Gene 96693.m00072 (T.vaginalis)
96693.m00072
Species: T.vaginalis
Alias: TvagK0868, 96693.m00072
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 96693.m00072.AA | Protein | None | 318 | None | Fasta, JSON |
| 96693.m00072.kin_dom | Protein Kinase Domain | None | 216 | None | Fasta, JSON |
Protein domains of 96693.m00072.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 96693.m00072.AA | WNK | 65-157 | 40 | 1.5e-20 | 63.0 | In-house | 54-148 (261) | Show / Hide |
Range on Protein: 65-157 Range on HMM: 54-148/261 Sequence Identity: 40% (39 aa) QIKHPNLLQISRAWLDS--ARKTFVYVTEVFSRKTLRNYLTELTTRPATSVISKWCIQILNGLMALHNAVP-PIIHNDLTCNNIYIDVNTGIIKIG ...||| ... | . .| | ||| ||. || | .|| |||.|| || .| |||| || | ||.| || .||| KLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMKPK-VLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIG |
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| Kinase | 96693.m00072.AA | NRBP | 18-157 | 27 | 2.3e-15 | 50.2 | In-house | 2-147 (261) | Show / Hide |
Range on Protein: 18-157 Range on HMM: 2-147/261 Sequence Identity: 27% (41 aa) RQKINRTTVYKCLDQEESSPADWYEISIENMPPESLSSLKV--FMTSFSQIKHPNLLQISRAWLDS--ARKTFVYVTEVFSRKTLRNYLTELTTRPATSV |. ..| .|.|| | |. . . |. |..|.|. .. . |.|. .. ...|| | .. .| . RDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNMN IS---KWCIQILNGLMALHNAVPPIIHNDLTCNNIYIDVNTGIIKIG . .|| ||| | || . ||||| |||. |.| | |.|||| EKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHN-GLIKIG |
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| Kinase | 96693.m00072.AA | STE | 185-258 | 22 | 1.3e-11 | 37.34 | In-house | 248-359 (359) | Show / Hide |
Range on Protein: 185-258 Range on HMM: 248-359/359 Sequence Identity: 22% (25 aa) RSDVWSLGLCVIEMATGEQPYSDKPSPKDSILKG-----------------ESPSSVGQVSD------------------PSVADFITCCL-LPVDMRPS ..|.||||...||||||. |..| . .. .. ..|. .|. |. ||| || . ||. KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT TQALFE--YTLI .. | . | ASQLLKSEHPFI |
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| Kinase | 96693.m00072.AA | Ciliate-E3 | 63-157 | 30 | 1.7e-10 | 29.23 | In-house | 56-148 (202) | Show / Hide |
Range on Protein: 63-157 Range on HMM: 56-148/202 Sequence Identity: 30% (30 aa) FSQIKHPNLLQISRAWLDSARKTFVYVTEVFSRKTLRNYLTELTTRPATSVISKWCIQILNGLMALHNAVPPIIHNDLTCNNIYIDVNTG--IIKIG ..||.. |.... . .| | | |. |. | .|. .. | . ||||. |..|.| ||| |. || .| | . ||||. CQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK--TQNIIYDICIQIIQGMIAIHEKN--IIHSDIKPDNILVDKNNNQLIIKIC |
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| S_TKc | 96693.m00072.AA | S_TKc | 12-258 | 17 | 2.2e-10 | -24.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-258 Range on HMM: 1-231/231 Sequence Identity: 17% (49 aa) YLR------------CEVRQKI-NRTTVYKCLDQEESSPADWYEISIENMPPESLSSLKVFMTSFSQIKHPNLLQISRAWLDSARKTFVYVTEVFSR--K | . .| | .| |... .. ... . .|||. .. .. | . . |.| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLG TLRNYLTELTTRP-----ATSVISKWCIQILNGLMALHNAVPPIIHNDLTCNNIYIDVNTGIIKIG-------IPSFEAVLFNWISPVAPIEVQKGLAEP .|. |. . ... .. ... ||...| .|. ||| || || .| |||. . . . ....| || | . DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAP----EVL-GYGKC RSDVWSLGLCVIEMATGEQPYSDKPSPKDSILKGESPSSVGQVSDPSVADFITCCLL-PVDMRPSTQALFE-------YTLI ..|.||.| ...||..|. |.. . ..| .|.. ||| || . ||. ... . KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 96693.m00072.AA | MEK3 | 185-205 | 66 | 3.9e-08 | 23.74 | In-house | 186-206 (264) | Show / Hide |
Range on Protein: 185-205 Range on HMM: 186-206/264 Sequence Identity: 66% (14 aa) RSDVWSLGLCVIEMATGEQPY .||||||| .||||.| || KSDVWSLGITMIEMAIGRYPY |
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| Kinase | 96693.m00072.AA | STE20 | 185-209 | 57 | 4.7e-08 | 25.83 | In-house | 207-232 (288) | Show / Hide |
Range on Protein: 185-209 Range on HMM: 207-232/288 Sequence Identity: 57% (15 aa) RSDVWSLGLCVIEMATGEQPYSD-KP ..|.|||| . ||||.|| ||.| | KCDIWSLGITAIEMAEGEPPYFDMHP |
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| Kinase | 96693.m00072.AA | SLK | 185-258 | 31 | 1.9e-07 | 21.07 | In-house | 182-259 (259) | Show / Hide |
Range on Protein: 185-258 Range on HMM: 182-259/259 Sequence Identity: 31% (25 aa) RSDVWSLGLCVIEMATGEQPYSDKPSPKDSILK--GESPSSVGQVSDPSV--ADFITCCLL-PVDMRPSTQALFEYTLI ..|.||||. .|||| .| |... .| .|| | . | | |. ||.. || .. |..|. |... . KADIWSLGITLIEMAQMEPPHHEM-NPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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| Kinase | 96693.m00072.AA | WNK | 187-258 | 31 | 2e-07 | 19.96 | In-house | 186-261 (261) | Show / Hide |
Range on Protein: 187-258 Range on HMM: 186-261/261 Sequence Identity: 31% (24 aa) DVWSLGLCVIEMATGEQPYSDKPSPKD---SILKGESPSSVGQVSDPSVADFITCCLLPVD-MRPSTQALFEYTLI || . | |. ||||.| ||| .. . | | | . .|.| ..| |. ||| | | . . DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF |
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| TyrKc | 96693.m00072.AA | TyrKc | 13-258 | 16 | 5e-06 | -125.5 | SMART | 16-280 (280) | Show / Hide |
Range on Protein: 13-258 Range on HMM: 16-280/280 Sequence Identity: 16% (47 aa) LRCEVRQKINRTTVYKCLDQEESSPADWYEISIENMPPESLSSLKVFMTSFSQI--KHPNLLQISRAWLDSAR-----KTFVYVTEVFSRKTLRNYLTEL ... . .. |.| . . . . ... .|||.... . ... | . |.| . |..|| . YKGTWK----IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH TTRPATSVISKWCIQILNGLMALHNAVPPIIHNDLTCNNIYIDVNTGIIKIG-------IPSF-------EAVLF----NWI--SPVA--PIEVQ-KGLA . .. ..|.|| .| || ..|| || . |. .. | ..||. | . . . |. ..|. .| RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF EPRSDVWSLGLCVIEMAT-GEQPYSD----KPSPKD---SILKGESPSSVGQV-------SDPSVADFITCCLLP-VDMRPSTQALFEYTLI . ||||| | | |. | |.|||.. . |... . .|. . . . . . ...| ..||. ... . .. TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 96693.m00072.AA | ASK | 187-258 | 25 | 5e-06 | 15.96 | In-house | 179-254 (254) | Show / Hide |
Range on Protein: 187-258 Range on HMM: 179-254/254 Sequence Identity: 25% (19 aa) DVWSLGLCVIEMATGEQPYSDKPSPKDSILK----GESPSSVGQVSDPSVADFITCCLLPVDMRPSTQALFEYTLI |.||.| ..||||| |. . .|. . | . | ..|. . . | .. |.|.| | . . DIWSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL |
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| Kinase | 96693.m00072.AA | TKL-Unique | 186-207 | 35 | 1.4e-05 | 15.81 | In-house | 209-236 (290) | Show / Hide |
Range on Protein: 186-207 Range on HMM: 209-236/290 Sequence Identity: 35% (10 aa) SDVWSLGLCVIEMATGEQ------PYSD |||.| | ...|.||... ||.. SDVYSFGIVLWEIATRKITKTYKKPYQG |
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| Kinase | 96693.m00072.AA | Pkinase | 184-240 | 19 | 3e-05 | 19.65 | Pfam | 191-274 (293) | Show / Hide |
Range on Protein: 184-240 Range on HMM: 191-274/293 Sequence Identity: 19% (16 aa) PRSDVWSLGLCVIEMATGEQPYS--------DKPSPKDSILKGESPSSVGQVSD-------------------PSVADFITCCL |..|.||.|. ..||..|. |.. |. . |.... ... . .. .. |||..|| PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL |
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| Kinase | 96693.m00072.AA | TKL | 173-207 | 25 | 4.9e-05 | 14.09 | In-house | 258-291 (364) | Show / Hide |
Range on Protein: 173-207 Range on HMM: 258-291/364 Sequence Identity: 25% (9 aa) APIEVQKGLAEPRSDVWSLGLCVIEMATGEQPYSD .. . ... . ...||.| |.. |..|...||.| DE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD |
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| Kinase | 96693.m00072.AA | TKL | 97-157 | 26 | 5.6e-05 | 13.89 | In-house | 124-196 (364) | Show / Hide |
Range on Protein: 97-157 Range on HMM: 124-196/364 Sequence Identity: 26% (21 aa) TLRNYLTELTTRPATSVISKWCIQILNGLMALHNAV------PPIIHNDLTCNNIYIDVN-------------TGIIKIG .|..||. ... .|...| |. ||. ||||| ||. .|| .| | .. .||. SLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC |
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| Kinase | 96693.m00072.AA | TKL-Unique | 89-148 | 27 | 8.1e-05 | 13.12 | In-house | 78-146 (290) | Show / Hide |
Range on Protein: 89-148 Range on HMM: 78-146/290 Sequence Identity: 27% (19 aa) VTEVFSRKTLRNYLT---------ELTTRPATSVISKWCIQILNGLMALHNAVPPIIHNDLTCNNIYID |.| ... .|...|. . . . ... | |.| |. ||. ||||| ||. |...| VMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVD |
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| Kinase | 96693.m00072.AA | NRBP | 187-259 | 25 | 0.000339 | 10.3 | In-house | 188-261 (261) | Show / Hide |
Range on Protein: 187-259 Range on HMM: 188-261/261 Sequence Identity: 25% (19 aa) DVWSLGLCVIEMATGEQPYSDKPSPKDSILKGESPSSVGQVSDPSVADFITCCLLP-VDMRPSTQALFEYTLIS |..| |.| .||| | . . . . . . ... ..|| ||| .|| . ||| . | . .. DIYSFGMCALEMAVLEIQSGCQNGESEYVTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF |
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| Kinase | 96693.m00072.AA | Pkinase_Tyr | 186-213 | 46 | 0.000475 | 14.34 | Pfam | 195-223 (270) | Show / Hide |
Range on Protein: 186-213 Range on HMM: 195-223/270 Sequence Identity: 46% (14 aa) SDVWSLGLCVIEMAT-GEQP-YSDKPSPKD ||||| | . |. | |||| | . |. . SDVWSFGVLMWEIFTYGEQPTYPGM-SNEE |
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| Kinase | 96693.m00072.AA | ASK | 120-156 | 37 | 0.001047 | 7.99 | In-house | 102-136 (254) | Show / Hide |
Range on Protein: 120-156 Range on HMM: 102-136/254 Sequence Identity: 37% (14 aa) QILNGLMALHNAVPPIIHNDLTCNNIYIDVNTGIIKI |||.|| ||. |.| |. |. . |..|| QILEGLKYLHENQ--IVHRDIKGDNVLVNTYSGVVKI |
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| Kinase | 96693.m00072.AA | SLK | 26-153 | 24 | 0.01369 | 4.42 | In-house | 15-136 (259) | Show / Hide |
Range on Protein: 26-153 Range on HMM: 15-136/259 Sequence Identity: 24% (31 aa) VYKCLDQEESSPADWYEISIENMPPESLSSLKVFMTSFSQIKHPNLLQISRAWLDSARKTFVYVTEVFSRKTLRNYLTELTTRPATSVISKWCIQILNGL ||| ..|.. | | |.. | |. | . |..||||.... |. . . . | . | . || . | | .....| VYKAQHKEQKVFAAAKMIEIKDE--EELEDYMVEIDILSECKHPNIVKLYEAY--YYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEAL MALHNAVPPIIHNDLTCNNIYIDVNTGI ||. .|| || || . .. .. NWLHSNK--VIHRDLKAGNILMTMDGDV |
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| Kinase | 96693.m00072.AA | Pkinase | 67-157 | 29 | 9.640923 | 0.17 | Pfam | 58-154 (293) | Show / Hide |
Range on Protein: 67-157 Range on HMM: 58-154/293 Sequence Identity: 29% (30 aa) KHPNLLQISRAWLDSARKTFVY-VTEVFSRK----TLRNYLT-ELTTRP--ATSVISKWCIQILNGLMALHNAVPPIIHNDLTCNNIYIDVNTGII---- .||| ... ... | |. .| |.| | |.. . .. .. ... ||| || .|. ||| || || || |.| | NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACV KIG ||. KIC |
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