMKKCLHMDPDERMTCEQLMHHPYF

Kinase 89154.m00301.AA DYRK1 228-255 39 0.000277 10.39 In-house 294-321 (321) Show / Hide
Range on Protein: 228-255
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

YEDFIARCLTWDPIARTTATQLLQHPWL
..| | | | .|| .| |  . |||...
FKDLIKRMLQYDPKQRITPYYALQHSFF

Kinase 89154.m00301.AA YAK 230-255 38 0.003593 6.18 In-house 322-347 (347) Show / Hide
Range on Protein: 230-255
Range on HMM: 322-347/347
Sequence Identity: 38% (10 aa)

DFIARCLTWDPIARTTATQLLQHPWL
|||   |  .|  | .. |  ||| .
DFINQLLQLNPRERWKPMQAMQHPFI